جست‌وجوی استاد و پژوهشگر

Ulrich Eckhardمشاهده پروفایل

پژوهشگر

• Protease Research
• Structural Biology
• Proteomics
• +۳ مورد دیگر

Ulrich Eckhard is a researcher with expertise in structural biochemistry and enzymology, focusing on proteases and their roles in biological systems. He holds a PhD in Molecular Biology from the University of Salzburg (2012) and completed postdoctoral research at the University of British Columbia (2012-2016) under Prof. Chris Overall, and later at the Proteolysis Lab, Structural Biology Unit, IBMB-CSIC in Barcelona, Spain, funded by the Beatriu de Pinós COFUND program. His research integrates structural biology, proteomics, and enzymology to study bacterial collagenases and matrix metalloproteinases. Key techniques include TAILS (Terminal Amine Isotopic Labeling of Substrates) and PICS (Proteomic Identification of protease Cleavage Sites) for protease profiling. He has contributed to understanding collagen degradation mechanisms and proteolytic processing in health and disease, including dental pulp, blood platelets, and skin inflammation. Ulrich's work spans interdisciplinary collaborations, with publications in top journals like Nature Structural & Molecular Biology, Journal of Biological Chemistry, and Nature Methods. His current position in Barcelona focuses on the intersection of protease degradomics and structural biology.

• Glycobiology
• Chemical Biology
• Neurobiology
• +۳ مورد دیگر

Linda Hsieh-Wilson serves as the Milton and Rosalind Chang Professor of Chemistry and Merkin Institute Professor at the California Institute of Technology, leading the Hsieh-Wilson Lab within the Division of Chemistry and Chemical Biology. Her research program integrates chemical synthesis, biochemical assays, and in vivo studies to investigate glycan molecular functions and structure-activity relationships across physiological and pathological contexts. Her work centers on glycobiology with emphasis on glycosaminoglycan sulfation patterns, O-GlcNAc post-translational modifications, and neurobiological applications. Key discoveries include elucidating how specific heparan sulfate sequences regulate synaptic plasticity and social memory, and developing chemical tools to decode glycan roles in cancer biomarker detection and vascular development. This research bridges chemical biology and neuroscience through innovative methodological approaches. Recent publications demonstrate a consistent trajectory in developing chemoenzymatic labeling techniques, systems-level analysis of glycan networks, and structural characterization of sulfation codes. These efforts focus on translating fundamental glycan science into applications for neurological disorders and cancer diagnostics, with particular emphasis on heparan sulfate and O-GlcNAcylation pathways. Her major scientific recognition includes: Election to the National Academy of Sciences (2022) Professor Hsieh-Wilson maintains an active mentorship program with 16 documented graduate students including current PhD candidates Sophia Gonzalez, Andrew Schilling, and Stefan Hansel, alongside recent graduates like Gracie Zhang. Her lab recruits new members annually and supports undergraduate researchers such as John Stauffer SURF fellow Ardra Charath, fostering interdisciplinary training in chemical neurobiology. The Hsieh-Wilson Lab operates from the Norman W. Church Laboratory for Chemical Biology at Caltech, comprising graduate students, postdocs including Ankita Paul and Rajat Singh, and undergraduate researchers. The team collaborates across chemical synthesis, neurobiological assays, and translational biomarker development, maintaining strong industry and clinical partnerships for disease-focused glycan research.

• Molecular Biology
• Biochemistry
• Cell Biology
• +۷ مورد دیگر

Dr. Robert Weinzierl is an Associate Professor in Molecular Biology at the Department of Life Sciences, Faculty of Natural Sciences, Imperial College London. His research focuses on the structure and function of gene-specific transcription factors (GSTFs) acting as oncoproteins, particularly c-MYC, which plays a central role in over two-thirds of human cancers. His work integrates computational simulations of intrinsically disordered proteins (IDPs) with high-throughput robotic approaches to study transcriptional activation domains and protein-protein interactions. Key areas of research include: Structure-function relationships in oncogenic transcription factors Computational modeling of IDP dynamics High-throughput methods for protein analysis Publications highlight his contributions to understanding RNA polymerase mechanisms, transcriptional coactivator interactions, and archaeal transcription machinery. His work bridges molecular biology, structural biology, and computational modeling to address fundamental questions in cancer biology and gene regulation. Notable collaborations include studies on FOXO3 signaling, MED25 coactivator binding, and robotic systems for protein purification. While no formal awards are listed, his research has been published in high-impact journals and aligns with Imperial College's priority areas in molecular medicine and synthetic biology. Current investigations explore the role of oncoproteins in senescence processes and the development of novel tools for studying disordered protein systems.

• Virology
• Ebola Virus Research
• Lassa Fever Virus
• +۳ مورد دیگر

James Morgan Cunningham is an Associate Professor of Medicine (Microbiology and Molecular Genetics) at Brigham and Women's Hospital, affiliated with Harvard Medical School. His research focuses on viral entry mechanisms, particularly for Ebola and Lassa viruses, with a focus on developing antiviral therapies and understanding host-pathogen interactions. He has held part-time academic roles since at least 2024, as noted in his most recent publications. Research Interests: Dr. Cunningham's work spans viral pathogenesis, antiviral drug discovery, and the structural biology of viral glycoproteins. He has made significant contributions to understanding how cholesterol metabolism and cellular receptors (like LAMP1) influence viral entry. His research also explores the biochemical basis of Ebola glycoprotein activity during outbreaks and the development of small molecule inhibitors targeting enveloped viruses. Grants & Collaborations: He has secured NIH funding for projects like the New England Regional Center of Excellence in Biodefense and Emerging Infectious Diseases (2003-2015) and studies on small molecule inhibitors for viral entry (2014-2019). Notable collaborations include work with Sean Whelan on Ebola virus entry and Dennis Kasper on biodefense strategies. Publications: His work spans over three decades, with key contributions to understanding Ebola virus glycoprotein proteolysis (Science, 2005), Lassa fever virus cholesterol dependency (2018), and co-authorships with leaders in virology like Kartik Chandran and Kartik Chandran. Recent studies (2024) explore NAD metabolome changes in severe COVID-19 cases.

Neil Hunterمشاهده پروفایل

استاد

• Photosynthesis
• Chlorophyll Biosynthesis
• Light-Harvesting Complexes
• +۵ مورد دیگر

Professor Neil Hunter FRS is the Krebs Chair of Biochemistry at the University of Sheffield’s School of Biosciences. His career spans over four decades, with key roles including Professor (1993–2008), Reader (1990–1993), and Senior Lecturer (1988–1990) at the University of Sheffield, and earlier positions at Imperial College London and Rutgers University. He leads research on photosynthesis, focusing on chlorophyll biosynthesis, light-harvesting complex assembly, and photosynthetic membrane organization. His work integrates molecular genetics, structural biology (e.g., cryo-EM), and nanotechnology to understand energy conversion in photosynthetic systems. Research Interests: Dr. Hunter’s lab investigates chlorophyll biosynthesis pathways, engineering light-harvesting complexes, and membrane organization using atomic force microscopy and cryo-EM. Projects include metabolic engineering of E. coli to produce chlorophyll, bionanotechnology for artificial photosynthetic systems, and collaborations on computational modeling of photosynthetic membranes. Publications: Over 200 peer-reviewed articles, including recent work on reaction center-LH1 complex structures (2023), perovskite solar cell manufacturing (2025), and CO₂-fixing bacteria (2022). His research bridges fundamental biology and applied technologies like bio-inspired energy systems. Achievements: Awarded Fellow of the Royal Society (FRS) for contributions to photosynthesis research. Collaborates globally with institutions in the UK, Europe, the U.S., and China on structural biology and synthetic biology projects. Labs/Teams: Leads the Sheffield Photosynthesis Research group, focusing on interdisciplinary approaches to photosynthetic systems. Active in initiatives like the PhotoRedesign consortium to redesign photosynthetic light reactions.

• EPR Spectroscopy
• Biomacromolecular Complexes
• Structural Biology
• +۴ مورد دیگر

Prof. Olav Schiemann is a Professor at the University of Bonn's Institute of Physical and Theoretical Chemistry under the Faculty of Mathematics and Natural Sciences. He is a key member of the Transdisciplinary Research Area (TRA) Matter, focusing on advanced EPR spectroscopy techniques. His research integrates method development, biomacromolecular complex analysis, and structural-functional relationships in proteins and nucleic acids. His work emphasizes pulsed EPR methods like PELDOR/DEER for nanometer-scale distance measurements, with applications to enzymology, RNA structure, and metal-protein interactions. Schiemann's lab designs novel spin labels (e.g., SLIM/trityl) for in-cell and in-vitro studies, advancing understanding of biomolecule dynamics under native conditions. Publications highlight innovations in spin label chemistry, metal ion localization, and structural biology applications. His articles span 2021–2025, reflecting continuous contributions to EPR methodology and biophysical systems analysis. Despite no listed awards, his TRA affiliation underscores institutional recognition of his transdisciplinary impact.

Andrzej Marek Brzozowskiمشاهده پروفایل

استاد

• Structural Biology
• Medicinal Chemistry
• Hormonal Signaling
• +۳ مورد دیگر

Professor Andrzej Marek Brzozowski is a Professor of Chemistry at the University of York, specializing in structural endocrinology and medicinal chemistry. His research focuses on understanding molecular mechanisms of hormonal signaling (insulin and IGF systems) and structural biology approaches for neglected diseases (e.g., Leishmania and Chlamydia). Education: PhD from University of Łódź, Poland (1980) Postdoctoral research at Max-Planck-Institut für Experimentelle Medizin (Göttingen) and University of York Research Interests: His work integrates structural biology, protein engineering, and drug discovery. Key areas include: Insulin:IR/IGF-1R complex structures Design of insulin analogues for oral delivery Structural studies of proteins in neglected diseases (Leishmania N-myristoyltransferase, Chlamydia adhesins) Protein crystallization methodologies (Clear Strategy screens, YSBL microplates) Grants & Collaborations: Funded by MRC for insulin/IGF pathway studies Collaborations with institutes in Czech Republic, Ireland, Australia Projects on drug development for leishmaniasis and chlamydial infections Labs/Teams: Leads structural biology research at York Structural Biology Laboratory (YSBL), advancing crystallography and drug discovery tools.

• Structural Enzymology
• Biocatalysis
• Enzyme Engineering
• +۳ مورد دیگر

Professor Gideon Grogan is a leading researcher at the University of York's Department of Chemistry, focusing on structural and applied enzymology. His research employs a multidisciplinary approach combining synthetic chemistry, microbiology, molecular biology, and X-ray crystallography to develop novel biocatalysts for pharmaceutical and industrial applications. Current investigations target oxygenases, reductases, lyases, and ligases, with an emphasis on enzyme engineering through in vitro evolution techniques. His research interests encompass biocatalytic transformations including asymmetric synthesis, sustainable bioprocessing, and enzyme mechanism elucidation. Key areas include P450 enzymes, flavoprotein monooxygenases, ketone reductases, imine reductases, and alkene hydratases. These biocatalysts enable efficient production of chiral pharmaceutical intermediates and valorization of renewable feedstocks. Professor Grogan maintains an extensive publication record in premier journals including Nature, Nature Catalysis, and JACS, with research advancing fundamental enzymology while addressing industrial biotechnology challenges. His group develops innovative biocatalytic strategies for chemical synthesis while exploring enzyme biodiversity and structure-function relationships.

• Polymer Chemistry
• Nanotechnology
• Materials Science
• +۳ مورد دیگر

Bernd Stühn is a Professor in the Department of Physics, specializing in advanced materials and soft matter systems. His research focuses on polymer physics, nanotechnology, and the structural characterization of complex materials using techniques like X-ray scattering and neutron spectroscopy. Key research areas include the synthesis and self-assembly of block copolymers, nanotube fabrication via ion-track technology, and the study of magnetic nanoparticle systems. He has extensively investigated confinement effects on polymer dynamics, phase behavior of water/PEG mixtures, and the development of redox-responsive materials. His work combines experimental approaches (e.g., small-angle X-ray scattering, dielectric spectroscopy) with theoretical modeling to understand structure-property relationships in nanocomposites, colloidal systems, and confined environments. Over 15 years of publications reflect a sustained focus on advancing materials science through interdisciplinary methodologies.

James Priceمشاهده پروفایل

پژوهشگر ارشد

• Nematology
• Molecular Biology
• Plant Pathology
• +۳ مورد دیگر

Dr. James Price is an Honorary Research Fellow at the School of Biology, University of St Andrews. His research focuses on plant-parasitic nematodes, particularly the potato cyst nematodes Globodera rostochiensis and G. pallida . His work explores molecular mechanisms underlying host-parasite interactions, including eggshell biology, surface proteins, and life cycle regulation. Key research interests include nematode molecular biology, host adaptation strategies, and agricultural pest management. His recent studies highlight the role of annexins in nematode life cycles and the structural analysis of surface coat proteins critical for host recognition. Publications emphasize interdisciplinary approaches combining molecular genetics and parasitology. Research contributes to UN Sustainable Development Goal 2 (Zero Hunger) by advancing understanding of crop-threatening pests.

Erika Lisabethمشاهده پروفایل

استادیار

• Drug Discovery
• Pharmacology
• Cancer Biology
• +۳ مورد دیگر

Erika Lisabeth, PhD, is an Assistant Professor (Fixed-Term) and Director of the Assay Development and Drug Repurposing Core (ADDRC) in the Department of Pharmacology & Toxicology at Michigan State University. She is affiliated with the College of Osteopathic Medicine and contributes to the MSU Drug Discovery initiative. Her work focuses on drug discovery targeting antifibrotic agents, proteasome enhancers, and Rho/MRTF pathway inhibitors. Education: BS in Chemistry, Michigan State University (1999—2023) PhD in Chemistry and Biochemistry, University of California, San Diego (2003—2009) Post-doctoral Training in Cancer Biology, Sanford Burnham Prebys Medical Discovery Institute (2009—2013) Research Interests: Development of novel antifibrotic compounds Mechanisms of Rho/MRTF/SRF-mediated gene transcription in cancer Targeting Eph receptor tyrosine kinases in lung cancer Optimization of drug delivery systems for fibrosis treatment Funding Highlights: National Institute of Neurological Disorders and Stroke (NINDS): Development of cellular HTS for 20S proteasome enhancers (2019–2022) Tobacco-Related Disease Research Program: Mapping the EphA Receptor Landscape in Lung Cancer (2011–2014) Lab Facilities: Assay Development and Drug Repurposing Core (ADDRC) Collaborations with the Pharmacology & Toxicology department's research infrastructure Teaching: PHM 801: Fundamental Principles of Pharmacology and Toxicology (Fall) PHM 803: Chemical Disposition in Mammals (Fall) PHM 805: Receptor Pharmacology (Fall)

• Malaria Research
• Parasitology
• Drug Development
• +۳ مورد دیگر

Dr. Danny Wilson is an Externally-Funded Research Fellow (C) at the University of Adelaide, affiliated with the School of Biological Sciences within the Faculty of Sciences, Engineering and Technology. His research focuses on understanding the unique biology of single-cell parasites like malaria (Plasmodium spp.) and Toxoplasma gondii, aiming to develop novel vaccines and drug treatments. He has secured significant grants and fellowships, including the NHMRC Peter Doherty Early Career Fellowship and multiple DAAD/Universities Australia-Germany collaborations. His work employs advanced techniques such as gene editing, fluorescence microscopy, and proteomic analysis to study parasite invasion mechanisms and identify therapeutic targets. The lab also investigates the efficacy of azithromycin analogues and other small molecules against malaria and Toxoplasma, with a focus on overcoming drug resistance. Dr. Wilson has been awarded several prestigious fellowships, including the Hospital Research Foundation Mid-career Fellowship and the University of Adelaide Beacon Fellowship. These accolades reflect his contributions to malaria research and drug development. In terms of grants and funding, he has served as Chief Investigator (CIA), Lead-CI, or Co-CI on projects from NHMRC, ARC, DAAD/Universities Australia-Germany, and the South Australian Sheep Industry Fund. His research has also been supported through collaborations with international institutions and industry partners. Dr. Wilson is actively involved in teaching, including lectures on Infection and Immunity A, Biomedical Science, and mentoring undergraduate students. He is eligible to supervise Masters and PhD students, fostering the next generation of researchers in malaria and parasitology. His laboratory is equipped with advanced microscopy systems, such as the Oxford Nano-imager NIM 4 and Imaris software, enabling cutting-edge analysis of parasite biology. These tools are critical for his work in mapping subcellular structures and identifying drug targets.

Julian Leibowitzمشاهده پروفایل

استاد

• Microbial Pathogenesis
• Virology
• Immunology
• +۳ مورد دیگر

Julian Leibowitz, MD, PhD, is a Professor and Director of the MD/PhD Program at the Texas A&M University Health Science Center College of Medicine, Department of Microbial Pathogenesis & Immunology. He leads the Leibowtiz Lab, focusing on coronavirus replication and host interactions. His work includes developing murine hepatitis virus (MHV) models for SARS and multiple sclerosis, and studying viral UTR structures. Education includes a BA from Alfred University (1968) and MD/PhD from Albert Einstein College of Medicine (1975). Research interests center on MHV replication mechanisms, including cis-acting RNA elements and host protein interactions. Key projects involve SARS-CoV modeling and understanding viral RNA dynamics. Over 50 publications span virology, immunology, and molecular biology. Contact: jleibowitz@tamu.edu. Lab location: Medical Research & Education Building II, Bryan, TX. No awards explicitly listed, but contributions to coronavirus research are notable. Advising and grants details are not provided in available texts.

Thomas Turnerمشاهده پروفایل

دانشیار

• Evolution
• Evolutionary Genetics
• Marine Biology
• +۳ مورد دیگر

Thomas Turner is an Associate Professor in the Department of Ecology, Evolution, and Marine Biology at the University of California, Santa Barbara (UCSB). His research focuses on evolutionary genetics, marine biology, and zoology, with a particular emphasis on marine sponges and their ecological roles in rocky reef habitats. He leads the Turner Lab, which investigates sponge diversity, evolutionary history, and ecological services. His work spans taxonomy, phylogenetics, and molecular biology of marine invertebrates, with contributions to understanding cryptic species and global biogeography. Research Interests: - Evolutionary mechanisms in marine invertebrates - Sponge biodiversity and biogeography - Molecular systematics and phylogenetics - Behavioral ecology of insects, especially Drosophila species Publications reflect a blend of sponge-focused studies and behavioral genetics, including work on silk production in crustaceans and mate choice evolution in Drosophila. His lab’s current projects emphasize California’s marine sponge communities, combining field surveys with genomic analyses. Labs/Teams: The Turner Lab integrates fieldwork, molecular biology, and computational tools to study evolutionary and ecological questions in marine systems. Collaborations focus on taxonomic revisions and ecological impact assessments of invasive species.

• Evolutionary Biology
• Mitochondrial Evolution
• Protistology
• +۳ مورد دیگر

Jeremy Wideman is an Assistant Professor at Arizona State University's School of Life Sciences. His research focuses on evolutionary biology, mitochondrial evolution, protistology, and comparative genomics. He investigates fundamental questions about eukaryotic evolution, including mitochondrial genome diversity, organelle biogenesis, and the evolutionary relationships among protists. Professor Wideman's research explores cellular evolution through advanced genomic and proteomic approaches. His work spans mitochondrial dynamics, endosymbiotic theory validation, and the development of computational tools for phylogenetic analysis. Recent investigations focus on cristae architecture formation and the evolutionary trajectories of mitochondrial protein complexes across diverse eukaryotic lineages. His publications consistently demonstrate a strong emphasis on developing genomic databases (EukProt), advancing single-cell analysis techniques for protists, and reconstructing ancestral cellular states. The research integrates experimental biology with bioinformatic approaches to understand organelle evolution and cellular complexity.