جستجوی استاد راهنمای دانشگاهی

Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.

• cryo-electron microscopy
• structural biology
• drug-design
• +۴ مورد دیگر

Christopher M. Overall is a Full Professor at the University of British Columbia in the Faculty of Dentistry, Department of Oral Biological and Medical Sciences . He is also a Principal Scientist at the Centre for Blood Research and holds associate memberships in UBC's Biochemistry & Molecular Biology , Obstetrics and Gynecology , and Bioinformatics Graduate Program departments. As a Canada Research Chair Laureate , he pioneered the field of degradomics to study proteases in vivo. B.D.S., University of Adelaide Ph.D., University of Toronto Postdoctoral Fellowship, UBC (with Nobel Laureate Michael Smith) Dr. Overall’s research focuses on protease proteomics and systems biology , particularly degradomics to analyze protease substrates in diseases like COVID-19 and immunodeficiency . His work on matrix metalloproteinases has revealed new therapeutic strategies for inflammatory diseases and cancer . His 15 most recent articles (2015–2008) demonstrate expertise in TAILS proteomics , protein terminomics , and protease network analysis with applications in arthritis , antiviral immunity , and precision medicine . Scientific Awards 2022 Helmut Holzer Award 2018 Royal Society of Canada Fellow 2014 Tony Pawson Canadian Proteomics Award 2013 IADR Distinguished Scientist Award Dr. Overall has mentored 61 trainees , including 9 full professors with department chairs, and received the UBC John McNeill Mentorship Award (2023). He leads the HUPO Chromosome-centric Human Proteome Project and consults for Genentech and Novartis .

• Protease Proteomics
• Systems Biology
• Degradomics
• +۶ مورد دیگر

John D Brennan is a Professor in the Department of Chemistry & Chemical Biology at McMaster University. He is affiliated with the Biointerfaces Institute and focuses on developing innovative biosensing technologies and functional nucleic acid-based assays. His research integrates materials science, biochemistry, and analytical chemistry to create practical diagnostic tools for healthcare applications. Key research areas include the design of DNA aptamers and DNAzymes for detecting biomarkers (e.g., eosinophil peroxidase, SARS-CoV-2 spike proteins), development of paper-based diagnostic platforms, and optimization of sol-gel materials for enzyme entrapment. His work emphasizes high-throughput screening, point-of-care testing, and CRISPR-based biosensing systems. Notable contributions include a rapid sputum-based assay for asthma biomarkers and a universal DNA aptamer for SARS-CoV-2 variants. His lab also explores functional nucleic acid circuits and their integration into scalable diagnostic devices. Brennan’s teaching includes advanced courses in analytical chemistry and biochemical assay development. His work has been featured in journals like *Angewandte Chemie*, *Analytical Chemistry*, and *ChemBioChem*, with a focus on translating fundamental research into practical clinical applications.

• Biosensors
• Functional Nucleic Acids
• Sol-Gel Materials
• +۳ مورد دیگر

Trent K. Bollinger is a Professor in the Department of Veterinary Pathology at the University of Saskatchewan's Western College of Veterinary Medicine (WCVM), and serves as Regional Director for the Western/Northern Region of the Canadian Wildlife Health Cooperative (CWHC). His academic credentials include a BSc (Honours) from the University of Saskatchewan (1984), a DVM (Distinction) from the University of Saskatchewan (1988), and a DVSc in Pathology from the Ontario Veterinary College (1992). Dr. Bollinger's research focuses on the pathology and epidemiology of diseases in wildlife and fish, with particular emphasis on chronic wasting disease in deer/elk and white-nose syndrome in bats. He has conducted extensive studies on disease transmission dynamics, wildlife population health, and the ecological impacts of emerging pathogens. His work bridges veterinary science, ecology, and conservation biology. His publications demonstrate expertise in viral and bacterial zoonoses, fungal pathogens affecting bats, and spatial epidemiology of wildlife diseases. Recent research highlights include investigating sylvatic plague in prairie dogs, coronavirus persistence in hibernating bats, and landscape connectivity's role in chronic wasting disease spread. His studies often combine molecular diagnostics, field observations, and ecological modeling. Dr. Bollinger collaborates with national and international wildlife agencies, contributing to disease surveillance and management strategies for endangered species. His work emphasizes the interconnectedness of wildlife health, ecosystem health, and public health concerns.

• Wildlife Disease Pathology
• Epidemiology
• Chronic Wasting Disease
• +۳ مورد دیگر

Sachdev Sidhu is a Research Professor and Entrepreneur in Residence at the University of Waterloo. His research focuses on synthetic antibodies, protein engineering, and biotechnological applications. He leads efforts in developing novel therapeutic antibodies, engineered protein systems, and molecular tools for biomedical research. His work spans cancer therapy, viral infection countermeasures, and regenerative medicine. Sidhu is also involved in translational research, bridging academic discoveries with commercial applications through entrepreneurial ventures. Key research interests include synthetic antibody libraries, CAR T-cell engineering, ubiquitin-based therapeutics, and phage display technologies. He has contributed to advancements in targeted therapies for glioblastoma, leukemia, and ocular diseases. His team develops innovative methods for protein design, such as engineered ubiquitin variants and modular antibody architectures. Publications highlight breakthroughs in antibody-based treatments, including synNotch CAR T cells for glioblastoma and neutralizing antibodies against SARS-CoV-2. His work integrates structural biology, molecular biology, and computational approaches to address complex biomedical challenges. Sidhu collaborates with industry partners to advance technologies into clinical and commercial settings.

• Synthetic Antibodies
• Protein Engineering
• Biotechnology
• +۵ مورد دیگر

Dr. Manisha Kulkarni is a Professor at the School of Epidemiology and Public Health, University of Ottawa, where she holds the University Research Chair in Climate Change and Emerging Diseases. She is also the Director of the INSIGHT (Interdisciplinary Spatial Informatics for Global Health) research lab and serves as Scientific Director of the Canadian Lyme Disease Research Network (TickNet Canada). Her work spans global public health, with a focus on vector-borne and zoonotic diseases. PhD in Medical Entomology, McGill University (2006) BSc in Environmental Biology, McGill University (2001) Dr. Kulkarni's research centers on the socio-ecological determinants of infectious disease emergence, particularly malaria, Lyme disease, and West Nile virus. She applies population surveys, entomological field sampling, molecular diagnostics, and GIS to study spatio-temporal patterns and the impacts of climate change and landscape transformation on disease transmission. Her work emphasizes One Health approaches and capacity building in low-resource settings. Her recent research trends show a strong focus on geospatial modeling of vector-borne diseases, climate change adaptation, urban tick surveillance, and international collaborations in Tanzania, Benin, and Latin America. She leads interdisciplinary projects integrating drone mapping, citizen science (e.g., eTick.ca), and community participation to identify disease risk factors. Scientific awards and recognitions include: University Research Chair in Climate Change and Emerging Diseases Ontario Early Researcher Award Faculty of Medicine Award for Leadership in Global Health (2023) Researcher of the Year, Faculty of Medicine (2019) Member, College of New Scholars, Royal Society of Canada NSERC Discovery Grant and CIHR funding Dr. Kulkarni has successfully advised multiple PhD and Master’s students and leads major funded projects supported by CIHR, PHAC, CFI, IDRC, and NSERC. She has held leadership roles as Associate Dean of Global Health (2021–2024) and currently serves on the CIHR Institute of Infection and Immunity advisory board. Her lab, INSIGHT, fosters an interdisciplinary training environment combining field, lab, and analytical methods for global health research. Key research teams and collaborations include: INSIGHT Lab, University of Ottawa Pan-African Malaria Vector Research Consortium (PAMVERC) Canadian Lyme Disease Research Network (TickNet Canada) London School of Hygiene & Tropical Medicine (LSHTM) National Microbiology Lab, PHAC Centre de Recherche Entomologique de Cotonou (CREC), Benin

• Vector-borne Diseases
• Climate Change and Health
• Epidemiology
• +۱۴ مورد دیگر

Lawrence Goodridge is a Professor and Director of the Canadian Research Institute for Food Safety (CRIFS) at the University of Guelph's Ontario Agricultural College. He holds the Leung Family Professorship in Food Safety and leads research at the intersection of food safety, antibiotic resistance, and One Health principles. His work focuses on applying genomic technologies to study foodborne pathogens (E. coli, Salmonella, Listeria, Cronobacter) and leveraging wastewater surveillance for infectious disease outbreak prediction. Academic History: BSc Microbiology (University of Guelph, 1995), MSc Food Microbiology (2003), PhD Food Microbiology (2002), followed by post-doctoral training in Food Safety at the University of Georgia (2002). Joined CRIFS in 2003. Research Interests: Genomic analysis of pathogen emergence, wastewater-based epidemiology, bacteriophage applications, and consumer education strategies for food safety. His lab develops innovative methods for rapid pathogen detection in food systems and environmental samples. Articles Trends: Over 100 peer-reviewed publications emphasize genomic surveillance of foodborne pathogens and SARS-CoV-2, with a focus on wastewater sampling innovations. Recent work explores multi-modal data integration for public health forecasting and ethical data protection frameworks for surveillance programs. Awards: While no specific prizes are listed, his $50M+ research funding from Canadian/international sources underscores recognition of his impactful work. Grants support projects like phage-based sanitization and antimicrobial resistance tracking. Advising & Labs: Leads CRIFS laboratory operations and collaborates globally on food safety initiatives. His research has informed food industry guidelines and policy frameworks for mitigating pathogen risks in agricultural and environmental systems.

• Food Safety
• Antibiotic Resistance
• Foodborne Pathogens
• +۶ مورد دیگر

Dr. Anil Kumar is an Assistant Professor in the Department of Biochemistry, Microbiology & Immunology at the University of Saskatchewan's College of Medicine. He specializes in molecular virology, focusing on positive-stranded RNA viruses and their interactions with host immune systems. His research employs high-throughput genetic screens and reverse genetics systems to identify host factors critical for viral infection. Education includes a BSc in Agricultural Sciences (1999, Kerala Agricultural University), MSc in Plant Pathology (2001, Indian Agricultural Research Institute), and PhD in Molecular Virology (2010, University of Heidelberg). Postdoctoral training included stints at the University of Heidelberg (2010–2013) and the University of Alberta (2014–2020). Research interests center on Eastern Equine Encephalitis virus (EEEV) and Enterovirus D68 (EV-D68). For EEEV, his lab investigates immune evasion mechanisms and host-virus protein interactions to identify therapeutic targets. For EV-D68, they study CNS invasion mechanisms and novel host dependency factors linked to acute flaccid myelitis (AFM). Recent work includes studies on SARS-CoV-2, uncovering roles for host proteins like Argonaute 2 in viral restriction. His lab integrates molecular biology, virology, and systems biology approaches, with a focus on translational research for antiviral drug development. Collaborations include work on respiratory syncytial virus (RSV) entry mechanisms and dengue virus replication regulation.

• Molecular Virology
• Virus-host Interactions
• Innate Immune Response
• +۳ مورد دیگر

Simon Sharpe is a Professor in the Department of Biochemistry at the University of Toronto and a Senior Scientist at The Hospital for Sick Children. His research focuses on the structural and dynamic properties of self-assembling proteins, particularly those involved in degenerative diseases, elastomeric proteins, and biological phase separation. The Sharpe Lab utilizes advanced biophysical techniques such as NMR spectroscopy, X-ray scattering, and electron microscopy to investigate these phenomena. BSc: Memorial University of Newfoundland (Cell Biology and Biochemistry, 1997) PhD: University of Western Ontario (Biochemistry, 2002) Postdoctoral Training: NIH (Solid-State NMR, 2002-2006) Research interests include: Protein self-assembly mechanisms Amyloid formation in neurodegenerative diseases Elastin and resilin biophysics Lipid-protein interactions Biological phase separation Structure-function relationships Lab members include Research Associate Dr. Sean Reichheld and PhD students James Otis, Asal Nady, and Robert Lu. The lab has dedicated access to 600 and 700 MHz NMR spectrometers and collaborates with SickKids facilities including the SBC Facility and Imaging Facility. Scientific awards: Canada Research Chair (2006-2016) Ontario Early Researcher Award (2010) Dr. Sharpe has taught courses including BCH374Y1 (Research Project in Biochemistry) and BCH425H (Structural Biology: Principles and Practice). His recent publications examine topics ranging from serum amyloid A structure to bacterial phase separation defenses, with methodologies combining solid-state NMR, fluorescence microscopy, and computational approaches.

• Biophysics
• Structural Biology
• Molecular Biophysics
• +۹ مورد دیگر

Dr. Jacques Archambault is a Professor in the Department of Microbiology and Immunology at McGill University , and an associate member of the Division of Experimental Medicine since 2016. His research focuses on the molecular biology and pathogenesis of human papillomaviruses (HPVs) and polyomaviruses (HPyVs), with an emphasis on their replication mechanisms as episomes in host cells. The Archambault laboratory employs functional genomics, proteomics, and chemical biology approaches to identify cellular pathways exploited by these viruses and develop high-throughput assays for screening small molecule inhibitors of viral replication. Analysis of his recent publications reveals a strong focus on HPV and HPyV replication machinery, including studies on the E1 helicase, UAF1-USP1 interactions, and structural characterization of viral proteins involved in DNA replication. His work bridges virology, oncology, and drug discovery, particularly targeting oncogenic HPV types implicated in anogenital and oropharyngeal cancers, as well as HPyVs like BKPyV and JCPyV that cause pathologies in immunosuppressed patients. Current efforts in the lab aim to elucidate the molecular mechanisms by which HPVs and HPyVs replicate their genomes and to develop antiviral therapies targeting these processes. Techniques such as fluorescence anisotropy, NMR spectroscopy, and crystallography are frequently employed to study protein-DNA and protein-protein interactions critical to viral replication.

• Human Papillomavirus (HPV)
• Polyomavirus
• Viral DNA Replication
• +۴ مورد دیگر

Hong Han is an Assistant Professor in the Department of Biochemistry & Biomedical Sciences within McMaster University's Faculty of Health Sciences and a member of the Centre for Discovery in Cancer Research (CDCR). She holds a Canada Research Chair and leads the Han Lab, which focuses on cancer biology, RNA regulation, and innovative high-throughput technologies for therapeutic discovery. Dr. Han earned her Ph.D. from the University of Toronto (2010-2016) and has established herself as a leading researcher in glioblastoma and alternative splicing regulation. Her interdisciplinary research integrates cancer biology, RNA science, and multilayer gene regulation to uncover mechanisms underlying cancer progression and treatment resistance. Her laboratory pioneers integrated technological platforms for large-scale genetic/drug screening and ultra-high-throughput single-cell profiling. The research focuses on three main areas: alternative splicing regulation in cancer (particularly glioblastoma and prostate cancer), multilayer mechanisms of glioblastoma heterogeneity and microenvironment evolution, and multiplexed screening approaches for therapeutic discovery in treatment-resistant cancers. Analysis of Dr. Han's recent publications reveals a strong emphasis on single-cell technologies to characterize glioblastoma heterogeneity, minimal residual disease states, and tumor-immune interactions. Her work increasingly bridges basic RNA biology with translational applications, particularly in developing novel therapeutic strategies targeting splicing networks and immune evasion mechanisms. Canada Research Chair Dr. Han teaches Advanced Techniques in the Biomedical Sciences (BIOCHEM 734). Her research program is supported by multiple funding sources, as evidenced by her extensive publication record in high-impact journals including Nature, Cell, Molecular Cell, and Nature Communications. She employs a comprehensive approach combining in vitro, in vivo, and patient cohort studies with cutting-edge genomic technologies. The Han Lab has developed innovative multiplexed screening platforms that enable simultaneous interrogation of thousands of conditions, ranging from CAR-T cells to small molecule therapeutics. This approach accelerates the discovery of novel cancer targets and therapeutic strategies for treatment-resistant cancers.

• Cancer Biology
• Gene Regulation
• RNA Splicing
• +۵ مورد دیگر

Samuel W.K. Wong is an Associate Professor in the Department of Statistics and Actuarial Science at the University of Waterloo. He holds a Ph.D. in Statistics from Harvard University (2013) under Prof. Samuel Kou. His research focuses on statistical methodology for complex data science challenges in protein structure modeling, dynamic systems inference, and reliability engineering of wood-based products. He has held academic positions at the University of Florida (2013–2018) and has been at Waterloo since 2018. His research interests include Bayesian computation, statistical inference for dynamic systems, and spatial-temporal data analysis. Notable contributions include the development of manifold-constrained Gaussian processes (MAGI package) and sequential Monte Carlo methods for protein folding studies. He has advised over 15 graduate students and researchers, many of whom are now in academic or industry roles worldwide. Wong has received teaching distinctions at Harvard and holds awards including the Nash Medal (2008) for academic excellence. His work bridges computational statistics with applications in bioinformatics, structural engineering, and environmental science. He has published extensively in top-tier journals like Journal of Computational and Graphical Statistics and Biometrics , and collaborates with wood scientists to improve real-time lumber quality assessment using laser imaging data. His teaching portfolio includes courses on probability theory, statistical inference, and spatial data analysis at both undergraduate and graduate levels. Beyond academia, he maintains an active passion for classical piano performance, having performed recitals combining music with his statistical research interests.

• Data Science Methodology
• Protein Structure Analysis
• Reliability Engineering
• +۴ مورد دیگر

Stephen L. Bearne is a Professor in the Departments of Biochemistry and Molecular Biology and Chemistry at Dalhousie University, affiliated with the Faculty of Medicine. He has been a department member since 1996 and served as Department Head from 2012 to 2022. His research focuses on enzymology, enzyme catalysis, and protein engineering, with a particular emphasis on transition state analogues, enzyme inhibition mechanisms, and the chemical basis of disease-associated enzymes. His work integrates organic synthesis, biophysical techniques, and computational modeling to explore enzyme function and design inhibitors for therapeutic applications. Dr. Bearne holds a PhD from the University of Toronto and an MDCM from McGill University. His lab is part of the Protein Assembly Research Team and the BioActives CREATE Training Program. Current research themes include understanding carbon acid substrate catalysis in mandelate racemase, developing inhibitors for CTP synthase and racemases involved in diseases like cancer and neglected tropical infections, and proteomic tools for enzymatic activity profiling. His research leverages advanced techniques such as site-directed mutagenesis, isothermal titration calorimetry, NMR spectroscopy, and macroion mobility spectrometry. His lab supports equity, diversity, and inclusivity and has been funded by NSERC, CIHR, and other agencies. Recent publications highlight advancements in enzyme inhibition strategies, allosteric regulation mechanisms, and enzyme filamentation roles in metabolic pathways.

• Enzymology
• Protein Engineering
• Biochemical Recognition
• +۳ مورد دیگر

Caitlin Mullarkey is an Associate Professor in the Department of Biochemistry and Biomedical Sciences at McMaster University's Faculty of Health Sciences. She teaches across multiple undergraduate programs including Biochemistry, Biomedicine, and Health Sciences, with courses ranging from Cellular and Molecular Biology to Immunological Principles in Practice and Principles of Virology. Dr. Mullarkey's research focuses on immunology and virology with particular emphasis on influenza virus immunity, antibody-mediated responses, and vaccine development. Her work explores intricate mechanisms of antibody function including Fc-mediated effector functions, neutrophil responses to viral infection, and the role of broadly neutralizing antibodies. She also investigates innovative approaches to biomedical education through virtual laboratory simulations and online course development. Analysis of her publication record reveals a strong focus on influenza immunology, with particular expertise in antibody structure-function relationships, hemagglutinin stalk-specific antibodies, and Fc-mediated immune responses. Her work bridges basic immunological mechanisms with practical vaccine development approaches, demonstrating consistent contributions to understanding host-pathogen interactions and immune protection mechanisms. Scientific Awards: Equality of Opportunity Award from the Government of Ontario (2024) for developing and leading McMaster's Biochemistry and Biomedical Sciences Summer Scholars Program Dr. Mullarkey actively supervises undergraduate research through Senior Research Thesis and Senior Thesis courses, providing mentorship to students across multiple academic years. Her teaching portfolio demonstrates significant commitment to both foundational and advanced topics in biochemistry and immunology. Beyond formal teaching, she leads the Summer Scholars Program which provides full research scholarships to students who identify as Black, Indigenous, and/or 2SLGBTQIA+, addressing barriers to participation in STEM research through comprehensive support for training, mentorship, and living expenses. As Chair of the Biochemistry and Biomedical Sciences Summer Scholars Program, Dr. Mullarkey has graduated 17 diverse scholars in just two years, with many continuing research at McMaster and receiving competitive awards. The program, supported by McMaster's Global Nexus and Michael G. DeGroote Institute for Infectious Disease Research, exemplifies her commitment to creating inclusive research opportunities in biomedical sciences.

• Immunology
• Virology
• Influenza Research
• +۵ مورد دیگر

Dr. Ryan Ziels is an Associate Professor in the Department of Civil Engineering at the University of British Columbia's Faculty of Applied Science. His research focuses on sustainable biological wastewater treatment and resource recovery through advanced microbial biotechnologies, with affiliations to the BioProducts Institute and Clean Energy Research Centre. Education: PhD and MSE in Civil and Environmental Engineering, University of Washington BS in Environmental Resources Engineering, Humboldt State University Research Focus: Ziels pioneers microbial ecology studies in engineered waste treatment systems, employing multi-omics approaches to optimize anaerobic digestion for biomethane production and biological nutrient removal. His work targets recovery of water, nutrients, and bioenergy while enhancing human and environmental health through microbial community engineering. Publication Trends: Recent publications (2022-2025) reveal intensified focus on metaproteomics for syntrophic metabolism characterization, high-throughput sequencing for microbial community analysis, and wastewater-based epidemiology for pathogen surveillance. His research increasingly integrates ethical frameworks for public health applications while advancing fundamental understanding of microbial processes in anaerobic systems. Academic Engagement: Ziels teaches core courses including Fundamentals of Environmental Engineering (CIVL 204), Environmental Lab Analysis (CIVL 407), and Environmental Biotechnology (CIVL 569). He supervises graduate students in Civil Engineering and Genome Science and Technology programs through UBC's Graduate and Postdoctoral Studies, directing the EMBERr Lab for microbiome engineering research.

• Environmental Engineering
• Microbial Ecology
• Sustainable Wastewater Treatment
• +۵ مورد دیگر