جستجوی استاد راهنمای دانشگاهی

Floris Hofstede is an Assistant Professor at Utrecht University Medical Center (UMC Utrecht), specializing in medical genetics and neurodevelopmental disorders. His research focuses on characterizing genetic and metabolic conditions affecting neurological development in children. Research Interests: Dr. Hofstede investigates rare genetic disorders including molybdenum cofactor deficiency, tyrosinemia, phenylketonuria, and BAF-related syndromes. His work spans: Genetic basis of neurodevelopmental disorders Metabolic dysfunction in neurological damage Phenotype-genotype correlations Pediatric neurological manifestations Publication Trends: Recent work (2021-2024) demonstrates focus on: Timing mechanisms in cerebral damage progression Expansion of clinical phenotypes in genetic disorders Multi-omics approaches to rare diseases

• Genetic Disorders
• Metabolic Disorders
• Neurodevelopmental Disorders
• +۲ مورد دیگر

Prof. Eddy van der Zee is a Professor at the University of Groningen's Faculty of Science and Engineering, leading the Van der Zee lab in Molecular Neurobiology. His research focuses on neuroscience topics including hippocampal function, circadian rhythms, and neurodegenerative diseases like dementia and Parkinson's. He has received the Dutch Zoology Prize (1996) and leads major projects such as BIRD-NL (dementia prevention) and AL-III (Parkinson's treatment via whole-body vibration). Academic Roles: Professor, Molecular Neurobiology Lab Director Key Research Areas: Neurodegeneration, Behavioral Neuroscience, Circadian Biology Recent studies investigate social health integration in dementia, cortical activation via vibration, and circadian dysfunction in PKU models. He supervises PhD students including Ronde, Ahuja-Wilming, and van der Goot. His work bridges preclinical and clinical research, with datasets on vibration therapy and PKU interventions. Editorial roles include Frontiers in Aging Neuroscience.

• Neuroscience
• Molecular Neurobiology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Danique Draaisma-van Vliet is a researcher at the University of Groningen, specializing in phenylketonuria (PKU) and metabolic disorders. Her work integrates biochemistry, nutrition, and clinical research to advance understanding of PKU pathophysiology and treatment strategies. Research Focus: Phenylalanine metabolism and its neurological impacts Dietary interventions including amino acid supplementation Gut microbiome interactions in metabolic disorders Mouse models for PKU research Patient-centered care approaches for rare diseases Her publications demonstrate consistent focus on PKU biomarkers, therapeutic interventions, and patient outcomes, with recent work emphasizing nutritional biochemistry and neurocognitive correlations. Collaborative projects span multiple countries, including Germany and the UK. She contributed to a significant open dataset on dietary interventions in PKU, widely accessed through the University of Groningen repository.

• Phenylketonuria
• Phenylalanine Metabolism
• Dietary Supplementation
• +۵ مورد دیگر

Prof. E.A. (Eddy) van der Zee is a Full Professor at the University of Groningen, affiliated with the Faculty of Science and Engineering and the Groningen Institute for Evolutionary Life Sciences. His primary role is as a Molecular Neurobiology researcher within the Van der Zee Lab. He holds additional leadership roles including Chair of IvD-UMCG, Education Director of the Groningen Institute for Evolutionary Life Sciences, and President of WAVEX (an international society for whole-body vibration research). He is also a member of the College van Beroep voor de Examens. His research focuses on neurosciences, behavioral sciences, and biology, with specializations in neurodegenerative disorders, cognitive neuroscience, and the neurobiological impacts of whole-body vibration. He leads major projects such as BIRD-NL (focusing on dementia prevention), AL-III (combating Parkinson’s disease via LRKK2 modulation), and studies on microbiome effects in Phenylketonuria (PKU). Prof. van der Zee has been awarded the Dutch Zoology Prize (1996). His recent work integrates human and animal models to explore social health, cognitive decline, and neuroplasticity. He collaborates internationally and actively contributes to editorial roles in journals like Frontiers in Aging Neuroscience and Journal of Integrative Neuroscience . He mentors a diverse group of researchers and PhD candidates, advancing translational neuroscience and public health initiatives. His lab emphasizes interdisciplinary approaches to address complex neurological challenges.

• Neurosciences
• Behavioural Sciences
• Biology
• +۶ مورد دیگر

Paul Sijens is a Researcher at the University of Groningen , affiliated with the Faculty of Medical Sciences and the BRIDGE (Basic and Translational Research and Imaging Methodology Development in Groningen) program. His career spans academic and clinical research in Magnetic Resonance Imaging (MRI) and NMR spectroscopy , with key contributions to oncology, neurochemistry, and breast imaging. Education: PhD in 31P NMR spectroscopy of tumors from Utrecht University (awarded October 24, 1988). Professional Experience: Led MR Spectroscopy at Daniel den Hoed Cancer Center (1991-2000), postdoctoral work at Cleveland Clinic Foundation (1989-1991) funded by NIH. His research focuses on MRI applications in breast cancer screening , phenylketonuria , and tumor metabolism , integrating deep learning and radiomics to enhance diagnostic precision. Recent publications highlight inter-individual variability in brain phenylalanine transport and AI-driven lesion localization in breast imaging. Notable scientific awards include the EPOS Magna Cum Laude Award (2017) and the Koning Albert Gedenkpenning from FWO Vlaanderen (2017). He serves as an editor for the Journal of Magnetic Resonance Imaging (since 2023) and on editorial boards for radiology journals. Collaborations span institutions like Cleveland Clinic Foundation and European Radiology teams.

• Medical Imaging
• Neuroscience
• Radiology
• +۳ مورد دیگر

Dr. Rebecca Heiner-Fokkema is a Clinical Chemist specializing in inborn errors of metabolism at the University of Groningen's Faculty of Medical Sciences. Her research encompasses: Newborn screening methodologies Metabolic disorder diagnostics Biochemical monitoring of inherited disorders Metabolomics applications Her extensive publication record demonstrates significant contributions to phenylketonuria research and neonatal screening programs. Research focuses include: Development of DNA-first newborn screening approaches Metabolic profiling in genetic disorders Biomarker discovery for treatment monitoring Point-of-care testing for metabolic diseases She actively contributes to international consortia evaluating tyrosinemia screening and develops novel diagnostic algorithms using machine learning approaches for rare metabolic conditions.

• Inborn Errors of Metabolism
• Newborn Screening
• Clinical Chemistry
• +۲ مورد دیگر

Dr. Rebecca Fokkema serves as a Researcher within the Metabolism and Transport (MT) department at the Faculty of Medical Sciences, University of Groningen (UMCG). Her work focuses on inherited metabolic disorders with emphasis on phenylketonuria, newborn screening methodologies, and metabolic homeostasis. Her research interests span Phenylketonuria pathophysiology and treatment optimization Novel newborn screening approaches including DNA-first strategies Phenylalanine and creatine homeostasis mechanisms Dried blood spot monitoring for remote patient management Metabolic consequences of kidney transplantation Current work integrates machine learning with metabolomics for rare disease diagnosis. Recent publications demonstrate strong focus on translational applications, particularly in Glycogen storage disorder diagnostics using acylcarnitine profiles Individualized phenylalanine management in neurological contexts Treatability criteria for expanding newborn screening panels Her team actively contributes to European metabolic disorder research networks. Dr. Fokkema has supervised 4 research projects and delivered multiple professional presentations including 'Dried blood spot monitoring in Tyrosinaemia type I' (2020) and 'Aspartame in soft drinks across Europe' (2019). She has contributed to 16 research datasets with emphasis on mitochondrial fatty-acid oxidation disorders and metabolic modeling.

• Phenylketonuria
• Newborn Screening
• Phenylalanine Metabolism
• +۵ مورد دیگر

Robbert Havekes is an Associate Professor at the University of Groningen's Faculty of Science and Engineering, specializing in the Neuroscience of Memory and Sleep. He leads the Havekes lab, which investigates molecular mechanisms underlying memory storage and how sleep deprivation impacts these processes. His work integrates behavioral studies, genetic/pharmacological approaches, and optogenetics. Education: PhD in Neurobiology (University of Groningen, 2007). Postdoctoral training at the University of Pennsylvania (2007-2015). Research focuses on synaptic plasticity, hippocampal function, sleep deprivation effects, and translational approaches like chemogenetics and viral models. Research Interests: Molecular underpinnings of memory, sleep deprivation's neurobiological effects, neurodevelopmental disorders, and circadian rhythms. Key topics include cAMP signaling, synaptic spines, and memory engram manipulation. Grants & Awards: Over €1.5M in funding, including an HFSP Young Investigator Grant (2017-2020) and Dutch Rubicon Fellowship (2007-2009). Recognitions include best oral/poster awards at sleep research conferences. Students & Labs: Supervises PhD students on projects like memory engrams, autism spectrum disorders, and hibernation neurobiology. Collaborates with teams studying PKU and sleep's role in modern society. Labs/Teams: Co-leads the BioClock consortium exploring circadian rhythms and light effects. Active in editorial roles for Frontiers in Behavioral Neurosciences and Neurobiology of Learning and Memory.

• Learning and Memory
• Hippocampal function
• Synaptic plasticity
• +۷ مورد دیگر

Kerensa Broersen is a Full Professor in Applied Stem Cell Technologies and an Associate Professor at the TechMed Centre, University of Twente. Her research focuses on stem cell engineering, organoid development, and neurodegenerative diseases, particularly Alzheimer's and Parkinson's. She leads interdisciplinary projects combining microfluidics, protein biochemistry, and biomedical engineering to model diseases and develop therapeutic strategies. Her work addresses protein aggregation mechanisms, blood-brain barrier modeling, and organ-on-chip systems. Broersen has received prestigious grants including the Internationale Stichting Alzheimer Onderzoek (2012) and ZONMW Grant (2014). Her lab collaborates globally on topics like amyloid beta toxicity and novel drug delivery systems. Key Research Themes: Alzheimer's pathology, organoid engineering, protein misfolding Technical Expertise: Microfluidic devices, stem cell differentiation, in vitro disease modeling Broersen's recent work advances biopurification techniques for plant proteins and investigates TNFR1 antagonists for neuroprotection. She has published over 50 peer-reviewed articles and reviews, with significant contributions to understanding amyloid-beta aggregation dynamics and oxidative stress mechanisms in neurodegeneration.

• Stem Cell Technologies
• Neurodegenerative Diseases
• Organoid Engineering
• +۶ مورد دیگر

Francjan van Spronsen is a full Professor in Pediatrics and a pediatrician specializing in Inherited Metabolic Diseases at the University Medical Centre Groningen (UMCG) and Beatrix Children's Hospital. He holds a leadership role as head of the Division of Metabolic Diseases. His research focuses on metabolic disorders such as Phenylketonuria (PKU) and Tyrosinemia Type I, emphasizing metabolic control, neurocognitive outcomes, and treatment innovations. He has authored over 100 publications in these areas. Education: MD from University of Groningen, PhD (1996) on PKU, specialization in Pediatrics (1997). Roles: Chair of Dutch Advisory Committee for Neonatal Screening, European Society of PKU Scientific Advisory Board, and multiple international advisory roles. Research interests include newborn screening protocols, metabolic pathway analysis, and long-term management strategies for amino acid disorders. He collaborates globally on guidelines for PKU and Tyrosinemia, including European treatment protocols. Key contributions: Over 150 articles on metabolic diseases, leadership in newborn screening evaluation, and advocacy for patient-centered care. Active in clinical trials for therapies like sapropterin and enzyme replacement.

• Pediatrics
• Metabolic Disorders
• Inherited Metabolic Diseases
• +۴ مورد دیگر

Theo Boer is a researcher active in metabolomics, lipidomics, and bile acid metabolism studies. His work intersects with biomedical research and clinical nutrition, particularly in mouse models and human intestinal physiology. Primary research areas include metabolomics, lipidomics, and bile acid metabolism Contributions to phenylketonuria studies and kidney transplant nutrition Pioneering methods for analyzing small intestinal samples Recent publications focus on metabolic profiling in rare diseases, bile acid regulation via FXR activation, and nutritional biomarkers for mortality risk. His work combines gas chromatography , mass spectrometry , and isotopologue analysis for precise metabolite quantification. Media engagements include expert commentary on medical ethics related to euthanasia in Canada, demonstrating his role as a public science communicator. This aligns with SDG 3 (Good Health and Well-being) through metabolic disease research and ethical healthcare discourse.

• Metabolomics
• Lipidomics
• Bile Acid Metabolism
• +۵ مورد دیگر

Dr. Stefanie Vink is a Researcher at the University of Groningen , affiliated with the Groningen Institute for Evolutionary Life Sciences and the GREEN Microbial Ecology cluster . Her work focuses on microbial ecology in semi-natural ecosystems and low-input agriculture, particularly plant-microbial interactions. She is currently leading the potatoMETAbiome project and owns GreenFinch Research . Education and Expertise : Stefanie holds expertise in microbial and plant ecology, bioinformatics, and molecular data analysis. Her research spans bacterial, fungal, and nematode communities in agricultural and conservation contexts. Research Themes : Key areas include microbial community dynamics in vineyards, coffee agroecosystems, and Machair ecosystems. She investigates how soil management, irrigation, and land use impact microbiota, with applications to sustainable agriculture and biodiversity conservation. Publications : Recent work highlights persistent bacterial associations in pest insects, gut microbiome responses to phenylketonuria, and grapevine rootstock interactions. Her studies often blend field observations with advanced molecular techniques. Grants and Projects : Received €2M from Waddenfonds for coastal projects. Collaborations include Molecular Biology Systems for rapid diagnostic tools (e.g., E. coli detection). Labs/Teams : Active in interdisciplinary teams at the GREEN cluster, focusing on microbial ecology and agroecosystem resilience.

• Ecology
• Microbiology
• Soil Science
• +۳ مورد دیگر

Stephanus Huijbregts is an Assistant Professor in the Department of Clinical Neurodevelopmental Sciences at Leiden University, specializing in the interplay between cognition, social functioning, and neurobiological processes. His research spans typically developing children, those with psychopathology (aggression/antisocial behavior, substance use), genetic syndromes (NF1, PKU, TT1), and perinatal risk factors. Affiliated with the Leiden Institute for Brain and Cognition since 2010, he leads interdisciplinary projects integrating near-infrared spectroscopy, neuroimaging, and longitudinal assessments. Education: PhD in Clinical Neuropsychology (Vrije Universiteit Amsterdam, 2002), Psychology (Leiden University, Cognitive Psychology), postdoctoral research (Université de Montréal, 2003-2004), Lecturer (University of Southampton, 2005-2009) His research on genetic syndromes (NF1, PKU, TT1) and environmental risks (prenatal tobacco exposure) has yielded over 97 publications. Key projects include grants from Leiden University Fund, NWO, ZonMW, and international collaborations on European PKU guidelines. He has supervised 9 PhD candidates, including studies on executive function in PKU, social cognition in NF1, and stress reactivity in prenatal risk populations. Scientific Awards: Teva/Aventis Young Investigator Award (2004) for Multiple Sclerosis research His work emphasizes the role of executive functions, autonomic nervous system reactivity, and early intervention in shaping developmental outcomes. Current activities include editorial roles, grant reviewing, and organizing international conferences on behavioral phenotypes.

• Aggression
• Behavioral Problems
• Genetic Syndromes
• +۴ مورد دیگر