جست‌وجوی استاد و پژوهشگر

Loli Molina Jiménezمشاهده پروفایل

استاد

• Genetics
• Developmental Biology
• Stem Cell Research
• +۶ مورد دیگر

Maria Dolores (Loli) Molina Jiménez serves as a Full Professor in the Department of Bioengineering at IQS School of Engineering, Universitat Ramon Llull. Her academic career spans prestigious institutions including the University of Barcelona, Institut de Biologie Valrose in France, and Observatoire Oceanographique de Villefranche. She holds a PhD in Genetics from the University of Barcelona (2011) and has established herself as a leading researcher in developmental biology using planarian and sea urchin models. PhD in Genetics, University of Barcelona (2011) Diploma of Advanced Studies (DEA) in Genetics and Development, University of Barcelona (2007) Degree in Biochemistry, University of Barcelona (2010) Degree in Biology, University of Barcelona (2005) Professor Molina Jiménez's research focuses on genetic regulation of stem cell homeostasis and differentiation during planarian regeneration, with applications to cancer biology and environmental monitoring. Her work bridges molecular biology, developmental genetics, and regenerative medicine, utilizing advanced techniques including in vivo imaging, molecular biology, gene expression analysis, immunohistochemistry, and microscopy. She has made significant contributions to understanding LIM-HD transcription factors in axial patterning and cell identity specification in planarians, as well as TGF-β signaling in sea urchin embryonic development. Her recent publications demonstrate expertise across developmental biology, genomics, and environmental toxicology, with notable work on sea urchin genome evolution, planarian regeneration mechanisms, and the developmental toxicity of plastic pollutants. Her research has attracted significant attention, with multiple articles picked up by news outlets and cited across scientific platforms. Beatriu de Pinós Fellowship Marie Sklodowska-Curie COFUND Postdoctoral Fellowship EMBO Long-Term Postdoctoral Fellowship Professor Molina Jiménez has supervised numerous research projects and students, contributing to both the Bachelor's Degree in Biomedical Sciences and the Master's Degree in Bioengineering at IQS. Her laboratory maintains specialized planarian cultures and employs cutting-edge molecular techniques to investigate fundamental questions in regeneration and development. Her collaborative network extends across Europe, with significant contributions to large-scale genomic projects and environmental impact studies.

Stefan Strickerمشاهده پروفایل

استاد

• CRISPR-based epigenetic engineering
• Neural stem cells
• Brain tumours
• +۳ مورد دیگر

Prof. Dr. Stefan Stricker is a full member of the Graduate School of Systemic Neurosciences (GSN) and a regular member of the Munich Center for Neurosciences (MCN) at Ludwig-Maximilians-Universität München (LMU). He leads the Physiological Genomics research group jointly housed at the Biomedical Center LMU and Helmholtz Zentrum München, where he explores CRISPR-based epigenetic engineering, neural stem cell biology and brain tumour reprogramming. Research Interests: CRISPR-based epigenetic engineering – developing precise tools to rewrite chromatin states in somatic and cancer cells. Neural stem cell identity – decoding transcriptional and epigenetic networks that govern self-renewal versus differentiation. Brain tumour reprogramming – converting malignant glioma cells to a pluripotent, non-tumourigenic state to interrogate cancer epigenetics. Long non-coding RNAs (lncRNAs) – investigating Airn and other macro ncRNAs in genomic imprinting and gene-silencing mechanisms. Across more than fifteen years his work has produced a coherent body of literature that moves from fundamental imprinting biology in embryonic stem cells to translational applications in glioblastoma. Re-occurring themes include DNA-methylation resetting, allele-specific expression biases, and the therapeutic vulnerabilities of glioblastoma initiating cells. Selected Publications & Trends: The 15 most recent publications (2004-2014) reveal a clear progression from mechanistic studies of lncRNA-mediated silencing ( Airn , Igf2r ) to high-impact investigations of glioblastoma stem-cell biology and CRISPR-mediated reprogramming. Collectively these works sit at the intersection of epigenetics , cancer biology and neurodevelopment . Scientific Awards & Fellowships: While no specific prizes are listed, multiple papers were recommended or highlighted by Faculty of 1000 and featured research highlights in Cancer Research and Nature Reviews Cancer . Advising & Training: Graduated GSN student: Dr. Valentin Baumann Laboratory & Institutional Affiliations: Prof. Stricker’s Physiological Genomics group is physically embedded within the Biomedical Center LMU and the Helmholtz Zentrum München, facilitating close collaboration between the university medical faculty and Germany’s largest biomedical research organisation.

Nevenka Meštrovićمشاهده پروفایل

استاد پژوهشی

• Genetics
• Evolution
• Satellite DNA
• +۴ مورد دیگر

Dr. Nevenka Meštrović is a senior research scientist and Head of the Laboratory of non-coding DNA at the Ruđer Bošković Institute, Division of Molecular Biology, in Zagreb, Croatia. She is also a mentor and supervisor for doctoral students at the University of Zagreb and other Croatian universities. Education: Ph.D. in Genetics and Evolution, Faculty of Science, University of Zagreb (1999) Mr.Sc. in Biochemistry, Faculty of Science, University of Zagreb (1994) B.Sc. in Molecular Biology, Faculty of Science, University of Zagreb (1989) Research Interests: Dr. Meštrović's research focuses on the evolution and function of non-coding DNA , particularly satellite DNA sequences and their role in centromere biology , genome evolution , and chromosomal organization . Her work spans in silico analyses, molecular cytogenetics, and comparative genomics across nematodes, beetles, and other model organisms. She also explores the epigenetic regulation of repetitive DNA and its implications in development and speciation. Recent publications highlight her expertise in Tribolium castaneum genomics, holocentric chromosomes, and satellite DNA dynamics across taxa. Her research integrates long-read sequencing, transcriptomics, and bioinformatics to uncover the mechanisms behind repetitive DNA proliferation and its evolutionary significance. Scientific Awards: Annual Award of the Ruđer Bošković Institute for best scientific papers (2020) Award J. J. Strossmayer (Croatian Academy of Sciences and Arts, 2008) Supervision & Grants: Dr. Meštrović has supervised multiple PhD students, including Evelin Despot-Slade and Martina Pavlek. She has led or collaborated on numerous nationally and internationally funded projects, including: Principal Investigator: "(Epi)genomics and transcriptomics of euchromatic satellite DNAs" (Croatian Science Foundation, 2020–2024) Principal Investigator: "Development of genomic markers for parasitic nematodes" (Adris Foundation, 2019–2022) Collaborator: COST Action 872, FP7-REGPOT, Croatian-French bilateral projects, and more. Laboratory & Team: As Head of the Laboratory of non-coding DNA at the Ruđer Bošković Institute, Dr. Meštrović leads a dynamic team focused on satellite DNA evolution, centromere genomics, and epigenetic regulation. The lab utilizes cutting-edge genomic and cytogenetic tools to study model organisms such as Tribolium castaneum and root-knot nematodes.

Diego Villarمشاهده پروفایل

مدرس ارشد

• Gene Regulation
• Epigenetics
• Genomics
• +۴ مورد دیگر

Dr. Diego Villar is a Non-clinical Senior Lecturer at Queen Mary University of London's Blizard Institute, Faculty of Medicine and Dentistry. His laboratory integrates genomics, epigenetics, and bioinformatics to investigate myocardial gene regulation mechanisms and their implications in cardiovascular disease, while also exploring evolutionary adaptations in African mole-rats through comparative genomics. PhD in Molecular Biology Postdoctoral training in neurodegeneration Established BHF-funded independent research group Research focuses on transcriptional dynamics in mammals through: Functional genomics of non-coding elements Cardiovascular epigenetic profiling Evolutionary enhancer analysis Recent publications examine DNA methylation networks in mammalian traits, lineage-specific adaptations in subterranean species, and regulatory element contributions to cardiovascular pathology. Key projects include characterizing myocardial enhancers with disease-associated variants and exploring stress resistance mechanisms in hypoxia-adapted rodents. Scientific recognitions include: British Heart Foundation Basic Science Fellowship (2018) EMBO Short Term Fellowships (2016, 2009) Ramon y Cajal Merit Award (2016) CRUK Travel Award (2012) Current supervision includes: Dr. Stephanie Frost (BHF-funded Postdoctoral Scientist) Mr. Yu Huang (Regenerative Medicine MSc student) Alumni: Daniel Pavon Heredia (CONACYT MSc) and Yiling Wan (undergraduate project)

• Bioinformatics
• Genomics
• Computational Biology
• +۴ مورد دیگر

Dr. Alexander Johan Nederbragt ("Lex Nederbragt") is a Senior Lecturer at the University of Oslo's Faculty of Mathematics and Natural Sciences, affiliated with the Centre for Ecological and Evolutionary Synthesis (CEES) and former member of the Centre for Computational Inference in Evolutionary Life Science (CELS). He leads the "Computing in Science Education" initiative within the Bioscience bachelor's program, developing courses like BIOS1100 that integrate Python programming with biological modeling. His educational philosophy emphasizes reverse instructional design and constructive alignment, with a focus on student-active learning and AI-driven pedagogical innovation. Researchwise, Nederbragt specializes in Bioinformatics and Genomics , particularly Evolutionary genomics of fish (Atlantic cod, haddock, grayling) Graph-based reference genome methodologies Genomic repeat element analysis Horizontal gene transfer in diatoms Computational microbiome studies His work spans comparative genomics, genome assembly validation, and bioinformatics software development (NucDiff, NucBreak). Scientific contributions reveal expertise in High-throughput sequencing Genomic architecture Evolutionary adaptation Computational methods Publication trends from 2012-2023 His research frequently intersects with ecological and evolutionary questions, particularly in teleost fishes. Scientific Awards Merittert Utdanner (Excellent Teaching Practitioner), University of Oslo (2023) Olav Thon Foundation National Award for Excellence in Teaching (2025)

Molly Megrawمشاهده پروفایل

دانشیار

• Transcription Factors
• Machine Learning
• Arabidopsis
• +۶ مورد دیگر

Molly Megraw is an Associate Professor at Oregon State University's College of Agricultural Sciences , affiliated with the Department of Botany and Plant Pathology , Molecular and Cellular Biology Program , and Center for Genome Research and Biocomputing . She also collaborates with the Department of Electrical Engineering and Computer Science. Education : Ph.D. in Bioinformatics (2007) from the University of Pennsylvania Her research integrates computational biology , machine learning , and plant genomics to study: Transcriptional regulation of Pol-II genes and miRNAs in plants Network motif analysis in TF-miRNA circuits Chromatin accessibility and promoter identification via nanoCAGE Synthetic biology applications in plant systems Recent publications focus on: Salinity stress responses in rice miRNA editing in human cancer Network motif discovery algorithms PlantSimLab modeling platform Scientific accomplishments include: NSF CAREER Award (2018) for machine learning models of gene regulation MiRGen database development for miRNA genomic organization She supervises graduate students in Biological and Physical Sciences (BPP) and teaches computational courses like BDS 470/570 Introduction to Computing in the Life Sciences . Her lab maintains active collaborations across plant biology and computational disciplines.

Katelyn Mikaمشاهده پروفایل

استادیار

• Molecular Evolution
• Evolutionary Developmental Biology
• Marine Biology
• +۴ مورد دیگر

Katelyn Mika serves as an Assistant Professor in the Department of Biological Science at the University of Tulsa, where her research investigates the molecular evolution and development of novel traits in marine organisms. She employs cutting-edge genomic techniques on both model and non-model species to uncover genetic mechanisms driving adaptation in ocean environments. Her academic background includes a Ph.D. in Molecular Evolution of Pregnancy from the University of Chicago and dual Bachelor's degrees (B.S. and B.A.) from Indiana University. This foundation supports her interdisciplinary approach to evolutionary questions. Dr. Mika's work spans molecular evolution , evolutionary developmental biology (EvoDevo) , and marine genomics , with specific focus on marine appendage formation (e.g., zebrafish pectoral fins and skate wings), depth adaptation across aquatic ecosystems, and host-microbiome interactions in vertebrates. Her lab pioneers single cell transcriptomics applications in non-model marine organisms to reveal both conserved and novel molecular pathways underlying phenotypic innovation. Analysis of her publication record reveals strong methodological consistency in evolutionary transcriptomics applied to reproductive biology and marine adaptation, with increasing emphasis on non-model systems since 2020. The work bridges comparative genomics with functional validation to address fundamental questions about evolutionary innovation. Her significant recognitions include: National Association of Underwater Instructors (NAUI) Worldwide Dr. Charlie Brown Memorial Award (2022) University of Chicago Biological Sciences Division Postdoc Trainee Diversity, Equity, and Inclusion Award (2021) Women Divers Hall of Fame Instructor Advanced Education Grant (2020) The Microbiome Center Pilot Award (2019) Dr. Mika leads an active research laboratory funded by competitive grants including the Microbiome Center Pilot Award. Her mentorship extends to graduate students in biological sciences, with research collaborations spanning marine genomics and evolutionary developmental biology. Based in Oliphant Hall, the Mika Lab maintains specialized facilities for marine organism handling and genomic analysis. Current projects focus on comparative studies of marine appendage development and host-microbiome coevolution, with future work expanding into environmental adaptation mechanisms in changing ocean ecosystems.

• Single-cell Genomics
• Machine Learning
• Gene Regulation
• +۴ مورد دیگر

Ravza Gur is a Postdoctoral Computational Biologist at the University of Oxford's MRC Weatherall Institute of Molecular Medicine (MRC WIMM) and member of the Genome Biology Lab. Her work focuses on integrating single-cell multiomic epigenetics and transcriptomics with machine learning to study non-coding genetic variations in human diseases. Affiliation: University of Oxford Department: MRC WIMM Centre for Computational Biology Role: Postdoctoral Computational Biologist Volunteer: President of ISCB SC RSG-Turkiye (2023) Her research spans single-cell genomics , machine learning , and gene regulation , with a focus on improving scATAC-seq resolution and developing tools like the CREST-GV platform. Current work involves Deep Neural Network methods for analyzing non-coding genomic regions. Scientific contributions include 14 publications on scATAC-seq, chromatin accessibility, and multiomic disease analysis. Her Google Scholar highlights projects like REnformer and GTAC. Recent work emphasizes epigenetic variation in AML and IMiD-induced neutropenia . 2023: Elected President of ISCB SC RSG-Turkiye 2022: Analyzed ATRX chromatin remodelling mechanisms Labs & Collaborations: Genome Biology Lab (Oxford) Centre for Computational Biology (MRC WIMM) ISCB SC RSG-Turkiye

Michael Leeمشاهده پروفایل

دانشیار

• Medical Education
• Pediatric Oncology
• Genomics
• +۳ مورد دیگر

Dr. Michael Lee is an Associate Professor in the Department of Pediatrics at UT Southwestern Medical Center. He actively contributes to clinical education as the course director for The Ambulatory Care Rotation and serves as a continuity attending at Children’s Health Pediatric Group. Medical Degree: UT Southwestern Medical School Pediatric Residency: Children’s Medical Center of Dallas His research spans genomics , chromatin biology , and nano-toxicology , with recent work focusing on: Transposable elements in cancer evolution CRISPR-based chromatin interaction analysis Integrase-independent retrotransposition mechanisms Environmental adaptation via genomic plasticity Carbon nanotube-cell interactions Publications reveal a strong emphasis on genomic instability and non-coding DNA across species, from yeast to mammals. His work bridges fundamental molecular biology with clinical applications in pediatric oncology. Scientific recognition includes: Fellowship in the American Academy of Pediatrics Dr. Lee's career integrates medical education, pediatric clinical practice, and interdisciplinary research at the intersection of genetics and nanotechnology.

• Bioinformatics
• Computational Biology
• RNA Biology
• +۵ مورد دیگر

Chao Zeng is an Associate Professor at Waseda University’s Research Institute for Science and Engineering, affiliated with the School of Advanced Science and Engineering. He holds a PhD in Science from the University of Tokyo (2016) and a Master’s in Information Science from Kyoto University (2013). His research integrates computational biology and RNA genomics, focusing on non-coding RNAs, RNA localization mechanisms, and repetitive genetic elements. Dr. Zeng’s work spans bioinformatics algorithm development , RNA structure-function relationships , and transcriptomic regulation in disease . Key interests include lncRNA interactions with ribosomes, phase separation of RNA, and RNA-binding protein networks. His lab employs high-throughput sequencing, machine learning, and comparative genomics to decode RNA regulatory systems across species. His publications emphasize RNA biology in cancer and fibrosis , with recent work exploring mitotic RNA editing, inflammatory recovery pathways, and RNA quality control. Article analyses reveal consistent themes: lncRNA mechanisms (35%), RNA-protein interactions (25%), computational methods (20%), splicing/localization (15%), and translational applications (5%). Awards & Grants: Waseda University Teaching Award (2022) JSPS Grants: PI for ‘Repetitive Elements in Genome Regulation’ (2022-2025) and ‘lncRNAs in Genetic Compensation’ (2020-2022) Co-investigator for Phase Separation Research (2023-2026) and Cancer RNA Mechanisms (2021-2023) He leads the RNA Bioinformatics group at Waseda, collaborating with the Hamada Lab and international teams. Future work targets RNA-based therapeutics and multi-omics integration for disease modeling.

Auli Karhuمشاهده پروفایل

پژوهشگر

• Biomedicine
• Tumor Genetics
• Cancer Genomics
• +۳ مورد دیگر

Auli Karhu is a University Researcher at the Department of Medical and Clinical Genetics within the Faculty of Medicine at the University of Helsinki. She is affiliated with the ATG (Applied Tumor Genomics) research group and serves as a Supervisor for the Doctoral Programme in Integrative Life Science. Dr. Karhu is currently an active participant in the Centre of Excellence in Tumor Genetics Research (COETG), a major project funded by the Research Council of Finland running from 2023-2025. Dr. Karhu's research focuses on tumor genetics, with particular expertise in: Genetic and epigenetic alterations in uterine leiomyomas (fibroids) Retrotransposition events in cancer development Molecular mechanisms of gastrointestinal tumors Population genetics approaches through the FinnGen project With 81 publications spanning over two decades, Dr. Karhu has established a consistent research trajectory with notable output in high-impact journals. Her recent work (2023-2025) demonstrates continued productivity in tumor genomics, with publications in Nature Communications, Gastroenterology, and Mobile DNA. Analysis of her publication history shows sustained research activity, with peak years producing up to 10 publications. Dr. Karhu has received support through significant research projects, most notably her current involvement in the Centre of Excellence in Tumor Genetics Research. Her supervision of doctoral students, including work on 'Genetic, Molecular and Clinical Aspects of Familial Pituitary Adenomas' (2009-2014), demonstrates her commitment to training the next generation of researchers. Dr. Karhu is actively involved in the ATG (Applied Tumor Genomics) research group at the University of Helsinki, where she contributes to advancing our understanding of the genetic basis of tumor development. Her work bridges basic genomic research with clinical applications, particularly through population-based studies that leverage Finland's unique genetic heritage.

Davide Seruggiaمشاهده پروفایل

استاد مدعو

• Chromatin Biology
• Genome Editing
• Pediatric Cancer Research
• +۳ مورد دیگر

Davide Seruggia is an Adjunct Professor at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Principal Investigator at St. Anna Children’s Cancer Research Institute (CCRI), Vienna, Austria. His career spans institutions including Boston Children’s Hospital, Harvard Medical School, and the National Center for Biotechnology (CNB-CSIC), Madrid. Dr. Seruggia obtained his PhD in Molecular Biology from CNB-CSIC (2014) and specialized in chromatin biology, genome editing, and pediatric leukemia during postdoctoral work at Boston Children’s Hospital (2015–2021). He was promoted to Instructor in Pediatrics at Harvard Medical School (2019) and secured an ERC Starting Grant (2020) to launch his independent group. Research Focus His laboratory investigates: Non-coding regulatory sequences (enhancers, insulators) in pediatric leukemia 3D genome architecture and drug resistance mechanisms TFIID/SAGA chromatin complex roles in MYC-driven cancers CRISPR-based functional genomics and computational biology approaches Translational implications for targeted therapies in hematologic malignancies Recent Publications Dr. Seruggia’s work on enhancer dependence in gene regulation (2020), SAGA complex vulnerabilities in leukemia (2025), and HDAC1 roles in immune-oncology (2025) highlights his expertise in cross-disciplinary cancer research. His CRISPR-CLEAR methodology (2024) enables high-resolution mapping of regulatory elements. Awards & Funding ERC Starting Grant (2020) WES Foundation grant Pedals for Pediatrics funding Students & Collaborators His team includes postdoctoral fellows (Paul Batty, Ana Patricia Kutschat), predoctoral students (Hannah Beneder, Leonie Lehmayer, Sandra Wittibschlager), a diploma student (Carlos Roche), and technical staff (Gerlinde Karbon, Sophie Müller).

Matjaz Barboricمشاهده پروفایل

پژوهشگر

• Transcription Elongation
• RNA Polymerase II
• Gene Expression Regulation
• +۷ مورد دیگر

Matjaz Barboric is a University Researcher in the Department of Biochemistry and Developmental Biology at the University of Helsinki, where he serves as a Supervisor in the Doctoral Programme in Biomedicine. His research is supported by multiple active projects funded by the Academy of Finland, Cancer Foundation, Sigrid Jusélius Foundation, and Magnus Ehrnrooths Foundation, with research extending through 2028. Dr. Barboric's research program focuses on the fundamental mechanisms of metazoan gene transcription by RNA polymerase II, particularly investigating regulatory factors that modulate transcription at the elongation level. His laboratory studies key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of Rbp1 at Serine 2. Using biochemical, genetic, and systems biology approaches, his team explores how transcription elongation connects to pre-mRNA processing events like alternative splicing through Ser2-P CTD modification. A critical aspect of his work examines how deregulation of RNAPII elongation control contributes to cancer development and investigates the significance of transcription elongation kinases in embryonic development. Analysis of Dr. Barboric's publication record spanning over two decades reveals consistent focus on transcriptional regulation mechanisms, with recent work increasingly connecting fundamental transcription processes to cancer biology. His research demonstrates strong interdisciplinary connections between basic molecular mechanisms and clinical applications, particularly in identifying how transcriptional dysregulation contributes to disease states and potential therapeutic targets. Dr. Barboric currently leads multiple research projects including 'Combinatorial targeting of transcriptional kinases in cancer' funded by the Academy of Finland (2024-2028), multiple Cancer Foundation projects (2024-2026), and the M&GC. Ehrnrooth Foundation project (2025). He serves as a supervisor for doctoral students in the Biomedicine program, with documented supervision of research on 'Regulation of Pol II polymerase transcriptional response to DNA damage by RBM7 and P-TEFb' in 2020.

• Cytogenetics
• Translocations and inversions
• Next generation sequencing
• +۷ مورد دیگر

Niels Tommerup is a Professor of Medical Genetics at the Department of Cellular and Molecular Medicine, University of Copenhagen, where he has served since 1996. He previously directed the Wilhelm Johannsen Centre for Functional Genome Research (2001-2013) and was Deputy Head of Department (2007-2019). His research group focuses on mapping balanced chromosomal rearrangements (BCR) to identify disease genes, regulatory domains (Topological Associating Domains), and novel genetic mechanisms, as well as characterizing germline chromothripsis and functional studies of non-coding RNA genes. Tommerup earned his DMSc. in genetics (1994) and medical degree (Cand.med., 1978) from the University of Copenhagen. His early career included positions as a junior doctor, research assistant, and senior doctor at the J.F. Kennedy Institute in Denmark (1978-89), and as a Consultant at the Department of Medical Genetics, Ullevål University Hospital in Oslo, Norway (1989-91). He has held visiting scientist positions at institutions in London, Australia, and Norway. His research spans multiple areas including cytogenetics, translocations and inversions, next generation sequencing, Topological Associating Domains, Long Range Position Effects, 3D-genome organization, and long noncoding RNAs. Tommerup coordinates the International Breakpoint Mapping Consortium (2014-present), involving over 100 diagnostic cytogenetic laboratories from more than 50 countries across six continents. His work has established that direct gene truncation may explain approximately 18% of BCR-associated developmental disorders, and that long-range position effects may be at least as frequent a cause as gene truncation. His recent publications reveal trends in understanding sex differential responses to viral infections (particularly focusing on the X-chromosome), linking anatomical variation to genetic variation, and developing methods for visualization of nuclear genome organization. His work bridges basic genomic research with clinical applications in developmental disorders, intellectual disability, autism, epilepsy, and other conditions. Det Classenske Fideicommis Boglegat (1987) Iris Preuss's Mindelegat (1994) First Harold Klinger Memmorial Award Lecture, Atlanta, USA (2006) Tommerup has supervised 27 PhD students and 10 postdocs. His editorial roles include service on the boards of Briefings in Functional Genomics, Clinical Genetics, Computational and Structural Biotechnology Journal, PeerJ, and Australasian Med J. He has organized numerous academic events including the International Summer School in Functional Genomics and the Wilhelm Johannsen Symposium. His international collaborations include the EU-concerted action Mendelian Cytogenetics Network and the International Breakpoint Mapping Consortium. Tommerup leads the Tommerup Group which coordinates the International Breakpoint Mapping Consortium and collaborates with Michael Talkowski's group at Harvard to accumulate the largest collection of sequence-resolved germline balanced chromosomal rearrangements. His laboratory combines DNA-DNA-interaction (Hi-C) studies with short and long read sequencing to improve the dissection of complex chromosomal rearrangements. The group has initiated systematic X-inactivation studies of sequence-resolved X;autosomal translocations and X-inversions, and conducts research on germline chromothripsis and host genetic factors underlying sex differential responses to viral infections.

• Epigenetics
• Genome Biology
• Embryonic Development
• +۷ مورد دیگر

Zachary Smith is an Assistant Professor (Adjunct) in the Department of Genetics at Yale School of Medicine, with additional affiliations at the Yale Stem Cell Center, Center for RNA Science and Medicine, and the Genomics, Genetics, and Epigenetics program. His research focuses on epigenetic regulation during mammalian development. Dr. Smith received his B.S. in Biology from M.I.T. in 2008 and his Ph.D. in Biology from Harvard University in 2019. His doctoral work focused on applying cutting-edge genomic technologies to understand chromatin dynamics during mammalian development. He joined the Yale Stem Cell Center and Department of Genetics as an Assistant Professor in September 2020. Dr. Smith's research program investigates three critical developmental processes: fertilization, implantation, and gastrulation. His lab seeks to understand how the genome is reconstructed after fertilization, how distinct epigenetic states are established in embryonic versus extraembryonic lineages, and how chromatin regulators orchestrate the complex process of gastrulation. They employ advanced genomic techniques including single-cell sequencing, Cas9-mediated genome editing, and novel molecular recording technologies. His recent publications highlight significant contributions to understanding DNA methylation dynamics in development and disease, X-chromosome biology, and the development of innovative genomic technologies. Dr. Smith's work bridges fundamental developmental biology with potential applications to understanding developmental disorders and cancer. Epigenetic regulation of mammalian development Chromatin dynamics during embryogenesis DNA methylation reprogramming Single-cell genomic analysis Novel molecular recording technologies Dr. Smith's lab collaborates extensively with researchers at Yale and other institutions, including Michael Caplan, Berna Sozen, and Biff Forbush. His interdisciplinary approach combines expertise in genetics, developmental biology, and technology development to address fundamental questions about how epigenetic mechanisms shape development. Students and postdocs in Dr. Smith's lab have opportunities to work at the forefront of developmental epigenetics, gaining expertise in both experimental and computational approaches to studying genome regulation during development.