- Genome stability
- DNA replication
- DNA repair
- +۵ مورد دیگر
Xiaolan Zhao, PhD, is a tenured Professor at Memorial Sloan Kettering Cancer Center, leading the Xiaolan Zhao Lab within the Molecular Biology Program . Her work focuses on understanding the molecular mechanisms of genome stability , DNA replication , DNA repair , and the DNA damage response , particularly through the lens of SUMOylation and chromosomal organization. She is committed to mentoring and training the next generation of scientists in a collaborative environment. Education: PhD, Columbia University Research Interests: Dr. Zhao's lab investigates the 3Rs : DNA replication, repair, and damage response. These processes are essential for maintaining genome integrity and preventing diseases such as cancer , neurodegeneration , and developmental disorders . The lab uses multi-disciplinary approaches including genetics, biochemistry, cell biology, structural biology, and genomics to uncover how cells safeguard their genetic material under stress and during normal growth. Key research areas include: Mechanisms of genome duplication under normal and stress conditions DNA repair processes following genotoxic exposure DNA damage response systems and their signaling pathways Smc5/6 complex in replication and repair SUMO-based DNA damage response (DDIS) Scientific Awards: Bressler Scholar , Alfred W. Bressler Scholar Endowment Fund Research Scholar , American Cancer Society Scholar , Leukemia & Lymphoma Society Lab Environment & Mentorship: The Zhao lab provides a nurturing and collaborative environment for trainees at all levels. Former lab members have gone on to establish independent research groups and leadership roles in academia, biotech, and non-profits. Current lab members include graduate students, postdocs, research scientists, and undergraduates, all contributing to cutting-edge discoveries in genome maintenance.









