Ying Ge is a Professor at the University of Wisconsin–Madison, jointly appointed in the Department of Cell and Regenerative Biology and the Department of Chemistry. Her research integrates chemistry, biology, and medicine, focusing on advanced mass spectrometry-based proteomic and metabolomic technologies to address cardiovascular diseases. Education: B.S., Peking University (1997) Ph.D., Cornell University (2002) Ying Ge's work centers on developing ultra high-resolution mass spectrometry platforms for top-down proteomics and metabolomics, applied to systems biology studies of heart failure and regenerative medicine. Key projects include myofilament protein modification mapping, stem cell therapy evaluation, and biomarker discovery for cardiac conditions. The 15 most recent articles highlight her lab's methodological innovations (e.g., photocleavable surfactants, native mass spectrometry) and biological discoveries in AMPK structural heterogeneity, RBM20-mediated cardiotoxicity, and sarcomere-metabolism cross-talk during regeneration. These publications span proteomics, metabolomics, structural biology, and clinical applications.
Ramesh Shanmughom Pillai is a Full Professor at the Department of Molecular Biology, University of Geneva, Switzerland. He holds additional roles as a Visiting Professor at the University of Kumamoto, Japan, and has been a Group Leader at EMBL Grenoble and a postdoctoral fellow at the Friedrich Miescher Institute. His research focuses on RNA modifications, epigenetics, and piRNA pathways in germline biology. Pillai has received prestigious awards including the ERC Consolidator Grant and The RNA Society Scaringe Award. Education: BSc Botany (University of Kerala, India) MSc Biotechnology (IIT Roorkee, India) PhD in Cell Biology (University of Bern, Switzerland) Research Interests: Pillai’s work centers on RNA biology, particularly the role of RNA modifications (e.g., m6A, m6Am) in development and fertility. He investigates piRNA biogenesis, transposon silencing, and the molecular mechanisms of RNA-protein interactions. His studies bridge biochemistry, genetics, and structural biology to elucidate how RNA molecules regulate critical biological processes. Teaching & Service: At the University of Geneva, he teaches Molecular Biology courses (BSc/MSc levels) and advises 5 PhD students and 4 postdocs. He chairs the ERC Consolidator Grant Review Panel and organizes major conferences like the PIWI/piRNAs Meeting and Swiss RNA Workshop. Pillai also serves on editorial boards for Nucleic Acids Research and RNA . Awards: ERC Consolidator Grant (2015) Best PhD Thesis Award (2003) RNA Society Scaringe Award (2005) Grants & Labs: Funded by ERC Starting and Consolidator Grants, his lab explores RNA modification networks in germ cells. Former trainees include Professors Simon Conn (Flinders University) and Hao Wu (CAS, China).
Tobias Dick serves as Professor and Head of the Division of Redox Regulation at the German Cancer Research Center (DKFZ) in Heidelberg, maintaining a primary affiliation with Heidelberg University's Faculty of Biosciences. His leadership spans molecular switch research within the SFB/TRR186 consortium focusing on spatio-temporal control of cellular signal transmission. Academic Background: PhD in Biochemistry, Freie Universität Berlin (1997, summa cum laude) Habilitation in Biochemistry, Heidelberg University (2009) Diploma thesis at German Cancer Research Center (1994) Study program in Biochemistry, Freie Universität Berlin (1989-1994) Research Focus: Dick pioneers investigations into thiol-based redox switches governing cellular signal transduction. His work establishes fundamental mechanisms of peroxiredoxin-mediated hydrogen peroxide signaling, protein persulfidation dynamics, and sulfur-based radical scavenging systems. Key contributions include developing real-time imaging probes for redox species and elucidating redox relays connecting peroxiredoxins to transcription factors like STAT3. Current research explores hydropersulfide protection against ferroptosis and metabolic adaptation through redox-sensitive enzymes. Publication Trends: Over 15 years of high-impact publications reveal an evolutionary trajectory from foundational redox imaging techniques (2008-2011) to sophisticated molecular mechanism studies (2013-2020), culminating in recent breakthroughs on sulfur signaling in cell death pathways (2023). His work consistently appears in premier journals like Nature Chemical Biology , demonstrating sustained innovation in redox biology methodology and conceptual frameworks. Scientific Recognition: ERC Advanced Grant (2017) Society for Free Radical Research Europe Basic Science Award (2017) Chica- and Heinz-Schaller-Award for young scientists (2009) Marie Curie Excellence Grant (2004) DFG Postdoctoral Fellowship (1998-2000) Studienstiftung des Deutschen Volkes Scholarship (1989-1994) Leadership & Mentorship: As founding vice-coordinator of DFG priority program SPP1710 (2014-present) and GBM Redox Biology Study Group (2011-2017), Dick shapes national research agendas. His division at DKFZ mentors next-generation scientists through ERC and DFG-funded projects, with trainees contributing to landmark publications on redox switches and cellular physiology. Research Infrastructure: The Division of Redox Regulation operates within DKFZ's state-of-the-art facilities, collaborating extensively through the SFB/TRR186 consortium. This environment enables cutting-edge investigations into redox-controlled cellular processes using advanced biochemical, imaging, and computational approaches.
Dr. Zhiwen Jonathan Zhang serves as Associate Professor in the Department of Bioengineering at Santa Clara University's School of Engineering since 2011, with research spanning biomolecular engineering, drug discovery, and BIOAI to combat super-bacterial infections and advance precision protein technologies. Education: Ph.D. in Chemistry and Biochemistry, University of Texas at Austin (2001) Postdoctoral Research, The Scripps Research Institute (2001-2004) His interdisciplinary research pioneers unnatural genetic codes, trM2H systems, site-specific protein cross-linking, and synthetic antibodies. Current focus includes mitochondrial peptide transport, BIOAI design, subcellular protein synthesis, and engineering bacteria for micro-plastics degradation. His lab unraveled molecular dialogues between mammalian and Gram-positive bacterial cells, enabling groundbreaking anti-infective therapies. Publication trends reveal consistent innovation in protein engineering and translational bioengineering, with recent work emphasizing sortase A applications, fluorescent peptide development, and unnatural amino acid incorporation in mammalian systems—demonstrating a trajectory from fundamental biochemistry to industry-ready biotech platforms. Dr. Zhang has mentored 7 post-doctoral researchers, 2 visiting professors, and 5 Ph.D. students while securing grants from NIH NCI R01, NSF SBIR, American Heart Association, Welch Foundation, JOINN Foundation, IBM, and SCU Internal Research. His patented "Biotech+Techbio" platform has co-founded multiple biotech ventures, including two publicly traded companies and a 2024 acquisition. His laboratory maintains active collaborations with Bay Area biotech firms and academic institutions, driving translational research through the patented Biotech+Techbio platform while advancing BIOAI-assisted enzyme discovery for micro-plastics degradation and next-generation antibacterial therapies.
Dr. Julia Kamenz is an Assistant Professor (Rosalind Franklin fellow) at the University of Groningen's Faculty of Science and Engineering, where she leads research in the Molecular Systems Biology group within the Groningen Biomolecular Sciences and Biotechnology Institute (GBB). Her work focuses on understanding the molecular mechanisms that regulate cell cycle progression and cell division. Dr. Kamenz received her undergraduate training in Biochemistry at the University of Tuebingen, completed her PhD at the Friedrich Miescher Laboratory of the Max Planck Society under Dr. Silke Hauf (defended February 2015 with highest honors), and conducted postdoctoral research at Stanford University with Prof. James E. Ferrell. Her PhD work was supported by a Boehringer Ingelheim Fonds fellowship, and her postdoc was funded by a German Research Foundation (DFG) Postdoctoral Fellowship. Her research expertise spans cell cycle regulation and dynamics, post-translational modifications, Xenopus laevis model systems, and live cell microscopy. Dr. Kamenz investigates how kinases and phosphatases intricately regulate cell proliferation and division, with particular interest in the molecular mechanisms that ensure faithful chromosome segregation during mitosis. Her recent work has revealed novel insights into mitotic checkpoint signaling, particularly in early embryonic development where these checkpoints appear to function differently than in somatic cells. Dr. Kamenz's publication record demonstrates a strong focus on the dynamics of cell cycle transitions, with recent papers appearing in high-impact journals including Nature, The Journal of Biological Chemistry, and The Journal of Cell Biology. Her research integrates experimental biochemistry, live-cell imaging, and computational modeling approaches to understand complex regulatory networks. ERC Starting Grant (November 2022) NWO Vidi Grant (July 2021) Mansour Postdoctoral Travel Award (2019) Dr. Kamenz has secured significant research funding including an ERC Starting Grant (€1.5 million) and an NWO XS grant (€50,000) for her project "What limits mitotic checkpoint signaling in the early embryo?" Her research contributes to understanding fundamental biological processes with implications for developmental biology and cancer research. She collaborates extensively within the University of Groningen and with international partners, particularly in the areas of cell cycle research and biophysical approaches to biological problems. Dr. Kamenz leads a research group focused on cell cycle regulation within the Molecular Systems Biology division of the Groningen Biomolecular Sciences and Biotechnology Institute. Her lab combines biochemical approaches using Xenopus egg extracts with live-cell imaging and computational modeling to dissect the molecular mechanisms controlling cell division.
Gustavo M. Silva is the Jack H. Neely Associate Professor of Biology at Duke University's Trinity College of Arts & Sciences, a position he has held since 2025. Previously, he served as Associate Professor of Biology (2024-present) and Assistant Professor of Cell Biology (2022-present) at Duke. His research is conducted through the Silva Lab (sites.duke.edu/silvalab), which focuses on molecular mechanisms of cellular stress response. Education: Ph.D. from University of Sao Paulo (Brazil), 2010 B.Sc. from University of Sao Paulo (Brazil), 2004 Dr. Silva's research centers on understanding how gene expression is regulated at transcriptional and translational levels during cellular stress. His lab specifically investigates how the ubiquitin system controls protein synthesis and degradation dynamics under stress conditions, which are critical for cellular physiology. His work has significant implications for understanding disease mechanisms where protein homeostasis is disrupted. The research combines biochemical, genetic, and proteomic approaches to dissect these complex regulatory networks. His publication record demonstrates a clear evolution from fundamental studies on redox regulation and proteasome function to more complex investigations of ubiquitin signaling in translation control and stress response. Recent work increasingly focuses on K63-linked ubiquitination's role in ribosome function and translation regulation, with growing emphasis on the clinical implications of these mechanisms in disease contexts including cancer. Scientific Awards & Recognition: Paul T. Englund Emerging Scholar Award (Johns Hopkins School of Medicine, 2024) Dean's Award for Excellence in Mentoring (Duke Graduate School, 2023) Science Diversity Leadership Award (Chan Zuckerberg Initiative, 2022) Best Professor Award (Vanderbilt Basic Sciences Juneteenth Committee, 2022) 100 inspiring Black scientists in America (CellPress, 2020) Dr. Silva actively mentors students at multiple levels, as evidenced by his Dean's Award for Excellence in Mentoring. His research is supported by substantial funding including NIH grants such as the Tri-Institutional Molecular Mycology and Pathogenesis Training Program (2024-2029) and 'Stalling cancer at the ribosome' from the V Foundation for Cancer Research (2025-2028). He also serves as Principal Investigator on multiple R01 grants focused on ubiquitin's role in translation control and stress response. The Silva Lab maintains strong collaborative relationships with institutions including the Chan Zuckerberg Initiative and ETH Zurich, and participates in several interdisciplinary training programs at Duke that support underrepresented students in biomedical sciences.
Christopher Lawson is an Assistant Professor in the Department of Chemical Engineering and Applied Chemistry at the University of Toronto, affiliated with the Faculty of Applied Science and Engineering. He serves as Principal Investigator of the Microbiome Engineering Lab and is part of BioZone – the Centre for Applied Bioscience and Bioengineering. His research focuses on engineering anaerobic microbiomes for resource recovery from waste streams using systems biology, synthetic biology, and machine learning approaches. B.A.Sc., M.A.Sc. (University of British Columbia) Ph.D. (University of Wisconsin-Madison) Postdoctoral Training (Berkeley Lab) Lawson's work addresses the challenge of controlling complex microbial interactions in engineered systems to enable scalable biotechnologies for renewable energy, chemicals, and materials. His lab develops high-throughput methods integrating automation and computational tools to optimize microbiome assembly and metabolic fluxes. Recent publications highlight advancements in metabolic modeling , isotope tracing , and systems-level analysis of anaerobic microbiomes, with applications in wastewater treatment , anammox granules , and bioenergy production . His research bridges fundamental microbiology with industrial-scale bioprocess engineering. Scientific Awards ISME/IWA BioCluster Rising Star Award (2022) Jacobs Engineering Group/AEESP Outstanding Doctoral Dissertation Award (2020) Wesley Eckenfelder Graduate Research Award (2019) WEF Canham Graduate Studies Scholarship (2018) NSERC Post-Graduate Scholarship – Doctoral (2014) Lawson actively mentors students and postdocs, emphasizing technical rigor, communication skills, and independence. His lab collaborates within BioZone and with industry partners to advance "team science" principles. Current projects focus on creating engineered microbiomes for commercial-scale waste valorization.
Prof. Casper Hoogenraad is a full professor in Molecular Neuroscience at the Department of Cell Biology, Faculty of Science, Utrecht University. His research focuses on understanding how intracellular protein trafficking underlies neuronal development and function, with particular emphasis on the microtubule cytoskeleton, synaptic cargo trafficking, and synaptic plasticity. He leads an active research group within Utrecht University's Cell Biology department and collaborates extensively with other neuroscience research groups. Education: PhD, Erasmus University Rotterdam (1996-2001) Postdoc, Massachusetts Institute of Technology (2002-2005) Hoogenraad's research spans three main themes: cytoskeleton dynamics during neurodevelopment and synaptic plasticity, motor proteins and adaptors as regulators of synaptic transport, and psychiatric and neurologic disease disorders linked to intracellular transport. His work combines genetics, biochemistry, molecular, and cellular biology methods in in vitro (neuron cultures), ex vivo (brain slices), and in vivo (mice) systems, along with advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging, and photo-activated localization microscopy (PALM). Analysis of Hoogenraad's recent publications reveals a strong focus on microtubule organization, neuronal polarity, and the molecular mechanisms underlying synaptic function and dysfunction. His work frequently explores how disruptions in intracellular transport contribute to neurological disorders including Alzheimer's disease, schizophrenia, and autism spectrum disorders, with particular attention to the relationship between cytoskeletal organization and cargo transport in neuronal compartments. Scientific Awards and Memberships: ZonMW-VIDI (2004) European Young Investigators (EURYI) award (2005) NWO-ALW VICI (2011) ERC Consolidator grants (2013) FENS-Kavli Network of Excellence (2014) European Molecular Biology Organization (EMBO) (2015) Young Academy of Europe (YAE) (2015) IBRO Kemali Prize (2016) Hoogenraad leads a research group studying neuronal development and function, with a particular focus on how intracellular transport mechanisms contribute to both normal brain function and neurological disorders. His laboratory employs a multidisciplinary approach combining molecular, cellular, and systems neuroscience techniques to investigate the molecular basis of neuronal polarity, synaptic plasticity, and the pathogenesis of neurological disorders. He has secured significant research funding through prestigious grants including ERC Consolidator grants. The Hoogenraad lab operates within the Cell Biology department at Utrecht University, collaborating with other research groups focusing on cellular dynamics, biophysics, and neurobiology. The lab utilizes advanced microscopy techniques including immunofluorescent confocal microscopy, high-resolution live cell imaging (spinning disc microscopy and total internal reflection fluorescence microscopy), and quantitative analysis using advanced high-resolution microscopy (photo-activated localization microscopy). Current lab technicians include Phebe Wulf and Bart de Haan.
Prof. Oliver Seitz leads the Bioorganic Synthesis research group at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Humboldt University of Berlin. His lab focuses on cutting-edge chemical biology approaches for protein/nucleic acid interrogation, with recent work advancing DNA/RNA-programmed assemblies for cellular imaging and therapeutic applications. Research spans chemical protein synthesis, glycoprotein/phosphoprotein engineering, and nucleic acid-templated reactions. Key innovations include Forced Intercalation (FIT) probes for wash-free RNA imaging, loss-of-affinity principles for catalytic efficiency, and peptide-PNA conjugates for targeted cellular delivery. The group actively develops tools for live-cell protein labeling and biomolecular spatial screening. Recent publications (2021-2024) emphasize fluorescence-based detection systems, catalytic templated reactions, and therapeutic peptide synthesis. Trends show increasing sophistication in multi-dye probes, glycan engineering, and RNA-triggered pro-drug activation. Scientific awards include: Max Bergmann Award (2019) Prof. Seitz actively advises doctoral students, with recent graduates Marvin Björn Stutz (2023, magna cum laude ), Dino Gluhacevic von Krüchten (2023, summa cum laude ), and Sophie Schöllkopf (2023, magna cum laude ). Current PhD candidates include Ekaterina Kazakova (glycoprotein synthesis), Alina Herfort (phosphoproteins), and Lina-Marie Beck (peptide-nucleic acid conjugates), with postdocs like Dr. Mandana Oloub (viscosity sensors). The Bioorganic Synthesis lab operates within Berlin's vibrant chemical research ecosystem, utilizing specialized techniques for chemical protein synthesis and nucleic acid detection. Recent team growth reflects ongoing projects in RNA imaging, catalytic templated reactions, and therapeutic conjugate development, supported by open positions for new researchers.
Gary M. Shaw is the Rosemarie Hess Professor and Professor (Research) at Stanford University , with courtesy appointments in the Department of Epidemiology and Population Health and Department of Obstetrics & Gynecology - Maternal Fetal Medicine . He serves as Co-PI of the March of Dimes Prematurity Research Center at Stanford and PI of the California Center for Finding Causes and Preventives of Birth Defects . His research focuses on the Epidemiology of birth defects Gene-environment interactions in perinatal outcomes Nutritional factors in reproductive health . He has developed machine learning approaches for precision parenteral nutrition and predictive models for preterm birth, while investigating persistent metabolomic signatures following hypertensive pregnancy disorders. Shaw's recent work explores Climate change impacts on reproductive health Maternal-fetal immune interactions Epigenetic mechanisms in perinatal disease with applications of multiomics to neonatal intensive care units. As a member of Bio-X and the Maternal & Child Health Research Institute , he contributes to translational research networks while serving as Associate Editor for Birth Defects Research and American Journal of Medical Genetics . He supervises Med Scholar Project student Richard Liang Doctoral co-advisor for Saskia Comess and Richard Liang Master's advisor for Lenae Joe while leading the Division of Neonatology as Associate Chair for Clinical Research (2012-2025). His laboratory work integrates Metabolomic profiling Proteomic analysis Computational modeling Machine learning for biomedical data to advance neonatal care through precision medicine approaches.
Eric W. Schmidt is a Distinguished Professor of Medicinal Chemistry at the University of Utah, with adjunct appointments in Biological Sciences and Chemistry. His research focuses on natural products chemistry, biosynthesis, synthetic biology, and pharmaceutical applications of marine animal microbiomes. University of California, San Diego (BS, PhD) Research areas include: Biosynthesis in animals and their microbiomes Synthetic biology approaches to chemical engineering Drug design from marine natural products Metagenomic analysis of symbiotic relationships Neuroactive compound discovery Antibiotic development against resistant pathogens His lab has pioneered methods for: Biosynthetic gene cluster identification Heterologous expression in E. coli Enzymatic modification of peptides Chemical analysis of marine invertebrates Recent publications highlight discoveries in: Marine animal chemical defense mechanisms Evolution of biosynthetic pathways Antibiotic resistance profiling Ionic channel-targeting compounds Peptide macrocyclization techniques Lipid-polyketide biosynthesis continuum Email: ews1@utah.edu Honors include: Distinguished Professor recognition
Joshua J. Coon is a Professor at the University of Wisconsin-Madison with appointments in the Department of Biomolecular Chemistry and the Department of Chemistry. He leads the Coon Group, focusing on advancing mass spectrometry technologies for proteomics, metabolomics, and lipidomics. His research addresses fundamental questions in cell biology, including stem cell differentiation, epigenetic regulation, and cancer biomarker discovery. Affiliations : Director of the NIGMS National Center for Quantitative Biology of Complex Systems. Research Emphasis : Instrumentation development, data analysis software, ion chemistry, and biological applications of proteomics. Laboratory : Located in the Genome Center of Wisconsin with a dozen hybrid mass spectrometers, including Orbitrap systems. Collaborations : Long-term partnership with Thermo Fisher Scientific and the Wisconsin Alumni Research Foundation (WARF) for technology commercialization. Training : Mentored 27 Ph.D. students since 2009, emphasizing interdisciplinary research and professional development.
Dr. Shawn Gomez is a Professor in the Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and North Carolina State University and in the Department of Pharmacology at UNC-Chapel Hill. He serves as the Executive Director of FastTraCS, a component of the NC TraCS Institute funded through the NIH CTSA Program, and is a UNC Lineberger Comprehensive Cancer Center member. His educational background includes a PhD in Biomedical Engineering from Columbia University (1999), an MS in Aerospace Engineering Sciences from the University of Colorado, Boulder (1993), and a BS in Aerospace Engineering Sciences from the same institution (1990). He completed postdoctoral training in Bioinformatics and Computational Biology at the Judith P. Sulzberger Columbia Genome Center and Institut Pasteur in Paris. Dr. Gomez's research spans systems biology , network pharmacology , and translational AI , with a focus on understanding cell signaling architecture in human disease. His lab develops computational approaches for network pharmacology and targeted cancer therapies, along with machine learning methodologies to address clinical needs and enhance clinical decision making. The research integrates computational modeling with experimental approaches to improve diagnostic and therapeutic interventions. His recent publications reveal a strong focus on kinome research, particularly in pancreatic cancer and understudied kinases, with increasing integration of machine learning techniques for predicting clinical outcomes and kinase-substrate relationships. The work spans from fundamental systems biology to translational applications in cancer therapeutics and surgical outcomes prediction. Scientific Awards: Leadership Advanced Program, UNC-Chapel Hill 2017 Chancellor's Entrepreneurship Boot Camp 2015 ACCLAIM Scholar (Academic Career Leadership Academy in Medicine) 2013-2014 UNC Research Council Award 2011 Carl Storm URM Fellowship 2008 UNC Junior Faculty Development Award 2006 Florence Gould Scholar 2005 Pasteur Foundation Fellow 2002-2005 Dr. Gomez directs the Gomez Lab, which focuses on systems biology, network pharmacology, and translational AI. The lab maintains several key resources including Darkkinome.org, FAAS, and IAS servers for kinome research. His work bridges computational biology with clinical applications, particularly in cancer therapeutics and surgical outcomes prediction through machine learning approaches.
Professor Forest M. White is a faculty member at MIT's Department of Biological Engineering , where he holds the Ned C. and Janet Bemis Rice Professorship . He is affiliated with the Koch Institute for Integrative Cancer Research and the MIT Center for Precision Cancer Medicine . His research focuses on systems biology and computational modeling of signaling networks in cancer, particularly at the tumor-immune interface . Education: B.S. in Chemistry (Framingham State College, 1993), Ph.D. in Analytical Chemistry (Florida State University, 1997) Professional Journey: Postdoc at University of Virginia, Research Scientist at MDS Proteomics, Assistant Professor at MIT (2003), Mitsui Career Development Professor (2005-2008) White employs high-resolution mass spectrometry to analyze protein phosphorylation and antigen presentation in cancer models, complementing genomic/transcriptomic approaches. His lab has identified chronic stress response enzymes linking high-fat diets to metabolic dysfunction and discovered resistance mechanisms in cancer therapies through phosphoproteomics . Scientific Awards: Mitsui Career Development Professorship (2005-2008) Ruth and Joel Spira Award for Excellence in Teaching (2010) Fellowship from the Ludwig Center at MIT The White Lab actively recruits trainees (undergraduates, graduates, postdocs) through programs like MSRP , CSB , and HST . His work is supported by grants from Break Through Cancer and Ludwig Center , with collaborations spanning Cima Lab , Swanson Biotechnology Center , and MIT Koch Institute .
Beat Fierz is an Associate Professor at École Polytechnique Fédérale de Lausanne (EPFL) in the School of Basic Sciences (SB), affiliated with the Institute of Chemical Sciences and Engineering (ISIC) and the Laboratory of Biophysical Chemistry of Macromolecules (LCBM). He holds additional roles as Director of the Doctoral Program in Chemistry and Chemical Engineering (EDCH) and oversees doctoral education within the SCGC teaching unit. His research focuses on chromatin dynamics, epigenetic regulation, and chemical biology approaches to study histone modifications and protein interactions. He has supervised over 14 PhD students and teaches courses in advanced chemistry and chemical biology. His work bridges molecular mechanisms of chromatin structure with cellular processes like DNA repair and transcriptional regulation. Research Interests: Dr. Fierz investigates how post-translational modifications of histones (e.g., ubiquitylation, acetylation) regulate chromatin compaction, silencing, and accessibility. He employs single-molecule techniques and chemical synthesis to reconstitute and analyze chromatin states, with applications in understanding epigenetic diseases, aging, and CRISPR-Cas9 genome editing dynamics. Recent studies highlight mechanisms of HP1α-mediated heterochromatin assembly and pioneer transcription factor invasion into compact chromatin. Doctoral Program Leadership: As Director of the EDCH program, he oversees training in chemistry and chemical engineering, ensuring academic rigor and interdisciplinary collaboration. His lab collaborates extensively with EPFL's Chemical Biology NCCR and contributes to initiatives like the Chemical Biology Seminar Series. Lab & Teams: The LCBM lab uses innovative tools like 'MagIC beads' and semisynthetic nucleosomes to study chromatin modifications. Current projects include exploring how ubiquitin signals modulate DNA repair proteins and how histone aging impacts chromatin stability. Collaborations span biophysics, biochemistry, and synthetic chemistry.
