Carlos Alberto Gueto Tettay is an active researcher at Infection Medicine , part of the Biomedical Center (BMC) at Lund University. His work integrates advanced proteomic methodologies with immunological research to address infectious disease mechanisms. Research Interests Epitope mapping and immunogenicity studies Proteome dynamics in blood plasma Structural modeling of pathogen-host interactions Computational approaches in mass spectrometry Streptococcal virulence factors Recent publications highlight his focus on developing multimodal mass spectrometry techniques for epitope characterization and applying deep learning to improve proteomic data interpretation. Collaborative efforts span structural biology, computational modeling, and translational infectious disease research.
Ruzbeh Mosadeghi, MD, PhD serves as Assistant Professor of Medicine at the University of California, San Francisco (UCSF) School of Medicine. His academic appointments reflect his dual training as a physician-scientist with expertise spanning basic molecular research and clinical gastroenterology. Dr. Mosadeghi completed his educational training through a rigorous physician-scientist pathway: PhD in Biology from California Institute of Technology (2015), MD from Keck School of Medicine of USC (2017), Internal Medicine Residency at Columbia University Medical Center (2019), and Gastroenterology Fellowship at UCSF (2023). His research focuses on fundamental mechanisms of protein degradation, particularly the ubiquitin-proteasome system and COP9 signalosome function. His work bridges molecular biochemistry with cellular signaling pathways, investigating how protein modification systems regulate cellular processes. Analysis of his publication timeline reveals an evolution from early work on flavin-containing monooxygenases (2007) to sophisticated structural and kinetic analyses of the ubiquitin system (2012-2016), demonstrating increasing specialization in protein regulation mechanisms. His scholarly contributions, though limited in number (4 publications between 2007-2016), have generated substantial impact with citations ranging from 9 to 78 per paper, indicating significance within specialized research communities. Network analysis of his publications reveals connections to key concepts including Cullin Proteins, Ubiquitins, Peptide Hydrolases, and Multienzyme Complexes. Dr. Mosadeghi collaborates with prominent researchers in the field, including Deshaies RJ, Rothenberg EV, and Aebersold R, suggesting integration within established research networks focused on protein regulation and cellular signaling pathways.
Dr. Sivakumar Dakshinamurthy is a Researcher at the Max Planck Institute for Dynamics of Complex Technical Systems , leading the Molecular Simulations and Design group. His research focuses on protein-protein/ligand interactions using molecular docking and simulation, as well as enzyme engineering employing QM/MM hybrid methods. He is affiliated with the institute’s Sandtorstr. 1, Magdeburg, Germany, and can be reached at sivakumar@dynamicsofcomplextechnicalsystems.mpg.de . His work integrates computational approaches to address challenges in drug design, enzyme specificity, and sustainable chemistry. Current projects include AI-driven de novo drug design for acute myeloid leukemia and studies on SARS-CoV-2 protease inhibitors. His research also explores CO2 conversion via multienzyme systems and anticancer compound evaluation. Dr. Dakshinamurthy’s contributions span over two decades, with notable publications on deubiquitinase specificity, Bcl-2 family proteins, and histidine kinase targeting in bacterial pathogens. He maintains active collaborations in structural bioinformatics and contributes to early career research panels on drug repurposing. His office is located in S 1.11, and professional networks include LinkedIn.
Prof. Paolo Melchiorre is a Professor of Chemistry at the University of Bologna and former ICREA Professor at the Institute of Chemical Research of Catalonia (ICIQ). His research focuses on catalytic photochemical processes, particularly the discovery of asymmetric organocatalytic and photochemical methods for sustainable organic synthesis. He leads the Melchiorre Group, which investigates light-driven reactions and their applications in synthesizing chiral molecules. Education: B.Sc. (1999) and Ph.D. (2003) in Chemistry from the University of Bologna, followed by postdoctoral research in Denmark and Bologna. Research interests include photo-organocatalysis, energy transfer mechanisms, and environmentally respectful synthetic methods. Key contributions include groundbreaking work on enantioselective photochemical reactions and ERC-funded projects like ORGA-NAUT and CATA-LUX. Awards: G. Ciamician Medal (2007), RSEQ Prize (2016), Modena Medal (2019), RSC Pedler Award (2021), and FRSC (2020). He is an Associate Editor of Chemical Science . Advising: Supervised over 40 PhD students and postdocs, many now in academia and industry. Active in securing competitive grants and fostering interdisciplinary collaborations.
Jonathan Lovell is the SUNY Empire Innovation Professor and Professor in the Department of Biomedical Engineering at the University at Buffalo, affiliated with the School of Engineering and Applied Sciences. He leads the Lovell Lab, focusing on nanomedicine, phototherapy, and vaccine development. His research integrates engineering principles with biomedical applications, particularly in cancer immunotherapy, infectious disease vaccines, and targeted drug delivery systems. Research interests span nanovaccine design, light-activated therapies, and biomaterials for gene delivery. Notable work includes engineering lipid nanoparticles for adjuvant-driven immune responses and developing photoacoustic imaging technologies for clinical applications. Collaborations emphasize bridging global health challenges through nanotechnology innovation. Publications highlight advancements in malaria, influenza, and cancer vaccines, as well as multimodal therapies combining chemotherapy and photothermal treatment. The lab’s work often involves interdisciplinary strategies to address unmet medical needs, such as oral cancer vaccines using genetically engineered bacteria and biomimetic micelle formulations for rheumatoid arthritis. Contact: 201 Bonner Hall, Buffalo NY 14260 | jflovell@buffalo.edu | Lovell Lab Website
Dr. Federico Sabbadin is a Lecturer in the Department of Biology at the University of York, affiliated with the Centre for Novel Agricultural Products (CNAP). His research focuses on discovering and characterising enzymes from plant pathogens, insects, and algae to address agricultural and industrial challenges. Key areas include microbial virulence factors in crop protection, biomass valorisation through insect enzymes, and algal polysaccharide metabolism. His work on Phytophthora infestans revealed critical roles of lytic polysaccharide monooxygenases (LPMOs) in plant infection, leading to novel crop protection strategies. Research on insects explores enzymes enabling digestion of recalcitrant polymers like cellulose and lignin, with applications in sustainable biotechnology. In algae, his group identified the first LPMO family in green microalgae, advancing algal biomass conversion technologies. Teaching emphasizes molecular machines (enzymes) and invertebrate biology, fostering student skills in scientific analysis, communication, and essay writing. Students engage in lab-based projects within CNAP, investigating enzymes from plant pathogens, algae, and insects using omics, molecular biology, and structural techniques. Lab investigations combine transcriptomics, proteomics, and 3D structural predictions to dissect pathogen virulence mechanisms and identify targets for crop protection. Current efforts explore biocatalytic applications of insect-derived enzymes and algal LPMOs for biofuel and material production. Sabbadin’s work bridges fundamental biology with applied solutions for food security and sustainable resource management.
Asst Prof Brandon I Morinaka is an Assistant Professor in the Department of Pharmacy and Pharmaceutical Sciences at the National University of Singapore (NUS), under the Faculty of Science. His research focuses on natural products, particularly secondary metabolites from microorganisms, and their application in drug discovery. The Morinaka Lab employs bioinformatics and synthetic biology to identify and engineer enzymes involved in peptide-based therapeutics and biomaterials. A key focus is radical SAM enzymes, which catalyze unique reactions forming cyclophanes in peptides. Recent work includes studying 3-residue cyclophane-forming enzymes (3-CyFEs) and their role in triceptide biosynthesis. Education: BSc Chemistry (University of California, Santa Cruz), PhD Chemistry (University of California, San Diego). Research Interests: Natural product drug discovery, biosynthetic enzymes, peptide modifications, radical SAM enzymes, microbial secondary metabolites. Publications highlight advancements in understanding enzyme mechanisms, such as cyclophane formation and β-hydroxylation, as well as genome-mining approaches to discover novel bioactive peptides like landornamides and tolypamide.
Alessio Peracchi is a tenured Associate Professor at the University of Parma, Department of Chemical, Life and Environmental Sustainability Sciences. His career spans fundamental research in enzyme mechanisms, RNA/DNA catalysis, and metabolic pathways, with significant contributions to understanding PLP-dependent enzymes and deoxyribozymes. Education: Laurea in Veterinary Medicine (1989, cum laude), University of Parma Postdoctoral training: Stanford University (1994-1997), University of Parma (1997-1998) Research focuses on: Biochemical characterization of catalytic DNA molecules (deoxyribozymes) Glyoxylate metabolism and primary hyperoxaluria Functional genomics of PLP-dependent enzymes Development of kinetic techniques for RNA/DNA enzymes Enzyme mimics using calixarenes Recent publications highlight interdisciplinary approaches combining structural biology, bioinformatics, and metabolic disease research. Scientific awards include EMBO Young Investigator status and multiple international fellowships. He teaches Biochemistry and Proteomics Methods at both undergraduate and graduate levels.
Dr. Thomas Rexer is a Team Leader in Synthetic Glycobiotechnology at the Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, Germany. He has held this position since 2018, following his postdoctoral work at the same institution from 2014-2018. His educational background includes: PhD from Newcastle University (2010-2013) MSc in Advanced Chemical Engineering from The University of Manchester (2009-2010) BSc in Process Engineering from the University of Stuttgart (2005-2008) Dr. Rexer's research focuses on synthetic biotechnology with emphasis on cell-free biocatalytic processes for nucleotide sugar synthesis and purification. His work develops synthetic platforms for the in vitro glycosylation of proteins , integrating protein expression & purification, high-performance metabolite- and glycoanalytics, and mathematical modeling of multienzyme networks. His research has significant implications for therapeutic protein development, as approximately 70% of therapeutic proteins are glycoproteins yet understanding of glycan structure-function relationships remains limited. His recent publications demonstrate expertise in cell-free multi-enzyme systems for synthesizing various nucleotide sugars (UDP-galactose, UDP-GlcNAc, GDP-mannose, GDP-L-fucose) and applying these systems to glycoengineer proteins including the SARS-CoV-2 spike protein. His work bridges biochemistry, bioprocess engineering, and glycobiology to address challenges in protein glycosylation. Current research funding includes: "Deciphering the impact of Sars-CoV-2 envelope protein glycosylation on human pathogenicity" (DFG) "SynGlyco" (Exist-Forschungstransfer, BMWK) Previously: "Aufbau einer Plattform zur in-vitro N-Glykosylierung von Proteinen" (BMBF) Dr. Rexer leads a research team including Dr. Mariana Juárez-Osorio, Tuan Hoang Son, and Johannes Ruhnau. He collaborates extensively with researchers at Otto von Guericke University Magdeburg and Hannover Medical School. His laboratory develops integrated process platforms that combine protein expression, purification, analytics, and mathematical modeling to advance synthetic glycobiotechnology.
Heloise Ribeiro De Barros is a Fixed-term Assistant Professor at the Department of Applied Science and Technology (DISAT) , Politecnico di Torino . She serves as a member of the College of Chemical and Materials Engineering and an invited member of the College of Mechanical, Aerospace, and Automotive Engineering . Her research focuses on nano-bio interfaces , plasmonic biocatalysis , and colloid chemistry , with applications in nanozymes , smart materials , and biomedical systems . ERC Skills : PE5_10 (Colloid chemistry), PE11_5 (Hybrid materials), PE4_10 (Heterogeneous catalysis) Scientific Sector : PHYS-03/A - Experimental Physics of Matter and Applications Her recent work investigates gold nanoparticle interactions with enzymes and stimuli-responsive biocatalysis , particularly using thermoresponsive polymers and laser excitation to modulate enzyme activity. Key themes include catalytic regulation , nano-bio interface dynamics , and environmental applications of nanomaterials. Notable publications include: 2025: Polymer nanocomposites (Elsevier) 2024: Smart Materials for Biocatalysis (ChemCatChem) 2023: Cytochrome C on AuNPs (ChemCatChem) She collaborates on Physics I courses for Automotive Engineering and supervises Chiara Angela De Rosa , whose PhD research explores gold nanostars for viral RNA polymerase modulation . Her work spans bioanalysis , catalysis , and nanostructured materials .
Marianne Pusztai-Carey is an Associate Professor in the Department of Biochemistry at Case Western Reserve University School of Medicine . Her research focuses on the molecular mechanisms of Bacillus thuringiensis (Bt) insecticidal proteins and their applications in transgenic crops, alongside studies on β-lactamase enzymes and antibiotic resistance. Education: PhD in Biochemistry, University of Debrecen Postdoctoral work in Biochemistry (University of Debrecen) and Pharmacology (Mount Sinai School of Medicine) Research Interests include: Mechanistic studies of Bt toxins in Bacillus thuringiensis Insect resistance management in transgenic crops Protein structure-function relationships of β-lactamases Applications of Raman spectroscopy and crystallography Biofilm formation chemistry Recent Publications highlight her work on Bt toxin mechanisms (2008), β-lactamase inhibition (2015-2013), and biofilm analysis (2017). Her collaborations span entomology, microbiology, and pharmacology domains.
Bhushan Nagar is a Professor in the Department of Biochemistry at McGill University , leading the Nagar Lab within the Centre de Recherche en Biologie Structurale (CRBS) . His research focuses on the structural biology of signal transduction in the innate immune system and lysosomal proteins , using X-ray crystallography , Cryo-EM , and biophysical techniques . Key research areas: Structural analysis of Toll-like receptors (TLRs) and IRAK family proteins Molecular mechanisms of IFIT proteins in viral RNA recognition RNA-binding proteins like Argonaute2 and DAP5 Lysosomal enzyme structures (e.g., acid ceramidase , mannosidase ) Drug discovery targeting eIF4A and DEAD-box helicases Recent publication trends (2018-2023) highlight structural insights into innate immune sensors ( IFIT1 , NEU1 ) lysosomal pathways ( GlcNAc-1-phosphotransferase , saposin D ) translational control ( eIF4A , mTORC1/S6K axis ) deubiquitinase activity ( MYSM1 in hematopoiesis) allosteric enzyme inhibition ( caspase-6 , acid ceramidase ) Laboratory members: Current: Zixian Li, Garvit Bhatt, Danilo Ide, Alexei Gorelik Alumni: Filipp Frank, Jason Liang, Heidi Olesen, Genevieve Virgili, and others
Haissi Cui is an Assistant Professor in the Department of Chemistry at the University of Toronto. Her research focuses on understanding RNA maturation and decoding processes in disease contexts, combining chemical tools, protein engineering, and cell biology. She leads the Cui Lab, which explores how RNA and protein localization impact inflammation, neurological diseases, and developmental disorders. Education: PhD (Dr. rer. nat.) in Experimental Medicine from Technical University of Munich, with postdoctoral training at Scripps Research Institute and Technical University of Munich. Affiliations: Principal Investigator at University of Toronto, Department of Chemistry. Research interests include aminoacyl-tRNA synthetases, tRNA regulation, and nuclear organization. Her lab has developed chemical tools to study mRNA splicing and metabolic pathways linked to disease. Recent work highlights the role of arginyl-tRNA synthetase in inflammatory processes and RNA splicing. Key achievements include a Nature Cell Biology paper on arg-tRNA synthetase’s role in inflammation, and a cover article on metabolic regulation of mRNA splicing. Awards include Human Frontiers Science Program and Deutsche Forschungsgemeinschaft fellowships. Scientific Awards: CIHR Postdoc Fellowship, Paul Schimmel Scholarship, Ontario Graduate Scholarship, NSERC USRA. Lab Members: Includes PhD students (Noha, Santiago, Samuel, Qingyu, Colette), postdocs (Jamie), and undergraduates across multiple projects. Grants & Funding: Supported by fellowships and institutional grants for interdisciplinary research initiatives. Collaborative efforts include work on non-viral mRNA delivery and structural biology. The lab emphasizes diversity and outreach through initiatives like ChemClub and Women in Science programs.
Bonnie Murphy is a Research Group Leader at the Max Planck Institute of Biophysics in Frankfurt, Germany, leading an independent research group focused on understanding the structure and mechanism of redox and metalloproteins. Her work combines single-particle cryo-electron microscopy (cryo-EM) with biochemical and electrochemical techniques to study proteins involved in bioenergetic processes, particularly metalloproteins and redox proteins critical for climate, health, and planetary systems. Her research emphasizes structural dynamics linked to redox states, enabling insights into protein function through conformational changes. She develops novel cryo-EM methods, such as elemental mapping via reconstructed electron energy-loss analysis, to improve the interpretation of protein complexes. Her interdisciplinary team welcomes candidates from microbiology, biochemistry, chemistry, and physics. Key projects include structural studies of methanogenic megacomplexes, mitochondrial iron-sulfur cluster assembly, and Streptococcus pneumoniae NADPH oxidase. Recent publications highlight breakthroughs in anaerobic carbon fixation mechanisms and sulfur transfer dynamics during protein complex assembly. Bonnie Murphy’s group is part of the Max Planck Institute of Biophysics, collaborating internationally to advance structural biology and biophysical methods. Contact: bonnie.murphy@... or via the group’s webpage.
Lei Zhang is a Researcher in the Department of Pharmacology at the Yale School of Medicine. His research focuses on advanced biomaterials and enzyme engineering, with a particular emphasis on developing stable enzyme systems through biomimetic strategies. Key areas include enzyme immobilization on magnetic carriers, microcapsule fabrication for biocatalytic applications, and membrane technologies for environmental remediation such as desalination and resource recovery. His work integrates principles from materials science, biochemistry, and engineering to create innovative solutions for biomedical and industrial challenges. Notable contributions include the development of polydopamine-based microcapsules for multienzyme systems, biomimetic mineralization techniques, and sandwich-structured enzyme reactors. These advancements aim to enhance catalytic efficiency and stability while enabling scalable applications in fields like renewable energy (CO2 conversion) and sustainable water treatment. Dr. Zhang’s research portfolio demonstrates a strong interdisciplinary approach, bridging the gap between fundamental material science and practical biotechnological applications. His recent studies (2018-2010) highlight advancements in magnetic nanoparticle-based enzyme carriers and computational modeling of membrane distillation processes.
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