Christopher Mark Overall

Christopher Mark Overall is a Professor in the Department of Oral Biological & Medical Sciences within the Faculty of Dentistry at the University of British Columbia (UBC). His research spans proteomics, terminomics, and protease biology with significant contributions to the Human Proteome Project. He supervises graduate students in Bioinformatics, Craniofacial Science, and Genome Science and Technology programs.

His research focuses on proteolytic mechanisms in viral infections, inflammation, and immunodeficiency. Key areas include viral protease functions (particularly SARS-CoV-2), host-pathogen interactions, and the development of proteomic methodologies like TAILS (Terminal Amine Isotopic Labeling of Substrates). His work integrates 'One Health' perspectives across human, animal, and environmental systems.

Analysis of his recent publications reveals dominant themes in viral protease evolution (SARS-CoV-2), bacterial membrane proteases, and strategic AI applications in proteomics. His work frequently appears in high-impact journals and contributes to major international consortia like HUPO.

Overall maintains active research collaborations through UBC's Centre for Blood Research, Life Sciences Institute, and Vancouver Prostate Centre. His laboratory develops cutting-edge proteomic technologies for substrate identification and has received continuous funding for protease-related research.