Dr. Spencer E. Szczesny is an Associate Professor in the Departments of Biomedical Engineering and Orthopaedics & Rehabilitation at Pennsylvania State University. His research explores the interplay between tendon multiscale mechanics and mechanobiology in tissue remodeling contexts such as degeneration, repair, and development. Ph.D., Bioengineering, University of Pennsylvania (2015) M.S., Mechanical Engineering, MIT (2005) B.S., Mechanical Engineering, University of Pennsylvania (2003) Dr. Szczesny’s work addresses critical questions in Biomedical Engineering and Mechanobiology , including how mechanical stimuli influence tendon pathology, how embryonic development informs tissue engineering, and how cyclic loading affects anterior cruciate ligament (ACL) repair. His lab employs multidisciplinary approaches like multiscale mechanical testing , computational modeling , and biomaterial fabrication to enhance understanding of human health applications. Recent publications highlight his focus on Tendon Degeneration under hypoxic conditions, ACL Repair Mechanisms in sex-specific contexts, and Developmental Tendon Maturation through mechanical stimulation. His work also extends to open-source bioreactor design and digital strain measurement techniques . NSF CAREER Award (2022) CMBE Rising Star Award (2022) Acta Student Award (2015) Dr. Szczesny mentors graduate students including Maria L. Canonicco Castro (PhD candidate), M.H. Capalbo (PhD), and Vivek S. (MS). His lab’s outreach initiatives—such as interactive workshops on tendon mechanics for K-12 students—demonstrate a commitment to improving representation of underrepresented groups in STEM.










