جست‌وجوی استاد و پژوهشگر

• Gene Therapy
• Vascular Biology
• Neurology
• +۳ مورد دیگر

Jakob Körbelin is a Principal Investigator at the University Medical Center Hamburg-Eppendorf (UKE), affiliated with the Faculty of Medicine and the II. Medical Clinic and Polyclinic. His research focuses on vascular biology, gene therapy, and neurological disorders, particularly targeting the blood-brain barrier using adeno-associated viral (AAV) vectors. He leads studies on pulmonary hypertension, neurovascular interactions, and genetic diseases like Niemann-Pick type C2. His work bridges basic science and translational medicine, emphasizing AAV engineering and therapeutic applications. Key research interests include endothelial cell biology, neuroinflammation, and the pathophysiology of vascular diseases. Notably, he received the UCCH Hubertus Wald Young Investigator Award 2013 for his contributions. His lab explores mechanisms of vascular dysfunction, gene delivery optimization, and the impact of viral vectors in treating rare diseases. Collaborations span molecular neurobiology, immunology, and translational oncology. Publications highlight breakthroughs in AAV-mediated therapies, such as reversing neurodegeneration in NPC2 models and identifying novel targets for pulmonary hypertension. Ongoing projects address microvascular brain pathology in SARS-CoV-2 infection and the role of transcription factors in vascular diseases.

• Immunology
• Biochemistry and Cell Biology
• Clinical Sciences
• +۳ مورد دیگر

Professor Daniel Davis MBE FMedSci is the Head of the Department of Life Sciences and Professor of Immunology at Imperial College London. He holds affiliations with the Institute of Chemical Biology, the CDT in Chemical Biology: Innovation in Life Sciences (as a supervisor), and research groups in Immunology and Molecular Mechanisms of Disease. His academic journey includes a doctorate in Physics from Harvard University and prior roles as Director of Research at the Manchester Collaborative Centre for Inflammation Research (University of Manchester). His research focuses on nanoscale biology of immune cell interactions, employing advanced microscopy techniques to study immune synapse formation, cytotoxicity mechanisms, and immunological regulation. Notable contributions include elucidating how immune cells use adhesion, signaling, and structural reorganization to target pathogens and cancer cells. Professor Davis has authored four popular science books, including Self Defence: A Myth-Busting Guide to Immune Health (2025), The Beautiful Cure (2018), and The Compatibility Gene (2014), which bridge public understanding of immunology and biology. His work has been recognized with prestigious awards such as the Royal Society Science Book Prize and the Prose Award. His articles span topics like NK cell heterogeneity, gene therapy for neurological disorders, and super-resolution microscopy applications. Grants and collaborations include work on AAV-based gene therapies and immunomodulatory drug development. Davis actively engages in public science communication through festivals, media outlets (e.g., BBC, Guardian), and international speaking engagements. His research labs at Imperial College focus on interdisciplinary approaches, combining biophysics, genetics, and clinical applications to advance immunology and translational medicine.

Freddy Radtkeمشاهده پروفایل

استاد

• Molecular Biology
• Cellular Biology
• Cancer Research
• +۹ مورد دیگر

Freddy Radtke is a Full Professor at the School of Life Sciences at École polytechnique fédérale de Lausanne (EPFL), where he leads the Radtke Lab (UPRAD) within the Swiss Institute for Experimental Cancer Research (ISREC). He holds multiple affiliations across EPFL, including in the SSV-ENS and EDMS-ENS programs, reflecting his broad engagement in teaching and doctoral education in life sciences. His research is centered on the molecular mechanisms of stem cell maintenance and differentiation, particularly through the Notch signaling pathway. His work spans several self-renewing systems: the hematopoietic system, skin, and gut. Key findings include the identification of Delta-like 4 as the essential Notch1 ligand for T cell commitment, the tumor suppressor role of Notch1 in skin, and its critical function as a gatekeeper of intestinal progenitor cells by repressing CDK inhibitors. These discoveries have significant implications for understanding cancer development and regenerative processes. The recent publications highlight a consistent focus on Notch signaling across diverse biological contexts—hematopoiesis, skin development, intestinal regeneration, and stem cell systems biology. The keywords and subfields reflect deep mechanistic investigations into cell fate decisions, signal transduction, and tissue homeostasis, with strong translational relevance to cancer and inflammatory diseases. Freddy Radtke has mentored numerous Ph.D. students and is actively involved in teaching courses such as Stem Cells and Organoids and Scientific Project Design in Translational Oncology . His lab conducts research supported by external funding, and he collaborates across disciplines to integrate systems biology with stem cell research. The lab includes scientists, doctoral assistants, technicians, and administrative staff, indicating a vibrant and multidisciplinary research team.

Helen Byrneمشاهده پروفایل

استاد

• Mathematical Biology
• Computational Biology
• Tumour Modeling
• +۵ مورد دیگر

Helen Byrne is a Professor of Applied Mathematics at the University of Oxford and a Tutorial Fellow at Keble College. Her academic roles include former Examiner for Final Honour School Mathematics, Associate Head of Department for Planning and Equality and Diversity, and Director of Equality and Diversity in the university’s MPLS Division. DPhil MSc BA/MA Her research focuses on developing mathematical and computational models to study biomedical systems, particularly solid tumours, wound healing, and tissue engineering. She aims to uncover mechanisms behind biological phenomena and derive novel mathematical insights from these models. Recent publications highlight her work in tumor-immune interactions, atherosclerosis, antibody dynamics, and radiation therapy, employing techniques like spatial modeling, agent-based simulations, and multiscale approaches. Her research bridges theoretical mathematics and practical biomedical challenges. 2019: Leah Edelstein-Keshet Prize (Senior Award), Society for Mathematical Biology 2020: Fellow of the Society for Mathematical Biology Helen Byrne has supervised numerous students and researchers, contributing to mathematical biology and biomedical modeling. Her teaching includes courses on multivariable calculus, applied partial differential equations, and advanced mathematical biology.

Yuuki Obataمشاهده پروفایل

استادیار

• Gut Microbiota Research
• Immune System Regulation
• Enteric Nervous System Development
• +۳ مورد دیگر

Dr. Yuuki Obata is an Assistant Professor in the Department of Immunology and Neuroscience at UT Southwestern Medical Center, USA. He holds an Investigator role at the O'Donnell Brain Institute. Previously, he served as a postdoctoral fellow at the Francis Crick Institute (2016-2021) and the University of Tokyo (2015-2016). His research focuses on how environmental signals (microbiota, diet, circadian rhythms) shape intestinal neural circuits and immune networks. He employs advanced techniques including imaging, viral tracing, gnotobiotic systems, and multi-omics approaches. Education: PhD in Immunology from Chiba University (RIKEN Joint Graduate School Program), Japan. Postdoctoral training included JSPS Superlative Postdoctoral Fellowships (Japan) and EMBO/HFSP fellowships (UK). Research interests span microbiota-immune interactions, enteric nervous system development, gut-brain axis communication, and epigenetic regulation of immune responses. His lab investigates mechanisms linking microbial metabolites to host physiology, particularly in metabolic and neural contexts. Key findings include microbiota's role in IgA responses, T cell differentiation, and neuronal programming. Collaborations emphasize inter-organ communication and translational applications in immunology and neuroscience. Laboratory: The Obata Lab at UT Southwestern employs interdisciplinary methods to address how environmental factors reprogram gut neural and immune systems. Future work includes exploring microbiota-based therapies and neuroimmune interactions in disease models.

Ramana V Davuluriمشاهده پروفایل

استاد

• Machine Learning
• Cancer Data Science
• Gene Regulation
• +۴ مورد دیگر

Ramana V Davuluri serves as Professor in the Department of Biomedical Informatics at Stony Brook University's Renaissance School of Medicine. With over 20 years of experience in bioinformatics and computational genomics, he leads research at the intersection of machine learning and cancer genomics, focusing on translating high-dimensional -omic data into clinically actionable insights through statistically rigorous methodologies. Dr. Davuluri's research spans Machine Learning applications in Cancer Data Science , isoform-level gene regulation , and precision-medicine development. His lab pioneers bioinformatics solutions for genomic data interpretation, with emphasis on developing machine learning algorithms that convert NextGen sequencing outputs into experimentally testable discovery models. A core focus involves creating rapid biomarker identification systems from human tissue and blood samples through integrated computational-experimental approaches in systems biology. Analysis of his 2023-2025 publications reveals a dominant trend toward genomic foundation models (e.g., DNABERT variants), multi-omic cancer subtyping , and time-dependent therapeutic strategies for pediatric brain tumors and ovarian cancer. His work consistently bridges computational innovation with biological validation across diverse cancer types including glioma, lung adenocarcinoma, and high-grade serous carcinoma. As Principal Investigator for multiple multi-investigator and multi-site projects, Dr. Davuluri directs research integrating high-throughput experimental procedures with advanced data-mining techniques. His laboratory maintains strong collaborations across oncology, neuroscience, and immunology domains while developing genomics-based decision support systems for clinical translation. The Davuluri Lab employs a systems biology framework to develop novel informatics tools for precision oncology, with particular emphasis on translating genomic discoveries into clinical applications through biomarker discovery and therapeutic strategy optimization.

David Weisblatمشاهده پروفایل

استاد

• Developmental Biology
• Evolutionary Developmental Biology (Evo-Devo)
• Molecular Phylogenetics
• +۴ مورد دیگر

David Weisblat is a Professor in the Department of Molecular and Cell Biology at UC Berkeley's College of Letters & Science. His research focuses on developmental and evolutionary processes in glossiphoniid leeches (e.g., Helobdella ), particularly their segmentation mechanisms and molecular phylogeny within Lophotrochozoa. He leads studies integrating embryological, genomic, and genetic approaches to understand how developmental pathways evolved across bilaterian animals. Research Interests: Weisblat’s work addresses how cell fates and signaling pathways (WNT, NOTCH, TGFβ) shape leech development, with emphasis on the evolutionary origins of segmentation. His lab combines microinjection techniques, transcriptome analysis, and CRISPR mutagenesis to explore stem cell dynamics and conserved developmental programs. Key Projects: Current efforts investigate grandparental stem cell divisions in segmentation and intercellular signaling during early embryogenesis. The lab’s genomic resources—including BAC libraries and EST databases—facilitate comparative studies across Lophotrochozoan taxa. Lab Contributions: The Weisblat lab pioneered Helobdella as a model organism, enabling breakthroughs in Evo-Devo. Their findings bridge developmental plasticity and evolutionary innovation, particularly in annelids versus arthropods/deuterostomes.

Wanfen Xiongمشاهده پروفایل

دانشیار

• Vascular Surgery
• Cardiovascular Disease
• Aortic Aneurysm Research
• +۳ مورد دیگر

Wanfen Xiong, MD, PhD, is an Associate Professor specializing in General Surgery, with a focus on cardiovascular and vascular pathologies. Their research primarily investigates aortic aneurysms, Marfan syndrome, and inflammatory mechanisms in vascular diseases using mouse models and humanized systems. Xiong serves as Principal Investigator (PI) for two major projects exploring the role of smooth muscle cell phenotypic switches in aortic pathology associated with Marfan syndrome. With a strong publication record spanning over two decades, they have contributed significantly to understanding molecular pathways like Notch3 signaling and CD95L-mediated inflammation in cardiovascular disorders. Their work integrates immunology and molecular biology to develop therapeutic strategies for complex vascular conditions. Research interests include vascular biology, genetic disorders affecting the aorta, and translational approaches to inhibit aneurysm progression. Xiong's studies frequently utilize mouse models to simulate human pathologies, with recent emphasis on regulatory T cells and neuroinflammation in heart failure contexts. Their findings have been cited over 3,389 times, reflecting impactful contributions to cardiovascular research.

Michael Nothnagelمشاهده پروفایل

استاد

• Statistical Genetics
• Genetic Epidemiology
• Population Genetics
• +۵ مورد دیگر

Michael Nothnagel is a Professor at the University of Cologne, where he leads the Department of Statistical Genetics and Bioinformatics within the Cologne Center for Genomics (CCG). His work spans statistical genetics, genetic epidemiology, and forensic genetics, focusing on methodological development and large-scale genomic data analysis. His research interests encompass theoretical and applied statistical genetics, with emphasis on human genetic diversity, disease etiology, and forensic applications. Key areas include Y-chromosomal phylogeography, genome-wide association studies for complex diseases, development of statistical methods for variant interpretation, and forensic marker optimization. His group leverages next-generation sequencing data and specialized forensic markers to address questions in population history, disease mechanisms, and identification systems. Recent publications reveal a strong focus on computational approaches to genetic analysis, including spatial frequency interpolation for haplogroup mapping, polygenic risk score applications for behavioral traits, and advanced methods for variant classification. His work demonstrates consistent integration of statistical theory with practical applications in medical and forensic genetics, often through international collaborations like the VISAGE Consortium. Nothnagel maintains active involvement in the Cologne Center for Genomics, contributing to seminars and collaborative projects including the upcoming 34th International Genetic Epidemiology Society meeting. His research group operates at the intersection of computational biology and medicine, with particular strengths in handling complex genomic datasets and developing novel analytical frameworks for genetic epidemiology.

Carmen Birchmeierمشاهده پروفایل

استاد

• Developmental Biology
• Cell Biology
• Neuroscience
• +۳ مورد دیگر

Carmen Birchmeier is a Full Professor at the Medical Faculty of Charité - Universitätsmedizin Berlin and a leading researcher at the Max Delbrück Center for Molecular Medicine (MDC). She coordinates the MDC Neuroscience Program and serves on the Executive Board of the NeuroCure Cluster of Excellence. Her research focuses on developmental biology, cell signaling, and the molecular mechanisms underlying nervous system and muscle development. Education: PhD in Molecular Biology from the University of Zürich (1984), followed by postdoctoral training at Cold Spring Harbor Laboratory (1984–1989). She established her independent research group at the Max Delbrück Lab in Cologne (1989–1995) before moving to Berlin. Research Interests: Investigates signal transduction pathways (e.g., Notch, ErbB, and c-Met) in developmental processes, including neural crest cell migration, muscle progenitor cell differentiation, and Schwann cell myelination. Her work bridges molecular genetics, mouse models, and cellular biology to uncover mechanisms of tissue formation and disease. Awards: Recipient of the Leibniz Award (2002) and EMBO Membership (2001). Her contributions to developmental neurobiology have been recognized internationally. Leadership & Grants: Deputy Speaker of SFB 665 (Developmental Disturbances of the Brain), DFG Fachkollegium Member, and advisor to multiple institutes including the Max Planck Institute for Biophysical Chemistry. Her work spans academic and clinical research collaborations. Labs/Teams: Heads the Signal Transduction/Developmental Biology Research Group at MDC, focusing on interdisciplinary approaches to understand developmental disorders and regenerative medicine strategies.

Albert Erivesمشاهده پروفایل

دانشیار

• Regulatory Genomics
• Evolutionary Genomics
• Evolution of Metazoa
• +۶ مورد دیگر

Albert Erives is an Associate Professor in the Department of Biology at the University of Iowa , specializing in regulatory genomics, evolutionary genomics, and the evolution of metazoans. His research focuses on decoding gene regulatory logic in DNA sequences, particularly during animal embryogenesis, using comparative genomics to identify regulatory modules driving phylogenetic transitions. PhD from University of California, Berkeley His work spans eukaryotic gene regulation, integrating biochemistry, molecular genetics, and computational biology to uncover principles of organismal evolution. Recent studies include viral nucleosome structure, Notch signaling pathway evolution, and enhancer organization in model organisms like Drosophila and Ciona . Notable scientific awards include the NSF CAREER Award (2012, 2010) . He actively seeks graduate students and postdoctoral researchers for his laboratory, which utilizes core facilities such as the Carver Center for Genomics.

• Developmental Biology
• Genetics
• Molecular Biology
• +۵ مورد دیگر

Professor Kim Dale is a distinguished researcher and academic at the University of Dundee's School of Life Sciences, Department of Cell and Molecular Biology. With an extensive publication record spanning from 1997 to the present, her work focuses on the molecular mechanisms underlying embryonic development, particularly the segmentation clock and somitogenesis processes. Her research interests center on developmental biology with specific expertise in Notch signaling, segmentation clock dynamics, somitogenesis, and cell fate determination during embryonic development. Professor Dale's work integrates molecular biology, genetics, and stem cell approaches to understand how oscillatory gene expression patterns guide the formation of body segments in developing embryos. Her research has significant implications for understanding congenital disorders and developmental abnormalities. Analysis of Professor Dale's recent publications reveals a consistent focus on the molecular mechanisms of the segmentation clock, with increasing use of hiPSC-derived models and advanced imaging techniques. Her work bridges basic developmental biology with potential clinical applications, particularly in understanding how disruptions in segmentation processes lead to developmental disorders. The research shows a trajectory from fundamental mechanism discovery toward translational applications using stem cell models. Professor Dale has secured significant funding from the Medical Research Council for multiple projects spanning from 2004 to 2027, demonstrating sustained research excellence and impact. Her work on the segmentation clock, Notch signaling, and cell fate decisions has established her as a leader in developmental biology. As an active educator and mentor, Professor Dale has supervised numerous students including Scott Haston through vacation scholarships. She is also engaged in public outreach activities, having participated in events like the Dundee Science Centre International Women's Day Campaign, Women in STEM webinars, and Discovery Days, demonstrating her commitment to science communication and inspiring the next generation of researchers.

Steven D Leachمشاهده پروفایل

استاد

• Pancreatic Cancer Biology
• Cancer Development and Tumorigenesis
• Molecular and Systems Biology
• +۸ مورد دیگر

Steven D. Leach is Professor of Molecular and Systems Biology, Surgery, and Medicine at the Geisel School of Medicine at Dartmouth, where he also holds the Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer and serves as Director of the Dartmouth Cancer Center (Norris Cotton Cancer Center). He has previously held leadership and faculty positions at Memorial Sloan Kettering and Johns Hopkins University. MD, Emory University BS in Biology, Princeton University (with high honors) Additional training at Yale and MD Anderson Dr. Leach's research is centered on pancreatic cancer biology, with a focus on understanding early tumorigenic events through developmental and molecular pathways. His lab utilizes mouse and zebrafish models to investigate epithelial plasticity, oncogenic signaling (particularly Notch and Kras), immune responses, and clonal evolution in pancreatic neoplasia. His work has revealed key mechanisms linking pancreatic development to cancer, including the role of acinar cells as cells of origin and the discovery of unique immune neoepitopes in long-term survivors. The selected publications, spanning from 2003 to 2017, reflect a sustained focus on the molecular and immunological underpinnings of pancreatic cancer. Themes include oncogenic signaling (Notch, Kras), tumor microenvironment interactions, epithelial-mesenchymal transition, and immune neoantigen landscapes. These works, published in top journals like Nature and Cell , demonstrate a trajectory from mechanistic discovery to translational immunology. Fellow of the American Association for the Advancement of Science (AAAS), 2019 Robert Woodruff Fellow, Emory University Dr. Leach has a strong record of mentorship, having trained 32 graduate students and postdoctoral fellows, many of whom have achieved independent faculty positions and NIH funding. He has been the principal investigator on numerous NIH grants, including R01, P01, P30, U01, S10, and T32 awards, supporting both research and training initiatives. His lab currently includes research scientists, graduate students, and postdoctoral associates engaged in projects on mRNA splicing, chromatin dynamics, and clonal evolution. The Leach Laboratory is an active research group within the Dartmouth Cancer Center, focusing on translational pancreatic cancer research. Lab members include graduate students from the Molecular and Cellular Biology program, postdoctoral researchers, and research scientists, working collaboratively on projects that bridge basic science and clinical applications. The lab utilizes advanced model systems and genomic technologies to uncover fundamental mechanisms of cancer initiation and progression.

• Systems Biology
• Stress Response
• Stem Cell Differentiation
• +۳ مورد دیگر

Ala Trusina is an Associate Professor at the Niels Bohr Institute , University of Copenhagen , specializing in Biocomplexity and Biophysics . Her research integrates coarse-grained modeling to study complex biological systems. Key Research Areas Stress Response Systems (diabetes, aging, cancer, inflammation) Stem Cell Differentiation (cell fate coordination, reversibility of states) Complex Systems (species coexistence, epidemics, CRISPR-phage interactions) Methodologies Theoretical: Agent-based modeling, in-silico simulations Experimental: Quantitative single-cell imaging, RNA/protein profiling Collaborations Joshua Brickman (ES cells), Anne Grapin-Botton (pancreas), Feroz Papa (diabetes), Else Kai Hoffman (p53 dynamics) Thomas Mandrup-Poulsen (inflammation), Savas Tay (spatio-temporal regulation) Teaching Physics of Molecular Diseases Numerical Methods in Physics

David M. Langenauمشاهده پروفایل

استاد

• Pediatric Oncology
• Cancer Biology
• Zebrafish Models
• +۳ مورد دیگر

David M. Langenau is a Professor of Pathology at Harvard Medical School and Director of Research Education at Mass General Brigham Pathology . His work focuses on elucidating molecular mechanisms of relapse in pediatric sarcomas and leukemias using zebrafish models, human cell lines, and patient-derived xenografts. Institutional Affiliations : Harvard Medical School, Mass General Brigham, Krantz Family Center for Cancer Research, Harvard Stem Cell Institute Research Themes : Tumor relapse biology, cancer stem cells, oncogenic pathways, zebrafish avatars, drug discovery Langenau's research has identified novel combination therapies (e.g., Olaparib-Temozolomide for RMS) and uncovered evolutionarily conserved oncogenic drivers in T-ALL. His team's work bridges zebrafish genetics and clinical translation, including the first zebrafish-origin clinical trial for pediatric cancer. Selected Research Trends : Recent publications highlight single-cell transcriptomics in RMS, checkpoint pathways in immunotherapy, and PI3K-AKT-mTOR signaling in T-ALL. These studies integrate bioinformatics, functional assays, and clinical data. Grants and Collaborations : His laboratory receives over $19 million annually in research funding and collaborates with institutions like Dana-Farber Cancer Institute and MGH Pathology Service .