جست‌وجوی استاد و پژوهشگر

• Stem Cell Research
• Cancer Biology
• Skin Biology
• +۱۲ مورد دیگر

Gernot Walko is a tenured Associate Professor in the Department of Life Sciences at Queen Mary University of London, where he joined in October 2022 as Senior Lecturer in Squamous Cell Carcinogenesis. He is affiliated with the Centre for Oral Immunobiology and Regenerative Medicine and the Bart's Centre for Squamous Cancer. He maintains an honorary appointment at the University of Bath, where he was Principal Investigator from 2018 to 2022. His research focuses on epidermal stem cells and their role in skin regeneration and cancer. Doctor rerum naturalium (PhD), Molecular Biology, University of Vienna, 2008 Master of Natural Science, Microbiology, University of Vienna, 2002 Dr. Walko's research interests include epidermal stem cell self-renewal, long-term ex vivo culture of keratinocytes, the Hippo/YAP/TAZ signalling pathway, and the molecular basis of cutaneous squamous cell carcinoma. He employs multi-omics, genetic manipulation, and 3D cell culture models, including zebrafish xenografts, to dissect mechanisms of stemness and tumorigenesis. His work bridges regenerative medicine and cancer biology, with implications for therapy development. His recent publications highlight a strong focus on YAP/TAZ regulation in skin cancer, stem cell differentiation via topographical cues, and Notch signalling in epidermal homeostasis. Articles span high-impact journals in dermatology, cell biology, and biomaterials, indicating interdisciplinary contributions to understanding skin biology and disease mechanisms. Scientific Awards: Marie Curie Intra-European Fellowship Fellowship of the Higher Education Academy (FHEA) Dr. Walko actively supervises PhD students and postdocs, including Alexander Howard and Jodie Bojko. He has secured multiple research grants as Principal Investigator from major funders such as the Biotechnology and Biological Sciences Research Council (BBSRC), The Royal Society, The Academy of Medical Sciences, and the British Skin Foundation, supporting projects on epidermal stemness, YAP/TAZ dependencies, and confocal imaging infrastructure. His laboratory, now based at Queen Mary University of London, investigates the transcriptional control of epidermal stem cells and their transformation in cancer. The lab combines molecular biology, cell engineering, and animal models to explore novel therapeutic strategies for skin cancers.

• Hematology
• Oncology
• Epigenetics
• +۵ مورد دیگر

Prof. Dr. Carsten Müller-Tidow is a Medical Director at the Department of Hematology, Oncology, and Rheumatology at Heidelberg University Hospital (UKHD) and a member of the National Center for Tumor Diseases (NCT). He leads research groups focused on epigenomics in AML and the Molecular Medicine Partnership Unit (MMPU). His clinical roles include managing the Task Force Acute Myeloid Leukemia and operating a private outpatient clinic. His research interests center on acute leukemias, myelodysplastic syndromes (MDS), and innovative therapy approaches for hematologic malignancies. Key areas include epigenetic mechanisms, stem cell biology, and early clinical trials targeting AML and multiple myeloma. Müller-Tidow has pioneered studies on CAR-T cell therapies and epigenetic modifiers like venetoclax. Recent work highlights the role of clonal hematopoiesis in disease progression and leverages single-cell multi-omics to dissect AML heterogeneity. Collaborative efforts with the MMPU integrate clinical and experimental research to advance personalized medicine.

• Neuroscience
• Alzheimer's Disease Research
• Neurodegenerative Disorders
• +۳ مورد دیگر

Alejandro Marmolejo Garza is a researcher at the University of Groningen specializing in neuroscience with a focus on Alzheimer's disease and neurodegenerative disorders. His work investigates mitochondrial dysfunction, ferroptosis, and calcium signaling pathways using advanced techniques including transcriptomics, proteomics, and in vitro models to uncover molecular mechanisms of neurodegeneration. He completed his PhD at the University of Groningen in 2024 with a dissertation titled 'Interrogating mitochondrial and metabolic involvement in Alzheimer’s disease: a focus on tissue analysis, in vitro platforms and mitochondrial calcium'. His research profile shows deep expertise in mitochondrial biology and metabolic alterations in neurodegenerative contexts. Dr. Marmolejo Garza's research interests center on amyloid-beta pathology, ferroptosis induction, and mitochondrial calcium dysregulation in Alzheimer's progression. His work bridges fundamental molecular mechanisms with potential therapeutic interventions, utilizing brain-region-specific analyses and disease modeling to identify novel targets for neuroprotection. Analysis of his recent publications reveals a cohesive trajectory examining oxidative stress pathways, bioenergetic failure, and cell death mechanisms in neurodegeneration. His studies consistently employ multi-omics approaches to dissect tissue-specific vulnerabilities and mitochondrial contributions across different disease stages. Scientific Awards: No scientific awards were mentioned in the available information. Advising and Grants: There is no information available regarding students advised or research grants obtained by Dr. Marmolejo Garza. Labs and Teams: He is an active collaborator within the neuroscience research group at the University of Groningen, working closely with Dr. Dolga's team. This interdisciplinary environment integrates molecular, cellular, and systems neuroscience approaches to address complex questions in neurodegenerative disease mechanisms and therapeutic development.

Jiekun Yangمشاهده پروفایل

استادیار

• Computational Genomics
• Bioinformatics
• Statistical Genetics
• +۷ مورد دیگر

Jiekun Yang is an Assistant Professor in the Department of Genetics at Rutgers, The State University of New Jersey, School of Arts and Sciences. He leads the Yang Lab of Computational and Systems Biology, which officially launched on January 1, 2024, under the Human Genetics Institute of New Jersey. His research integrates advanced computational methods with high-throughput genomics to decode gene regulatory networks in myeloid cells. Research Interests: Dr. Yang specializes in computational genomics and systems biology, with a focus on myeloid cell circuitry in health and disease. His work leverages single-cell multi-omics, spatial-omics, and functional genomics to model cellular dynamics in complex biological systems such as cancer, neurodegeneration, and metabolic disorders. Recent Research Trends: Although specific publications are not listed, his research direction indicates a strong emphasis on gene regulatory network inference, cellular reprogramming, and multimodal data integration, particularly in immune and disease contexts. His work bridges computational innovation with biological insight, aiming to uncover mechanistic drivers of cell behavior. Scientific Awards: No awards are mentioned in the provided text. Advising and Teaching: Dr. Yang mentors undergraduate researchers through the SURF program and delivers lectures on single-cell transcriptomics. His lab supports early-career scientists in computational and molecular biosciences, fostering interdisciplinary training in data science and genomics. Laboratory and Team: The Yang Lab, based in the Life Sciences Building (Room 326), focuses on developing and applying computational models to dissect myeloid cell responses in disease. The team integrates data from human and mouse models to build comprehensive, predictive frameworks of gene regulation.

Hunter Shainمشاهده پروفایل

استادیار

• Skin Cancer Biology
• Melanoma
• Cutaneous Squamous Cell Carcinoma
• +۵ مورد دیگر

Hunter Shain, PhD, is an Assistant Professor in the Department of Dermatology at the University of California San Francisco (UCSF) School of Medicine. His laboratory focuses on understanding skin cancer biology through advanced genomic approaches, with primary emphasis on melanoma and cutaneous squamous cell carcinoma. Dr. Shain's academic training includes a BS in Biochemistry from the University of Illinois (2006), a PhD in Cancer Biology from Stanford University (2012), and postdoctoral training at UCSF (2017). BS: Biochemistry, University of Illinois (2006) PhD: Cancer Biology, Stanford University (2012) Postdoctoral Fellow: UCSF (2017) His research integrates DNA/RNA sequencing, spatial transcriptomics, and single-cell technologies to investigate driver genes, mutational processes, precursor lesions (nevi/actinic keratoses), cellular origins (melanocytes/keratinocytes), and tumor microenvironment dynamics. By mapping cancer progression from single cells to metastases, his work has enhanced diagnostic staging and informed skin cancer prevention strategies. Current projects focus on early tumorigenesis events and pre-cancer atlas development. Analysis of Dr. Shain's recent publications reveals a dominant focus on genetic evolution in skin cancers, particularly acral melanoma and squamous cell carcinoma. His work consistently applies multi-omics approaches to dissect tumor heterogeneity, with growing emphasis on spatial and single-cell resolution. Key themes include driver mutation identification, computational tool development (e.g., STmut), and translation of genomic findings into clinical applications for early detection. Dr. Shain has received significant recognition: NCI K22 Career Development Award (2016) AACR Next Generation Stars (2018) Society of Melanoma Research Young Investigator Awards (2018, 2021) LEO Foundation Award for skin cancer research (2024) HTAN leadership in Pre-cancer Atlas project (2024) As principal investigator of the Shain Laboratory within UCSF's Helen Diller Family Comprehensive Cancer Center, he directs research supported by the NCI K22 award and HTAN funding. His lab trains researchers in cancer genomics with future work prioritizing pre-cancer lesion characterization and clinical translation. Dr. Shain maintains active collaborations with UCSF clinical dermatology and melanoma research groups.

• Immunology
• Autoimmunity
• T cell biology
• +۴ مورد دیگر

Joseph Craft is the Paul B. Beeson Professor of Medicine in Rheumatology and Professor of Immunobiology at Yale School of Medicine. He directs the Colton Center for Autoimmunity at Yale and has served as Director of the Investigative Medicine MD to PhD program for over 20 years. His research focuses on understanding host responses to pathogen challenge and autoimmunity, with particular expertise in T follicular helper cells and lupus pathogenesis. Dr. Craft received his MD from the University of North Carolina School of Medicine in 1977. He completed his internship and residency at Yale-New Haven Hospital in 1978 and 1980 respectively, followed by fellowship training at Yale School of Medicine in 1985. He is board certified in Internal Medicine (1980) and Rheumatology (1988). His research program has made seminal contributions to understanding T cell biology in autoimmunity, particularly in lupus. His laboratory was among the first to dissect the transcriptional regulation of T follicular helper cells, a discovery recognized as a milestone in T cell development by Nature. Current research focuses on identifying developmental pathways of CD4 T cells that provide B cell help and promote inflammation, as well as determining tissue environmental factors that regulate T cell metabolism at inflammatory sites. Analysis of Dr. Craft's recent publications reveals a strong focus on T cell and B cell interactions in autoimmune diseases, particularly lupus. His work spans multiple disciplines including immunology, molecular biology, genomics, and translational medicine. Key themes include T follicular helper cell biology, mechanisms of autoimmune tissue damage, and the role of specific signaling pathways in immune dysregulation. His research increasingly incorporates advanced technologies like spatial transcriptomics and single-cell analysis to understand cellular heterogeneity in disease contexts. Two-time NIH MERIT Awardee (10-year NIH grants) Yale Bohmfalk Basic Science Teaching Prize Elected Fellow of American Association for the Advancement of Science Pew Scholar in the Biomedical Sciences Distinguished Innovator Award (2022) from Lupus Research Alliance Kirkland Scholar (2002, 2005) Charles W. Bohmfalk Teaching Prize in Basic Sciences (2004) Dr. Craft has trained over 40 postdoctoral fellows and 26 PhD and MD/PhD graduate students throughout his career. He has directed the Investigative Medicine Program at Yale for more than two decades, training 70 MD/PhD students. His laboratory research is supported by multiple NIH grants, reflecting the significance of his work in understanding autoimmune mechanisms. The Colton Center for Autoimmunity, which he directs, serves as a hub for interdisciplinary research on autoimmune diseases at Yale. Dr. Craft leads the Craft Lab at Yale, which focuses on host responses to pathogen challenge and autoimmunity. His research team includes postdoctoral fellows, graduate students, and research staff working collaboratively on projects related to T cell biology, lupus pathogenesis, and immune regulation. The lab maintains strong collaborations with other research groups at Yale, particularly within the Cancer Immunology Program and the Yale Center for Immuno-Oncology.

Peter DiGennaroمشاهده پروفایل

استاد

• Molecular Plant Nematology
• Root-Knot Nematode (Meloidogyne spp.) Pathogenesis
• Plant-Parasitic Nematode Diagnostics
• +۵ مورد دیگر

Peter DiGennaro serves as Professor in the Department of Plant Pathology at the University of Wisconsin-Madison's College of Agricultural and Life Sciences, where he leads research on molecular mechanisms of plant-nematode interactions. His program integrates genomic, biochemical, and AI-driven approaches to address agricultural challenges posed by root-knot nematodes. Education: B.S. in Biochemistry, State University of New York at Geneseo (2007) Ph.D. in Functional Genomics, NC State University (2013) Research Focus: Dr. DiGennaro's laboratory investigates root-knot nematode pathogenesis with emphasis on nematode signaling molecules (particularly C-terminally Encoded Peptides) that manipulate plant nitrogen assimilation and form specialized feeding sites. His team employs temporal transcriptomics to map diurnally regulated gene networks during infection and develops monoclonal antibody diagnostics for field applications. Recent work increasingly incorporates deep learning for nematode identification in complex samples and examines climate change impacts (elevated CO2) on nematode-plant interactions. Research Trends: Analysis of his 2021-2025 publications reveals three converging trajectories: (1) Molecular dissection of nematode effectors influencing plant nutrition, (2) AI/bioinformatics integration for nematode diagnostics and management, and (3) Expansion into zoonotic nematode systems (e.g., Trichinella , Pseudoterranova ) with food safety applications. His work consistently bridges fundamental mechanisms with agricultural solutions, particularly for tomato and cowpea systems. Educational Impact: Dr. DiGennaro actively engages students through Course-Based Undergraduate Research Experiences (CUREs) and developed the university's online DNA Day program, which significantly improved high school students' science perceptions. His outreach extends to rural Florida high schools through plant health career initiatives and the Plant Disease Diagnostics Clinic's public services. Laboratory Infrastructure: Based in Russell Laboratories, his research leverages UW-Madison's Plant Pathology core facilities for genomic sequencing, proteomics, and nematode culturing. Collaborations span entomology (parasitoid genomics), plant breeding (cowpea diversity), and data science teams to address complex nematology challenges.

• Pain Neurobiology
• Transcriptomics
• Bioinformatics
• +۵ مورد دیگر

Allison Barry (BSc, MSc, DPhil) is a Canadian-British-German pain neurobiologist currently conducting postdoctoral research at the University of Vienna and University of Texas at Dallas . Formerly a DPhil student at University of Oxford under Prof. David Bennett and Prof. Georgios Baskozos, she specializes in multi-omics approaches to pain pathophysiology, focusing on dorsal root ganglia (DRG) proteomics , spatial compartmental profiling , and iPSC-derived nociceptor modeling . Her work is rooted in open science advocacy and chronic migraine patient perspectives. Education: BSc Neuroscience (2015), Dalhousie University MSc Neurosciences (2017), Max Planck Institute/University of Göttingen DPhil Ion Channels & Disease (2022), University of Oxford Research Focus spans neuropathic pain mechanisms , multi-omics data integration , and sex-specific pain pathways . She employs spatial proteomics , proximity labeling , and synaptosome profiling to dissect sensory neuron subtypes in disease contexts. Her lab-generated DRG Directory database hosts processed sequencing datasets for community reuse. Publication Trends reveal interdisciplinary work bridging neuroscience with bioinformatics , emphasizing TNFα signaling , NKG2D ligand discovery , and neuroimmune interactions . Her methodological critiques (e.g., limitations of silhouette scores in single-cell analysis) highlight rigor in computational pain research . Grants & Collaborations: Funded by NIH, Wellcome Trust, and former Medical Research Council/NSERC support, she collaborates with teams across Harvard , King’s College London , and MDC Berlin . Her work intersects with open science movements and chronic migraine advocacy . Labs & Networks: Previously affiliated with Oxford’s Neural Injury Group, she now contributes to Vienna’s Starkl Lab (immunology focus) and Dallas’ WeirLab (chronic pain reversal strategies). She actively engages with global consortia like Bioconductor and PAIN Journal editorial initiatives.

• Breast cancer
• Translational oncology
• Circulating tumour cells
• +۶ مورد دیگر

Alexios Matikas, MD, PhD , is Associate Professor of Oncology at Karolinska Institutet and Senior Consultant in Medical Oncology at the Karolinska Comprehensive Cancer Center Breast Center. Appointed Docent in May 2021, he leads translational breast-cancer research within the Theodoros Foukakis Group at the Department of Oncology-Pathology. Since 2024 he also serves as Deputy Director of Doctoral Education at the department and sits on Karolinska Institutet’s central Dissertation Committee. Education & Training MD, Aristotle University Medical School, Greece (with scholarship for academic excellence) MSc Cancer Cell Biology, Athens Medical School (valedictorian) PhD, Circulating Tumour Cells, Crete Medical School ESMO Georges Mathé Fellowship in Immuno-Oncology, Karolinska Institutet (2016–2017) Post-doc in breast-cancer immunology, Karolinska Institutet (2017–) Research Focus Matikas’ work integrates clinical trials, real-world evidence and high-resolution multi-omics to dissect the tumour-host interface in breast cancer. He is principal investigator of the international academic ARIADNE trial (NCT05900206) exploring biology-driven neoadjuvant HER2-targeted therapy, and leads registry-based studies using Swedish national databases to answer clinically relevant questions. His laboratory interrogates spatial and temporal tumour-immune dynamics using digital pathology, single-cell sequencing and proteomics to identify predictive biomarkers and therapeutic vulnerabilities. Scientific Awards & Honours ESMO Georges Mathé Fellowship in Immuno-Oncology (2016–2017) Percy Falk stipend for breast and prostate cancer research Aristotle University scholarship for academic excellence Teaching & Mentorship He is main supervisor for three and co-supervisor for five PhD candidates across Karolinska Institutet and Sahlgrenska Academy. He has accrued 260 hours of formal teaching at KI and co-created the doctoral course “Basic principles of clinical and translational research”. Together with international experts he founded the Academy of Breast Oncology , a webinar series for young oncologists (2020–2025, 13 sessions). Leadership & Service Within ESMO he previously sat on the Young Oncologists Committee (2020–2023) and now contributes to the Leadership Development Committee, OncologyPRO working group and Magnitude of Clinical Benefit Scale working group. Nationally, he coordinates adjuvant therapy guidelines for the Swedish National Breast Cancer Guidelines and serves on the Stockholm regional treatment guidelines committee.

• Cancer and Oncology
• Bioinformatics
• Computational Biology
• +۷ مورد دیگر

Michael Mints is an Affiliated to Research and Docent in the Department of Oncology-Pathology at Karolinska Institutet, Stockholm. As a core member of the Schlisio Lab, he investigates oxygen sensing pathways, cancer biology, and intratumor heterogeneity using advanced genomic techniques. His academic credentials include: Docent in Experimental Oncology, Karolinska Institutet (2025) PhD in Oncology-Pathology, Karolinska Institutet (2015) Medical Degree, Karolinska Institutet (2013) Dr. Mints' research spans cancer genomics, bioinformatics, and tumor immunology with focus on head and neck squamous cell carcinoma, HPV-related cancers, and bladder cancer. He pioneers single-cell and spatial transcriptomic approaches to dissect tumor microenvironments and immune interactions, revealing critical insights into intratumor heterogeneity and therapeutic resistance mechanisms. His recent publications (2025-2020) demonstrate consistent output in high-impact journals, with increasing emphasis on multi-omic integration and clinical translation. Key trends include HPV stratification in head and neck cancer, exosome-based biomarker discovery in urology, and oxygen-sensing pathways in tumor development. As a Docent, Dr. Mints supervises doctoral students and contributes to Karolinska's educational mission. His research is supported by active grants evidenced by continuous high-impact publications and international collaborations across oncology, immunology, and computational biology domains. He leads projects within the Schlisio Lab focusing on tumor heterogeneity, with strong connections to clinical oncology through Karolinska University Hospital. Current work involves translating single-cell findings into precision medicine applications for head and neck cancer patients.

Mingyao Liمشاهده پروفایل

دانشیار

• Bioinformatics
• Biostatistics
• Genetics
• +۲ مورد دیگر

Mingyao Li, PhD, is an Associate Professor of Biostatistics whose scholarship bridges high-dimensional statistics with modern genomics and spatial biology. Her work is recognised for advancing computational methods that dissect complex tissue architecture and disease heterogeneity at single-cell resolution. Research Interests Bioinformatics and computational biology Statistical methods for high-dimensional genomic data Single-cell and spatial multi-omics integration Genetics and genomics of cardiovascular and cancer systems Systems biology approaches to disease mechanisms Across more than one hundred peer-reviewed publications, Li’s research exhibits a clear trajectory from developing rigorous statistical frameworks—such as hypothesis testing in stochastic block models—to large-scale applications in human disease. A dominant theme is the fusion of spatial transcriptomics, single-cell multi-omics and AI-driven image analysis to uncover cell-type heterogeneity, lineage relationships and microenvironmental crosstalk in atherosclerosis, lung adenocarcinoma, pancreatic cancer and neurodegenerative disorders. Scientific Awards & Recognition While specific awards are not listed in the provided text, the consistent appearance of Dr Li as senior or corresponding author on high-impact papers in Nature family journals and the development of widely-used computational tools (e.g., MISO, iSCALE) attest to significant scholarly recognition. Research Support & Teams Granting agencies and collaborative networks are not explicitly detailed, but the scale and scope of the projects—from whole-organ spatial atlases to primate genome-editing studies—imply substantial multi-institutional funding and interdisciplinary teams integrating biostatisticians, wet-lab scientists and clinician-scientists.

Benjamin Voightمشاهده پروفایل

دانشیار

• bioinformatics
• genomics
• human genetics
• +۱ مورد دیگر

Benjamin Voight, PhD, is an Associate Professor of Systems Pharmacology and Translational Therapeutics. His research program sits at the intersection of computational biology, genomics, and clinical translation, with a particular focus on understanding how human genetic variation influences complex disease susceptibility and therapeutic response. Research Interests Bioinformatics & Computational Genomics: Development of algorithms and statistical frameworks for large-scale genomic data integration. Human Genetics & Population Genetics: Leveraging diverse global cohorts to uncover ancestry-specific and shared genetic signals underlying cardiometabolic traits. Systems Pharmacology: Translating genetic discoveries into therapeutic hypotheses and pharmacogenomic applications. Across more than 60 recent publications (2020-2025), Dr. Voight’s group has consistently advanced multi-ancestry genome-wide association studies (GWAS), polygenic risk score development, and single-cell multi-omic dissection of pancreatic, hepatic, renal, and cardiovascular tissues. These works collectively illuminate pleiotropic networks connecting type 2 diabetes, coronary artery disease, heart failure, atrial fibrillation, gallstone disease, and non-alcoholic fatty liver disease. Scientific Recognition No specific awards are listed in the provided text. Advising & Collaborative Teams While individual trainees are not named, the extensive co-authorship patterns across the Million Veteran Program, trans-ancestry consortia, and interdisciplinary pharmacogenomic initiatives indicate substantial mentorship and collaboration with both pre- and post-doctoral researchers.

Madhvi Menonمشاهده پروفایل

پژوهشگر ارشد

• Immunology
• Respiratory Diseases
• Autoimmunity
• +۲ مورد دیگر

Dr. Madhvi Menon is a UKRI Future Leaders Fellow at the University of Manchester, affiliated with the Division of Immunology, Immunity to Infection and Respiratory Medicine. Her research focuses on B cell interactions in chronic respiratory diseases and autoimmunity, with a specific emphasis on COPD, autoantibody mechanisms, and interferon signaling pathways. Education: PhD in Immunology from University College London (2015) Postdoctoral Training: Harvard Medical School (age-related macular degeneration research), University College London (rheumatoid arthritis pathogenesis) Research trends include inflammatory pathway analysis in autoimmune disorders, miRNA/cytokine profiling in viral infections, and monocyte migration dynamics in acute/long COVID-19. Key subfields span autoantibody functionality, interferon isoform interactions, and spatially-resolved omics applications. Scientific Award: UKRI Future Leaders Fellowship Currently supervises three PhD students (Holly Sedgwick, Maana Layeghi, Rebecca Rowan) and collaborates on multi-institutional projects like 'Laser capture dissection for spatially-resolved -omics analysis.'

Julia TCWمشاهده پروفایل

استادیار

• Alzheimer's Disease
• APOE4 Genetics
• Stem Cell Biology
• +۴ مورد دیگر

Julia TCW is an Assistant Professor at Boston University, leading a research laboratory focused on Alzheimer's Disease (AD) mechanisms, particularly the role of the APOE4 genetic variant in human brain cells. Her lab integrates CRISPR/Cas9 genome-edited induced pluripotent stem cells (iPSCs), multi-omics bioinformatics, and 3D brain organoid models to study neuroinflammation, lipid metabolism, and glial dysfunction in AD pathogenesis. She holds a Ph.D. and A.M. in Molecular and Cellular Biology from Harvard University. Her research investigates: 1) APOE4-driven disruptions in cholesterol homeostasis and matrisome pathways; 2) iPSC-derived microglia/astrocyte responses to AD risks; 3) Computational pipelines for genetic subtyping and drug repositioning. Key methodologies include developing human brain pericytes , microglia , and 3D organoids for high-throughput drug screening, with active industry collaborations for therapeutic discovery. Recent publications (2023–2025) emphasize APOE4 pathology in glial cells, revealing impaired lipophagy, cellular senescence, and neurovascular defects. Computational studies advance genetic risk modeling and multi-omics data integration, while experimental work validates targets like BIN1 and IL1RAP in neuronal-glial interactions. Her team is pioneering chimeric mouse models to dissect APOE3/APOE4 astrocyte effects in vivo. Dr. TCW's lab actively develops next-generation human brain models and computational tools to bridge molecular insights with clinical translation for Alzheimer's therapeutics.

Suming Huangمشاهده پروفایل

استاد

• Epigenetics
• Gene Regulation
• Leukemia Research
• +۵ مورد دیگر

Suming Huang serves as Professor and Chair of the Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology at Penn State University's College of Medicine. Holding dual appointments in the Department of Pediatrics Division of Hematology and Oncology and the Department of Molecular and Precision Medicine, Huang directs research within the Penn State Cancer Institute's Mechanisms of Carcinogenesis program. With an h-index of 36 and over 4,000 citations, Huang maintains an active research profile through the National Cancer Institute. Huang's research centers on epigenetic mechanisms in leukemia development, specializing in transcriptional regulation, non-coding RNA functions, and chromatin organization. Key focus areas include TAL1/SCL regulation in T-cell leukemia, lncRNA-mediated genome organization in AML, and the role of histone modifiers like HDAC1 in tumor suppression. The research integrates hematopoietic stem cell biology with leukemogenesis pathways, particularly examining how non-coding RNAs reprogram chromatin architecture in NUP98-rearranged leukemias and other hematological malignancies. Current publication trends reveal consistent output in high-impact oncology journals, with 2025 publications examining CK2α deletion effects on stem cells, IKAROS/HDAC1 heterochromatin regulation, guanine biosynthesis blockade in MLL leukemias, and HoxBlinc lncRNA functions. These works demonstrate Huang's shift toward therapeutic targeting of epigenetic vulnerabilities while maintaining core investigations into transcriptional dysregulation in pediatric cancers. Huang leads eight major research projects including the active National Cancer Institute grant Role of lncRNA mediated R-loops in CTCF boundary function and AML genome organization (2021-2025). Past projects span leukemogenesis mechanisms, long non-coding RNA functions in hematopoiesis, and TAL1 regulation in T-cell leukemia, securing sustained NCI funding since 2008. The research program maintains strong collaborations across hematology-oncology and molecular medicine departments. The Four Diamonds Epigenetics and Gene Regulation Research Program in Pediatric Oncology serves as Huang's primary research hub, focusing on translating epigenetic discoveries into therapeutic strategies for childhood leukemias. Current work integrates multi-omics approaches to dissect lncRNA-mediated chromatin reorganization in leukemic stem cells.