جستجوی استاد راهنمای دانشگاهی

Caitriona M. O'Driscoll is Professor and Chair of Pharmaceutics at University College Cork's School of Pharmacy, Ireland. With over four decades of academic experience, she previously served as Head of the School of Pharmacy at UCC from 2003-2009 and 2010-2013. Her established drug delivery research team spans from pre-formulation through to production and manufacture of prototype delivery systems suitable for clinical trial, with strong industry links underpinning many research projects. Her research interests focus on translational drug delivery with emphasis on 'problem' drugs including poorly water soluble compounds and biopharmaceuticals like peptide/protein drugs, plasma DNA and siRNA. She develops nano-sized delivery constructs that are robust enough to survive processing, stable on storage, and achieve cell/site specific delivery in vivo. Greater than 40% of new chemical entities are poorly water soluble Biopharmaceuticals now approach 50% of all new drugs in development Major barrier is design of efficient delivery systems Special focus on oral drug delivery despite challenges Analysis of her recent publications reveals a strong emphasis on targeted nanodelivery systems for cancer therapy, particularly prostate and colorectal cancer, as well as neurodegenerative diseases like Huntington's. Her work demonstrates expertise in cyclodextrin-based nanoparticles, siRNA delivery, and disease-specific formulations that account for conditions like Crohn's disease that affect drug delivery. Scientific awards include: 'Person of the Year award' by Parenteral Drug Association (Ireland Chapter) in 2013 'Award for Professional Excellence' by Helix Health in 2007/2008 'Award for Pharmacist of the Year' by Helix Health in 2007/2008 With €10.5M in career research income and 25 PhDs graduated, Professor O'Driscoll's work has attracted funding from diverse sources including Science Foundation Ireland, Enterprise Ireland, and industry partners. Her research group maintains strong links with Pharmaceutical Chemistry and Process & Chemical Engineering at UCC, creating a unique strength for drug development research from design through to clinical trial. She has served as external examiner for multiple universities and as PhD thesis examiner at institutions worldwide. Her research team operates within UCC's drug delivery group, which has established expertise spanning from pre-formulation through to production and manufacture of prototype delivery systems. The group maintains strong industry connections and offers various PhD positions, focusing particularly on translational research with product-driven applications.

• Drug Delivery
• Pharmaceutics
• Nanomedicine
• +۵ مورد دیگر

Professor Aideen Sullivan is Head of the Department of Anatomy and Neuroscience at University College Cork (UCC). With a career spanning over two decades at UCC, she leads research on neuroprotective therapies for Parkinson's disease, focusing on growth factors, stem cell applications, and epigenetic mechanisms. She established Ireland's first BSc in Neuroscience and co-developed the cross-College BSc in Medical and Health Sciences (CK707). BSc (First Class Honours) in Pharmacology, University College Dublin (1992) PhD in Neuropharmacology, University of Cambridge (1995) Her research program investigates Parkinson's disease through five key themes: viral vector delivery of neurotrophic factors, molecular mechanisms of neuroprotection, biomarker discovery, neuronal degeneration models, and stem cell-based treatments. She has secured significant grants from Health Research Board, Enterprise Ireland, and the Wellcome Trust. Recent publications (2022-2020) emphasize epigenetic regulation (HDAC inhibitors), microbiome-gut-brain axis interactions, and novel neurotrophic strategies. Articles highlight GDF5's neuroprotective effects, miRNA modulation, and molecular pathways like BMP-Smad and p38-MAPK. Scientific awards include: Postgraduate Certificate in Teaching and Learning (UCC, 2006) FETAC Certificate in Peer-Mentoring (2010) Leadership Foundation Aurora Programme Scholarship (2015) Over €2 million in research grants She mentors undergraduate and postgraduate students, chairs UCC's Athena SWAN 'Flexible Working' group, and serves as Editor-in-Chief of Neuronal Signaling . Her work spans laboratory research, public engagement, and educational innovation.

• Neuroscience
• Neuropharmacology
• Neurodegenerative Diseases
• +۵ مورد دیگر

George Barreto is an Associate Professor at the University of Limerick, affiliated with the Department of Biological Sciences, Bernal Institute, Health Research Institute, and Limerick Digital Cancer Research Centre. His research focuses on hormonal regulation of mitochondrial functions in the brain, neurodegenerative diseases, and drug development targeting mitochondria. He holds a PhD in Biological Sciences from Complutense University of Madrid (2009) and completed postdoctoral training at Stanford University (2009–present). His expertise spans neuroendocrinology, neurobiology, and neurodegenerative diseases, with a focus on sex differences in brain function. His research interests include the role of androgens/estrogens in neuroprotection, lipid metabolism in neuroimmune responses, and the therapeutic potential of synthetic hormones like tibolone. He has contributed to over 375 publications and actively reviews grants for national and international funding bodies. Key Research Themes: Mitochondrial dysfunction, neuroinflammation, traumatic brain injury, Alzheimer’s disease, and drug repurposing. Awards: Postdoctoral Fellowship and WERC/FENS PhD Fellowship. Collaborations: Global networks investigating glial cell biology, neuroprotective agents, and nutraceutical interventions.

• Neuroendocrinology
• Neurobiology
• Neurodegenerative Diseases
• +۷ مورد دیگر

Dr. Melanie Föcking is a Senior Lecturer in the Department of Psychiatry at the Royal College of Surgeons in Ireland (RCSI), based at Beaumont Hospital, Dublin. She joined RCSI in 2004 as a Research Fellow and transitioned to Lecturer (2005–2023) before her current role. Her research focuses on psychiatric neuroscience, particularly proteomic investigations of schizophrenia, bipolar disorder, and psychosis biomarkers, with emphasis on complement/coagulation pathways and neuroinflammation. Föcking holds an MSc from the University of Giessen (1998), a PhD from the Max Planck Institute/University of Maastricht (2003), a postgraduate diploma in Health Professions Education (2019), and an HDip in Leadership (2008). She is fluent in German, English, and Dutch. Her research integrates proteomics, immunopsychiatry, and clinical neuroscience to identify biomarkers for psychosis transition and treatment response. Recent work explores inflammatory dysregulation (e.g., complement proteins, matrix metalloproteinases) in schizophrenia spectrum disorders, cannabis-related neuroinflammation, and omega-3 fatty acid mechanisms. A consistent theme is the transdiagnostic role of inflammation across psychiatric conditions. Föcking received the Investigator Prize (2018), Young Investigator Award (2013), and Travel Fellowship (2010). As Neuroscience Module Lead at RCSI, she oversees curriculum development for medicine and physiotherapy students, coordinates student research programs, and mentors PhD/MSc/summer students. She secured grants from the Health Research Board, Wellcome Trust, and Science Foundation Ireland for projects on postsynaptic density proteomics, psychosis biomarkers, and nutritional interventions.

• Psychiatric Neuroscience
• Proteomics
• Schizophrenia
• +۳ مورد دیگر

CLINT leads the Lab for Clinical & Integrative Neuroscience (Lab CLINT) at Trinity College Dublin , focusing on brain disorders through multimodal imaging and neuromodulation. The lab investigates predictive coding theory in phantom perceptions like tinnitus, Parkinson's, and chronic pain, while developing treatments through peripheral nerve stimulation. Research Pillars : Predictive coding, thalamocortical dysrhythmia, locus coeruleus noradrenergic pathways Key Disorders : Tinnitus, Alzheimer's, chronic pain, depression Scientific Contributions include: Developing TIDE consortium for tinnitus biomarkers Implementing BRAI3N clinic for neuromodulation therapies Creating Tinnitus Éire community for peer support Recent publications analyze: Deep learning applications for tinnitus prognosis HD-tACS effects on attention networks Bayesian models of chronic pain comorbidities CLINT's work bridges laboratory research with clinical translation, emphasizing patient-centered approaches and interdisciplinary collaborations across Europe and North America.

• Neuroscience
• Neurology
• Psychiatry
• +۳ مورد دیگر

Christian Waeber is a Professor of Pharmacology at University College Cork (UCC), with a joint appointment between the School of Pharmacy and the Department of Pharmacology and Therapeutics. He currently serves as Head of the Department of Pharmacology and Therapeutics. His research focuses on sphingosine-1-phosphate (S1P) receptor signaling in cerebrovascular disorders, stroke neuroprotection, and neuroinflammation. Waeber's work bridges basic science and clinical applications, including the development of therapies targeting S1P receptors for stroke and migraine. He has contributed to understanding the role of fingolimod in stroke recovery and immune modulation. His studies also explore the mechanisms of preconditioning and the neuroprotective effects of S1P signaling pathways. Research Interests: S1P receptor biology, ischemic stroke, neurovascular interactions, immune modulation in brain injury, and migraine pathophysiology. Waeber leads projects investigating the therapeutic potential of S1P modulators and the role of regulatory T cells in stroke outcomes. He collaborates on clinical studies analyzing immune profiles post-stroke to improve patient recovery strategies. Professional Contributions: Over 200 peer-reviewed publications, including high-impact articles on S1P signaling and neuroprotection. Active in translational research, Waeber bridges pharmacology and clinical practice, with a focus on drug development for stroke and neurodegenerative conditions. He has contributed to textbooks on headache mechanisms and cerebral blood flow methods.

• Sphingosine-1-phosphate (S1P) signaling
• Cerebrovascular disorders
• Stroke neuroprotection
• +۴ مورد دیگر

Dr. Gary Brennan is an Assistant Professor at the School of Biomolecular and Biomedical Science, University College Dublin, and a member of the Conway Institute. He is a Funded Investigator at the FutureNeuro Research Center and has held affiliations with institutions including the Royal College of Surgeons in Ireland (RCSI) and the University of California-Irvine. His research focuses on the molecular mechanisms of epilepsy, particularly epigenetic and epitranscriptomic regulation, RNA modifications, and neuroinflammatory pathways. Education: PhD in Physiology & Medical Physics from RCSI (2015) Postdoctoral Training: University of California-Irvine (2012-2015) under Prof. Tallie Z. Baram; RCSI (2016-2018) under Prof. David Henshall His research program addresses three critical challenges: (1) understanding molecular reprogramming after brain insults, (2) developing RNA-based therapies targeting epigenetic processes, and (3) identifying peripheral biomarkers for epilepsy prediction. Key contributions include studies on microRNA regulation of seizure networks, m6A RNA methylation in temporal lobe epilepsy, and systemic delivery of antagomirs timed with blood-brain barrier disruption. His work has been published in journals like Nature Reviews Neurology , JCI Insight , and Molecular Brain . Recent funding includes grants from Science Foundation Ireland (SFI), Health Research Board (HRB), and the European Union. He has received awards such as the CURE Taking Flight Award and Marie Curie Fellowship. Dr. Brennan also supervises PhD students and coordinates modules on CNS diseases and multicellular systems.

• Epigenetics
• RNA Biology
• Epilepsy
• +۲ مورد دیگر

Brian Caulfield is a Professor and Lead Investigator at the ARCH (Applied Research for Connected Health) Centre at University College Dublin, where he directs industry-focused research on technology-enhanced human performance in connected health and sport. He leads the Sensing and Actuation research group and has co-authored 180+ publications and 6 patents. His research integrates: Wearable technology for real-world mobility assessment and gait analysis Machine learning applications in sports injury prevention and rehabilitation Digital biomarker validation for chronic conditions (COPD, Parkinson's, MS) Athlete health frameworks and pain assessment toolkits Recent articles (2024-2025) demonstrate strong focus on: Clinical translation of digital mobility metrics Wearable device validation across diverse populations AI-driven training optimization for athletes Global health applications in resource-limited settings He has supervised over 20 graduate students (MSc/PhD) and contributes to major consortia like Mobilise-D and INTERLIVE-Network, developing standards for wearable data in clinical trials.

• Connected Health
• Sport Science
• Wearable Technology
• +۶ مورد دیگر

Andreas Grabrucker is a Professor at the University of Limerick (Ireland), holding joint appointments in the Bernal Institute, Department of Biological Sciences, Health Research Institute, and Limerick Digital Cancer Research Centre. His research focuses on trace metal biology, particularly zinc’s role in synaptic function, neurodevelopmental disorders, and gut-brain interactions. He has pioneered studies on zinc’s regulatory mechanisms in the CNS and developed novel nanotechnology-based drug delivery systems. Key areas include autism spectrum disorders (ASD), Alzheimer’s disease, and the interplay of genetic and environmental factors in neurological conditions. Education: Diploma in Biology (TU Munich, Germany, 2005) PhD in Molecular Medicine (University Ulm, Germany, 2009) Research Interests: His work investigates how zinc dysregulation contributes to synaptic dysfunction in ASD and neurodegenerative diseases. He explores nanocarrier technologies to deliver therapeutic agents across the blood-brain barrier and uses 3D organoid models derived from human induced pluripotent stem cells (hIPSCs) to study disease mechanisms. Recent studies emphasize zinc’s role in gut microbiota composition, inflammatory bowel disease, and depression. Awards: Teaching Hero Award (2021) Collaborations & Leadership: He served as Executive Director of the Neurocenter at Ulm University (2011–2016) and currently leads a research cluster at the Bernal Institute. He is a Guest Associate Professor at the University of Modena and Reggio Emilia (Italy) and actively contributes to initiatives addressing UN Sustainable Development Goals related to health and innovation. Labs & Teams: His lab focuses on metallomics, nanomedicine, and translational research in neurodevelopmental disorders. Collaborations involve multidisciplinary teams studying drug delivery systems, organoid models, and clinical biomarkers for ASD and Alzheimer’s.

• Neuroscience
• Trace Metal Biology
• Synaptopathies
• +۴ مورد دیگر

Dr. John Southern is an Assistant Professor in the Department of Chemistry at Trinity College Dublin (TCD), where he conducts research at the intersection of organic, medicinal, and chemical biology. His work focuses on the synthesis of novel nucleobase analogs and small molecules with therapeutic potential for autoimmune and neuroinflammatory diseases. Assistant Professor, Department of Chemistry, Trinity College Dublin Visiting Professor, Louvain-la-Neuve University, Belgium (2006) His research interests include medicinal chemistry, tRNA modification, autoimmune disease modulation, and synthetic methodology development. He has pioneered work on artificial nucleobase incorporation into tRNA, demonstrating disease remission in animal models of multiple sclerosis. His group designs bioactive heterocycles, including thiophenes, pyrrolidines, and piperidines, with applications in immunology and neuroscience. The recent publications highlight a strong trend toward developing novel agents for autoimmune conditions such as rheumatoid arthritis and multiple sclerosis. These studies combine synthetic organic chemistry with biological evaluation, focusing on cytokine regulation (e.g., IL-6), tRNA modification enzymes, and neuroinflammatory pathways. The work bridges chemical synthesis and translational medicine, aiming to deliver new therapeutic strategies through nucleic acid and small molecule interventions. Scientific Awards and Honors: Visiting Professor, University of Louvain-la-Neuve, Belgium (Jan–Apr 2006) Dr. Southern has advised several graduate students and postdoctoral researchers, though specific names are not listed in the source material. His research has been supported by peer-reviewed grants, particularly in the areas of autoimmune disease therapeutics and nucleic acid chemistry, although grant details are not specified. He collaborates closely with researchers such as Prof. Stephen J. Connon and Prof. Vincent P. Kelly. While no dedicated laboratory name is mentioned, his research group operates within the School of Chemistry at TCD, contributing to the institution’s strengths in pharmaceutical and synthetic chemistry. The team employs techniques in organic synthesis, enzymology, and molecular biology to explore novel biochemical interventions.

• Medicinal Chemistry
• Organic Chemistry
• Autoimmune Diseases
• +۵ مورد دیگر

Kieran McDermott is a Professor of Anatomy and Head of Teaching and Research in Anatomy at the School of Medicine, University of Limerick. Previously, he held positions at University College Cork (UCC), where he established Ireland's first BSc (Hons) in Neuroscience and led the Department of Anatomy's relocation to modern facilities. BSc (Hons) in Zoology, University College Cork MSc in Experimental Pathology and Toxicology, Royal Postgraduate Medical School, London PhD in Developmental Neurobiology, Institute of Psychiatry, London His research spans Developmental Neurobiology , focusing on neural cell lineage determinants and neurodegenerative disease pathophysiology (Parkinson's, Multiple Sclerosis), alongside pioneering work on Mesenteric Anatomy . Recent publications highlight the gut-brain axis, maternal immune activation effects, and mesentery's structural evolution. Scientific leadership includes presidency of Neuroscience Ireland and Fellowship of the Anatomical Society . He has served as external examiner and journal reviewer, integrating his expertise into national and international academic frameworks.

• Developmental Neurobiology
• Neural Cell Types
• Neurodegenerative Diseases
• +۴ مورد دیگر

Dr. Jennifer Dowling is a Lecturer in Immunology and Biotherapeutics at the Royal College of Surgeons in Ireland (RCSI), affiliated with the School of Pharmacy and Biomolecular Sciences and the Molecular and Cellular Therapeutics department. She leads the Brain inflammation Group Ireland (BIGie), focusing on neuroinflammation and macrophage biology in neurological diseases and injury. Dr. Dowling holds a BSc in Biotechnology and a PhD in Immunology from Dublin City University, followed by postdoctoral research at Trinity College Dublin and the Hudson Institute of Medical Research in Australia. Key roles include Council Member of Neuroscience Ireland and Guest Editor for a neuroimmunology research topic. Her research focuses on macrophage function in neuroinflammation, including hypoxic brain injury mechanisms and inflammatory pathways in diseases like multiple sclerosis. Notable achievements include securing a Marie Skłodowska-Curie Actions Fellowship for the 'OxyBaby' project (2020–2022) and receiving RCSI awards for Innovation and Early Career Research. Over 30 peer-reviewed publications span immunology, neurobiology, and biomaterials, with emphasis on inflammasomes, arginase-2 modulation, and neuroimmune interactions. Teaching contributions include health professions education certifications and supervision of PhD students in projects involving arginase-2 in cancer metastasis, miR-155 in neonatal seizures, and ulcerative colitis pathogenesis. Active grants include funding from Enterprise Ireland, Science Foundation Ireland, and Horizon 2020 for projects targeting chronic inflammation and CNS repair strategies.

• Immunology
• Neuroinflammation
• Macrophage Biology
• +۶ مورد دیگر

Yvonne Nolan is a Professor in Anatomy and Neuroscience at University College Cork (UCC), serving as a Funded Investigator in APC Microbiome Ireland and Vice Dean of Graduate Studies in the College of Medicine and Health. She holds dual roles as a researcher and academic leader, advancing both scientific discovery and graduate education. Dr. Nolan earned her BSc (Hons) in Biochemistry and PhD in Neuropharmacology from NUI Galway. Her postdoctoral training included visiting scholar positions at McGill University (Canada) and Trinity College Dublin. She joined UCC in 2003 as a Lecturer, advancing to Senior Lecturer (2011) and Professor (2020). Her research focuses on how lifestyle factors (exercise, stress, diet) impact brain health across the lifespan, emphasizing neuroinflammation, hippocampal neurogenesis, and the gut microbiome. Key themes include Alzheimer’s/Parkinson’s disease mechanisms, adolescent brain resilience, and translational interventions like exercise and marine-derived nutraceuticals. Dr. Nolan has supervised over 40 PhD/MSc researchers and secured €6M+ in grants from SFI, the Weston Trust, and industry partners. Awards include UCC’s 2016 Research Supervisor of the Year and a Society for Neuroscience Professional Development Award. As Vice Dean, she champions student-centered graduate education, fostering curiosity-driven research to address global health challenges. Her leadership extends to national initiatives like the ICAT program and public engagement via conferences, media, and educational outreach (e.g., ‘Brainpower’ online course). Research highlights include identifying exercise as a mitigator of neuroinflammation, demonstrating gut microbiota’s role in cognitive aging, and exploring music therapy for Down Syndrome. Collaborations span academia and industry (e.g., Marigot Ltd., Vasogen Inc.).

• Neuroinflammation
• Neurodegenerative Disorders
• Hippocampal Neurogenesis
• +۷ مورد دیگر

Dr. Gavin Stewart is an academic researcher at University College Dublin, focusing on urea transport mechanisms across diverse biological systems. His work spans neurodegenerative diseases, ruminant physiology, and plant evolution, with a strong emphasis on translational research. Key areas include Alzheimer's disease pathophysiology, rumen nitrogen recycling in livestock, and the role of urea transporters in microglial activation. Research interests include neuroinflammation modulation, cellular metabolism, and evolutionary adaptations in plant systems. He has contributed to pharmacology review articles and educational initiatives like the university evolution garden project. His studies frequently utilize animal models, cell lines, and proteomic approaches.

• Urea Transporters
• Neurodegenerative Diseases
• Ruminant Physiology
• +۳ مورد دیگر

Professor Andrew Bowie is a Professor of Innate Immunology and Biochemistry at Trinity College Dublin, where he serves as Head of the School of Biochemistry and Immunology. His research focuses on innate immune sensing mechanisms and their modulation by viruses, establishing him as a global leader in this field. Bowie obtained his PhD in Biochemistry from Trinity College Dublin in 1997, following postdoctoral training with Prof Luke O'Neill. He was appointed as lecturer in the Department of Pharmacology in UCD before returning to TCD in 2001 to establish Ireland's first Immunology undergraduate degree course, which he coordinated from 2002-2006. He served as Director of Research in the School of Biochemistry and Immunology from 2005-2009, and as Head of Immunology from 2011-2017. His research occupies a unique space at the interface between virology, immunology and disease pathogenesis. He investigates how pattern recognition receptors (PRRs) recognize pathogens, leading to interferon and cytokine production, and discovered IFI16 as a key cellular DNA sensor in 2010. His work has shed light on viral immune evasion mechanisms and how innate immune sensors drive inflammation. His laboratory has identified novel roles for innate immune proteins in regulating inflammation through cytokine modulation. Analysis of his recent publications reveals continued leadership in innate immunity research with a focus on viral sensing mechanisms, DNA recognition systems, inflammation regulation, and host-pathogen interactions. His work spans fundamental immunology to potential therapeutic applications, with publications in top journals including Nature Communications, Cell Reports, and Immunity. Highly cited researcher (Clarivate, top 1% by citations) 2018 Irish Society for Immunology Public Lecture Award Medal 2017 Elected to the Royal Irish Academy 2014 Elected Fellow of TCD 2008 Sheldon Wolff Prize in Cytokine Research 1999 Placed first in class (B.A. (Mod)) 1993 Professor Bowie has graduated 14 PhD students to date and secured over €9 million in research funding from national and international agencies including Science Foundation Ireland, the EU, and the US National Institutes of Health, as well as private industry. His laboratory investigates how pathogens engage with human cells through pattern recognition receptors and how viruses evade immune detection. He is actively involved in both undergraduate and postgraduate Immunology teaching, contributing significantly to TCD's global reputation as a center of excellence for Immunology teaching and research.

• Innate Immunology
• Virology
• Viral Evasion
• +۷ مورد دیگر