Ejung Moon is a Group Leader in Radiation Biology and the Tumour Microenvironment at the Department of Oncology, University of Oxford's Medical Sciences Division. Her research focuses on hypoxia-driven tumor progression and radiation response mechanisms. Education: PhD in Pharmacology and Cancer Biology from Duke University Training: Postdoctoral work with Amato Giaccia at Stanford University Research Interests: Elucidating how hypoxia-induced MAFF protein regulates tumor cell invasion, metastasis, and radiation resistance through antioxidant response pathways. Current work explores MAFF dimerization dynamics and metabolic reprogramming in hypoxic tumors. Scientific Contributions: Identified MAFF's role in radiation-induced antioxidant gene regulation (2021, Nature Communications ). Recent studies investigate iron metabolism's impact on FLASH radiotherapy effects. Scientific Awards: Breast Cancer Research Program (BCRP) predoctoral fellowship Laboratory & Collaborations: Moon Lab collaborates with Oxford Cancer and NHS Cancer and Haematology Centre. Key partnerships include Stanford University's radiobiology research groups.
Deborah Frances Smith is a Professor affiliated with the Centre for Immunology and Infection. She has held former roles including Head Of Department, Biology Pro-Vice-Chancellor for Research, and Special Adviser to the Vice Chancellor in the Vice Chancellor's Office. She is also associated with CNAP (Cancer and Neuroscience Academic Programme) and the Jack Birch Unit. Her research focuses on leishmaniasis, parasite biology, and drug/vaccine development. Key projects include leading the 'C2D2 research 1a & 2b' (2012–2012) to establish sandfly colonies for leishmaniasis studies and co-investigating an integrated crystallization facility (2013–2018). She secured the Wolfson Research merit Award (2009–2010) from the Royal Society. Her work spans academic leadership, collaborative research, and translational medicine targeting neglected tropical diseases.
Dr. Samira Lakhal-Littleton is an Associate Professor of Cell Physiology and MRC Senior Non-Clinical Research Fellow at the University of Oxford, affiliated with the Department of Physiology, Anatomy and Genetics and Brasenose College. Her research focuses on iron homeostasis, systems biology, and oxygen sensing mechanisms in cardiovascular and systemic physiology. Education: BSc in Human Genetics (University College London), DPhil in Molecular Medicine (University of Oxford) Her work bridges cell physiology and translational medicine, with key discoveries on hypoxia-inducible factors (HIFs), iron regulatory genes TMPRSS6 and GDF15 , and the role of hepcidin in altitude adaptation and chronic diseases. She utilizes tissue-specific animal models to study iron regulation in heart, kidney, placenta, and vasculature. Recent publications highlight her contributions to understanding: FLASH radiotherapy effects linked to iron-dependent lipid peroxidation Clinical implications of myocardial iron dynamics in heart failure Hepcidin's role in vascular protection and placental iron transfer Biomarker development for predictive iron deficiency diagnostics Scientific Leadership: British Heart Foundation Intermediate Fellowship (2012) MRC Senior Fellowship (2020) BioIron Society Board Member (2019) She collaborates with clinical teams on translational projects and serves as a Tutorial Fellow in Medicine at Brasenose College, mentoring students in physiological sciences.
Karen Piper Hanley is Professor of Molecular Medicine and Head of Division in the Division of Diabetes, Endocrinology & Gastroenterology at the University of Manchester. She serves as the fibrosis lead in the Wellcome Trust Centre for Cell-Matrix Research and previously served as Director of Core Research Technologies (2019-2022). She is also an editorial board member for Scientific Reports. Her research focuses on fibrosis (scarring) mechanisms across multiple organs, particularly liver, kidney, and lung fibrosis. Her lab investigates the cellular and molecular basis of fibrotic disease, with emphasis on how pathological scar components are produced and how they signal to surrounding cells. Key areas include the role of SOX9 transcription factor, integrin beta-1 signaling, Group 1 PAKs, and YAP1 in fibrosis progression. Her recent publications reveal trends toward increased clinical translation of fibrosis research, with studies on health inequalities in liver cancer care, post-COVID diabetes incidence, and innovative approaches to liver disease detection. Her work increasingly integrates spatial transcriptomics and advanced omics technologies to understand cellular transitions in liver disease. Career-track postdoctoral fellowship from the University of Southampton (2006) As senior postgraduate tutor, she has mentored numerous PhD students who have presented at key conferences and authored high-quality manuscripts. All her PhD students have submitted and been awarded their degrees within 4 years. She has successfully guided previous Academic Clinical Fellows to win MRC clinical training fellowships. Her teaching extends to undergraduate Personal & Professional Development and supervision of MRes and BSc students, many of whom have achieved first-class degrees and prestigious awards. Her lab maintains active collaborations with Professor Neil Hanley's group on human development, stem cells, and regenerative medicine, bridging developmental biology with fibrosis research to understand why regeneration is impaired in chronic diseases.
James Briscoe is a Senior Group Leader at The Francis Crick Institute in London, where he leads a research group focused on developmental biology and morphogen signaling. He previously held positions at the Medical Research Council's National Institute for Medical Research, which later became part of the Francis Crick Institute. Education: BSc in Microbiology and Virology from the University of Warwick, UK PhD from Imperial Cancer Research Fund/King's College London Postdoctoral training at Columbia University with Thomas Jessell Dr. Briscoe's research focuses on the molecular and cellular mechanisms of graded signaling by morphogens and the role of transcriptional networks in cell fate specification. His laboratory employs a range of experimental and computational techniques using model systems including mouse and chick embryos and embryonic stem cells. His work has significant implications for understanding developmental processes and their relationship to disease. His recent publications demonstrate a continued focus on morphogen gradients, neural tube development, and computational approaches to understanding cell fate decisions. His research increasingly integrates single-cell technologies and computational modeling to unravel the complexities of developmental patterning. Scientific Awards and Honors: EMBO Young Investigator (2001) EMBO Gold Medal (2008) Elected to EMBO (2009) Fellow of the Academy of Medical Sciences (2019) Fellow of the Royal Society (2019) As Editor-in-Chief of the journal Development since 2018, Dr. Briscoe plays a significant role in shaping the field of developmental biology. His leadership extends to mentoring researchers and contributing to scientific policy discussions, as evidenced by his recent publication 'Science under siege: protecting scientific progress in turbulent times.' Dr. Briscoe's laboratory at the Crick Institute is well-equipped with access to advanced facilities including light microscopy, flow cytometry, genomics, and computational resources, enabling a multidisciplinary approach to developmental biology questions.
Professor Mark Coles serves as Professor of Immunology and Lead for Industrial Strategy and Entrepreneurship at the Kennedy Institute of Rheumatology, University of Oxford, holding concurrent roles as Kennedy Trust Senior Research Fellow, Official Fellow at Reuben College, and Affiliate Faculty at the Wolfson Centre of Mathematical Biology. His interdisciplinary work bridges immunology, computational modeling, and translational research to accelerate therapies for immune-mediated inflammatory diseases. His academic journey began with a BSc in Microbiology from Cornell University (1992), followed by a PhD in Molecular and Cell Biology at UC Berkeley under David Raulet, and postdoctoral training with Dimitris Kioussis at the National Institute of Medical Research. At the University of York (2006-2017), he pioneered stromal immunology research and co-founded the York Computational Immunology Laboratory. Coles' research centers on stromal and systems immunology, with core expertise in stromal cell biology, inflammatory disease mechanisms, and mathematical modeling of immune responses. He champions 3Rs-based approaches (Replacement, Reduction, Refinement) to reduce animal testing through in silico models, integrating spatial single-cell biology with multi-scale computational frameworks to dissect immune function in human tissues. His 2025 publications reveal a cohesive research trajectory applying interdisciplinary methods across diverse disease contexts—from cardiac fibrosis and vaccine responses to arthritis pathogenesis and CAR-T cell therapy—unified by focus on stromal-immune crosstalk and quantitative modeling to identify therapeutic targets. Key honors include: Fellow of the Royal Society of Biology Kennedy Trust Senior Research Fellow As former Director of Graduate Studies (2017-2024) at the Kennedy Institute, Coles mentored numerous graduate students while co-leading major initiatives including the Arthritis Therapy Acceleration Program and Human Cell Atlas medicalization. His entrepreneurial impact spans three co-founded ventures: Simomics Ltd (in silico disease modeling), Lightox Ltd (phototherapy for oral cancer), and Mestag Therapeutics (fibroblast-targeted therapies for cancer/inflammation). He directs the Laboratory of Stromal and Systems Immunology and Oxford Mathematical Immunology Group, fostering collaborations with Christopher Buckley, Calliope Dendrou, and Eamonn Gaffney to develop Quantitative Systems Pharmacology models that translate mechanistic insights into patient therapies.
Calliope Dendrou is an Associate Professor in Clinical Pathology and Inflammation at the Kennedy Institute of Rheumatology (KIR), University of Oxford, leading the Immune Disease Multiomics Laboratory. She previously held a Wellcome & Royal Society Sir Henry Dale Fellowship at the University of Oxford’s Centre for Human Genetics before joining KIR in 2023. Her research focuses on immune disease mechanisms using multiomics approaches, including genomic profiling to identify therapeutic targets across tissues and immune-mediated diseases. She co-leads large-scale projects like the Oxford-J&J Cartography Consortium and the Chan Zuckerberg Initiative’s LEGACY Network, and teaches on the MSc in Genomic Medicine program. Educational Background: BSc (Biology, Imperial College London, 2005; Forbes Memorial Medal Winner); PhD in Infection & Immunity (University of Cambridge, 2010). Postdoctoral training at the Weatherall Institute of Molecular Medicine under Prof. Lars Fugger. Research interests include immunogenetics, cytokine signaling pathways, drug repositioning, and cross-disease pathophysiology. Her work integrates single-cell and spatial transcriptomics to dissect immune-cell interactions in diseases like rheumatoid arthritis, inflammatory bowel disease, and celiac disease. Recent articles highlight her contributions to understanding vaccine adjuvant responses, Th17 cell roles in spondyloarthritis, and immune-epithelial networks in celiac disease. Collaborations emphasize multi-omic data analysis (e.g., Panpipes pipeline) and translational studies toward precision medicine. Awards: Forbes Memorial Medal (BSc), Wellcome & Royal Society Sir Henry Dale Fellowship. Leadership roles include Equality, Diversity, and Inclusion Champion and 'Single-Cell & Spatial Omics for Precision Medicine' Module Lead. Lab & Teams: Immune Disease Multiomics Lab at KIR. Active in collaborative initiatives such as the LEGACY Network, focusing on large-scale immune profiling in ancestrally diverse populations.
Andrew Regan is a Senior Lecturer in the School of Chemistry at the University of Manchester, specializing in organic synthesis and drug discovery. He holds a B.A. (1981), M.A. (1985), and Ph.D. (1985) from the University of Cambridge. His career includes postdoctoral research at Columbia University and a lectureship at the University of Kent before joining Manchester in 1991. Research interests focus on synthesizing biologically active compounds, such as phosphinic acids for anticancer agents, and developing novel synthetic methods. His work contributes to drug discovery, green chemistry, and efficient chemical processes. He currently supervises two PhD students researching phosphinic acid analogues and simplified erythromycin analogues. Key achievements include the synthesis of epibatidine and advancements in macrolide antibiotic design. His research aligns with sustainable development goals through eco-friendly synthesis methods.
Professor John Pickett serves as Chair of the School of Chemistry at Cardiff University, where he holds the position of Professor of Biological Chemistry. His research program has established him as a leading figure in chemical ecology with significant contributions to understanding chemically mediated interactions between organisms. Professor Pickett's research focuses on chemical ecology involving chemically mediated interactions between various organisms, particularly pests attacking plants and animals. His work encompasses the chemical characterisation of pheromones and other semiochemicals across plants and animals, including insect pests and beneficial organisms. He investigates stress-related chemical signalling by plants and vertebrates (including humans and farm animals), elucidates biosynthetic pathways to pheromones and other semiochemicals, and explores how these compounds can be exploited in pest management through ecological approaches and genetic modification. Analysis of Professor Pickett's recent publications reveals a sustained and impactful research trajectory spanning chemical ecology, agricultural science, and sustainable development. His work demonstrates remarkable continuity in investigating semiochemicals and pheromones while expanding into interdisciplinary areas including AI applications for sustainable futures and the economic impacts of agricultural innovations. A consistent theme throughout his career is the practical application of chemical ecology principles to develop sustainable pest management solutions, particularly through the development and refinement of push-pull farming systems that have transformed agricultural practices in Africa.
Professor David Grainger is a faculty member at the University of Birmingham's School of Biosciences, specializing in Molecular Microbiology. He leads the Grainger Lab, focusing on bacterial chromosome biology, pathogenicity, and antibiotic resistance. His research integrates high-throughput techniques and single-molecule analysis to study gene regulation and bacterial pathogenesis. Education: PhD (2004), PGCE (2000), BSc (1999) in Biochemistry from the University of Birmingham. Affiliations: Part of the Institute of Microbiology and Infection (IMI), collaborating with experts in genomics, proteomics, and structural biology. Research Interests: Deciphering chromosome biology of pathogenic bacteria, including transcriptional regulation, toxin production control, and antibiotic resistance pathways. Utilizes cutting-edge methods like Hi-C for 3D chromatin analysis and single-molecule microscopy. Recent Articles: Focused on transposon capture mechanisms, bacterial promoter diversity, and quorum sensing signaling. Highlights include studies on Salmonella regulons and Vibrio cholerae biofilm suppression. Awards: Wellcome Trust Career Development Fellowship (2008), Runner-up in 'Science Snaps' competition for scientific communication. Grants: Career Development Fellowship-funded establishment of his research group at the University of Warwick (2008). Labs/Teams: Grainger Lab at the University of Birmingham, part of the IMI network. Engages in public science outreach via Twitter and lab website.
Professor Wolfgang Wüster is a Professor in Zoology (Molecular Ecology) at Bangor University's School of Environmental and Natural Sciences. His research focuses on evolutionary biology, snake systematics, and venom toxicology, using snakes as model systems. He teaches courses in zoology and herpetology, including Arizona fieldwork and advanced herpetology modules. Education: PhD in Systematics of Asian cobras from the University of Aberdeen (1990). His research interests include the evolution of venom composition, species delimitation in snake complexes, warning signals, biogeography, and conservation genomics. He supervises postgraduate students in topics like European viper conservation and snake systematics. Recent publications highlight his work on snake venoms, taxonomy, and the impacts of climate change on reptile species. He collaborates globally, contributing to antivenom efficacy studies and venom evolution research. Professor Wüster has been involved in projects such as genomic studies of adders and the phylogeography of vipers. His work bridges molecular ecology with conservation, emphasizing practical applications in biodiversity preservation.
Mark Wallace is a Professor of Chemistry at King's College London, affiliated with the Department of Chemistry and the Faculty of Natural, Mathematical & Engineering Sciences. He holds a Royal Society University Research Fellowship (2005–2016) and has been a lecturer at Oxford University before joining King's in 2016. His research focuses on membrane protein function and artificial membrane mimics, combining optical microscopy and nanotechnology. He earned a PhD from the University of Cambridge (2002) and postdoctoral training at Stanford University and the National Institute for Medical Research. Key research interests include membrane protein dynamics, lipid bilayer engineering, and single-molecule imaging. He has pioneered techniques like droplet interface bilayers and interferometric scattering microscopy. His work has led to patents and applications in molecular sensing and medical research. Awards include the 2002 Gregorio Weber Prize and the 2015 RSC Norman Heatley Award. He is actively involved in public outreach, including video podcasts and educational competitions. Recent publications emphasize artificial ion channels, nanoparticle formation monitoring, and mitochondrial protein dynamics. His lab collaborates with institutions like the London Centre for Nanotechnology and the Rosalind Franklin Institute. Over 30 students and researchers have been mentored, with active grants from EPSRC, Wellcome Trust, and BBSRC.
Professor Carl Edward Rasmussen is affiliated with the University of Cambridge , where he focuses on Machine Learning , Probabilistic Inference , Decision Making , and Reasoning Under Uncertainty . His work bridges theoretical advancements with practical applications in robotics, control systems, and computational biology. Academic Affiliation: University of Cambridge Academic Role: Professor His research emphasizes scalable Gaussian process methods, Bayesian system identification, and reinforcement learning. Recent projects include transfer learning for antibacterial discovery , graph neural processes for molecular functions , and efficient variational inference techniques . Key themes in his publications highlight uncertainty quantification , model generalization , and nonparametric approaches . Notable Scientific Contributions Advancements in sparse Gaussian process hyperparameter estimation Framework for Bayesian system identification in dynamic systems Hybrid models combining transformers and Gaussian processes
Colin J Akerman is Professor of Neuroscience and Group Leader in the Department of Pharmacology at the University of Oxford, concurrently serving as Corange Fellow and Medical Tutor at Corpus Christi College. His research investigates fundamental mechanisms of synaptic circuit formation and plasticity, with direct implications for epilepsy, dementia, and schizophrenia through multidisciplinary approaches integrating electrophysiology, optical imaging, and computational modeling. His primary research interests encompass Synaptic Plasticity, Neural Circuit Formation, and Excitatory-Inhibitory Balance, with specific focus on neuronal progenitor influences on connectivity, chloride dynamics in inhibitory transmission, and learning mechanisms in disease contexts. The lab employs custom-built equipment and molecular tools to probe synaptic function across in vivo , in vitro , and in silico platforms, emphasizing how activity-dependent processes shape neural networks during development and disease. Recent publications (2023-2025) reveal strong thematic convergence on intracellular chloride regulation in sleep-wake cycles, cortical circuit assembly from embryonic progenitors, and innovative optical tools for neural monitoring. This work bridges molecular neuroscience with systems-level understanding of synaptic plasticity, particularly regarding ionic mechanisms in epilepsy and sleep homeostasis. No scientific awards or fellowships are explicitly documented in the source materials. Professor Akerman currently mentors four PhD students (Vourvoukelis, Selfe, Wang, Gemayel) and multiple postdoctoral researchers, having previously trained scientists now leading independent groups in Toronto, Edinburgh, Cape Town, Oxford, and London. His research is funded by the European Research Council, Innovative Medicines Initiative, and Wellcome Trust, supporting investigations into synaptic mechanisms underlying neurological disorders. The Akerman Group, established in 2008, operates as an integrative neuroscience hub within Oxford's Pharmacology Department. The 10-member team combines expertise in patch-clamp electrophysiology, optogenetics, multiphoton imaging, and computational modeling, with current projects spanning neuronal progenitor biology, inhibitory synaptic plasticity, and learning rule implementation in neural networks. The lab emphasizes technical innovation, regularly developing custom instrumentation and molecular tools for neural observation and manipulation.
Jonny Kohl is a Group Leader at the Francis Crick Institute , where he established the State-dependent Neural Processing Laboratory in 2019. His work bridges neural circuits and internal physiological states (e.g., hunger, pregnancy) to decode instinctive behaviors like parenting and aggression in mice. PhD: MRC Laboratory of Molecular Biology, Cambridge (2013) Postdoc: Harvard University (2014–2019) with support from EMBO, HFSP, and Wellcome Trust fellowships Research Interests : Kohl investigates how hormonal and metabolic states dynamically rewire neural circuits to drive adaptive behaviors. His lab combines circuit neuroscience , molecular biology , and behavioral profiling to study: State-dependent neural processing in parental behavior Chemosensory dominance hierarchies in mice Plasticity mechanisms in aggression circuits Development of ultrafast tissue labeling and cryoanesthesia tools Scientific Trends : His recent publications highlight hormone-mediated synaptic remodeling (2023), cost-effective lab tools (2023), and brain-wide activity mapping (2016). Collaborative work spans computational biology , metabolism , and imaging disciplines. Honors: NARSAD Young Investigator Award (2019), ERC Starting Grant (2019), Wellcome Trust Discovery Award (2025) Grants: BBSRC Research Grant (2025), BBSRC Pioneer Grant (2023) His lab mentors PhD and MSc students and has developed open-source neuroscience tools (e.g., cryoanesthesia device, 2023). Kohl's research has been featured in Nature , Science , and Cell .
