W. Steven Ward

W. Steven Ward is a Professor and Director of the Institute for Biogenesis Research (IBR) at the John A. Burns School of Medicine, University of Hawaii. He holds dual affiliations with the Department of Anatomy, Biochemistry and Physiology and the Department of Obstetrics, Gynecology & Women's Health.

• Education:
  • B.S. in Chemistry, American University of Beirut
  • M.S. in Biochemistry, American University of Beirut
  • Ph.D. in Biochemistry, Vanderbilt University (1985)

Research Interests
Dr. Ward's work focuses on chromatin structure during spermiogenesis and embryogenesis, particularly the organization of DNA in sperm cells. His lab developed a widely accepted model of sperm chromatin structure based on loop domains, which are critical for paternal DNA replication in embryos. Additional research explores ORC4 protein's role in chromatin expulsion during meiosis and erythrocyte maturation, alongside Exoc5's importance in folliculogenesis. Current projects span three areas: sperm chromatin structure, early embryonic DNA replication, and folliculogenesis biology.

Publication Trends
His 15 most recent articles (2023–1993) emphasize reproductive biology, developmental genetics, and molecular mechanisms of chromatin organization. Key themes include sperm DNA fragmentation, interspecies comparisons (hamster/mouse models), and the functional implications of chromatin expulsion in oocytes and red blood cells. Collaborative clinical research with urologists and geneticists is evident, particularly in studies linking chromatin structure to fertility outcomes.

Grants & Leadership
Dr. Ward has maintained continuous NIH funding since 1991 and led a $16M COBRE grant (2009–2025) to develop research capacity at the IBR. As Chief of the Obstetrics and Gynecology Division of Research (2014–), he bridges clinical and basic science, notably through studies on post-vasectomy DNA fragmentation and its developmental impacts.

Labs & Teams
As IBR director, he leads a multidisciplinary team investigating reproductive biogenesis, including spermatogenesis, oogenesis, and embryonic chromatin dynamics. The lab employs molecular, genetic, and clinical research approaches, often in collaboration with urology and obstetrics departments.