جست‌وجوی استاد و پژوهشگر

Irina Burdمشاهده پروفایل

استاد

• Maternal Fetal Medicine
• Fetal Neurosonology
• Fetal Echocardiography
• +۷ مورد دیگر

Dr. Irina Burd is the Sylvan Frieman, MD Endowed Professor and Chair of the Department of Obstetrics, Gynecology and Reproductive Sciences at the University of Maryland . With clinical expertise in high-risk pregnancy conditions and fetal brain development , she combines translational research with leadership in national women's health initiatives. BA in Biology, Rutgers University (1995) MD/PhD, Rutgers-Robert Wood Johnson Medical School (2003) Residency, Thomas Jefferson University Hospital (2007) Fellowship, University of Pennsylvania (2010) Her research focuses on fetal programming through intrauterine inflammation and infection , particularly examining neuroimmune mechanisms in perinatal brain injury. Current work explores Zika virus pathogenesis and nanomedicine approaches for preterm birth prevention. Selected publications reveal expertise in IL-1β signaling , P2X7 receptor antagonism , and CD8+ T cell immunomodulation , with 20+ years of NIH funding and leadership in NICHD study sections. Awards include the Passano Foundation Clinician Scientist Award and election to the American Society for Clinical Investigation (2023). Founded Fetal Neurosonology program at Johns Hopkins Secured NIH funding for Zika virus research (R01HD097608) Lead investigator for nanomedicine preterm birth studies (R01HD1031240) Principal Investigator, Healthy Brain and Child Development Consortium (U01DA055350)

Hernandez Moura Silvaمشاهده پروفایل

استادیار

• Immunology
• Tissue Physiology
• Metabolic Syndrome
• +۳ مورد دیگر

Hernandez Moura Silva is an Assistant Professor of Biology at MIT and a Core Member of the Ragon Institute of MGH, MIT & Harvard. His research focuses on immune-related pathways modulating organ and tissue physiology to develop therapeutic strategies for human diseases. His lab, the Laboratory of ImmunoPhysiology, employs an interdisciplinary approach to study macrophage biology and immune-tissue interactions. Education: PhD in Biology from the University of São Paulo (2011), MSc in Molecular Biology from the University of Brasilia (2008), and BS in Biology from the University of Brasilia (2005). Research Interests: Immunology, Tissue Physiology, Metabolic Syndrome, Inflammatory Disease, Macrophage Biology, and Immunotherapy. His work emphasizes how immune cells like macrophages maintain tissue homeostasis and contribute to pathologies like obesity, metabolic syndrome, and cancer. Notable Awards: 2012 CAPES Thesis Award (Brazil). Grants & Collaborations: His work is supported by initiatives like the HHMI Freeman Hrabowski Scholar program. He collaborates widely, evidenced by co-authored studies on topics like p53 mutation effects in pancreatic cancer and Th17 cell regulation. Labs/Teams: Leads the ImmunoPhysiology Lab at MIT, integrating immunology, physiology, and systems biology to study immune-tissue interfaces.

• Mucosal Immunology
• Inflammatory Bowel Disease
• Microbiome Research
• +۵ مورد دیگر

Dr. Penelope Felipe Pelczar is a prominent researcher at the University Medical Center Hamburg-Eppendorf, affiliated with the Faculty of Medicine and specifically the I. Medical Clinic and Polyclinic. With a doctoral degree (Dr. rer. nat.), she has established herself as a leading investigator in mucosal immunology and inflammatory bowel disease research. Her research focuses on the intricate relationship between the immune system, gut microbiota, and intestinal inflammation, with particular expertise in T cell biology, cytokine signaling (especially IL-22 pathways), and the mechanisms underlying inflammatory bowel disease and associated cancers. Dr. Pelczar's work bridges basic immunological mechanisms with clinical applications, contributing significantly to our understanding of mucosal immunity and its dysregulation in disease. Her recent publications in high-impact journals like Nature, Science Immunology, and Gut demonstrate her continued leadership in the field, with research spanning from fundamental immune mechanisms to translational applications in gastrointestinal diseases and cancer. Her work on microbiome-host interactions, particularly regarding how microbial metabolites influence disease processes and treatment responses, represents a cutting-edge area of immunological research. While specific awards are not documented in the provided information, her consistent publication record in top-tier journals and collaborative work with leading researchers in immunology and gastroenterology speaks to her standing in the scientific community. Her research has been supported by what appears to be substantial institutional and possibly external funding, enabling sophisticated methodologies including single-cell analyses and advanced imaging techniques. Dr. Pelczar appears to be actively involved in research teams focusing on immunology, immunity, and infection (C3i) as well as oncological research through the UCCH consortium at the University Medical Center Hamburg-Eppendorf, contributing to the vibrant research ecosystem documented in the institution's key research areas.

• Neuroscience
• Epilepsy
• Neuropharmacology
• +۵ مورد دیگر

Sean Quinlan is a Lecturer in Neuroscience at the School of Biomolecular and Biomedical Science, University College Dublin. His research focuses on the pathophysiology of early-life seizures and their role in epilepsy etiology, particularly examining calcium-activated potassium channels, intracellular calcium receptors, and hippocampal cellular dynamics. His work emphasizes neurotoxicity profiles of anti-seizure medications, transcriptomic alterations in the hippocampus, and the intersection of neuroinflammation with seizure pathology. Recent studies explore purinergic signaling, microRNA detection methods, and neurodevelopmental outcomes of drug interventions. Quinlan's publications span seizure suppression mechanisms (Padsevonil), comparative neurotoxicity analysis (phenobarbital vs. levetiracetam), and advanced diagnostic approaches for neonatal encephalopathy using purine nucleosides. His research integrates molecular neuroscience, pharmacology, and clinical translational models. Scientific awards include the Conway Fellow (University College Dublin, 2024) MSCA Research Fellow (2022-2024) Quinlan teaches Membrane Biology (Neur30080, 2024) and holds certifications in Bioinformatics and Data Analytics from University College Dublin.

• Cardiovascular Disease
• Chronic Kidney Disease
• Inflammation
• +۷ مورد دیگر

Dr. Heidi Noels is a Researcher at the Institute for Molecular Cardiovascular Research (IMCAR) within the Medical Faculty of RWTH Aachen University . Her work bridges cardiovascular disease and chronic kidney disease (CKD) , focusing on molecular mechanisms linking renal dysfunction to cardiovascular complications. Current Affiliation: IMCAR, RWTH Aachen University Collaborations: Saarland University, University Hospital Aachen, European Uremic Toxin Work Group Research Focus: Dr. Noels investigates uremic cardiomyopathy , vascular calcification , inflammatory signaling , and platelet abnormalities in CKD . Her studies explore how uremic toxins drive endothelial dysfunction and atherosclerosis , using murine models and meta-analyses of clinical data. Publication Trends: Recent work highlights renal-cardiac crosstalk (2025), chemokine pathways in myocardial repair , and mitochondrial dysfunction in CKD. She contributes to endothelial cell studies , complement receptor signaling , and dietary interventions like the Mediterranean diet in aging populations. Lab & Consortium Involvement: Dr. Noels is integral to the SFB/TRR219 Research Centre , a collaborative effort between Aachen University Hospital and Saarland University, aiming to translate findings into therapies for CKD-associated cardiovascular risks.

Kwang Poo Changمشاهده پروفایل

استاد

• Microbial Virulence
• Leishmania Pathogenesis
• Molecular Parasitology
• +۷ مورد دیگر

Dr. Kwang Poo Chang is a Professor of Microbiology and Immunology at Chicago Medical School, Rosalind Franklin University of Medicine and Science, where he has maintained an active research program since 1983. His work focuses on molecular mechanisms of microbial virulence using Leishmania as a model system to dissect invasive/evasive determinants and pathoantigenic determinants responsible for disease manifestation. Dr. Chang earned his BS in Entomology from National Taiwan University (1965), followed by MA and PhD in cell biology/endosymbiosis from the University of Guelph, Canada (1968, 1972). After postdoctoral training at Rockefeller University (1972-1974), he served on their faculty as Research Associate (1974-1976), Assistant Professor (1976-1979), and Associate Professor (1979-1983) before joining Rosalind Franklin University. His research spans molecular biology of virulence genes, biochemical characterization of Leishmania enzymes (gp63, nucleoside diphosphate kinase), host-parasite cellular interactions, and photodynamic approaches for vaccination and therapy. Current projects include genetic dissection of heme biosynthesis defects in trypanosomatids and development of photo-medicines for infectious diseases and cancer. Analysis of Dr. Chang's publication record reveals sustained contributions to parasitology with recent emphasis on photodynamic vaccination (2018), vector control (2016), and disease epidemiology (2015). His work bridges fundamental molecular mechanisms with translational applications, particularly in neglected tropical diseases. Dr. Chang's NIH-funded research demonstrates significant scholarly impact, with over 50 peer-reviewed publications spanning five decades. His laboratory within the Center for Cancer Cell Biology, Immunology, and Infection provides interdisciplinary training in molecular parasitology and therapeutic development. Students in Dr. Chang's laboratory gain expertise in gene transfection systems, protein purification techniques, host-pathogen interaction assays, and photodynamic therapy applications. His international collaborations with researchers in Brazil, China, and other countries provide additional opportunities for global health engagement.

• Organic Chemistry
• Medicinal Chemistry
• Bioorganic Chemistry
• +۷ مورد دیگر

Professor John Spencer is a Professor of Bioorganic Chemistry and Director of the Sussex Drug Discovery Centre within the School of Life Sciences at the University of Sussex. With a distinguished career spanning academia and the pharmaceutical industry, he leads a research group focused on innovative drug discovery approaches. His educational background includes a first-class honors degree from Sussex, a PhD from the University of Strasbourg (1990-1994), and postdoctoral studies at ETH Zurich. After 10 years in the pharmaceutical industry, he held academic positions first as Reader at Greenwich University (5 years) and then at the University of Sussex where he progressed from Reader to Professor. Professor Spencer's research spans organic synthetic methodology, fragment-based drug design, PROTAC development, and C-H activation chemistry with applications in cancer, neurodegenerative disorders, and infectious diseases. His work bridges fundamental chemical research with therapeutic applications, particularly in targeted protein degradation and novel drug delivery systems. Analysis of his recent publications (2023-2025) reveals a strong focus on structure-guided drug design, with significant contributions to PROTAC technology, fragment-based screening methods, and the development of novel therapeutic approaches for cancer and infectious diseases. His work frequently appears in high-impact journals including Nature Communications, Angewandte Chemie, and Journal of Medicinal Chemistry. Over 30 active and recent grants from major funding bodies including Wellcome Trust, EPSRC, Cancer Research UK, and industry partners Significant contributions to the Open Science discovery of SARS-CoV-2 main protease inhibitors Leadership in the Sussex Drug Discovery Centre infrastructure Professor Spencer actively supervises multiple PhD students and postdocs while maintaining strong industry collaborations. His advisory roles include the Prostate Cancer UK Research Advisory Committee (2023-2027) and previous service on the Worldwide Cancer Research advisory board. He teaches Bioorganic Chemistry (Year 3), Advanced Organic Chemistry (Year 4), and Advanced Medicinal Chemistry for MSc students. The Sussex Drug Discovery Centre under Professor Spencer's leadership serves as a hub for collaborative drug discovery research, connecting academic researchers with pharmaceutical industry partners to advance novel therapeutic approaches from concept to preclinical development.

• Ion Channel Biology
• Neuroscience
• Pharmacology
• +۴ مورد دیگر

Dr. Ruth Murrell-Lagnado is an Associate Professor in Neuroscience at the School of Life Sciences, University of Sussex. She previously held a lectureship in the Department of Pharmacology at the University of Cambridge from 1993 to 2015. Her academic journey began with a Pharmacology degree at University College London, followed by a PhD at Cambridge studying ion channels under Denis Haydon. She completed postdoctoral training at Oxford University with Aviva Tolkovsky and at Stanford University with Rick Aldrich. Dr. Murrell-Lagnado's research focuses on ion channel biology, particularly the P2X purinergic receptor family. Her work investigates the structure, function, and regulation of P2X receptors, their role in lysosome function, calcium signaling, and implications in disease. She has made significant contributions to understanding how membrane cholesterol regulates P2X receptor signaling and how P2X4 receptors function within lysosomes. Her recent publication record shows consistent output in high-impact journals, with research spanning from basic ion channel mechanisms to translational applications in cancer and neurological disorders. Her work demonstrates a progression from fundamental ion channel studies to more complex cellular and disease-related mechanisms. Editorial Board Member, Journal of Physiology Editorial Board Member, Journal of General Physiology Dr. Murrell-Lagnado has secured competitive research funding from major organizations including the Medical Research Council, Wellcome Trust, Alzheimer's Research UK, and the European Union. Her current projects include investigating Kv2.1 channel openers for dementia applications and developing non-opioid analgesics. She has trained numerous PhD students and postdocs who have gone on to careers in pharmaceutical and biotech industries. Her laboratory employs a multidisciplinary approach combining electrophysiology, fluorescence microscopy, molecular biology, and drug discovery techniques to investigate ion channel function and regulation. The lab has particular expertise in studying P2X receptor signaling in the context of lysosomal function and cancer biology.

Brian D. Gulbransenمشاهده پروفایل

استاد

• Neuroinflammation
• Neuroglia
• Enteric Nervous System
• +۵ مورد دیگر

Brian D. Gulbransen is a Professor in the Department of Physiology at Michigan State University, holding the MSU Research Foundation Professorship. His work focuses on neuroinflammation and enteric nervous system (ENS) biology, particularly neuron-glia interactions in gut physiology and disease. Department of Physiology, Michigan State University MSU Research Foundation Professor Research Interests : Understanding how neuroinflammation alters neural circuitry through glial cell mechanisms, with applications to functional bowel disorders like IBS and IBD. Key techniques include fluorescence microscopy, genetic models (DREADDs, cell-specific knockouts), electrophysiology, organ physiology, and transcriptomics. Scientific Trends : Analysis of his 15 most recent publications reveals: Purinergic signaling (P2X7, P2Y receptors) Enteric glia-neuron-macrophage crosstalk Role of connexin-43 hemichannels Microbiota-glia interactions Stress-induced gut dysfunction Neuroimmune regulation of motility Education : University of Wyoming (B.S. Zoology & Physiology, 2003) University of Colorado Anschutz (Ph.D. Neuroscience, 2007) University of Calgary (Postdoctoral Fellow, 2014) Collaborations span neurogastroenterology, immunology, and metabolic disease research, with grants supporting studies on neuroinflammation, microbiome interactions, and gut motility disorders.

Liana Asatryanمشاهده پروفایل

استادیار

• Alcohol Use Disorder
• Neuroscience
• Neuroimmunology
• +۸ مورد دیگر

Liana Asatryan, PhD is an Assistant Professor of Clinical Pharmacy at the University of Southern California's School of Pharmacy, where she serves in the Titus Family Department of Clinical Pharmacy. She lectures in the undergraduate and MS in Management of Drug Development degree programs within the Regulatory Science program at USC Mann and directs the Clinical and Experimental Therapeutics program. Dr. Asatryan earned her PhD in Biochemistry from the Institute of Molecular Biology, National Academy of Sciences of Armenia and completed a Graduate Certificate in Clinical Research Design & Management in Regulatory Science at USC. Dr. Asatryan's research focuses on understanding mechanisms of neuro-immune communication and their role in the development of alcohol use disorder (AUD) and other neurological disorders as well as alcohol liver disease. Her work identifies novel targets for therapeutic strategies to prevent or treat AUD-related inflammation and neuroinflammation, with particular emphasis on ligand-gated ion channels implicated in neuroinflammation and neurodegeneration. Recent developments in her research explore the gut-immune-brain axis communication, focusing on the role of microbiome in AUD and alcoholic liver disease. Her recent publications demonstrate a strong focus on the role of purinergic receptors, particularly P2X4 and P2X7 receptors, in alcohol-related disorders. Research trends show increasing attention to the gut microbiome's influence on alcohol consumption behavior and neuroinflammation, with exploration of therapeutic interventions like sodium butyrate and avermectins for treating AUD. Dr. Asatryan has received several prestigious awards and grants for her research: KO1 Career Development Grant from National Institutes of Alcoholism and Alcohol Abuse Rose Hills Foundation Innovator Grant for "Alcohol and Host Microbiome Interactions in Alcohol Consumption Behavior" (2019-2021) Zumberge Fund Individual Grant for "The Role of P2X7 Receptors in Alcohol-induced Neuroinflammation and Degeneration" (2014-2015) National Institutes of Alcoholism and Alcohol Abuse KO1 Grant for "Sites of Ethanol Action in Purinergic P2X4 Receptors" (2008-2013) Dr. Asatryan serves as Principal Investigator on multiple research projects investigating the relationship between gut microbiome and neurological conditions including AUD, targeting purinergic P2X7 receptors for conferring inflammation in brain and liver induced by chronic alcohol exposure, and screening drug candidates for activities in brain receptors to treat mild cognitive impairment and Alzheimer's Disease. Her collaborative research with Dr. Daryl Davies has been particularly productive in advancing our understanding of alcohol use disorders. Her laboratory employs various murine models including Drinking in the Dark and Two-bottle Choice paradigms to assess preclinical efficacy of lead anti-alcohol compounds. Current research directions include exploring the therapeutic potential of sodium butyrate and other compounds targeting the gut-brain axis in alcohol use disorders.

• Ion Channel Pharmacology
• Receptor Biology
• Molecular Pharmacology
• +۵ مورد دیگر

Mette Homann Poulsen serves as an Assistant Professor in the Department of Drug Design and Pharmacology at the University of Copenhagen, with additional affiliation as a Guest Researcher in the Biopharmaceuticals section of the same department. Her research bridges molecular pharmacology and drug design with a focus on ion channel mechanisms. Her primary research interests span Ion Channel Pharmacology , Receptor Biology , and Molecular Pharmacology , particularly investigating P2X and AMPA receptor families. Her work examines pH-sensing mechanisms, transporter-channel crosstalk, and receptor variants in disease contexts including cancer and mental disorders. She employs techniques ranging from protein engineering to cellular electrophysiology to develop pharmacological tools and understand disease mechanisms. Analysis of her recent publications (2018-2025) reveals a strong emphasis on receptor variant functionality, with significant contributions to understanding P2X7 receptor polymorphisms in pancreatic cancer and mental health disorders. Her work integrates biophysical approaches with disease modeling, demonstrating translational potential in oncology and neuroscience. No scientific awards were explicitly mentioned in the source material. Dr. Poulsen maintains active collaborations with researchers including S.A. Pless, N.R. Jørgensen, and I. Novak across multiple institutions. Her research has attracted substantial attention, with publications generating significant Mendeley readership and social media engagement, particularly her 2020 Nature Communications paper which garnered 117 Mendeley readers and 17 social media interactions. While specific laboratory or team structures weren't detailed in the source material, her publication patterns suggest active participation in interdisciplinary research groups focusing on receptor pharmacology and protein engineering within the Department of Drug Design and Pharmacology.