جست‌وجوی استاد و پژوهشگر

Kenichi Yokoyamaمشاهده پروفایل

دانشیار

• Natural Products Biosynthesis
• Enzymology
• Antibiotics Research
• +۴ مورد دیگر

Kenichi Yokoyama serves as Associate Professor of Biochemistry (2019-Present), Associate Professor of Chemistry (2022-Present), and Associate Professor of Cell Biology (2022-Present) at Duke University. His primary appointment resides in the Department of Biochemistry within the Basic Science Departments, with secondary appointments in the Department of Chemistry under Trinity College of Arts & Sciences and the Department of Cell Biology. Dr. Yokoyama's research focuses on biosynthesis and mechanisms of action of naturally occurring bioactive molecules, particularly antifungals and antibiotics. His lab investigates biosynthetic enzymes and bacterial/fungal producers of bioactive metabolites to discover novel compounds with applications in research and medicine. His specific interests include free-radical mediated enzyme catalysis (metallo-enzymology), cofactor biosynthesis in humans and pathogenic bacteria, natural product biosynthesis and genome mining, and fungal cell wall biosynthesis with antifungal mode of action. His recent publications reveal a strong trend toward ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotics like dynobactins and darobactins that target Gram-negative bacterial outer membranes. His work bridges organic chemistry, biochemistry, molecular biology, and spectroscopy with emphasis on functional and mechanistic characterization of enzymes, small molecule characterization, bacterial/fungal genetics, synthetic organic chemistry, and advanced spectroscopic techniques including NMR, EPR, and fluorescence microscopy. Scientific Awards: ACS Pfizer Award in Enzyme Chemistry (2019) - Recognizing fundamental research in enzyme chemistry by scientists under forty years of age Dr. Yokoyama maintains active grant funding from multiple NIH institutes (NIAID, NIGMS), NSF, and the American Heart Association, totaling over $10 million in current funding. His grants focus on molecular mycology, chitin synthesis inhibition, cell and molecular biology training, peptide antibiotic discovery, and advanced spectroscopy equipment. His lab also mentors students through various NIH-funded training programs including the Tri-Institutional Molecular Mycology and Pathogenesis Training Program and the Cell and Molecular Biology Training Program. The Yokoyama Lab operates at the intersection of enzymology and natural products research, maintaining strong collaborations across Duke's research ecosystem with particular emphasis on translating basic enzymatic discoveries into novel therapeutics for infectious diseases.

Laura Galazzoمشاهده پروفایل

مدرس

• Biophysics
• Protein Dynamics
• Molecular Biophysics
• +۳ مورد دیگر

Dr. Laura Galazzo is a Lecturer at the Department of Chemistry and Applied Biosciences, ETH Zurich, affiliated with the Institute of Molecular Physical Sciences (IMPS). Her research focuses on biophysical chemistry and molecular dynamics, employing advanced spectroscopic techniques like Electron Paramagnetic Resonance (EPR) to study protein structure, phase transitions, and membrane transport mechanisms. She investigates topics such as liquid-liquid phase separation in proteins, ABC transporter function, and nitroxide radical dynamics in aqueous environments. Dr. Galazzo also contributes to methodological advancements in pulsed dipolar spectroscopy and neural network applications in spectroscopic data analysis. Her work bridges theoretical and experimental approaches, combining computational methods (e.g., ab initio molecular dynamics) with experimental techniques to address complex biological systems. Key areas of study include protein aggregation, conformational changes in large complexes, and the interplay between solvent effects and biomolecular behavior. Recent research highlights include studies on mycobacterial iron uptake mechanisms and the structural dynamics of pro-apoptotic peptides. Dr. Galazzo’s publications reflect a strong emphasis on interdisciplinary approaches, integrating spectroscopy, computational modeling, and structural biology. Her contributions have advanced methodologies for distance measurements in biomolecules and provided insights into fundamental biological processes such as phase separation and membrane-mediated transport. She is actively engaged in promoting sustainable education through initiatives like the EquipSent project, aiming to enhance global access to scientific resources.

Timothy Schmidtمشاهده پروفایل

استاد

• Molecular Spectroscopy
• Astrochemistry
• Quantum Chemistry
• +۴ مورد دیگر

Professor Timothy Schmidt is the Head of the School of Chemistry at the University of New South Wales (UNSW). He holds a BSc (Hons 1M) from the University of Sydney (1997) and a PhD in femtosecond spectroscopy from the University of Cambridge (2002). His research focuses on molecular spectroscopy, astrochemistry, and quantum chemistry, with notable contributions to singlet fission, triplet-triplet annihilation, and exciton science. He is a Chief Investigator in the ARC Centre of Excellence in Exciton Science and has received prestigious awards such as the Coblentz Award (2010) and the RACI Physical Chemistry Medal (2021). His work spans solar energy conversion, interstellar chemistry, and advanced materials. Key grants include the $31.9M ARC Centre of Excellence in Exciton Science (2017-23) and a $403k Discovery Grant for astrochemical spectroscopy (2019-21). He leads the development of photon upconversion technologies and has pioneered studies on carbon-based molecules in space. His teaching includes courses in physical chemistry and advanced chemistry for first-year students. Prof. Schmidt’s labs are based in the Dalton Building and Science and Engineering Building at UNSW, with a focus on cutting-edge spectroscopic techniques. He actively engages in public science communication, including National Science Week talks. His research bridges fundamental physics and applied chemistry, addressing global challenges in energy and materials science.

Aaron Mendezمشاهده پروفایل

استادیار

• Virology
• Molecular Biology
• Microbiology
• +۳ مورد دیگر

Aaron Mendez is an Assistant Professor in the Department of Molecular Biology and Microbiology at Tufts University School of Medicine. His research focuses on understanding how viruses maximize their replicative output through the formation of replication compartments, using Kaposi's sarcoma-associated herpesvirus (KSHV) as a model system. Education: PhD in Chemistry & Chemical Biology from the University of California, San Francisco (2015); BSc in Biochemistry & Molecular Biology from the University of California, Irvine (2009). Research Interests: The lab employs a multidisciplinary approach combining molecular virology, biochemistry, and chemical genetics to uncover molecular mechanisms underlying viral replication compartment formation. Key areas include compartment dynamics, viral machinery organization, and evasion of host immune responses. Recent work highlights studies on SOX exonuclease activity in KSHV and SARS-CoV-2 nsp1 protein function. Publications: Recent articles (2014–2023) explore viral replication mechanisms, ER stress pathways, and protein engineering. Notable contributions include elucidating SOX's role in viral DNA processing and characterizing SARS-CoV-2 nsp1's suppression of host gene expression. Grants & Lab Activities: The lab develops novel tools for studying viral replication compartments, with potential applications in antiviral strategies. Current efforts aim to identify linchpin interactions critical for compartment assembly and function. Labs/Teams: Mendez leads a research group focused on advancing virology through innovative biochemical and genetic methodologies.

• Molecular Biophysics
• Structural Biology
• Protein Crystallography
• +۳ مورد دیگر

Takemasa Kawashima is a Researcher affiliated with the Engelman Lab at the Yale School of Medicine. He holds a PhD in Molecular Biophysics from Université Pierre et Marie Curie (1995). His research focuses on structural biology and protein crystallography, particularly studying bacterial translational machinery components like the EF-Tu.EF-Ts complex. He has contributed to understanding the structural dynamics and functional mechanisms of these complexes through X-ray crystallography. His work bridges molecular biophysics and enzymology, with implications for bacterial protein synthesis mechanisms. Education: PhD from Université Pierre et Marie Curie in Molecular Biophysics (1995) Research interests include protein dynamics, enzymatic interactions, and structural insights into molecular processes critical for bacterial physiology. His studies employ advanced crystallographic techniques to elucidate protein complexes at atomic resolution. Advising: No formal advisees listed. His contributions are primarily through collaborative research in the Engelman Lab, focusing on translational systems biology and structural enzymology. Labs/Teams: Active member of the Engelman Lab, engaged in interdisciplinary projects at the Bass Center (266 Whitney Avenue, Fl 4, Rm 425, New Haven, CT).

Ulrich H.E. Hansmannمشاهده پروفایل

استاد

• Biophysical Chemistry
• Protein Folding
• Aggregation Mechanisms
• +۳ مورد دیگر

Ulrich H.E. Hansmann is a Professor in the Department of Chemistry and Biochemistry at the University of Oklahoma. He holds a Ph.D. from Freie Universität Berlin (1990), followed by postdoctoral research at Florida State University and ETH Zürich. His research focuses on computational biophysical chemistry, specifically protein folding, aggregation, and enhanced sampling techniques. His lab develops algorithms and software, such as the SMMP package, to study biomolecular processes relevant to diseases like Alzheimer’s and cancer. Recent work includes investigating the role of microbial infections in amyloidogenesis and SARS-CoV-2 interactions with proteins. He leads the Hansmann Group, which collaborates on projects involving protein-ligand binding and membrane interactions. Education: M.A. (1983), Diplom (1985), Ph.D. (1990) from Freie Universität Berlin. Research Keywords: Protein folding, aggregation, enhanced sampling, amyloidosis, computational modeling. His research explores mechanisms of protein misfolding and aggregation, with applications in drug design and disease pathology. Collaborations include studies on viral proteins’ effects on amyloid formation and antibiotic peptide stability. The SMMP software, developed by his group, enables efficient simulations of large biomolecules.

Mingjiang Zhongمشاهده پروفایل

دانشیار

• Polymer Chemistry
• Materials Science
• Controlled Radical Polymerization
• +۱۲ مورد دیگر

Mingjiang Zhong is an Associate Professor in the Department of Chemical & Environmental Engineering at Yale University, with additional appointments in Materials Science and Chemistry. His research is centered on the development of advanced synthetic methodologies for functional organic materials and organic-inorganic hybrid systems. Education: B.S., Peking University Ph.D., Carnegie Mellon University His research interests lie at the intersection of polymer chemistry, materials science, and sustainability. He focuses on polymer-derived carbon materials and hierarchical nanostructures for applications in energy conversion, catalysis, and environmental technologies. His group combines sophisticated molecular design with advanced analytical techniques to probe and control complex soft matter behaviors . An analysis of his 15 most recent publications reveals a strong and consistent research trajectory in controlled radical polymerization , particularly in developing novel methods for branching and stereocontrol . His work frequently involves block copolymer self-assembly to create functional nanocomposites and membranes, with a growing emphasis on applications in water treatment (e.g., anti-scaling polymers, desalination membranes) and energy (e.g., electrocatalysts, ion conductors). Scientific Awards and Honors: Camille Dreyfus Teacher-Scholar Award (2022) Wiley Journal of Polymer Science Early Career Investigator (2021) 3M Non-Tenured Faculty Award (2020) National Science Foundation CAREER Award (2019) ACS PMSE Young Investigator (2019) ACS Petroleum Research Fund Doctoral New Investigator (2017) Dr. Zhong leads an active research group, mentoring numerous graduate students and postdoctoral scholars, as evidenced by frequent lab news celebrating student achievements such as passing qualifying exams and successful PhD defenses. His group has secured significant recognition, indicating strong support for research grants. The lab is equipped with state-of-the-art instrumentation for polymer synthesis and characterization, including GPC, GC, and preparative chromatography systems.

W. Steven Wardمشاهده پروفایل

استاد

• Sperm Chromatin Structure
• Early Embryonic DNA Replication
• Biology of Early Folliculogenesis
• +۲ مورد دیگر

W. Steven Ward is a Professor and Director of the Institute for Biogenesis Research (IBR) at the John A. Burns School of Medicine, University of Hawaii. He holds dual affiliations with the Department of Anatomy, Biochemistry and Physiology and the Department of Obstetrics, Gynecology & Women's Health . Education: B.S. in Chemistry, American University of Beirut M.S. in Biochemistry, American University of Beirut Ph.D. in Biochemistry, Vanderbilt University (1985) Research Interests Dr. Ward's work focuses on chromatin structure during spermiogenesis and embryogenesis, particularly the organization of DNA in sperm cells. His lab developed a widely accepted model of sperm chromatin structure based on loop domains, which are critical for paternal DNA replication in embryos. Additional research explores ORC4 protein's role in chromatin expulsion during meiosis and erythrocyte maturation, alongside Exoc5's importance in folliculogenesis. Current projects span three areas: sperm chromatin structure, early embryonic DNA replication, and folliculogenesis biology. Publication Trends His 15 most recent articles (2023–1993) emphasize reproductive biology, developmental genetics, and molecular mechanisms of chromatin organization. Key themes include sperm DNA fragmentation, interspecies comparisons (hamster/mouse models), and the functional implications of chromatin expulsion in oocytes and red blood cells. Collaborative clinical research with urologists and geneticists is evident, particularly in studies linking chromatin structure to fertility outcomes. Grants & Leadership Dr. Ward has maintained continuous NIH funding since 1991 and led a $16M COBRE grant (2009–2025) to develop research capacity at the IBR. As Chief of the Obstetrics and Gynecology Division of Research (2014–), he bridges clinical and basic science, notably through studies on post-vasectomy DNA fragmentation and its developmental impacts. Labs & Teams As IBR director, he leads a multidisciplinary team investigating reproductive biogenesis, including spermatogenesis, oogenesis, and embryonic chromatin dynamics. The lab employs molecular, genetic, and clinical research approaches, often in collaboration with urology and obstetrics departments.

Kevin Edgarمشاهده پروفایل

استاد

• Polysaccharide Chemistry
• Drug Delivery Systems
• Tissue Engineering
• +۷ مورد دیگر

Kevin Edgar is a Professor of Biomaterials and Bioprocessing and Director of the ICTAS Bio-Based Materials Center at Virginia Tech's College of Natural Resources and Environment, Department of Sustainable Biomaterials. With a Ph.D. in Organic Chemistry from Duke University (1979) and a B.S. in Chemistry from Bucknell University (1975), he has established himself as a leading researcher in polysaccharide chemistry and sustainable biomaterials. Dr. Edgar's research focuses on designing and creating derivatives of natural polysaccharides to address demanding performance requirements, exploring structure-property-performance relationships for applications including drug-delivery systems, tissue engineering, biodegradable plastics, polymer compatibilization, hydrogels, and block copolymers. His work specifically targets novel methods to control and utilize the nanostructure of polysaccharides, with emphasis on regioselective substitution reactions of complex polysaccharides. He investigates how to effectively utilize natural polysaccharides to address societal needs, leveraging their diverse natural functions from structural support to information storage. Analysis of his recent publications reveals a strong focus on hydrogel development, drug delivery systems, and polysaccharide modification techniques. His work spans fundamental chemistry of polysaccharides to applied pharmaceutical and medical applications, with particular emphasis on creating sustainable alternatives to fossil fuel-based materials. The research demonstrates consistent innovation in regioselective synthesis methods and structure-property relationships of polysaccharide derivatives. 2023 Appointed to Virginia Tech Academy of Faculty Leadership 2022 Virginia Tech College of Natural Resources and Environment Outstanding Graduate Student Mentor Award 2016 Anselme Payen Award for outstanding professional contributions to cellulose science 2010 Named Fellow of the ACS Division of Cellulose and Renewable Materials 2009 Named Fellow of ACS (inaugural class of ACS Fellows) Dr. Edgar has mentored numerous graduate students through their Ph.D. and Master's research, with many receiving prestigious awards including multiple Eastman Awards for outstanding graduate students. His research has been supported by significant grants from NSF, USDA NIFA, and other funding agencies. He leads the ICTAS Bio-Based Materials Center and co-directs the Infectious Disease Interdisciplinary Graduate Education Program, demonstrating strong leadership in interdisciplinary research. His lab actively develops sustainable biomaterials with applications in drug delivery, tissue engineering, and environmental health.

Camille Berthelotمشاهده پروفایل

پژوهشگر

• Comparative Functional Genomics
• Evolutionary Genomics
• Gene Regulation
• +۱۲ مورد دیگر

Camille Berthelot is a Principal Investigator and head of the Comparative Functional Genomics research group at the Institut Pasteur in Paris, France. Her work lies at the intersection of evolutionary biology, genomics, and reproductive physiology, with a focus on understanding how genomic changes drive evolutionary innovations in vertebrates, particularly the evolution of menstruation in primates. Her research leverages cutting-edge technologies including single-cell RNA sequencing, organoid models, and computational frameworks to compare gene expression and regulation across species such as humans, macaques, and mice. She investigates how evolutionary changes in gene function contribute to novel traits and how these relate to diseases like endometriosis. A major focus is the use of menstrual fluid as a non-invasive biomarker source for endometriosis, a direction highlighted in her systematic review published in Reproductive Biology and Endocrinology . Her recent publications span high-impact journals such as Science , Genome Research , and Nature Ecology & Evolution , covering topics from teleost fish phylogeny to regulatory evolution in mole-rats. These works reveal a consistent trend in using comparative genomics to decode deep evolutionary questions, often in collaboration with institutions like QMUL and INSERM. ERC Starting Grant (EVOMENS) – Decoding the genetics of menstruation evolution in primates Collaborative project on hypoxia adaptation in mole-rats Development of bioinformatics tools like FINSURF for non-coding variant classification She actively mentors a team of postdocs, PhD students, and master’s interns, including Claire Lavergne, Leo Zeitler, and Eulalie Liorzou. Former members such as Malgorzata Gazda and Axelle Brulport have gone on to independent academic positions, reflecting her role in training next-generation scientists. Camille Berthelot returned from maternity leave in June 2024 and remains actively engaged in research, publication, and team leadership at the Institut Pasteur.

• Computational Chemistry
• Molecular Modeling
• Structural Biology
• +۵ مورد دیگر

Dr. Magdalena Ślusarz serves as an Adjunct Professor in the Department of Theoretical Chemistry at the Faculty of Chemistry, University of Gdańsk. Her research focuses on computational approaches to structural biology problems, particularly in viral immunomodulation and receptor-ligand interactions. Her research interests span computational chemistry , molecular modeling of protein structures , and structural analysis of viral immune evasion mechanisms . She specializes in applying molecular dynamics simulations, NMR spectroscopy data interpretation, and UNRES force field methodologies to study herpesvirus proteins (particularly UL49.5), opioid receptor interactions, and vasopressin receptor systems. Her work bridges theoretical chemistry with biomedical applications including viral pathogenesis and neuropharmacology. Analysis of her recent publications reveals a strong focus on herpesvirus immunomodulation mechanisms (2023-2024), particularly how viral proteins hijack cellular degradation pathways. Earlier work demonstrates expertise in computational structural biology methodologies including UNRES force field development for membrane proteins (2019) and protein structure prediction (2016-2020). Her research consistently applies molecular modeling to solve biomedical problems ranging from viral immune evasion to neuropharmacology. Dr. Ślusarz maintains active research in the Laboratory of Molecular Modeling at the University of Gdańsk, where she applies computational approaches to protein structure-function relationships. Her work involves collaborations across international research teams, particularly evident in large-scale projects like the WeFold consortium for protein structure prediction.

• Chiral Recognition
• Enantiomeric Separations
• Ionic Liquids
• +۵ مورد دیگر

Daniel W Armstrong is a Professor at the University of Texas at Arlington in the Department of Chemistry and Biochemistry. With over 35 years of experience, he is a pioneering figure in chiral recognition, enantiomeric separations, and the biological relevance of D-amino acids. His work has led to over 740 publications, 35 patents, and 560 invited seminars worldwide. Developed first chiral recognition mechanism by cyclodextrins First to use macrocyclic antibiotics as chiral selectors Synthesized most new ionic liquids (ILs) globally Created ultra-fast separation techniques now standard in analytical chemistry Contributed to FDA 1992 guidelines on chiral drug separation His research focuses on chiral separations, ionic liquids, and the role of D-amino acids in biological systems. He has commercialized over 30 HPLC and GC columns, transforming analytical chemistry and pharmaceutical analysis. Recent publications demonstrate continued innovation in chiral chromatography, biomarker analysis, and AI-driven separation optimization. His grants include industry collaborations with Merck, Alcon, and Sigma-Aldrich, emphasizing practical applications of his work. Scientific honors include multiple lifetime achievement awards, fellowships in the Royal Society of Chemistry and American Chemical Society, the Chirality Medal, and induction into the National Academy of Inventors. He has mentored over 100 PhD students, many from first-generation college backgrounds.

Dirk Schneiderمشاهده پروفایل

استاد

• Membrane Biochemistry
• Biophysics
• Protein-Lipid Interactions
• +۴ مورد دیگر

Prof. Dirk Schneider is a Full Professor (W3) of Biochemistry at Johannes Gutenberg University Mainz since 2010, with previous appointments at the University of Freiburg (2003-2009) and postdoctoral training at Yale University. His research spans membrane biochemistry, biophysics, and transmembrane protein folding/assembly, focusing on thylakoid membrane biogenesis and protein-lipid interactions in cyanobacteria and chloroplasts. Current roles: Full Professor, University Mainz Previous roles: Assistant Professor (W1), University of Freiburg Education: PhD (summa cum laude) from Ruhr-University Bochum His research interests include: Membrane protein folding and stability ESCRT-III/Vipp1/PspA family structural dynamics ABC transporter activity regulation (e.g., BmrA) Protein-lipid interaction mechanisms Thylakoid membrane remodeling Comparative membrane biology between prokaryotes and eukaryotes Development of spectroscopic and computational methods Recent publications reveal trends in bacterial membrane remodeling (SynDLP, PspA), lipid effects on transporter activity (BmrA), and IM30/Vipp1-mediated membrane fusion. His work combines structural biology, biophysics, and functional assays to elucidate membrane dynamics. Awarded the Dr. Heinrich Kost Award (2001) and Leopoldina Fellowship (2001) , he has held leadership roles including Study Section Speaker (2010-2014) , Director of Institute of Pharmacy and Biochemistry (2013-2015) , and Dean of Faculty of Chemistry (2015-2020) . His scientific advisory roles include editorial board memberships and study section leadership.

Thomas V. O'Halloranمشاهده پروفایل

استاد

• Metallomics
• Metal Regulation
• Cancer Therapeutics
• +۴ مورد دیگر

Thomas V. O'Halloran is the Morrison Professor of Chemistry at Northwestern University, holding dual appointments in Molecular Biosciences and the Chemistry of Life Processes Institute (CLP). He directs the CLP Institute and serves as Associate Director of Basic Sciences at the Robert H. Lurie Comprehensive Cancer Center. His research integrates bioinorganic chemistry with molecular biology to study transition metal (zinc, copper, iron) regulation in biological systems. Dr. O’Halloran earned his B.S. from the University of Missouri (1979) and Ph.D. from Columbia University (1985). His work focuses on metalloregulatory proteins, metallochaperones, and metallome dysregulation in disease. Notable contributions include discovering zinc sparks during fertilization, developing arsenoplatin anticancer complexes, and pioneering nanobin drug delivery systems. Research interests span metallomics, metal trafficking in cancer, and zinc's role in developmental processes. His lab employs interdisciplinary methods: X-ray crystallography, fluorescence microscopy, ICP-MS metallomics, and nanoparticle engineering. Key projects include targeting ovarian cancer with uPA-receptor nanobins and understanding copper homeostasis in fungal pathogens. Education: B.S. University of Missouri (1979), Ph.D. Columbia University (1985) Affiliations: CLP Institute, Robert H. Lurie Cancer Center Key Techniques: Metal speciation analysis, nanoparticle synthesis, live-cell imaging His 150+ publications span Science , Nature Chemistry , and Angewandte Chemie . Awards include the Royal Society of Chemistry Dalton Award and NIH MERIT award.

Eric C. Boltonمشاهده پروفایل

دانشیار

• Cancer
• Developmental Biology
• Endocrinology
• +۴ مورد دیگر

Eric C. Bolton is an Associate Professor in the Department of Molecular & Integrative Physiology at the University of Illinois, affiliated with the School of Molecular & Cellular Biology. His research focuses on understanding the molecular mechanisms of prostate development and neoplasia, particularly the role of androgen receptor (AR) signaling in hormone-dependent cancers and developmental pathways. He holds a PhD from Johns Hopkins University and postdoctoral training at UCSF. Research interests include the AR's role in cell proliferation/differentiation, crosstalk with growth factor pathways, and the transition from normal prostate development to cancer. He employs mouse models and organ culture systems to study prostate gland morphogenesis and AR-mediated stress responses. Recent work also explores KCNQ2 mutations linked to epileptic encephalopathy, highlighting interdisciplinary research into neuroendocrine mechanisms. Teaching includes courses on human disease mechanisms and cancer pathophysiology. Bolton's lab investigates novel therapeutic targets for prostate cancer, including non-competitive AR inhibitors and pathways regulating cellular stress responses.