جستجوی استاد راهنمای دانشگاهی

María Virumbrales-Muñozمشاهده پروفایل

استادیار

• Microphysiological Systems
• Organ-on-a-Chip
• Cancer Biology
• +۱۲ مورد دیگر

María Virumbrales-Muñoz is an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Wisconsin–Madison, with an affiliate appointment in Biomedical Engineering. She is also the Principal Investigator of the Virumbrales-Muñoz Lab, where she leads research in microphysiological systems to model cancer and reproductive disorders. Position: Assistant Professor, Obstetrics & Gynecology Affiliation: Biomedical Engineering (Affiliate Faculty) Lab: Virumbrales-Muñoz Lab, University of Wisconsin–Madison Email: virumbralesm@wisc.edu She holds a PhD in Biomedical Engineering from the University of Zaragoza, Spain, and completed postdoctoral training at UW-Madison in Biomedical Engineering and Pathology & Laboratory Medicine. Her research lies at the intersection of bioengineering and women's health, focusing on 3D biomimetic modeling of diseases such as high-grade serous ovarian cancer (HGSOC) and preeclampsia. Using microfluidic technologies, her lab develops organ-on-a-chip models to study tumor microenvironments, metabolic heterogeneity, immune-endothelial interactions, and vascular dysfunction in reproductive diseases. The lab's recent publications reveal a strong focus on advancing microphysiological systems for cancer and vascular biology, with applications in drug screening, immune response modeling, and patient-specific disease modeling. Her work integrates molecular biology, bioengineering, and clinical data to improve understanding of disease mechanisms and therapeutic responses. Scientific Awards: Chester B. Martin Graduate Training Program Mentorship Award (2021) Dr. Virumbrales-Muñoz is an active mentor and educator, advising graduate and undergraduate students in biomedical engineering and reproductive sciences. She teaches in courses such as AN SCI 875 and OBS&GYN 710 and collaborates on major research grants, including NIH R01 proposals. Her lab is funded by the American Cancer Society, University of Wisconsin Carbone Cancer Center, and Meriter Foundation, among others. Research Labs and Teams: Virumbrales-Muñoz Lab: Focuses on microphysiological systems for cancer and preeclampsia Collaborations: UW-Madison Department of Biomedical Engineering, Pathology & Laboratory Medicine, and UnityPoint Health-Meriter Foundation Team Members: Includes postdoctoral researchers, PhD students, and research technicians working on ovarian cancer, breast cancer, and vascular modeling projects

Wonjae Leeمشاهده پروفایل

استادیار

• Neuroimmunology
• Blood-Brain Barrier
• Neurovascular Unit
• +۶ مورد دیگر

Dr. Wonjae Lee serves as Assistant Professor across three departments at Duke University School of Medicine: Neurosurgery (primary appointment), Neurobiology, and Pathology. He holds dual institute affiliations as a Member of the Duke Cancer Institute and Faculty Network Member of the Duke Institute for Brain Sciences, with his laboratory located at 3 Genome Ct. MSRB3 in Durham. Educational background: Ph.D. in Bioengineering, Stanford University (2010) Dr. Lee's pioneering research centers on neuroimmune crosstalk within the brain's unique microenvironment, with particular emphasis on the blood-brain barrier (BBB) as a critical mediator between neural and immune systems. His laboratory develops advanced neurovascular unit (NVU) models that replicate human brain physiology to study spatiotemporal immune dynamics during disease progression and therapeutic interventions. This work bridges tissue engineering and precision medicine , focusing on ischemic stroke, glioblastoma, and stem cell therapies through interdisciplinary collaborations spanning biomedical engineering, immunology, and oncology. Analysis of his 14 publications (2024-2008) reveals a cohesive research trajectory centered on organ-on-a-chip platforms for neurovascular and cardiac systems, innovative hydrogel-based biomaterials for 3D cell culture, and stem cell differentiation techniques. His recent work demonstrates increasing translational focus on personalized therapeutic approaches for neurological disorders, particularly through microphysiological stroke models and glioblastoma platforms. Current research funding includes three major grants: Comorbidity-Specific Microphysiological Stroke Models for Developing Personalized Stem Cell Therapies (2024-2027) Unveiling the Neurovascular Responses to Amyloid-Beta Antibodies: A Neurovascular Unit-on-a-Chip Approach for Personalized Passive Immunotherapy (2024-2026) Developing Human Cell-Based Glioblastoma Models Free from Animal Derivatives (2024-2025) Dr. Lee leads an interdisciplinary research team that engineers biomimetic tissue models to investigate disease mechanisms, with strong emphasis on translating engineering innovations into clinical neuroscience applications through partnerships with Duke's clinical departments.

Simon Grossemyمشاهده پروفایل

پژوهشگر ارشد

• Biomaterials
• Organ-on-a-chip
• Regenerative medicine

Simon Grossemy is a Research Fellow at the School of Engineering and Materials Science, Queen Mary University of London, based in Engineering 147 at the Mile End campus. His research focuses on: Biomaterials for tissue engineering Organ-on-a-chip microfluidic systems Regenerative medicine applications Supervised by Prof Hazel Screen and Prof Martin Knight, his work advances biomaterial design and microphysiological platforms for disease modeling and therapeutic development within the biomedical engineering domain.

Melissa Skalaمشاهده پروفایل

استاد

• Biomedical optical imaging
• Cancer metabolism
• Immunotherapy
• +۳ مورد دیگر

Melissa Skala, Ph.D., is the Carol Skornicka Chair of Biomedical Imaging at the Morgridge Institute for Research and a full Professor of Biomedical Engineering & Medical Physics at the University of Wisconsin–Madison. Her laboratory pioneers label-free optical imaging technologies—most notably fluorescence-lifetime microscopy and optical coherence tomography—to quantify metabolic heterogeneity in cancer, immune cells and engineered tissues, with direct translation to cell-therapy manufacturing and personalized cancer medicine. Education Ph.D. Biomedical Engineering, 2007, Duke University M.S. Biomedical Engineering, 2004, University of Wisconsin–Madison B.S. Physics, 2002, Washington State University Research Focus The Skala lab develops and applies cutting-edge photonics platforms—including autofluorescence lifetime imaging, optical redox ratio mapping, second-harmonic generation, and light-sheet microscopy—to interrogate metabolic states of single cells and organoids in vitro and in vivo . Major thrusts include: Cancer metabolism and immunotherapy response Immune cell activation and exhaustion Stem-cell and CAR-T manufacturing quality control Micro-physiological disease models Machine-learning–driven image analysis Publication Trends Across >250 peer-reviewed papers since 2004, she has progressed from foundational studies on NAD(P)H/FAD redox imaging in epithelial tissues to recent landmark reports defining metabolic biomarkers for T-cell activation, immune-cell subtyping, and patient-derived cancer organoid drug response. A 2025–2024 cluster emphasizes label-free metabolic monitoring of stem-cell-derived cardiomyocytes, neutrophil functional states, and collagen remodeling during immunotherapy. Scientific Honors Fellow, OSA, SPIE, AIMBE (2019) Carol Skornicka Chair, Morgridge Institute (2022) Daniel M. Albert Chair, Retina Research Foundation (2021) Stand Up To Cancer – Sharp Collaboration Award (2017) NSF CAREER Award (2016) NIH/NCI Pathway to Independence Award (K99/R00) (2010) Grants & Team Mentorship Dr. Skala directs multiple active NIH grants (R01, R35, P30) totaling several million dollars, focusing on metabolic imaging for cancer immunotherapy, stem-cell manufacturing, and infectious disease models. The Skala Laboratory actively recruits and mentors graduate students and post-doctoral researchers, fostering interdisciplinary collaborations across engineering, oncology and immunology. Laboratory & Infrastructure The Skala Lab is equipped with custom-built multimodal optical systems, high-throughput microfluidic platforms, and dedicated animal-imaging suites. Core capabilities include time-correlated single-photon counting, hyperspectral imaging, and AI-driven single-cell analytics.

• Tumour Immunology
• Microfluidic Technology
• Head and Neck Cancer
• +۴ مورد دیگر

Professor John Greenman is a tumour immunologist at the University of Hull’s Centre for Biomedicine, specializing in microfluidic technology for cancer diagnostics and personalized medicine. With over 200 peer-reviewed publications, he leads an interdisciplinary team collaborating with clinicians, chemists, and engineers. His research targets head/neck cancers and glioblastoma, exploring immune system subversion during carcinogenesis and clinical applications of lab-on-a-chip platforms. Research Interests: Greenman’s work integrates immunobiology, microfluidics, and oncology. Key areas include: Developing ex vivo tumour tissue models for drug testing and biomarker discovery. Investigating immune evasion mechanisms in head/neck cancers and glioblastoma. Engineering point-of-care diagnostic devices (e.g., HCV sensors, CTC analyzers). Publication Trends (2020s): Recent articles emphasize microfluidic innovations for clinical oncology: Advanced biosensors for rapid cancer/hepatitis diagnostics. Ex vivo perfusion systems to study radiotherapy/treatment responses. Extracellular vesicle biomarkers in thyroid/breast cancers. Epigenetic targeting in glioblastoma using perfusion-based models. Grants & Advising: Secured £1.2M+ in active funding (e.g., Breast Cancer UK, CEPI, Brain Research UK) for projects on endocrine disruptors, SARS-CoV-2 variants, and bispecific therapeutics. Supervised 100+ postgraduate students; current team includes 11 researchers. External roles include REF panel membership (UoA3) and examinerships at De Montfort/Chester Universities.

Jamel Aliمشاهده پروفایل

استادیار

• Micro/nanobiorobotics
• Microbial dynamics
• Cancer mechanobiology
• +۱ مورد دیگر

Jamel Ali, Ph.D. , is an Assistant Professor in the Department of Chemical & Biomedical Engineering at the FAMU–FSU College of Engineering, a joint unit of Florida A&M University and Florida State University. His office is located in Building B, Room B373F, and he can be reached via e-mail at jali@eng.famu.fsu.edu . Dr. Ali earned a B.S. (2011) and M.S. (2013) in Chemical Engineering from Howard University, followed by a Ph.D. (2016) in Mechanical Engineering & Mechanics from Drexel University. His research spans four tightly integrated thrusts: Micro/nanobiorobotics – design and wireless control of bacteria-inspired and erythrocyte-based micro/nanorobots for targeted therapy and minimally invasive surgery; Microbial dynamics – understanding how flagellar mechanics and collective motion govern bacterial locomotion in complex biological fluids; Cancer mechanobiology – elucidating mechanical cues that drive pancreatic cancer progression, adipocyte reprogramming, and acinar-ductal metaplasia; Biomaterials for biomedical applications – developing 3-D extracellular matrix scaffolds, hydrogels, and biofabricated organoids for regenerative medicine, drug screening, and personalized therapy. Across 40+ peer-reviewed articles (2015-2025), Dr. Ali’s work exhibits a clear trajectory from fundamental fluid-mechanics studies of microswimmers and colloidal gels to translational applications in diabetes, pancreatic cancer, and targeted drug delivery. Recent high-impact contributions include demonstrations of symmetry-breaking propulsion in viscoelastic fluids, magnetically actuated erythrocyte micromotors for localized therapy, and organoid-based reversal of hyperglycemia in type-1 diabetes models. Labs & Teams: While explicit laboratory names are not provided, Google-Scholar entries and publication affiliations indicate active collaboration with the Micro/Nanoscale Bio-Robotics Laboratory (formerly at Drexel) and ongoing participation in multi-university consortia such as the Florida-California CaRE2 Health Equity Center.

• Computational physiology
• Biophysics
• Scientific computing
• +۳ مورد دیگر

Aslak Tveito is a Professor and Simula Fellow at Simula Research Laboratory, working within the Department of Computational Physiology. His research spans computational physiology, biophysics, and scientific computing with a strong focus on cardiac electrophysiology and mathematical modeling. Dr. Tveito's research interests center on computational physiology, particularly in the domain of cardiac electrophysiology. His work integrates mathematical modeling, numerical analysis, and computational techniques to understand cardiac function at multiple scales - from cellular to tissue level. He has made significant contributions to developing computational frameworks for modeling excitable tissues, with particular emphasis on the heart. His research bridges the gap between theoretical mathematics and practical physiological applications, creating models that can predict cardiac behavior under normal and pathological conditions. The publication record reveals a strong trend toward increasingly detailed cellular-level modeling of cardiac electrophysiology. Recent work focuses on nano-scale phenomena, stem cell-derived cardiomyocyte modeling, and the development of efficient computational frameworks that maintain physiological accuracy. His research demonstrates a consistent trajectory from macroscopic cardiac models toward cellular and subcellular resolution, with growing integration of experimental data from microphysiological systems. There's also a clear emphasis on practical applications, particularly in drug testing and arrhythmia mechanisms. Dr. Tveito has established himself as a leading researcher in computational cardiac electrophysiology through his extensive publication record spanning multiple decades. His work has been published in high-impact journals across computational biology, physiology, and applied mathematics. His research program demonstrates strong continuity in mathematical modeling of cardiac systems, with evolving focus toward higher-resolution cellular models and integration with experimental cardiac microphysiological systems. The collaborative nature of his work is evident through numerous co-authorships with both computational scientists and experimental biologists.

• Computational Cardiac Physiology
• Cardiac Electromechanics
• Stem Cell-Derived Cardiomyocyte Modeling
• +۴ مورد دیگر

Samuel Wall serves as Chief Research Scientist and Research Professor in the Department of Computational Physiology at Simula Research Laboratory. His work focuses on developing computational models to understand cardiac electromechanics, with particular emphasis on stem cell-derived cardiomyocytes and personalized heart modeling approaches. His research interests span computational cardiac physiology, mechano-electric feedback mechanisms, stem cell-derived cardiomyocyte modeling, and drug response prediction. Wall's work integrates advanced computational methods with experimental cardiac physiology to create in-silico tools for evaluating cardiac function, tissue engineering applications, and drug effects. His research has significant implications for understanding arrhythmia mechanisms, cardiac remodeling, and developing more accurate preclinical drug testing platforms. Analysis of Wall's recent publications reveals a strong trend toward integrating computational modeling with microphysiological systems, particularly using human-induced pluripotent stem cell-derived cardiomyocytes. His work increasingly focuses on creating in-silico augmented platforms that combine experimental measurements with computational analysis to improve drug response prediction and understand fundamental cardiac mechanisms. The research spans multiple scales from sub-cellular mechanics to whole-organ function. Wall maintains active collaborations with leading institutions in cardiac modeling and biomedical engineering. His work frequently appears in high-impact journals spanning computational science, physiology, and biomedical engineering fields.

Amanda Zieglerمشاهده پروفایل

استادیار

• Gastroenterology
• Intestinal Barrier Repair
• Enteric Nervous System
• +۴ مورد دیگر

Amanda Ziegler, DVM, PhD is an Assistant Research Professor in the Department of Clinical Sciences at North Carolina State University. She leads the Comparative Gastroenterology Lab, focusing on intestinal barrier repair mechanisms, particularly in neonatal and juvenile large animal models. Her work bridges veterinary medicine, gastroenterology, and developmental biology to understand intestinal wound healing processes. Dr. Ziegler's primary research interests center on gastrointestinal biology and disease, with specific focus on: Intestinal barrier repair and restitution mechanisms Enteric nervous system development and function Neonatal intestinal development and repair Large animal models (particularly porcine) for translational research Comparative gastroenterology across species Intestinal wound healing following ischemic injury Her recent publications demonstrate a strong emphasis on molecular mechanisms of intestinal repair, particularly examining the role of enteric glial cells in regulating epithelial restitution. She has pioneered the use of single-cell transcriptomics to compare pig and human epithelial phenotypes, identifying a "restitution/hybrid EMT phenotype." Her work increasingly incorporates microbiome research, prebiotic interventions, and comparative approaches across species to understand fundamental mechanisms of intestinal healing. Dr. Ziegler has received notable recognition including a K01 award and the CGIBD Pilot and Feasibility Award in 2018. Her research has been supported by grants focused on understanding intestinal barrier repair in early life. As principal investigator of the Comparative Gastroenterology Lab, Dr. Ziegler leads research investigating how the developing enteric glial cell network regulates intestinal barrier repair in postnatal life. Her lab employs innovative large animal models to study intestinal wound healing with translational applications for neonatal care in both veterinary and human medicine.

Pierfrancesco Pagellaمشاهده پروفایل

دانشیار

• Bioengineering
• Stem Cell Biology
• Tissue Engineering
• +۶ مورد دیگر

Pierfrancesco Pagella is an Associate Professor (Docent) at Linköping University , affiliated with the Department of Physics, Chemistry and Biology (IFM) and the Biophysics and Bioengineering (BBIOBIO) division. His research focuses on unraveling mechanisms of organ and cell diversity to engineer 3D human organs with functional innervation, vascularization, and immune compartments, particularly in the oro/craniofacial complex (e.g., teeth, oral cancers). PhD in Molecular Life Sciences (2011–2015), University of Zurich/ETH Zurich Postdoctoral Fellow at Linköping University (2021–2023) and University of Zurich (2015–2017) His work integrates stem cell biology , tissue engineering , organ-on-chip systems , and genomics/proteomics to model developmental processes and diseases. Key contributions include a Tooth-On-Chip microfluidic device, studies on Wnt/β-catenin signaling in transcriptional regulation, and the role of Nogo-A in tooth enamel formation. Recent publications explore single-cell RNA sequencing in dental pulp remodeling, TBX3-Wnt interactions in colorectal cancer metastasis, and Notch signaling in tooth lineage specification. His research also develops CUT&RUN protocols for studying transcriptional co-factors and investigates tumor suppressor p53 in carcinoma regulation. He teaches Biotechnology Manufacturing , Production of Biopharmaceuticals , and Design of Biotechnical Processes courses. His laboratory affiliations include the Biophysics and Bioengineering (BBIOBIO) and Molecular Materials (BBMOLMAT) groups at Linköping University, focusing on multidisciplinary biomedical applications.

Marc Thilo Figgeمشاهده پروفایل

استاد

• Host-pathogen interaction of human pathogenic fungi
• Automated processing of microscopic images
• Spectroscopy data analysis
• +۷ مورد دیگر

Prof. Dr. Marc Thilo Figge serves as Professor (W3) for Applied Systems Biology at Friedrich Schiller University Jena and Head of the Applied Systems Biology Research Group at the Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) since 2011. His career spans theoretical physics, computational biology, and infection research, with significant leadership roles in national research initiatives including NFDI4Bioimage, DFG Research Training Groups, and the Excellence Cluster 'Balance of the Microverse'. His research focuses on three interconnected pillars: Host-pathogen interactions of human pathogenic fungi Automated image analysis through the open-source JIPipe platform Spatiotemporal computer simulations of infection dynamics These areas combine experimental microbiology with computational modeling to address fundamental questions in infection biology. Analysis of his 2025 publications reveals strong interdisciplinary output spanning microbiology, computational biology, and biomedical engineering. His work demonstrates consistent methodological innovation in image analysis (particularly through JIPipe) and computational modeling of fungal infections, with increasing applications in rapid diagnostics and organ-on-chip technologies. The publications show growing international collaboration and methodological transfer between fungal pathogenesis and broader infection biology contexts. His scientific recognition includes: medac Research Award (2023 and 2024) Adjunct Fellowship at Frankfurt Institute for Advanced Studies (2011-2017) Editorial roles at PLOS Complex Systems, Biological Imaging, and Scientific Reports Prof. Figge maintains an active supervision program with approximately 14 students across multiple graduate schools, supported by substantial funding from DFG, BMBF, and Leibniz Association initiatives. His group participates in the International Leibniz Research School and Jena School for Microbial Communication, with strong connections to the Microverse Imaging Center's advanced microscopy facilities. He regularly organizes the biennial international symposia on Image-based Systems Biology (IbSB) and Systems Biology of Microbial Infection (SBMI), fostering global collaboration in the field. The Applied Systems Biology group operates at the intersection of physics, computer science, and infection biology, developing computational tools that have gained international adoption in bioimage analysis. Current projects emphasize translation of fundamental research into diagnostic applications, particularly through microfluidics and organ-on-chip technologies.

Mo R. Ebrahimkhaniمشاهده پروفایل

دانشیار

• Organoids
• Synthetic Morphogenesis
• Genetic Engineering
• +۸ مورد دیگر

Mo R. Ebrahimkhani, MD is an Associate Professor with tenure in the Department of Pathology at the University of Pittsburgh School of Medicine. He is also a member of the Pittsburgh Liver Research Center, McGowan Institute for Regenerative Medicine, and Pittsburgh Department of Bioengineering. His research integrates synthetic biology, systems biology, and stem cell engineering to advance regenerative medicine through programming stem cell morphogenesis and developing novel multicellular systems. Dr. Ebrahimkhani's research focuses on five key areas: Human Organoids and Synthetic Niches, Modeling Embryogenesis, Tissue Ecology, Systems Biology of Multicellular Systems, and In-vivo Regenerative Technologies. His lab pioneered Designer Liver Organoids (DesLOs) that mimic native liver tissue for regenerative therapy and disease modeling. Recent work includes modeling post-implantation human development to yolk sac blood emergence (Nature, 2024) and developing genetically engineered endothelial niches for vascularized kidney organoids. Synthetic developmental biology: Build and control multicellular systems Programming morphogenesis through systems and synthetic biology Genetically engineering self-organization of human pluripotent stem cells CRISPR-based epigenetic tools for in vivo tissue homeostasis Tissue ecology and multicellular computation Dr. Ebrahimkhani has received significant recognition for his work including NIH RO1 grants, the Mayo Clinic accelerated regenerative medicine award, and the New Investigator Award from Arizona Biomedical Research Council. His research on modeling human development was highlighted in major media outlets including the New York Times. The lab actively trains graduate and undergraduate students in interdisciplinary approaches to regenerative medicine. Current projects include developing mature human liver organoids, modeling embryogenesis, studying tissue ecology, and developing CRISPR-based regenerative technologies. The lab maintains strong collaborations with computational biologists at Carnegie Mellon University and clinicians at UPMC. Dr. Ebrahimkhani leads the Laboratory for Synthetic Biology and Regenerative Medicine, which combines wet-lab experimentation with computational modeling to understand and engineer multicellular systems. The lab's work has significant implications for regenerative therapies, disease modeling, and drug discovery.

• Synthetic Biology
• Gene Editing
• Gene Therapy
• +۴ مورد دیگر

Dr. Samira Kiani serves as Associate Professor in the Department of Pathology at the University of Pittsburgh, specializing in the Division of Experimental Pathology. Her research integrates synthetic biology with therapeutic gene editing to develop clinically viable tools for disease modulation. Her laboratory pioneers three synergistic research thrusts: engineering controllable genetic circuits for immune modulation in mammalian systems; advancing in vivo CRISPR-based gene and epigenetic therapies using nanoparticle/AAV delivery; and developing human-relevant microphysiological platforms like Liver-on-Chip to assess editor safety. This work employs high-throughput genomic and proteomic assays to translate genetic circuits into clinically applicable therapeutics with enhanced safety profiles. Analysis of her 2009-2019 publications reveals consistent innovation in CRISPR tool engineering, with increasing focus on immune compatibility (e.g., immunosilenced Cas9) and complex circuit design. Her research bridges molecular biology, immunology, and tissue engineering, targeting therapeutic applications in liver disease and immune disorders through interdisciplinary approaches. Dr. Kiani maintains active grant-supported research with recent high-impact publications, though specific funding details aren't provided. She mentors students in gene editing and synthetic biology while expanding scientific impact through documentary filmmaking—co-producing 'The Human Game' and directing the 'Tomorrow.life' public engagement initiative. Her research group operates at the intersection of gene therapy and microphysiological systems, utilizing patient-derived Liver-on-Chip models to pioneer predictive biomarkers for gene editor toxicity. Current efforts focus on overcoming immune barriers to clinical translation through engineered editors and real-time response monitoring in human tissue contexts.

• Microphysiological Systems
• Biomedical Engineering
• Bioengineering
• +۷ مورد دیگر

Prof. Dr. Andries D. van der Meer is a faculty member at the University of Twente, holding the position of Professor of Microphysiological Systems within the Department of Bioengineering Technologies in the Faculty of Science and Technology. His research focuses on the design and application of Organs-on-Chips, including models like Retina-on-Chip, Lung-on-Chip, and Heart-on-Chip, with an emphasis on integrating blood vessels into these systems. He has affiliations with the MESA+ Institute and TechMed Centre. Educational Background: Ph.D. in Biomedical Engineering (2010) - University of Twente M.Sc. in Medical Biology (2005) - University of Groningen Van der Meer has previously worked as a Senior Research Fellow (2013-2015) at Harvard Medical School and the Wyss Institute, where he contributed to the DARPA Microphysiological Systems program. He was also a Post-Doctoral Fellow at the University of Twente's BIOS/Lab-on-a-Chip group. Notably, he co-founded the Dutch Human Organ and Disease Model Technologies (hDMT) consortium and currently serves as President of the European Organ-on-Chip Society (EUROoCS) and Chair of the CEN CENELEC Focus Group for Standardization for Organ-on-Chip.

• Vascular Biology
• Lung Development and Regeneration
• Mechanobiology
• +۴ مورد دیگر

Dr. Tadanori Mammoto is an Associate Professor in the Department of Pediatrics at the Medical College of Wisconsin, with a Divisional focus in Neonatology. He is also a member of the Cardiovascular Research Center, reflecting his interdisciplinary research approach spanning vascular biology, lung development, and mechanobiology. Dr. Mammoto's research focuses on the molecular mechanisms underlying vascular development and disease, with particular emphasis on how mechanical forces and extracellular matrix properties regulate cellular behavior. His work has significantly advanced understanding of the YAP/TAZ signaling pathway, Twist1 transcription factor, and angiopoietin-Tie2 system in lung vascular development and regeneration. His laboratory investigates how these pathways contribute to conditions such as pulmonary hypertension and impaired lung development in neonates. Analysis of Dr. Mammoto's publication record reveals a consistent trajectory of high-impact research, with numerous publications in top-tier journals including Nature, Science, and Nature Medicine. His work demonstrates strong translational potential, particularly in developing novel approaches for lung regeneration and understanding vascular complications in neonatal diseases. The increasing focus on organ-on-a-chip technology in recent years reflects his commitment to innovative methodologies for studying human vascular biology. Dr. Mammoto's research has been widely recognized, with several publications receiving hundreds of citations. His work on soluble endoglin in preeclampsia (2006) has been particularly influential, with over 1,600 citations, demonstrating the broad impact of his contributions to vascular biology. His collaborative approach is evident through extensive co-authorship with researchers at Harvard Medical School and affiliated institutions, particularly with Dr. Akiko Mammoto and Dr. Donald Ingber. This collaboration has produced groundbreaking work in organ-on-a-chip technology and vascular mechanobiology, bridging engineering and medical sciences to address complex biological questions. Dr. Mammoto's laboratory represents a dynamic research environment focused on understanding fundamental mechanisms of vascular development while developing innovative approaches to model and potentially treat vascular diseases affecting neonates and adults alike.