John S. Kaddis

John S. Kaddis, Ph.D. is an Associate Professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope. With over 15 years of experience at City of Hope, Dr. Kaddis has developed scientific resources for team-based research initiatives focused on type 1 diabetes, creating data systems, analysis tools, and websites used by researchers worldwide.

Dr. Kaddis earned his B.S. (Honors) in Biochemistry from California State University Los Angeles, where he completed undergraduate research supported by two National Science Foundation fellowships. He later earned his Ph.D. in Systems Biology and Disease from the University of Southern California. His academic journey includes positions as Assistant Professor since 2015 and Associate Professor since 2022 at City of Hope.

Dr. Kaddis's research primarily focuses on the complex mechanisms of type 1 diabetes through systems biology and bioinformatics approaches. His work centers on understanding islet cell biology, beta cell dysfunction, and the immunological aspects of type 1 diabetes. His research has evolved from developing collaborative data resources to conducting cutting-edge investigations into genetic factors in diabetes pathogenesis. He has pioneered the creation of bioinformatics platforms that enable global collaboration in diabetes research.

The trends in Dr. Kaddis's publications reveal a progression from foundational work on biobanking and data management toward increasingly sophisticated investigations of genetic and immunological mechanisms in type 1 diabetes. His recent work emphasizes translational applications, including potential therapeutic strategies and predictive models that span diverse ancestral backgrounds. His research bridges basic science with clinical applications through the Human Islet Research Network.

• Member, American Association for the Advancement of Science (2011-Present)
• Professional Member, American Diabetes Association (2010-Present)
• Member, Society of Clinical Research Associates (2003-2012)
• Lifetime Member, Tri-Beta Honor Society (2000-Present)

Dr. Kaddis serves as principal investigator and co-investigator on multiple NIH and JDRF-funded projects, including the Human Islet Research Network Bioinformatics Center and the JDRF nPOD DataShare initiative. His work has established critical infrastructure for collaborative diabetes research, enabling researchers worldwide to access and analyze complex datasets. His laboratory has developed specialized data management systems that facilitate the sharing of islet cell research data across international boundaries while maintaining appropriate security and privacy protections. Dr. Kaddis's athletic pursuits in marathons and triathlons mirror his research approach—requiring stamina and perseverance to achieve long-term goals in diabetes research.