جست‌وجوی استاد و پژوهشگر

• Neurogenetics
• Cerebellar Ataxia
• Spinocerebellar Ataxia
• +۶ مورد دیگر

Brent Linden Fogel is a Professor-in-Residence in both Neurology and Human Genetics at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He directs the UCLA Clinical Neurogenomics Research Center and the UCLA Neurogenetics Clinic, where he focuses on using genomic sequencing to identify rare and novel causes of neurological disease. Dr. Fogel also runs a specialized clinic for patients with Ataxia with Oculomotor Apraxia (AOA) and treats various disorders of balance and coordination at the UCLA Ataxia Center. His educational background includes a PHD in Microbiology & Molecular Genetics (2001) and an MD (2003) from the Medical College of Wisconsin, followed by residency in Medicine at Northwestern (2004), Neurology at UCLA Medical Center (2007), and Neurogenetics fellowship at UCLA Medical Center (2009). Dr. Fogel's research uses genomics, bioinformatics, and systems biology to understand how genetic mutations lead to neurodegenerative disorders such as spinocerebellar ataxia or neurodevelopmental conditions. His work specifically focuses on the molecular pathogenesis of ataxia with oculomotor apraxia (AOA), and he is developing gene therapy approaches to treat this disorder. His research spans gene regulation, RNA processing, and next-generation sequencing analysis. His extensive publication record shows a strong focus on cerebellar ataxias, with particular emphasis on spinocerebellar ataxia types, genetic mechanisms, and diagnostic approaches. Recent work demonstrates increasing integration of genomic and imaging techniques for precision medicine applications, along with development of bioinformatics tools for analyzing complex neurological disorders. Dr. Fogel's research has been funded by the American Academy of Neurology / American Brain Foundation, the National Institutes of Health (including R01NS082094 and K08MH086297), and the National Ataxia Foundation. His work bridges clinical neurology with cutting-edge genomic research to advance diagnosis and treatment of rare neurological disorders.

• Epigenetics
• Epigenomics
• Genetics
• +۴ مورد دیگر

Steven Erik Jacobsen is a Professor in the Molecular, Cell and Developmental Biology and Biological Chemistry departments at the University of California Los Angeles (UCLA) . His research focuses on epigenetics , particularly DNA methylation , gene regulation , and chromatin dynamics in Arabidopsis thaliana and other plant systems. Dr. Jacobsen's lab investigates how RNA-mediated pathways establish and maintain epigenetic marks, with applications in plant genomics , CRISPR-based editing , and transposable element silencing . His work spans molecular mechanisms, structural biology, and translational efforts in agricultural biotechnology. Recent publications highlight innovations in transgene-free genome editing , epigenetic disease resistance , and small RNA pathways in plants. His lab employs next-generation sequencing , biochemical assays , and structural modeling to dissect epigenetic regulation. Funded by the W. M. Keck Foundation , Jacobsen's team includes graduate students and postdoctoral researchers working on projects related to chromatin structure , RNA polymerases , and epigenetic inheritance . The lab actively recruits motivated researchers through UCLA's MBIDP , BioSciences , and Bioinformatics programs.

Gregory Velicerمشاهده پروفایل

استاد

• Microbial Evolution
• Social Behavior in Microbes
• Myxobacteria
• +۲ مورد دیگر

Gregory Velicer is a Full Professor at ETH Zurich's Department of Environmental Systems Science and Deputy Head of the Institute of Integrative Biology. His research investigates microbial social evolution, focusing on complex behaviors like predation and multicellular development in myxobacteria using ecological, molecular, and evolutionary approaches. Research explores: Genetic controls of bacterial cooperation Predator-prey dynamics in microbial communities Evolution of cheating resistance Ecological drivers of social exploitation Molecular regulation of developmental processes Recent publications emphasize bacterial social evolution in changing environments, with themes spanning molecular genetics, ecological adaptation, and applied biocontrol. Laboratory work integrates experimental evolution with genomic and transcriptomic analysis.

• RNA splicing regulation
• Alternative splicing mechanisms
• RNA metabolism in mammalian cells
• +۳ مورد دیگر

Douglas Lyne Black is a Professor in the Department of Molecular, Cell and Developmental Biology (MIMG) at the University of California, Los Angeles (UCLA), affiliated with the School of Medicine. He holds a BA in Chemistry from the University of California, Santa Cruz (1982) and a PhD in Molecular Biophysics and Biochemistry from Yale University (1987). His research focuses on RNA splicing regulation and its role in cellular differentiation, disease, and gene expression. Dr. Black's work explores how alternative splicing contributes to neuronal diversity and dysfunction in cancer, neurodegeneration, and inherited disorders. His research is supported by multiple NIH grants, including principal investigator roles on projects studying PTB and Rbfox proteins' roles in gene regulation (R35GM136426), Myc-driven splicing in prostate cancer (R01CA220238), and sexually dimorphic splicing in the brain (R01MH109166). Collaborative work includes ribonomic studies of innate immune responses (U01HG007912) and genomic splicing measurements (R24GM070857). Key research interests include RNA metabolism, RNA-binding protein structures, and posttranscriptional regulation in neurons. His lab investigates how splicing regulators like PTB, Rbfox, and XIST influence gene expression programs, with applications to human health. Notable contributions include discoveries on splicing mechanisms in cancer, neurobiology, and stem cell differentiation.

Mark F. Mehlerمشاهده پروفایل

استاد

• Stem Cell Biology
• Regenerative Medicine
• Epigenetics
• +۳ مورد دیگر

Mark F. Mehler, M.D., is a Professor in the Department of Neurology, Dominick P. Purpura Department of Neuroscience, and Department of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine. He serves as Chair of the Saul R. Korey Department of Neurology and holds the Alpern Family Foundation Chair in Cerebral Palsy Research. He directs the Institute for Brain Disorders and Neural Regeneration. His research focuses on neural stem cell biology, regenerative medicine, and epigenetic mechanisms underlying neurodegenerative and neurodevelopmental disorders. Dr. Mehler completed his medical education and residency at Albert Einstein College of Medicine. His work explores stem cell-based therapies for neurological diseases, including Alzheimer’s, Huntington’s, and Parkinson’s, emphasizing epigenetic and developmental pathways. He investigates how environmental and genetic factors influence neural development and disease susceptibility. Scientific achievements include identifying transcriptional codes that regulate neural cell identity and reprogramming stem cells for targeted regeneration. His research bridges developmental biology, neurology, and oncology, revealing shared mechanisms in neurodegeneration and fibrotic disorders. Awards: Alpern Family Foundation Chair in Cerebral Palsy Research Labs/Teams: Lead the Institute for Brain Disorders and Neural Regeneration Grants: Not explicitly detailed in the provided text.

Tamer I Sallamمشاهده پروفایل

دانشیار

• Cardiometabolic disease
• Atherosclerosis
• Long non-coding RNAs
• +۷ مورد دیگر

Tamer I Sallam is an Associate Professor of Medicine and Physiology at the University of California Los Angeles (UCLA), where he also serves as the Department Vice Chair for the Medicine Department. His research focuses on the molecular mechanisms underlying cardiometabolic diseases, with particular emphasis on the role of non-coding RNAs and RNA modifications in atherosclerosis, lipid metabolism, and obesity. Dr. Sallam's research interests span multiple interconnected fields in cardiovascular and metabolic biology. He investigates how long non-coding RNAs regulate cholesterol metabolism and atherosclerosis development, with recent work focusing on RNA modification (specifically N6-methyladenosine) and its role in sex-dimorphic metabolic traits. His laboratory also explores the molecular pathways connecting obesity, inflammation, and cardiovascular disease, with implications for therapeutic interventions in metabolic syndrome and related conditions. His work bridges basic molecular mechanisms with translational applications, particularly in understanding sex differences in cardiometabolic disease and developing novel therapeutic approaches. Analysis of Dr. Sallam's publication record reveals a strong focus on the intersection of RNA biology and cardiovascular metabolism. His work demonstrates how epitranscriptomic modifications influence sex-specific metabolic regulation, how long non-coding RNAs modulate lipid homeostasis, and how these mechanisms contribute to atherosclerosis development. His research spans from fundamental molecular mechanisms to clinical implications, with particular attention to sex differences in cardiometabolic disease. Dr. Sallam has secured significant research funding as Principal Investigator on multiple NIH grants, including R01 awards for studying RNA modification in cardiometabolic disease (R01DK127232, 2021-2026), LncRNAs in atherosclerosis (R01HL149766, 2020-2024), non-coding RNAs in adipogenesis and obesity (R01DK118086, 2018-2023), and RNA-binding proteins in atherosclerosis (R01HL139549, 2018-2023). He previously held a K08 career development award focused on long non-coding RNAs in cardiometabolic disease (K08HL128822, 2015-2021). His research is conducted within the Department of Medicine at UCLA, where he leads a laboratory investigating the molecular mechanisms of cardiovascular and metabolic diseases.

Paul Marshallمشاهده پروفایل

استاد پژوهشی

• Genomics
• Neuroscience
• Epigenetics
• +۴ مورد دیگر

Dr. Paul Marshall is a Group Leader in the Division of Genome Sciences and Cancer at the John Curtin School of Medical Research (JCSMR), ANU. His research focuses on genomic plasticity, investigating how dynamic DNA structures (e.g., G-quadruplex, Z-DNA) and non-classical DNA modifications regulate long-term memory formation and fear-related learning. He leads the Marshall Group, which employs advanced sequencing techniques (Illumina, Oxford Nanopore) to study memory stability in mice. Education: PhD in Neuroscience. Key affiliations include the ANU Researcher Portal and ORCID (0000-0002-7106-2298). Current projects include developing the HaloTag tool for RNA isolation in neurons and exploring DNA structural variants in neuroplasticity. Advising: Supervises PhD and Honours students such as Raymond Chen, Joshua Davies, and Anna Wilford. Research infrastructure includes state-of-the-art genomic and neurobiological facilities at JCSMR. Labs/Teams: The Marshall Group - Genomic Plasticity Lab investigates mechanisms linking DNA dynamics to memory persistence, with applications in neurodegenerative and psychiatric disorders.

• Cancer Research
• Breast Cancer
• Health Disparities
• +۵ مورد دیگر

Dr. Jaydutt V Vadgama is a Professor in the Department of Internal Medicine at Charles R. Drew University of Medicine and Science, where he directs significant cancer research initiatives focused on health disparities. His work bridges basic science and clinical applications, with particular emphasis on understanding cancer mechanisms in underserved populations. Dr. Vadgama's research interests span multiple critical areas in oncology, including breast cancer biology, molecular pathways of cancer progression, and the intersection of metabolic disorders like diabetes with cancer development. His work particularly focuses on health disparities affecting African American and Hispanic women, investigating how factors like obesity, diabetes, and hypertension exacerbate cancer risk in these populations. His laboratory explores molecular mechanisms including epithelial-mesenchymal transition, STAT3 signaling, and inflammatory pathways in cancer progression. Analysis of his recent publications reveals a strong trend toward translational research, with numerous studies examining therapeutic interventions, drug development, and biomarker discovery. His work consistently addresses the molecular basis of cancer disparities, with significant contributions to understanding breast cancer in minority populations. Recent publications show increasing focus on nanotechnology for drug delivery, natural compounds for cancer prevention, and the molecular underpinnings of treatment resistance. Dr. Vadgama has secured substantial research funding as Principal Investigator on multiple NIH grants, including the CDU-UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities (U54CA143931) and the Center for Accelerating Excellence in Translational Science (AXIS) (U54MD007598). His research program has been continuously funded by the NIH since 1987, demonstrating sustained scientific impact. His laboratory work spans molecular oncology, cancer cell biology, and translational research, with particular expertise in studying breast cancer in minority populations. The research program integrates basic science approaches with clinical applications to address cancer health disparities through multiple NIH-funded initiatives.

Srinivas Somarowthuمشاهده پروفایل

دانشیار

• Long non-coding RNAs
• Non-coding RNAs in viral genomes
• RNA-protein complexes
• +۴ مورد دیگر

Srinivas Somarowthu is an Associate Professor in the Department of Biochemistry & Molecular Biology at Drexel University College of Medicine. He serves as Director of the Biochemistry of Health and Disease graduate program, leading interdisciplinary research that combines biochemistry , molecular biology , and computational biology to study RNA mechanisms in cellular pathways. Postdoctoral Fellowship – Yale University (2016) PhD – Northeastern University (2011) MS – Indian Institute of Technology Delhi (2007) BS – Andhra Loyola College (2005) His research focuses on long non-coding RNAs (lncRNAs) and viral non-coding RNAs , particularly their roles in gene regulation, disease mechanisms, and RNA-protein interactions. His lab develops computational tools for modeling large RNA (>200 nts) structures, addressing limitations in experimental RNA structure determination. Recent publications highlight his group's work on structural characterization of lncRNAs like HOTAIR and lncTCF7 , RNA modeling pipelines, and viral RNA-host protein interactions. Notably, his lab received a 2023 CURE Program grant from the Commonwealth of Pennsylvania for hepatitis B virus research. Scientific Awards Commonwealth Universal Research Enhancement (CURE) Program Grant Recipient (2023) His laboratory provides critical resources for RNA structural analysis through webservers and plugins, while collaborating with investigators like Michael J. Bouchard and Joris Beld on liver cancer studies involving Fam99 gene family regulation.

David Williamsمشاهده پروفایل

استاد

• Immunology
• Infectious Diseases
• Cardiovascular Research
• +۶ مورد دیگر

Dr. David Williams holds the Carroll H. Long Chair of Excellence for Surgical Research at the Department of Surgery, leading research initiatives focused on immunity, sepsis, and infectious diseases. His work emphasizes host-pathogen interactions, trained immunity mechanisms, and translational therapies for conditions like cerebral adrenoleukodystrophy and parasitic infections. Supported by NIH grants, his research spans cellular biology, metabolic pathways, and drug discovery. Research Interests : Dr. Williams investigates innate immune memory mechanisms, sepsis pathophysiology, and the role of metabolic adaptations in immunity. His studies include inflammatory responses in cardiovascular diseases, therapeutic targeting of parasitic enzymes, and β-glucan-based immunomodulation strategies. He also explores the molecular underpinnings of cell senescence and organ crosstalk during critical illness. Key Projects : Gene therapy for cerebral adrenoleukodystrophy (CALD) Thioredoxin reductase inhibitors for寄生虫 diseases Trained immunity in aging and sepsis Awards : Carroll H. Long Chair of Excellence (2017-present) Labs & Affiliations : Kleinman Laboratory of Ocular Biology and Imaging, collaborating on ocular immunology and imaging technologies. Active in cross-departmental initiatives to enhance surgical research education and clinical translation.

Danyelle Townsendمشاهده پروفایل

استاد

• Cancer Biology
• Redox Signaling
• Drug Discovery
• +۳ مورد دیگر

Danyelle Townsend is a Professor at the Medical University of South Carolina (MUSC) in the College of Pharmacy's Department of Drug Discovery and Biomedical Sciences. Her research focuses on redox signaling pathways, mitochondrial dysfunction, and drug development for cancer and chronic diseases. Key areas include oxidative stress mechanisms, protein S-glutathionylation, and targeted drug delivery systems. Her work integrates molecular pharmacology with translational medicine, emphasizing therapeutic strategies for conditions like intervertebral disc degeneration, multiple myeloma, and melanoma. Notable contributions include studies on CYP3A4 metabolism in pediatric patients and development of pH-sensitive drug delivery systems. Research highlights include the role of microsomal glutathione transferase 1 (MGST1) in cancer progression and the application of synthetic mitochondrial RNAs to restore bioenergetics. She has published extensively on redox regulation in cell survival pathways and novel anti-cancer agents derived from natural compounds like lapachol. Dr. Townsend's studies often employ animal models and in vitro systems to evaluate drug efficacy, with a focus on mechanisms linking environmental exposures (e.g., cigarette smoke) to disease progression. Her interdisciplinary approach bridges basic science and clinical applications, targeting both drug discovery and precision medicine strategies.

• Chromosome Dynamics
• Epigenetics
• Genomic Instability
• +۳ مورد دیگر

Dr. Mathew J. Thayer is a Professor in the Department of Biochemistry and Molecular Biology at the University of Southern California, specializing in chromosome dynamics and epigenetic regulation. His research focuses on replication timing control, non-coding RNA interactions, and genomic stability mechanisms. California State University, Chico (BA: Microbiology & Chemistry, 1982) University of Southern California (PhD: Microbiology, 1988; Advisor: Dr. R.E.K. Fournier) Dr. Thayer's work has pioneered understanding of cis-acting elements that regulate DNA replication timing and chromosomal stability. He discovered ASAR lncRNA genes controlling replication patterns and identified chromosome-wide instability mechanisms linked to cancer. His recent publications demonstrate how heterogeneous nuclear ribonucleoproteins interact with ASAR RNAs to orchestrate replication timing, with implications for epigenetic inheritance and cancer genome evolution . Collaborations span cancer biology, developmental genetics, and chromatin research fields. Scientific recognition includes: John A. Resko Faculty Research Achievement and Mentoring Award (2017) Dr. Thayer has contributed to training students through publications and collaborative research, with ongoing work exploring RNA-based chromatin regulation and its role in disease states.

• High-Performance Computer Architectures
• Cloud Computing Systems
• Internet-of-Things (IoT)
• +۳ مورد دیگر

Panagiotis Tsanakas is a Professor of Computer Engineering at the National Technical University of Athens (NTUA), serving as Dean of the School of Electrical and Computer Engineering. He holds a PhD in Computer Engineering from NTUA (1988) and has extensive academic experience in parallel computing, medical informatics, and IoT applications. His work includes co-authoring seven textbooks on computer systems and supervising eight doctoral dissertations. Prof. Tsanakas has led major national and EU projects like EuroHPC and GRNET, managing Greece's academic networks and supercomputing infrastructure (ARIS). He pioneered systems like Eudoxus (textbook distribution), ZEUS (secure e-voting), and DIAVLOS (webcasting). His professional roles include Board membership of EuroHPC and leadership in GRNET, contributing to €60M annual savings through tech optimization. Research focuses on high-performance architectures, cloud systems, and AI in healthcare. He has published over 100 papers and actively teaches courses like Digital Health Technologies and Computer Architecture. His projects emphasize medical informatics, telemedicine platforms, and IoT-enabled health monitoring.

• Plant Physiology
• Epigenetics
• Tree Development
• +۴ مورد دیگر

Dr. MARCOS VIEJO SOMOANO is a **Professor** at the **Department of Functional Biology**, part of the **Faculty of Pharmacy** at the **University of Santiago de Compostela**. His research focuses on **Plant Physiology**, particularly **epigenetic regulation mechanisms** in trees, with emphasis on conifers like Norway spruce and chestnut species. He holds a PhD from the University of Oviedo (2015), where his thesis explored epigenetic regulation in European chestnut embryogenesis under Dr. María Jesús Cañal Villanueva and Dr. Peter E. Toorop. His work investigates how environmental stresses (temperature, light, and climate) induce **epigenetic memory** in plants, influencing traits like bud phenology and stress resilience. He leads the **BIOTEC (Biotechnology Research Group)**, focusing on molecular mechanisms underlying plant development and conservation biology. Key methodologies include transcriptomics, DNA methylation analysis, and small RNA profiling. Major research trends in his articles include **DNA methylation dynamics**, **non-coding RNA roles**, and **transgenerational stress memory** in long-lived tree species. His studies bridge basic epigenetic mechanisms with applied forestry and conservation challenges. No awards or grants are explicitly noted in the provided text.

Anneli Cooperمشاهده پروفایل

پژوهشگر

• Molecular Genetics
• Parasitology
• Host-Pathogen Interactions
• +۳ مورد دیگر

Dr. Anneli Cooper is a Researcher in the Host-Parasite Interactions & Pathogenesis group at the University of Glasgow. Her work focuses on understanding the co-evolutionary dynamics between African trypanosome parasites (e.g., Trypanosoma brucei ) and their mammalian hosts, particularly investigating molecular genetics underlying parasite infectivity and host immune responses. She has contributed to studies on APOL1 gene variants' dual roles in kidney disease and trypanosome resistance, as well as the role of IL-17 signaling in parasite burden regulation. Her research also explores diagnostic tools like Raman spectroscopy for Human African Trypanosomiasis and the role of skin reservoirs in parasite persistence. Key grants include Wellcome Trust funding for spatially-resolved studies on APOL1-mediated kidney disease (2025–2027) and parasite street science initiatives (2022–2023). Cooper’s interdisciplinary work bridges genetics, immunology, and clinical diagnostics, with a focus on vector-borne diseases and their global health implications. Her publications highlight collaborations on topics such as trypanosome flagellar biology, γδ T cell immunology, and the genetic basis of disease severity in myotonic dystrophy type 1. She is affiliated with the Henry Wellcome Building in Glasgow and maintains an active ORCID profile (https://orcid.org/0000-0002-1159-142X).