جست‌وجوی استاد و پژوهشگر

Monica P. Colaiacovoمشاهده پروفایل

استاد

• Meiosis
• Chromosome dynamics
• DNA repair
• +۶ مورد دیگر

Dr. Monica P. Colaiacovo is a Professor of Genetics at Harvard Medical School, where she leads research in the Department of Genetics within the Blavatnik Institute. Her laboratory is located in the New Research Building in Boston, Massachusetts. Dr. Colaiacovo's research focuses on the molecular mechanisms of meiosis, chromosome dynamics, and DNA repair in the Caenorhabditis elegans model system. Her work examines how environmental toxicants impact germline function and reproductive health, with particular emphasis on chromosome segregation, recombination, and the synaptonemal complex. Her publications reveal a consistent research trajectory examining critical aspects of meiotic chromosome behavior, including double-strand break formation and repair, crossover designation, and chromosome movement during prophase I. Her laboratory has made significant contributions to understanding how environmental exposures like bisphenol A and phthalates disrupt normal meiotic progression and lead to germline dysfunction. Dr. Colaiacovo's work demonstrates strong interdisciplinary connections between basic chromosome biology, environmental health sciences, and reproductive medicine. Her research group employs advanced genetic, molecular, and imaging techniques to dissect the complex mechanisms ensuring accurate chromosome segregation during gamete formation. Her laboratory actively collaborates with researchers studying aging, DNA repair pathways, and environmental toxicology, as evidenced by publications spanning multiple high-impact journals including Nature, PLoS Genetics, and Genetics.

Amy Catherine Rowatمشاهده پروفایل

استاد

• Mechanobiology
• Cancer biophysics
• Single-cell mechanics
• +۶ مورد دیگر

Amy Catherine Rowat is a full Professor in the Department of Integrative Biology and Physiology at UCLA's College of Letters and Science. She directs an interdisciplinary research program that integrates mechanobiology, microfluidics, cancer biophysics and food engineering to understand how physical forces shape cell behavior and to develop sustainable biotechnologies. Education & Affiliations: Professor, Department of Integrative Biology and Physiology, UCLA Member, UCLA College of Letters and Science Research Interests: Rowat's group deciphers how mechanical properties of cells and their nuclei influence disease progression and therapeutic response. Using high-throughput microfluidic deformability cytometry, her team discovered that cancer cells become stiffer and more invasive upon β-adrenergic signaling, linking stress hormones to metastatic potential. Parallel efforts focus on nuclear envelope mechanics, showing that histone H1.0 and transient nuclear deformation modulate chromatin structure and cell reprogramming. Beyond biomedicine, Rowat pioneers biophysical approaches for sustainable food production. She engineers edible scaffolds and emulsion-templated microcarriers to culture meat at scale, demonstrating spontaneous fusion of adipogenic and myogenic microtissues into marbled steak-like constructs. Recent Article Trends (2020-2025): Her latest publications reveal a cohesive trajectory: coupling mechanobiology to epigenetic regulation (viscoelastic matrix enhances chromatin remodeling), advancing single-cell mechanical phenotyping (optomagnetic arrays, high-throughput screens), translating findings to cancer therapy (β-blockers to sensitize chemotherapy) and expanding engineered foods (scalable cultured-meat bioprocessing). Funding & Awards: NIH R21 CA245667 (PI) – Repurposing beta-blockers to improve chemotherapy response (2021-2023) Laboratory & Teams: Rowat leads an active research laboratory at UCLA that trains graduate students and postdocs at the intersection of physics, engineering and biology. The lab maintains collaborations across UCLA Engineering, Jonsson Comprehensive Cancer Center, and external partners in food science and biotechnology companies.

• Materials Engineering
• Nanomaterials
• Energy Storage
• +۵ مورد دیگر

John Bell is a Professor and Deputy Vice-Chancellor (Research and Innovation) at the University of Southern Queensland (UniSQ), based at the Springfield Campus. He holds a BSc from the University of Sydney and a PhD from the University of New South Wales (UNSW). His leadership role involves overseeing research strategy and innovation initiatives across the institution. Bell's research spans advanced materials and energy technologies, with expertise in: Nanomaterials synthesis and characterization Renewable energy generation/storage (photovoltaics, batteries) Functional polymers and composite materials Semiconductor device engineering Smart building technologies His recent publications (2022-2025) demonstrate a strong focus on sustainable energy solutions, particularly next-generation batteries, solar cells, electrochromic devices, and nanotechnology-enabled sensors. Over 80% of his recent work addresses materials innovation for decarbonization and energy efficiency.

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

• Organoid Engineering
• Systems Biology
• Developmental Biology
• +۳ مورد دیگر

Keisuke Ishihara is an Assistant Professor in the Department of Computational and Systems Biology at the University of Pittsburgh School of Medicine. His research focuses on engineering human brain and cardiac organoids using genetic, chemical, and computational approaches to uncover novel regulatory mechanisms and physical principles underlying tissue development. His lab is located at Biomedical Science Tower 3, with an office in room 10020A. Dr. Ishihara holds a PhD in Systems Biology from Harvard University. His work bridges synthetic biology, developmental biology, and biophysics to address fundamental questions in organogenesis and cellular morphogenesis. Recent research highlights include studies on BMP-mediated neural tube patterning in organoids and the biophysical dynamics of microtubule assemblies in large cells. Publications from his lab emphasize interdisciplinary approaches to understand cell size scaling, mitotic spindle dynamics, and self-organization in synthetic tissues. His team has contributed to advancements in organoid technology, uncovering dormant genetic programs and physical principles governing tissue architecture. Laboratory activities are centered at the University of Pittsburgh, collaborating with the School of Medicine's computational and systems biology initiatives. For more details, visit his lab website linked below.

Roderick Limمشاهده پروفایل

دانشیار

• Nuclear Pore Complex Transport
• Mechanobiology of Cells and Tissues
• Biomimetic Molecular Transport Systems
• +۵ مورد دیگر

Prof. Dr. Roderick Lim is an Associate Professor at the Biozentrum, University of Basel , where he leads a research group since 2014. His work bridges biophysics, nanotechnology, and molecular biology , focusing on the nuclear pore complex (NPC) and mechanobiology of cells . He develops biomimetic systems for selective molecular transport and ARTIDIS , a nanomechanical tissue diagnostic platform commercialized for breast cancer prognosis . Education : BSc (UNC Chapel Hill), PhD (NUS/IMRE Singapore), Postdoc (Swiss Nanoscience Institute) Positions : Argovia Professor (2014–present), Tenure Track Asst. Prof. (2009–2013), Postdoc (2004–2008) His research on NPC transport selectivity reveals how karyopherins modulate the FG Nup barrier via multivalent interactions, with implications for viral entry and Alzheimer’s disease . His ARTIDIS platform uses atomic force microscopy to detect cancer via tissue softness, linking hypoxia to metastasis . Recent 2025 publications explore bacterial nanoharpoon defense mechanisms and DNA origami-based NPC mimics . Scientific Awards : Pierre-Gilles de Gennes Prize (2008), A*STAR Fellowship (2004) Collaborations : NCCR Molecular Systems Engineering, NanoTera, KTI He mentors PhD students in institutions across Switzerland, Singapore, Sweden, and the UK , with alumni working on polymersome delivery, mechanotransduction, and pathogen transport . His lab pioneered high-speed atomic force microscopy for real-time NPC dynamics and plasmonic nanopores for synthetic biology applications.

Ellenberg Janمشاهده پروفایل

پژوهشگر

• Cell biology
• Systems biology
• Cell division
• +۷ مورد دیگر

Jan Ellenberg is a Senior Scientist and Head of the Cell Biology and Biophysics Unit at the European Molecular Biology Laboratory (EMBL) since 2006 and 2010, respectively. He also serves as EMBL Delegate to the Euro-BioImaging Interim Board since 2014 and has coordinated multiple EMBL units and pan-European imaging infrastructure projects. PhD in biochemistry (1998, NIH & Freie Universität Berlin) Diploma in biology (1994, Universität Hamburg) His research focuses on cell biology , nuclear and chromosome dynamics , and advanced microscopy technologies . Key areas include mitosis/meiosis , nuclear pore complex organization , and super-resolution/light-sheet microscopy development. Scientific awards include the Allen Distinguished Investigator (2017), ERC Advanced Investigator (2016), and Walter Flemming Medal (2004). His publications (>130) frequently appear in top journals like Nature, Science, and Cell. 2017 Allen Distinguished Investigator 2016 ERC Advanced Investigator 2016 Honorary Doctor of Philosophy at Åbo Akademi University 2006 EMBO Member

• Autophagy
• Cell Biology
• Membrane Biology
• +۳ مورد دیگر

Thomas Melia is a Professor of Cell Biology at the Yale School of Medicine, part of Yale University. He leads the Melia Lab, focusing on autophagosome biogenesis and membrane dynamics during autophagy. His research integrates cell-based assays with advanced imaging techniques like electron cryo-microscopy. Key areas include understanding membrane sources for autophagosomes, lipid transport mechanisms, and organelle formation under cellular stress. Education: PhD in Biochemistry from Baylor College of Medicine (1999), BS in Biological Sciences from Carnegie Mellon University (1992) Research Interests: Autophagy, lysosomal biology, membrane trafficking, and protein aggregate clearance Lab Affiliations: Collaborates with departments like Biochemistry, Quantitative Biology, and Molecular Cell Biology Melia's work bridges molecular mechanisms with cellular function, particularly in how cells respond to starvation or pathogen invasion by degrading cytosolic components. Recent studies highlight roles for dynamin-like proteins in nuclear autophagy and lipid transfer proteins in organelle biogenesis.

Tomoyuki Tanakaمشاهده پروفایل

استاد

• Chromosome Segregation
• Mitosis
• Cell Cycle Regulation
• +۷ مورد دیگر

Professor Tomoyuki Tanaka holds the Chair of Cell and Molecular Biology at the University of Dundee within the School of Life Sciences . He serves as the Academic Lead of Dundee Imaging Facility (since 2018) and Deputy Head of the Division for Molecular Cell & Developmental Biology (since 2022). His research focuses on chromosome segregation mechanisms in mitosis and their implications in genetic diseases and cancer . Member of European Molecular Biology Organisation (EMBO, 2008–) Fellow of Royal Society of Edinburgh (2009–) Wellcome Trust Investigator (2020–) His lab investigates two key processes in early mitosis: chromosome reorganization (resolution and compaction of sister chromatids) and kinetochore-spindle interactions . These mechanisms are critical for preventing errors linked to aneuploidy, congenital disorders, and cancers . Using budding yeast as a model organism, his group combines genetic, proteomic, and imaging techniques to uncover conserved biological principles. Recent publications highlight discoveries in condensin exclusion during prophase , Aurora B kinase spatial regulation , and error correction mechanisms for accurate chromosome inheritance. The lab also contributes to in vitro reconstitution of chromosomal processes, including a 2021 breakthrough on chromosome positioning networks . 2020: Wellcome Investigator Award 2013: ERC Advanced Grant 2007: Hooke Medal (British Society for Cell Biology) 2000: EMBO Young Investigator He supervises PhD students and contributes to Level 3 undergraduate teaching (BS31006 Gene Regulation) and Honours research projects . His work aligns with UN Sustainable Development Goals for health and well-being through genetic disease research.

Ulrike Kutayمشاهده پروفایل

استاد

• Nuclear envelope structure and biogenesis
• Nucleo-cytoplasmic transport
• Metazoan ribosome biogenesis
• +۳ مورد دیگر

Ulrike Kutay is a Full Professor of Biochemistry at ETH Zurich, Switzerland, with a research focus on nuclear biology and dynamics. Her work investigates nuclear envelope structure/function, ribosome biogenesis, and nucleo-cytoplasmic transport. Diploma in Biochemistry (Free University Berlin, 1992) PhD in Natural Sciences (Humboldt University Berlin, 1996) Research interests center on nuclear compartmentalization, including mitotic nuclear envelope breakdown and reassembly, ribosome assembly pathways, and the molecular mechanisms governing nuclear transport. Her lab explores how nuclear dysfunction contributes to diseases like ribosomopathies and cancer. Recent publications highlight her work on SUN/KASH proteins in nuclear envelope dynamics, ribosome biogenesis steps, and nuclear pore complex regulation. Collaborations with groups like the Spahn lab in Berlin underscore her interdisciplinary approach. EMBO Member (2010) Leopoldina Member (2012) ERC Advanced Grant (2012) As a mentor, she has supervised PhD students including Chiara and Roja. She actively participates in editorial boards, grant review panels (e.g., ERC, DFG), and institutional leadership roles at ETH Zurich and the Biochemistry Center Heidelberg. The Kutay Group at ETH Zurich combines proteomics, functional analyses, and structural studies to unravel nuclear processes, fostering a collaborative environment with recent achievements in mitotic nuclear disassembly and ribosome maturation research.

Gabriel A. Cookمشاهده پروفایل

دانشیار

• Biochemistry
• Chemistry
• Nuclear Magnetic Resonance Spectroscopy (NMR)
• +۴ مورد دیگر

Gabriel A. Cook is an Associate Professor in the Department of Chemistry at Oklahoma State University (OSU), where he has held his current position since July 2024. Previously, he served as an Assistant Professor at OSU from 2014 to 2024. His academic background includes a PhD in Biochemistry from Kansas State University (2005) and a postdoctoral fellowship at the University of California San Diego (UCSD) focusing on membrane protein structural biology. Dr. Cook's research focuses on the structure, dynamics, and interactions of membrane glycoproteins, particularly their role in diseases such as muscular dystrophy and cancers. His lab employs nuclear magnetic resonance (NMR) spectroscopy to study these proteins in lipid environments, including the use of nanodiscs and solid-state NMR techniques. Key proteins under investigation include γ-sarcoglycan and Syndecan-1, which are linked to muscle integrity and cancer biomarkers, respectively. In addition to research, Cook teaches General Chemistry and graduate courses on biophysical chemistry. He supervises PhD students and collaborates on projects involving glycosylation studies and drug development. His lab has secured funding for initiatives such as the REU Site: Multi-disciplinary Research in Chemical Sciences and studies on SARS-CoV-2 entry proteins. Key grants include the NIH-funded 'Glycosylation and Structural Studies of SARS-CoV-2 Entry Membrane Protein TMPRSS2' and OSU's Henry Bellmon Research Center collaborations. His work has led to advancements in understanding viroporin function, bacterial pathogenesis, and protein-lipid interactions.

• Chemical Biology
• Fluorescence Guided Surgery
• Drug Delivery
• +۵ مورد دیگر

Prof. Donal O'Shea is a Professor in the Department of Chemistry at the Royal College of Surgeons in Ireland (RCSI). Previously, he held roles including Head of Pharmaceutical & Medicinal Chemistry at RCSI and Associate Professor/Senior Lecturer at University College Dublin (UCD). He earned a PhD (1993) and BSc (1990) in Chemistry from University College Galway. His research focuses on synthesizing complex molecules for applications in fluorescence-guided surgery , light-activated anti-cancer agents , and nanomedicine . Key areas include near-infrared fluorophores , drug delivery systems , and collaborations with medical imaging. He has led initiatives like the Centre for Synthesis & Chemical Biology at UCD and contributed to projects on exosome imaging and anti-microbial agents. Recent publications highlight innovations in fluorescence imaging probes , vaping health risk modeling , and bioorthogonal reactions . His work aligns with UN Sustainable Development Goal 3 (Good Health). Awards include the 2012 North/South Ireland Lectureship , Teacher of the Year (2008, 2011), and multiple visiting professorships. He has secured grants totaling millions, including SFI-funded projects on super-resolution imaging and colorectal cancer diagnostics . Prof. O'Shea oversees RCSI's Chemistry Department and collaborates internationally. His lab develops tools for real-time cellular imaging and targeted drug delivery , with applications in surgery and oncology.

Sabrina Büttnerمشاهده پروفایل

استاد

• Cellular Aging
• Organelle Communication
• Membrane Contact Sites
• +۵ مورد دیگر

Prof. Sabrina Büttner leads the Cell Biology group at the Institute of Integrative Cell Biology and Physiology, University of Münster. Her research focuses on intracellular communication during cellular aging, stress responses, and metabolic adaptation, utilizing yeast and Drosophila models. She investigates organelle connectivity via membrane contact sites and their role in proteostasis, neurodegeneration, and longevity. Her work integrates molecular biology, genetics, and imaging to explore: Organelle communication networks Proteostasis collapse in aging Autophagy and lipid metabolism Neurodegenerative disease mechanisms Recent publications emphasize membrane contact sites, stress-induced nuclear/vacuole dynamics, and autophagy regulation. Trends include organelle interfaces in proteostasis, mitochondrial quality control, and translational applications in longevity biotechnology. She mentors PhD students including Irene Álvarez-Guerra, Emma Block, Patricia Grabher, and Simon Prokisch. Her lab collaborates with CRC projects (e.g., CRC 1009, 1348, 1459, 944) and graduate programs (CiM-IMPRS, IRTG, SP BioSciences).

Buzz Baumمشاهده پروفایل

پژوهشگر ارشد

• Morphogenesis
• Cell Division
• Cytoskeleton Dynamics
• +۱۰ مورد دیگر

Buzz Baum is a Research Fellow at the MRC Laboratory of Molecular Biology (LMB) within the University of Cambridge. His work focuses on the generation of biological form ("morphogenesis") through the study of cell division across archaea and eukaryotes, with a particular emphasis on the role of the cytoskeleton and ESCRT-III proteins in evolutionary transitions. Key research themes: Morphogenesis, Cell Division, Evolutionary Cell Biology, Archaeal Biology, Eukaryogenesis, Membrane Remodeling His lab investigates cell division using Sulfolobus , a hyperthermophilic archaeon, to identify conserved processes and core principles. Recent work explores the application of imaging techniques in extremophiles and the evolutionary implications of ESCRT-III proteins in both archaea and humans. Future research will focus on Asgard archaea, the closest living relatives to eukaryotes, to study the origins of cell division and symbiosis. Collaborations include researchers at the LMB, UK institutions, and international partners. Group members include Alice Cezanne, Sherman Foo, Yin-Wei (Kris) Kuo, Magda Lechowska, Fraser MacLeod, Florian Mayer, Joe Parham, Arthur Radoux, Iain Richard, and Jeanne Salje.

Thomas Marescaمشاهده پروفایل

دانشیار

• Cell Biology
• Molecular Biology
• Chromosome Segregation
• +۳ مورد دیگر

Thomas Maresca is an Associate Professor in the Biology Department at the University of Massachusetts Amherst, serving as Graduate Program Director for Molecular & Cellular Biology within the Interdisciplinary Doctoral Graduate Program (IDGP). His research laboratory investigates fundamental mechanisms of cell division with institutional affiliation to the university's life sciences division. His academic training includes: Ph.D. in Cell Biology from the University of California at Berkeley (2005) B.S. in Biology from the University of North Carolina at Chapel Hill (1999) Dr. Maresca's research centers on chromosome segregation mechanics during mitosis, employing Drosophila and Xenopus model systems with advanced live-cell imaging techniques. His laboratory specializes in quantifying kinetochore-microtubule interactions , error correction mechanisms , and force generation during cell division. Key approaches include FLIM-FRET biosensors, single-molecule tracking, and micromanipulation in egg extracts to dissect how intrinsically disordered proteins, motor complexes (particularly dynein), and kinase networks (Aurora A/B, MPS1) ensure mitotic fidelity. Current work focuses on spatiotemporal regulation of phosphorylation gradients and mechanical feedback at the kinetochore-microtubule interface. Analysis of his 15 most recent publications reveals a consistent trajectory in mitotic mechanics with increasing emphasis on intrinsically disordered proteins as mechanical regulators and subcellular signaling hubs . His work bridges molecular biophysics with cellular function, demonstrating how microtubule plus-ends act as physical signaling platforms and how kinase crosstalk establishes precise spatiotemporal control during anaphase. Recent methodological innovations include commercial FLIM-FRET adaptation and quantitative force measurements at kinetochores. As Graduate Program Director, Dr. Maresca oversees curriculum development and student mentorship for the Molecular & Cellular Biology track. His laboratory (located in Morrill Science Center IV, Room 436) maintains active research programs in kinetochore mechanics and mitotic regulation, supported by continuous publication output since 2000. Collaborative networks include structural biologists and biophysicists investigating mechanochemical transduction in division processes.