جست‌وجوی استاد و پژوهشگر

Florian Sicklingerمشاهده پروفایل

پزشک-پژوهشگر

• Immunocardiology
• Cardiac inflammation
• Cardiac fibrosis
• +۴ مورد دیگر

Dr. Florian Sicklinger is a Physician-Scientist and Assistant Doctor in the Department of Cardiology, Angiology and Pulmonology at Heidelberg University Hospital. He has been working at the Medical Clinic of Heidelberg University Hospital since 2021 and has been a Physician-Scientist in the Immunocardiology Research Group under Prof. Dr. med. Florian Leuschner since 2022. Education Medical studies at Heidelberg University (2013-2020) Doctorate at Heidelberg University Hospital (2016-2022), supervised by Prof. Dr. med. Florian Leuschner Research Interests Dr. Sicklinger's research focuses on the role of the immune system in ischemic heart disease and heart valve diseases, as well as the therapeutic modulation of cardiac inflammation and fibrosis. His work bridges clinical cardiology with immunological mechanisms to develop novel therapeutic approaches for cardiac conditions. He has published extensively on immune cell interactions following myocardial infarction, including studies on basophils, endothelial cells, and macrophages. Publication Trends Dr. Sicklinger's publications demonstrate a strong focus on the intersection of immunology and cardiology, with a clear progression toward increasingly sophisticated methodologies. His early work established standardized approaches for cardiac research models, while his more recent publications employ cutting-edge techniques like single-cell transcriptomics and high-throughput screening. His research consistently addresses the immune mechanisms underlying cardiac injury and repair processes across multiple model systems from mice to pigs. Awards and Recognition Postdoc Start-up Grant from the German Center for Cardiovascular Research (2022-2023) DZHK Paper of the Month (2021 and 2020) Otto-Hess Doctoral Scholarship from the German Cardiac Society (2017-2018) Scholarship from the German National Academic Foundation (2013-2020) Research Leadership As a key member of the Immunocardiology Research Group at Heidelberg University Hospital, Dr. Sicklinger has contributed significantly to developing novel methodologies for cardiac research, including minimal-invasive techniques for inducing myocardial infarction and high-throughput echocardiography-guided approaches. His work on immune cell dynamics after cardiac injury has provided important insights into potential therapeutic targets for improving cardiac recovery following myocardial infarction.

• Beta Cell Biology
• Stem Cell Research
• Regenerative Medicine
• +۴ مورد دیگر

Senta K. Georgia is an Associate Professor of Pediatrics and Stem Cell Biology & Regenerative Medicine at the Keck School of Medicine of the University of Southern California , where she is also a Principal Investigator at the Center for Endocrinology, Diabetes, and Metabolism at Children’s Hospital Los Angeles (CHLA) . She was promoted to associate professor in 2023 and became the first Black PhD scientist to earn tenure at the Keck School since its founding in 1885. Education: BS in Biological Sciences from Stanford University (with dual departmental honors), PhD in Molecular Biology from UCLA Postdoctoral training: Hillblom Islet Research Center, UCLA Georgia’s research focuses on pancreatic beta cell differentiation during organogenesis , beta cell proliferation in metabolic stress , and beta cell regeneration for diabetes therapy . Her work emphasizes DNA methylation mechanisms in defining beta cell identity and exploring CRISPR-Cas9 technology for genetic diabetes. Recent studies include investigating how pregnancy hormones boost beta cells via serotonin and the role of cell cycle molecules in beta cell mass regulation. Her publications span diabetes pathophysiology , ß-cell biology , and regenerative medicine , with key contributions to understanding DNMT1-p53 interactions in pancreatic organogenesis and Skp2-p27 pathways in beta cell adaptive expansion. Current projects include CRISPR-based cures for rare diabetes and stem cell therapy development. Georgia leads the USC COMPASS program ($2.9M CIRM grant) to diversify stem cell science and chairs admissions for the PhD Programs in Biomedical & Biological Sciences (PIBBS) at Keck. She co-led the DEI committee for her department and advocates for underrepresented students in STEM. Labs/Teams: Georgia Lab at USC Stem Cell, collaborations with female faculty in USC Biomedical Engineering and Chemistry departments, partnerships with JEDI-WeST for institutional climate interventions.

Gail A. Cornwallمشاهده پروفایل

استاد

• Biological Amyloids
• Reproductive Biology
• Neurodegeneration
• +۴ مورد دیگر

Gail A. Cornwall, Ph.D., is a Professor in the Department of Cell Biology and Biochemistry at the Texas Tech University Health Sciences Center School of Medicine. Her research bridges reproductive biology, neuroscience, and structural biochemistry, focusing on the dual roles of biological amyloids in physiological functions and disease mechanisms. Education: Ph.D. in Reproductive Biology, Johns Hopkins Bloomberg School of Public Health Dr. Cornwall's pioneering work centers on functional amyloids—protein aggregates that perform critical biological roles rather than causing pathology. Her lab investigates three interconnected research pillars: the host defense functions of amyloid matrices in the reproductive tract, the structural mechanisms of functional amyloid assembly, and the potential role of sperm amyloids as epigenetic carriers of transgenerational disease. She discovered that the epididymal lumen contains a functional amyloid matrix that traps or kills bacteria depending on pathogen virulence, functioning as a mammalian counterpart to bacterial biofilms. Concurrently, her team explores how similar amyloid structures in the brain may regulate synaptic plasticity, and how environmental toxins induce transmissible amyloid formations in sperm that correlate with inherited disease phenotypes. Analysis of Dr. Cornwall's 15 most recent publications (2023-2012) reveals a cohesive trajectory examining amyloid plasticity across biological systems. Her work consistently integrates structural biology (X-ray crystallography, NMR spectroscopy), transgenic models, and translational approaches to demonstrate how functional amyloids provide evolutionary advantages in host defense while maintaining the structural versatility to contribute to neurodegenerative diseases when dysregulated. Dr. Cornwall leads a multidisciplinary laboratory employing biochemical, cell biological, and biophysical methodologies—including recombinant protein systems, gene knockout mouse models, and advanced imaging—to study amyloid dynamics. Her team maintains active collaborations with structural biologists (R. Bryan Sutton), NMR spectroscopists (Michael P. Latham, Benjamin J. Wylie), and reproductive physiologists to dissect amyloid assembly mechanisms at atomic resolution. Information regarding Dr. Cornwall's student advising roles and specific research grants was not provided in the source materials.

David Jay Juliusمشاهده پروفایل

استاد

• Pain sensation
• Thermosensation
• Molecular neuroscience
• +۷ مورد دیگر

David Julius is a professor and chair of the Department of Physiology at the University of California, San Francisco (UCSF) , where he has held faculty positions since 1989. His research focuses on the molecular mechanisms of touch and pain sensation , particularly through the study of TRP (transient receptor potential) ion channels activated by thermal and chemical stimuli like capsaicin and menthol . Education: BS in Life Sciences, Massachusetts Institute of Technology (1977) PhD in Biochemistry, University of California, Berkeley (1984) Postdoctoral training with Richard Axel at Columbia University (1984-1990) Research highlights: Julius's lab discovered and characterized TRPV1, TRPM8, and TRPA1 receptors , revealing how they detect temperature and chemical irritants. His work has implications for non-opioid pain therapies and understanding neurogenic inflammatory diseases . He has also contributed to the discovery of purinergic receptors and serotonin-activated ion channels . Scientific award trends: Julius has received numerous accolades for his groundbreaking work, including the 2021 Nobel Prize in Physiology or Medicine (with Ardem Patapoutian), the 2020 Breakthrough Prize in Life Sciences , the 2020 Kavli Prize in Neuroscience , and the 2013 Dr. Paul Janssen Award for Biomedical Research . Scientific Awards: Nobel Prize in Physiology or Medicine (2021) Breakthrough Prize in Life Sciences (2020) Kavli Prize in Neuroscience (2020) Dr. Paul Janssen Award for Biomedical Research (2013) Shaw Prize in Life Science and Medicine (2010) Gairdner Foundation International Award (2017) Prince of Asturias Prize for Technical and Scientific Research (2010) Leadership and service: Julius served as editor of the Annual Review of Physiology (2007-2020) and has been a scientific advisor for organizations like the Pew Scholars Program and Damon Runyon Cancer Research Foundation . He is married to fellow UCSF professor Holly Ingraham , with whom he has a son, Philip Julius .

• Genetic Epidemiology
• Mendelian Randomization
• Social Science Genetics
• +۳ مورد دیگر

Eric Slob is an Assistant Professor at the Erasmus School of Social and Behavioural Sciences, Department of Methods & Skills, specializing in statistical and computational methods for large genetic datasets. His research bridges social science and medicine through Mendelian randomization, focusing on causal relationships in health outcomes. Research interests revolve around genetic epidemiology, precision medicine, and cross-disciplinary causal inference. Recent publications highlight his work on: Mendelian randomization studies linking maternal hyperglycaemia to neonatal outcomes (2024) Proteomic and transcriptomic pathways in preeclampsia (2024) PCSK9-targeted therapies and mood disorders (2024) LDL cholesterol interventions and congenital malformations (2024) Birth weight impacts on cardiovascular structure (2024) He contributes to open-access datasets and has been featured in public engagement about genetic methods. Funded by the SSH-Breed program, his work addresses causal mechanisms in medical and social research.

Iannis Adamopoulosمشاهده پروفایل

دانشیار

• Osteoimmunology
• Autoimmunity
• Rheumatology
• +۳ مورد دیگر

Iannis Adamopoulos is an Associate Professor of Medicine at Harvard Medical School, affiliated with the Division of Rheumatology and Clinical Immunology and Beth Israel Deaconess Medical Center. His research focuses on the interplay between immune and skeletal systems within osteoimmunology, particularly examining cytokines like IL-23, IL-17, and RANKL in inflammatory bone loss and diseases such as osteoporosis, rheumatoid arthritis, and psoriatic arthritis. Research Focus Molecular mechanisms of osteoclast differentiation and activation Role of IL-23/IL-17 axis in autoimmune pathogenesis Development of animal models for inflammatory diseases Interactions between innate immune memory and bone destruction Publication Trends Dr. Adamopoulos has contributed extensively to understanding cytokine-driven inflammatory arthritis and osteoclastogenesis. His recent work explores trained immunity in osteoclasts, the impact of aging on osteoimmunology, and novel therapeutic strategies targeting IL-23/IL-17 pathways. His studies often integrate molecular immunology, glycomics, and single-cell analyses to uncover disease mechanisms. Scientific Recognition Paper highlighted by Nature Reviews Rheumatology (2015) Recommended by F1000 Prime (2011) Techniques and Collaborations His lab utilizes transgenic animal models, μCT imaging, and autophagy assays to study bone-immune interactions. Collaborations span institutions and disciplines, including bioinformatics, dermatology, and nephrology, reflecting a multidisciplinary approach to autoimmune and inflammatory diseases.

• Molecular Biology
• Hypertension
• Renin-Angiotensin System
• +۳ مورد دیگر

Timothy L. Reudelhuber is a Professor and Tenured Researcher at the Department of Medicine, Faculty of Medicine, Université de Montréal. He is affiliated with the Institut de recherches cliniques de Montréal (IRCM). His research focuses on the molecular mechanisms underlying hypertension, particularly the renin-angiotensin system and the regulation of renin activity. His work explores how angiotensin II and related peptides influence cardiovascular health and renal development. Research Interests: Molecular basis of angiotensin II signaling Role of proprotein convertases in regulated secretion Prorenin processing and its implications in health/disease Grant Activity: Lead researcher on multiple projects funded by the Canadian Institutes of Health Research (CIHR), including Identification of the Prorenin Processing Enzyme (2010–2014) and Prorenin in Health and Disease (2008–2011) . Advising: Supervised 10+ graduate students in topics such as prohormone convertase targeting, angiotensin II signaling modulation, and renal development. Notable advisees include Dimitrios Dikeakos (2008), Karim Benkirane (2006), and Danielle Méthot (1999). Labs: Leads the Molecular Biochemistry of Hypertension laboratory at IRCM, investigating molecular regulators of blood pressure and enzyme activity in cardiovascular systems.

• Cardiology
• Vascular Medicine
• Stroke Research
• +۴ مورد دیگر

Dr. H.M.M. van Beusekom is an Associate Professor at the Department of Cardiology, Erasmus University Medical Center. His research focuses on cardiovascular diseases, particularly stroke, aneurysms, and interventional cardiology. He has contributed to studies on thrombosis, vascular injury mechanisms, and genetic predispositions to vascular disorders. Collaborations include the MR CLEAN-LATE trial, investigating endovascular treatments for stroke. Education: Not explicitly mentioned in the text. Research Interests: Dr. van Beusekom’s work spans ischemic stroke pathophysiology, thrombus dynamics, aortic aneurysm genetics, and imaging techniques for vascular assessment. Recent studies address microthrombus formation post-endovascular therapy and the role of FURIN in aneurysm development. Articles Overview: His recent publications emphasize translational research, bridging clinical trials (e.g., MR CLEAN-LATE) with molecular mechanisms (e.g., TGF-β signaling in aneurysms) and imaging innovations (whole aorta scans for familial risk assessment). Advising & Grants: Supervised 4 academic works (specific details unlisted). Collaborations include multi-center trials and genetic studies funded by institutional grants. Teams: Works with groups like the MR CLEAN-LATE investigators, focusing on stroke treatment protocols and vascular imaging.

• Parkinson's Disease
• Neuroscience
• Antisense Oligonucleotides
• +۵ مورد دیگر

Dunhui Li serves as an Adjunct Lecturer at the UWA Medical School, The University of Western Australia, working within the Centre for Neuromuscular and Neurological Disorders at the Perron Institute. With a research focus spanning Parkinson's disease, neurodegenerative disorders, and molecular therapeutic approaches, Dr. Li contributes to advancing our understanding of neurological conditions through innovative research methodologies. Dr. Li's research interests center on Parkinson's disease, neuroscience, antisense oligonucleotides, alternative splicing, and neurodegenerative disorders. Their work explores molecular mechanisms underlying neurological conditions, particularly focusing on alpha-synuclein pathology in Parkinson's disease, PTBP1-related astrocyte-neuron transdifferentiation, and exon skipping strategies for therapeutic development. This research has significant implications for developing targeted treatments for neurodegenerative conditions and rare neurological diseases. Analysis of Dr. Li's recent publications reveals a strong emphasis on translational neuroscience, with particular focus on Parkinson's disease mechanisms and therapeutic approaches. The research spans molecular biology, genetics, and clinical applications, demonstrating a comprehensive approach to understanding and treating neurodegenerative disorders. Key themes include antisense oligonucleotide therapies, alternative splicing mechanisms, protein isoform regulation, and novel strategies for neuronal regeneration. Dr. Li actively collaborates with researchers including Wilton S., Mastaglia F., McDowall S., and Aung-Htut M. on projects related to neurological disorders and therapeutic development. Their research has been cited in Scopus, with publications appearing in high-impact journals such as Npj Parkinsons Disease, Frontiers in Neuroscience, and Translational Neurodegeneration. The work contributes to Sustainable Development Goals related to health and well-being, particularly in advancing treatments for neurological conditions. Based at the Centre for Neuromuscular and Neurological Disorders (Perron Institute), Dr. Li works within a specialized research environment focused on understanding and treating neuromuscular and neurological conditions. The center provides a collaborative platform for interdisciplinary research, bringing together clinicians, scientists, and students to address complex challenges in neurological disease research and treatment development.

Weijun Jinمشاهده پروفایل

استادیار

• Lipid Metabolism
• Cardiovascular Disease
• Proprotein Convertases
• +۵ مورد دیگر

Weijun Jin, MD, is an Assistant Professor in the Department of Cell Biology at SUNY Downstate Medical Center. His research focuses on lipid metabolism and its implications in cardiovascular disease, particularly through the study of proprotein convertases (PCs) such as PCSK9 and SKI-1/S1P. Research Highlights: Elucidating the role of PCSK9 in LDL receptor (LDLR) degradation and autosomal dominant hypercholesterolemia Investigating how classic PCs regulate HDL metabolism via endothelial lipase (EL) cleavage and activation of its inhibitor, ANG PTL3 Demonstrating EL's requirement for PC-mediated HDL elevation in vivo Exploring the interplay between PCs, lipoprotein pathways, and cholesterol homeostasis Scientific Impact: His work has advanced understanding of lipid regulation mechanisms, with potential therapeutic applications for cardiovascular disease.

Kimberley J. Evasonمشاهده پروفایل

استادیار

• Liver Cancer
• Hepatocellular Carcinoma
• Cancer Genetics
• +۳ مورد دیگر

Kimberley J. Evason is an Assistant Professor of Pathology at the University of Utah School of Medicine and heads the Hepatobiliary Pathology division. She directs a basic science research program at the Huntsman Cancer Institute , focusing on liver tumorigenesis mechanisms to develop improved therapies for hepatocellular carcinoma (HCC) . Her lab utilizes transgenic zebrafish models to study β-catenin-activated HCC and screen for druggable pathways. MD/PhD from Washington University in St. Louis Residency and fellowship at University of California, San Francisco (UCSF) Board Certified in Anatomic Pathology (American Board of Pathology) Research Interests include: Targeted therapies for β-catenin-activated HCC JNK and serotonergic antidepressants in liver tumor suppression Conserved genetic mechanisms in zebrafish and human HCC Lipid and mitochondrial metabolism in liver disease Zebrafish as a platform for chemical screening Epigenetic and transcriptional regulation in liver cancer Recent Publications highlight her work on: β-Catenin signaling in liver tumor development Novel therapeutic agents (e.g., amitriptyline, JNK inhibitors) Lysosomal biogenesis and metabolic dysregulation in HCC Role of microRNAs in inflammation and metabolic disease Scientific Awards : Damon Runyon Cancer Research Fellowship Award K08 award from NIH/NCI Lab Members : The Evason Lab employs zebrafish models to study liver cancer, with current members including Gabriel DeNiro (undergraduate student), Sharanya Kalasekar (postdoctoral fellow), Chloe Lim (undergraduate student), Liam O’Brien (technician), and Richard Smith (lab specialist).

Daniel Constamمشاهده پروفایل

دانشیار

• Cell Biology
• Cancer Biology
• Developmental Biology
• +۴ مورد دیگر

Prof. Daniel Constam is an Associate Professor at the École Polytechnique Fédérale de Lausanne (EPFL), leading the Constam Lab in the School of Life Sciences (SV) within the Institute of Bioengineering (ISREC). His research focuses on molecular mechanisms underlying cell growth, differentiation, and disease, particularly in cancer and polycystic kidney diseases. He holds roles in the EDMS-ENS, SSV-ENS, and ISREC departments, contributing to both education and doctoral programs. His lab investigates proprotein convertases, mRNA translation regulation, and cilia-related disorders. Notable achievements include elucidating Activin-A's role in tumor immunity and Bicc1's function in kidney cyst formation. Prof. Constam has advised over a dozen PhD students and published extensively in high-impact journals like Nature Communications and Cell Reports. His lab is located in Building SV 2837, Lausanne.

Mathieu Ferronمشاهده پروفایل

استاد

• Vitamin K Metabolism
• Energy Metabolism
• Diabetes Research
• +۴ مورد دیگر

Mathieu Ferron is a tenured Professor in the Department of Biochemistry and Molecular Medicine at the Université de Montréal. He leads the Integrative and Molecular Physiology Research Unit at the Montreal Clinical Research Institute (IRCM). His research focuses on the physiological and pathological roles of vitamin K and γ-carboxylation in energy metabolism, diabetes, and bone diseases. Ferron holds the Canada Research Chair in Bone and Energy Metabolism. His work bridges biochemistry, proteomics, and molecular biology to uncover novel mechanisms linking bone-derived hormones to systemic metabolism. Affiliations: IRCM, Réseau CMDO, Réseau RSBO Education: Ph.D. in Molecular Biology (2006, Université de Montréal), Postdoc at Columbia University (2013) Research Interests: Vitamin K-dependent proteins, osteocalcin, β-cell function, gamma-carboxylation, metabolic diseases . His lab uses genetically modified mice, proteomics, and CRISPR-Cas9 to study how vitamin K influences diabetes and osteoporosis. Recent breakthroughs include identifying novel γ-carboxylated proteins and their roles in endocrine signaling. Awards: 2020 Jean-Davignon Young Investigator Award, 2019 Étoiles Effervescence Prize, Pierre-Bois Excellence Award (2017). Grants: Over $32M in funding from CIHR, Diabetes Canada, and FRQS. Current projects include vitamin K’s role in beta-cell function and γ-carboxylome characterization. Labs/Teams: Head of the Integrative and Molecular Physiology Unit at IRCM, collaborates with the Montreal Diabetes Research Center.

• Cardiovascular Medicine
• Pharmaceutical Research
• LDL Cholesterol Management
• +۲ مورد دیگر

Flora Adams is a researcher affiliated with Vrije Universiteit Brussel (VUB) in Brussels, Belgium. Her academic work focuses on cardiovascular medicine and pharmaceutical research, with significant contributions to the field of lipid management and novel therapeutic approaches. Dr. Adams' research interests center around cardiovascular therapeutics, particularly focusing on bococizumab, LDL cholesterol management, and proprotein convertase 9 inhibition. Her work has contributed to understanding the safety profiles of novel lipid-lowering agents and their efficacy in high-risk patient populations. The fingerprint analysis of her work shows strong emphasis on bococizumab research (100%), safety assessment (29%), LDL cholesterol management (20%), placebo-controlled studies (19%), and proprotein convertase 9 inhibition (16%). Her most notable publication is the 2017 New England Journal of Medicine article on bococizumab, which has garnered significant attention with 538 citations in Scopus, coverage by 10 news outlets, mentions on 90 X (Twitter) accounts, and references in 5 clinical guideline sources. This research represents important work in the field of cardiovascular risk reduction through novel pharmacological approaches.

Britt Anne Goodsمشاهده پروفایل

استادیار

• Single-cell RNA-sequencing
• Reproductive health
• Cancer
• +۵ مورد دیگر

Britt Anne Goods is an Assistant Professor of Engineering at the Thayer School of Engineering , Dartmouth College. Her research focuses on the intersection of reproductive health, immunology, and biological engineering , utilizing advanced techniques such as single-cell RNA-sequencing , ex vivo models , and systems biology approaches . Education: BA in Biochemistry from Colby College (2010) BE in Chemical and Biochemical Engineering from Dartmouth (2011) PhD in Biological Engineering from MIT (2017) Her work addresses critical clinical challenges in reproductive health , including non-hormonal contraceptive discovery , uterine immunology , and lactation biology . By integrating single-cell transcriptomics with multi-omics datasets , she explores how sex hormones modulate immune cell behavior and tissue homeostasis. Dr. Goods' recent publications highlight her leadership in ovulation dynamics , macrophage biology , and human lactation studies . Her research has been recognized through prestigious awards, including the NRSA Postdoctoral Fellowship and National Science Foundation Graduate Research Fellowship . Scientific Awards: NRSA Postdoctoral Fellow (2017–2021) Seibel Scholar (2016) NSF Graduate Research Fellow (2013–2017) Howard A. Schroedel Fellow (2010–2011) Goldwater Scholarship Honorable Mention (2009) She mentors a diverse team of PhD students, postdoctoral researchers , and undergraduate trainees , contributing to collaborative initiatives like the Ovarian Contraceptive Discovery Initiative . Her lab is actively involved in open-access publishing and interdisciplinary training .