RNA Processing and Decay Professors and Supervisors | ApplySharif

جست‌وجوی استاد و پژوهشگر

استاد راهنما، استاد دانشگاه یا پژوهشگر مناسب برای مسیر پژوهشی‌تان را پیدا کنید و با او ارتباط بگیرید.

نمایش ۱-۱۵ از ۲۰۱ استاد راهنما

اطلاعات این پروفایل‌ها از صفحات عمومی دانشگاه‌ها جمع‌آوری شده و ممکن است به‌روز نباشد.

Waldemar Kolanusمشاهده پروفایل

استاد

Rhenish Friedrich Wilhelm University of BonnGermany

Prof. Waldemar Kolanus leads the Molecular Immunology and Cell Biology department at the University of Bonn's Life & Medical Sciences Institute (LIMES) . His research bridges immunoregulation , stem cell dynamics , and metabolic stress responses in immune cells. Unit 2 member at LIMES Principal investigator in SFB 704 and ImmunoSensation Cluster Leads a multidisciplinary lab with postdocs, PhD students, and technical staff His work focuses on intracellular signaling pathways connecting immune activation to tissue homeostasis, particularly through: Cytohesin proteins in integrin-mediated adhesion and migration TRIM71 in stem cell regulation and congenital hydrocephalus High-salt environments affecting macrophage function Publication trends show expertise in immune cell migration , genetic models , and chemical inhibition , with frequent use of mice and zebrafish for in vivo studies. Key articles explore: TRIM71's dual role in auditory development and germ cell maintenance Cytohesin family's Golgi regulation and insulin signaling Ruxolitinib's off-target migration inhibition of dendritic cells Contact details: Address: LIMES Institute, Carl-Troll-Straße 31, Bonn Email: kolanus.sekretariat@uni-bonn.de Phone: +49 228 73-62788

پروفایل رسمی دانشگاه

Jens S. Andersenمشاهده پروفایل

استاد

University of Southern DenmarkDenmark

Jens S. Andersen is a Professor in the Department of Biochemistry and Molecular Biology at the University of Southern Denmark, where he leads research in Biomedical Mass Spectrometry and Systems Biology. His work is centered on the development and application of quantitative mass spectrometry and microscopy-based proteomics to study human cell biology, particularly the structure and function of organelles such as centrosomes, cilia, autophagosomes, and mitochondria. His research focuses on determining the protein composition and dynamic properties of cellular organelles, the roles of specific protein groups, and their contributions to biological processes and diseases. He investigates cell signaling mediated by post-translational modifications, especially within the DNA damage response, autophagy, and immune systems. His lab, the Jens S. Andersen Lab, is part of the Research Section of Biomedical Mass Spectrometry. The analysis of his recent publications reveals a strong interdisciplinary trend combining proteomics, structural biology, and cell signaling. His work spans cilia biology, RNA metabolism, DNA repair, and cancer mechanisms, with frequent use of advanced techniques like mass spectrometry, CRISPR, and live-cell imaging. The integration of systems biology approaches is evident across his research outputs. Professor, Department of Biochemistry and Molecular Biology, University of Southern Denmark Head of Research, Biomedical Mass Spectrometry and Systems Biology Principal Investigator, Jens S. Andersen Lab ORCID: 0000-0002-6091-140X While no specific scientific awards are mentioned in the provided texts, his extensive publication record in high-impact journals such as Science , Nature Communications , Molecular Cell , and EMBO Journal reflects significant scholarly contributions. He has supervised research projects and collaborated widely across Europe, though specific names of students are not listed. His research is supported by multiple ongoing projects, reflecting sustained funding and academic leadership. The Jens S. Andersen Lab operates at the intersection of proteomics and cell biology, contributing to fundamental understanding of organelle dynamics and disease mechanisms. The lab's work is highly collaborative, involving partnerships with groups in structural biology, RNA research, and cancer biology.

پروفایل رسمی دانشگاه

Jianhua Xingمشاهده پروفایل

دانشیار

University of PittsburghUnited States

Jianhua Xing is an Associate Professor in the Department of Physics & Astronomy at the University of Pittsburgh , affiliated with the Dietrich School of Arts and Sciences . His research focuses on applying physics-based approaches to study biological systems, particularly cell phenotypic transitions (CPTs) and their underlying dynamics. He integrates quantitative single-cell measurements with computational and theoretical analyses to understand how cells transition between stable states. Key research areas include: Nonequilibrium systems and rate theories for biological transitions Single-cell trajectory analysis and live-cell imaging Epithelial-mesenchymal transition (EMT) dynamics Gene regulatory networks and stochastic processes Biological applications of dynamical systems theory Recent work highlights the coupling between EMT and cell cycle arrest, leveraging machine learning frameworks (e.g., LivecellX ) for high-resolution imaging analysis. His lab also explores chromosomal dynamics and mechanotransduction in stem cell aging. Publications emphasize data-driven modeling and theoretical insights, with contributions to frameworks like GraphVelo and Graph-Dynamo for inferring cellular state transitions. Collaborative efforts bridge physics, biology, and computational science to address fundamental biological questions. No awards or grants are explicitly listed in the provided texts. His research group focuses on advancing systems biology through interdisciplinary methods, with a lab dedicated to quantitative analysis of cellular processes.

پروفایل رسمی دانشگاه

Miler T. Leeمشاهده پروفایل

دانشیار

University of PittsburghUnited States

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

پروفایل رسمی دانشگاه

Guillaume Chanfreauمشاهده پروفایل

استاد

University of California, Los AngelesUnited States

Guillaume Chanfreau is a Professor in the Department of Chemistry and Biochemistry within the College of Letters and Science at the University of California Los Angeles (UCLA). His research focuses on fundamental mechanisms of RNA metabolism, with particular emphasis on RNA splicing, decay pathways, and ribonuclease functions. His work spans molecular biology, biochemistry, and genetics, utilizing yeast as a primary model organism to investigate conserved RNA processing mechanisms. Professor Chanfreau's research interests center on understanding how RNA processing pathways regulate gene expression. His work examines transcription termination, RNA splicing fidelity, RNA decay mechanisms, and the role of ribonucleases in cellular RNA homeostasis. He investigates how these processes are interconnected and how they respond to cellular stress conditions. His laboratory has made significant contributions to understanding how RNA quality control mechanisms prevent the accumulation of aberrant transcripts and maintain cellular health. Analysis of Chanfreau's recent publications (2020-2025) reveals a strong focus on RNA splicing mechanisms, RNA decay pathways, and ribonuclease functions. His work frequently employs yeast genetics combined with advanced RNA sequencing techniques. A notable trend is the increasing use of long-read sequencing technologies to analyze RNA isoforms and decay intermediates. His research consistently bridges fundamental molecular mechanisms with potential implications for understanding human diseases related to RNA processing defects. Professor Chanfreau has been continuously funded by the National Institutes of Health, with his current grant R35GM130370 (2019-2023) titled 'The Control of Gene Expression by Eukaryotic Ribonucleases' and previous long-term funding through R01GM061518 (2000-2019). His research program has supported numerous graduate students and postdoctoral researchers who have contributed to his extensive publication record spanning over two decades.

پروفایل رسمی دانشگاه

Christopher D. Limaمشاهده پروفایل

استاد

Memorial Sloan Kettering Cancer CenterUnited States

Christopher D. Lima is a Professor and Chair of the Structural Biology Program at the Sloan Kettering Institute (SKI), Memorial Sloan Kettering Cancer Center (MSKCC), and an Investigator of the Howard Hughes Medical Institute. He holds the Alfred P. Sloan Chair. His research focuses on understanding the structural, biochemical, and functional mechanisms of macromolecules involved in post-translational protein modification by ubiquitin-like proteins (e.g., SUMO) and RNA processing pathways, including co- and post-transcriptional RNA maturation and decay. His lab employs cryo-electron microscopy (cryo-EM), X-ray crystallography, and biochemical reconstitution to study these processes. Education: PhD, 1994, Northwestern University BA, 1989, The Ohio State University Research Interests: Structural basis of ubiquitin and SUMO conjugation pathways Mechanisms of RNA surveillance and decay by the nuclear exosome Role of RNA processing in cell cycle control and disease Interactions between RNA helicases and exosome complexes Awards & Honors: Member, National Academy of Sciences (2020) Fellow of the American Academy of Arts and Sciences (2017) HHMI Investigator (2013) Louise and Allston Boyer Young Investigator (2006) Advising & Grants: Lima mentors numerous graduate students and postdoctoral researchers. His lab has received funding from the NIH, HHMI, and other institutions to support research into RNA processing and ubiquitin pathways. He collaborates widely, including with teams at MSKCC and other academic institutions. Labs & Teams: The Lima Lab is part of the Tri-Institutional PhD Program in Chemical Biology and the Gerstner Sloan Kettering Graduate School. The lab has made groundbreaking contributions to understanding SUMOylation and RNA exosome mechanisms, with key findings published in Nature , Cell , and Science .

پروفایل رسمی دانشگاه

Michal Bassani-Sternbergمشاهده پروفایل

استادیار

University of LausanneSwitzerland

Michal Bassani-Sternberg is an Assistant Professor on conditional pre-tenure at the Faculty of Biology and Medicine, University of Lausanne (UNIL), and an Assistant Member at the Ludwig Institute for Cancer Research, Lausanne. She leads the Antigen Discovery Group and the Immunopeptidomics Unit at the Center for Experimental Therapies, Department of Oncology, UNIL-CHUV. Her work bridges proteogenomics, mass spectrometry, and computational biology to advance personalized cancer immunotherapy. Her educational background includes a Bachelor, Master, and Doctorate in Biology from the Technion – Israel Institute of Technology, Haifa, all earned with Cum Laude distinction. She completed postdoctoral training at the Technion and the Max Planck Institute for Biochemistry, Germany, in the group of Prof. Matthias Mann. Dr. Bassani-Sternberg's research focuses on identifying cancer-specific Human Leukocyte Antigen (HLA) ligands to guide the development of personalized immunotherapies. Her group develops cutting-edge proteogenomic and mass spectrometry-based immunopeptidomics approaches to discover tumor-associated antigens, neoantigens, and non-canonical peptides. A key contribution is the development of NeoDisc, a continuous bioinformatics pipeline that integrates genomics, transcriptomics, and immunopeptidomics data for direct neoantigen identification in clinical trials. Her recent publications, appearing in high-impact journals such as Nature , Nature Biotechnology , Immunity , and Nature Cancer , reflect a strong trend in integrating multi-omics data to understand tumor immunogenicity, T cell responses, and antigen presentation dynamics. Her work increasingly incorporates machine learning to improve neoantigen prediction and TCR specificity inference. She has been recognized with the Pfizer Research Prize in 2021 for her contributions to immuno-oncology. Pfizer Research Prize (2021) Dr. Bassani-Sternberg leads an active research group involved in phase I clinical trials for personalized cancer vaccines and adoptive T cell therapies. Her lab is supported by major grants from the Swiss Cancer League, Swiss National Science Foundation, and ISREC Foundation. She mentors doctoral and postdoctoral researchers and collaborates extensively within the Lausanne immuno-oncology ecosystem, including CHUV and Ludwig Lausanne. Her lab, the Bassani-Sternberg Lab, is part of the Department of Oncology’s research platforms and focuses on immunopeptidomics, antigen discovery, and the development of analytical tools for personalized immunotherapy.

پروفایل رسمی دانشگاه

Susanne Bornelövمشاهده پروفایل

استاد

University of CambridgeUnited Kingdom

Susanne Bornelöv is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on computational genomics and gene regulation, particularly exploring posttranscriptional mechanisms such as codon optimality-mediated mRNA decay and transposon silencing. She uses computational methods, ribosome profiling, and Drosophila models to study how codon usage, tRNA availability, and RNA modifications influence gene regulation and genome evolution. Her work integrates artificial intelligence (AI) and comparative genomics to model gene regulatory processes and design novel regulatory elements. Key research areas include piRNA clusters' roles in suppressing retroviruses, codon usage bias in pluripotent stem cells, and the interplay between mRNA methylation and protein synthesis. The Bornelöv Group collaborates widely, including with institutions like Cold Spring Harbor Laboratory, to advance understanding of fundamental gene expression principles. Publications highlight contributions to topics like deep learning in genomics, evolutionary conserved piRNA mechanisms, and transcriptional regulation. She leads a group open to interns, students, and researchers, fostering interdisciplinary approaches to address complex biological questions.

پروفایل رسمی دانشگاه

Debra Lynn Silverمشاهده پروفایل

استاد

Duke UniversityUnited States

Debra Lynn Silver is a Professor at Duke University in the Departments of Molecular Genetics and Microbiology, Cell Biology, and Neurobiology. She is affiliated with the Duke Regeneration Center, Duke Initiative for Science & Society, Duke Cancer Institute, and Duke Institute for Brain Sciences. Education: Ph.D., Johns Hopkins University (2003) Postdoctoral Fellowship, National Institutes of Health (2003-2010) B.S., Tufts University (1993) Her research focuses on developmental neurobiology , RNA biology , and human cortical evolution , exploring genetic mechanisms in neurodevelopmental disorders and brain evolution. Recent studies investigate DDX3X mutations in autism, EIF4A3 in neurogenesis, and human-specific enhancers regulating cortical development. Publications highlight her work on mRNA stability, RNA-binding proteins, and species-specific neurodevelopmental features. Grants include NIH funding for DDX3X pathology and cortical RNA localization studies (2018-present).

پروفایل رسمی دانشگاه

Heike Krebberمشاهده پروفایل

استاد

University of GöttingenGermany

Prof. Heike Krebber is a Professor for Molecular Genetics at Georg-August University Göttingen, Germany. Her research focuses on mRNA quality control and non-coding RNA functions, using the model organism Saccharomyces cerevisiae. She has held positions at the DKFZ (Heidelberg), Harvard Medical School, and Philipps-Universität Marburg. Her work addresses how mRNA processing defects contribute to diseases like cancer and neurodegeneration. Education & Positions: PhD (1996), Deutsches Krebsforschungszentrum Heisenberg Fellow (2006) Habilitation in Molecular Biology (2005) Professor since 2010 at Georg-August University Research Interests: Her lab investigates: RNA quality control mechanisms ensuring proper mRNA maturation and export Functions of non-coding RNAs (e.g., lncRNAs in iron metabolism and telomerase) Ribosome assembly and translation termination pathways Stress-induced bypass of mRNA quality control Awards: Heisenberg Fellowship (2006) Grants & Teams: Leads the Molecular Genetics group at the Institute for Microbiology and Genetics. Collaborates with the IMPRS Molecular Biology and GZMB (Molecular Biology of Cells) programs. Labs & Affiliations: Her group is part of the GGNB network, focusing on Microbiology and Biochemistry. The lab’s work spans fundamental molecular mechanisms with translational disease relevance.

پروفایل رسمی دانشگاه

Patricia J. Hillerenمشاهده پروفایل

دانشیار

Skidmore CollegeUnited States

Patricia J. Hilleren is an Associate Professor of Biology and current Department Chair at Skidmore College , Saratoga Springs, NY. Her research focuses on nuclear mRNA quality control systems and gene expression accuracy in eukaryotic cells, using Saccharomyces cerevisiae as a model organism. She earned her PhD in Biochemistry, Molecular Biology, and Biophysics from the University of Minnesota (1997) and completed postdoctoral research at the Howard Hughes Medical Institute, University of Arizona (1997-2003). Education: B.S., Microbiology (1987), St. Cloud State University Ph.D., Biochemistry, Molecular Biology, and Biophysics (1997), University of Minnesota Postdoctoral Research (1997-2003), Howard Hughes Medical Institute, University of Arizona Courses Taught: Liberal Sciences I Molecular Cell Biology (BI 242) Chromatin Structure, Maintenance and Function (BI 360) mRNA Synthesis, Processing, and Turnover (BI 363) Research Interests: Hilleren investigates nuclear quality control systems that ensure accurate gene expression, focusing on how defective pre-mRNAs are recognized, retained at transcription sites, and removed in eukaryotic cells. Her work addresses fundamental cellular mechanisms through yeast genetics and molecular biology approaches. Publication Trends: Her research spans RNA biology, gene expression regulation, and mRNA surveillance systems. Key themes include nuclear RNA processing errors, cytoplasmic degradation pathways, and molecular mechanisms of mRNA quality control in Saccharomyces cerevisiae . Contact: Office: Biology Department - CIS 210A Phone: (518) 580-8301 Email: phillere@skidmore.edu Office Hours: Tuesdays 10:30am-12noon, Thursdays 2:15pm-3:30pm

پروفایل رسمی دانشگاه

Christopher D. Limaمشاهده پروفایل

استاد

Cornell UniversityUnited States

Structural Biology
Ubiquitin and Ubiquitin-like Protein Pathways
RNA Processing and Decay
+۶ مورد دیگر

Christopher D. Lima is a Professor and Chair of the Structural Biology Program at the Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, and an Investigator at the Howard Hughes Medical Institute. He holds academic appointments at Weill Cornell Graduate School of Medical Sciences and is affiliated with the Tri-Institutional PhD Program in Chemical Biology. His research focuses on structural and biochemical mechanisms of ubiquitin and ubiquitin-like protein pathways and RNA quality control. PhD, Northwestern University Postdoctoral Training, Columbia University (Helen Hay Whitney Fellow) Dr. Lima’s research investigates the structural basis of post-translational modifications, particularly ubiquitination and SUMOylation, and RNA processing pathways. His lab combines cryo-EM, X-ray crystallography, and biochemistry to study enzyme mechanisms in ubiquitin activation and RNA exosome function. His work has elucidated key intermediates in E1 enzyme catalysis and the architecture of RNA surveillance complexes. These insights are fundamental to understanding cellular quality control and have implications for cancer and neurodegenerative diseases. His recent publications, including high-impact studies in Nature and Cell , reflect a consistent focus on macromolecular structure-function relationships in ubiquitin signaling and RNA metabolism. Trends in his publications show a deepening exploration of enzyme dynamics, conformational changes, and the development of chemical tools to probe these pathways. National Academy of Sciences (2020) American Academy of Arts and Sciences (2017) Howard Hughes Medical Institute Investigator (2013) Rita Allen Scholar (2003–2006) Beckman Young Investigator (1999–2002) Dr. Lima has advised numerous PhD students and postdoctoral fellows and has received continuous funding from the NIH and HHMI. His lab is actively involved in training and mentoring within the Tri-Institutional programs. He leads a multidisciplinary research team focused on structural mechanisms in cellular regulation and is engaged in collaborative and translational research, with disclosed interests in biotechnology companies such as Biogen and Vertex Pharmaceuticals. He is a member of the Structural Biology Program at SKI and leads a vibrant research laboratory that bridges basic science and disease mechanisms. His lab fosters innovation in structural biology and continues to make foundational contributions to the understanding of protein and RNA quality control pathways.

پروفایل رسمی دانشگاه

John S. Kaddisمشاهده پروفایل

دانشیار

Beckman Research Institute of City of HopeUnited States

John S. Kaddis, Ph.D. is an Associate Professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope. With over 15 years of experience at City of Hope, Dr. Kaddis has developed scientific resources for team-based research initiatives focused on type 1 diabetes, creating data systems, analysis tools, and websites used by researchers worldwide. Dr. Kaddis earned his B.S. (Honors) in Biochemistry from California State University Los Angeles, where he completed undergraduate research supported by two National Science Foundation fellowships. He later earned his Ph.D. in Systems Biology and Disease from the University of Southern California. His academic journey includes positions as Assistant Professor since 2015 and Associate Professor since 2022 at City of Hope. Dr. Kaddis's research primarily focuses on the complex mechanisms of type 1 diabetes through systems biology and bioinformatics approaches. His work centers on understanding islet cell biology, beta cell dysfunction, and the immunological aspects of type 1 diabetes. His research has evolved from developing collaborative data resources to conducting cutting-edge investigations into genetic factors in diabetes pathogenesis. He has pioneered the creation of bioinformatics platforms that enable global collaboration in diabetes research. The trends in Dr. Kaddis's publications reveal a progression from foundational work on biobanking and data management toward increasingly sophisticated investigations of genetic and immunological mechanisms in type 1 diabetes. His recent work emphasizes translational applications, including potential therapeutic strategies and predictive models that span diverse ancestral backgrounds. His research bridges basic science with clinical applications through the Human Islet Research Network. Member, American Association for the Advancement of Science (2011-Present) Professional Member, American Diabetes Association (2010-Present) Member, Society of Clinical Research Associates (2003-2012) Lifetime Member, Tri-Beta Honor Society (2000-Present) Dr. Kaddis serves as principal investigator and co-investigator on multiple NIH and JDRF-funded projects, including the Human Islet Research Network Bioinformatics Center and the JDRF nPOD DataShare initiative. His work has established critical infrastructure for collaborative diabetes research, enabling researchers worldwide to access and analyze complex datasets. His laboratory has developed specialized data management systems that facilitate the sharing of islet cell research data across international boundaries while maintaining appropriate security and privacy protections. Dr. Kaddis's athletic pursuits in marathons and triathlons mirror his research approach—requiring stamina and perseverance to achieve long-term goals in diabetes research.

پروفایل رسمی دانشگاه

Melissa J. Mooreمشاهده پروفایل

استاد

University of Massachusetts Chan Medical SchoolUnited States

Melissa J. Moore, PhD, is Professor at the University of Massachusetts Chan Medical School, where she holds the Eleanor Eustis Farrington Chair of Cancer Research and serves in the RNA Therapeutics Institute. She also holds appointments in the T. H. Chan School of Medicine (Department of Chemical Biology) and the Morningside Graduate School of Biomedical Sciences (Departments of Biochemistry & Molecular Biotechnology, Interdisciplinary Graduate Program, and Translational Science). Additional affiliations include campus-wide programs in Bioinformatics & Integrative Biology and Chemical Biology. Education: BS in Chemistry/Biology, College of William and Mary PhD in Biological Chemistry, Massachusetts Institute of Technology Research Focus: Melissa Moore’s laboratory investigates post-transcriptional gene regulation in eukaryotes, with emphasis on three interconnected themes: (1) spliceosome structure and catalytic mechanism, (2) nuclear-to-cytoplasmic control of mRNA metabolism, and (3) quality control and clearance of defective ribosomal and messenger RNAs. The group combines biochemistry, single-molecule biophysics, RNA structural biology, and cell biology to dissect these processes at molecular and systems levels. Scientific Awards & Honors: Eleanor Eustis Farrington Chair of Cancer Research Funding & Collaborations: Work is supported by grants from the National Institutes of Health and involves ongoing collaborations with investigators at Brandeis University, MIT, University of Rochester, and other institutions. Rotation projects for graduate students are available in all active research areas. Laboratory & Team: The Moore laboratory is located in the RNA Therapeutics Institute at UMass Chan Medical School, 364 Plantation Street, Worcester, MA. The team employs state-of-the-art single-molecule imaging, mass spectrometry, and high-throughput sequencing to advance understanding of RNA biology and to translate insights into therapeutic RNA technologies.

پروفایل رسمی دانشگاه

Javier Caceresمشاهده پروفایل

استاد

Graz University of TechnologyAustria

Javier Caceres is a Professor of RNA and Gene Expression holding a Personal Chair at the MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh. He has served as Head of the Genome Regulation Section since 2015, leading research on RNA-mediated genetic mechanisms. His educational background includes a Ph.D. in Molecular Biology (1989) and an MSc. in Biology (1985), both obtained from the University of Buenos Aires. These degrees established his foundation in molecular genetics before his postdoctoral work at Cold Spring Harbor Laboratory and the University of Wisconsin-Madison. Dr. Caceres' research centers on RNA biology with emphasis on post-transcriptional gene regulation. His work investigates alternative splicing mechanisms, nonsense-mediated decay pathways, microRNA functions, and RNA-protein interactions. These studies provide critical insights into genetic disorders and potential therapeutic targets, particularly in splicing-related diseases. His experimental approaches combine biochemical, genomic, and cellular techniques to dissect RNA regulatory networks. Analysis of his publication record reveals consistent focus on RNA processing mechanisms across three decades. His work demonstrates evolving technical sophistication from foundational splicing studies to contemporary systems-level analyses of RNA regulation, with sustained contributions to understanding how RNA dysregulation causes human disease. Key themes include RNA-binding proteins, mRNP dynamics, and quality control pathways. His major scientific recognitions include: Election as Fellow of the Royal Society of Edinburgh (FRSE) in 2011 Award of the Wellcome Trust Senior Investigator Award in 2011 Membership in the European Molecular Biology Organization (EMBO) since 2008 Dr. Caceres actively shapes scientific discourse through editorial leadership as Associate Editor of RNA (since 2011) and service on editorial boards of EMBO Journal and Nucleic Acids Research. He has evaluated research proposals for major funding bodies including the European Research Council (ERC Starting Grants panel), German Research Foundation (DFG), and Swiss National Foundation, focusing on molecular biology and RNA research initiatives. He directs the Genome Regulation Section at the MRC Human Genetics Unit, where his team employs cutting-edge methodologies to investigate RNA-mediated gene regulation mechanisms and their roles in human disease pathogenesis.

پروفایل رسمی دانشگاه