Christopher M. Overall

Christopher M. Overall is a Full Professor at the University of British Columbia in the Faculty of Dentistry, Department of Oral Biological and Medical Sciences. He is also a Principal Scientist at the Centre for Blood Research and holds associate memberships in UBC's Biochemistry & Molecular Biology, Obstetrics and Gynecology, and Bioinformatics Graduate Program departments. As a Canada Research Chair Laureate, he pioneered the field of degradomics to study proteases in vivo.

• B.D.S., University of Adelaide
• Ph.D., University of Toronto
• Postdoctoral Fellowship, UBC (with Nobel Laureate Michael Smith)

Dr. Overall’s research focuses on protease proteomics and systems biology, particularly degradomics to analyze protease substrates in diseases like COVID-19 and immunodeficiency. His work on matrix metalloproteinases has revealed new therapeutic strategies for inflammatory diseases and cancer.

His 15 most recent articles (2015–2008) demonstrate expertise in TAILS proteomics, protein terminomics, and protease network analysis with applications in arthritis, antiviral immunity, and precision medicine.

Scientific Awards

• 2022 Helmut Holzer Award
• 2018 Royal Society of Canada Fellow
• 2014 Tony Pawson Canadian Proteomics Award
• 2013 IADR Distinguished Scientist Award

Dr. Overall has mentored 61 trainees, including 9 full professors with department chairs, and received the UBC John McNeill Mentorship Award (2023). He leads the HUPO Chromosome-centric Human Proteome Project and consults for Genentech and Novartis.