جستجوی استاد راهنمای دانشگاهی

Remco Westerink is Associate Professor at Utrecht University's Faculty of Veterinary Medicine and head of the Neurotoxicology Research Group at the Institute for Risk Assessment Sciences (IRAS). His work focuses on cellular and molecular mechanisms of neurotoxicants in food, drugs, and environmental pollutants. Expertise Areas: In vitro toxicology, developmental neurotoxicology, neuropharmacology, microplastics, risk assessment of chemicals Techniques: Multi-electrode arrays, calcium imaging, PC12 cell models, human iPSC-derived neurons Research explores how pollutants like pesticides, flame retardants, and microplastics affect brain development, function, and degeneration through key projects including EU-funded initiatives (TUBE, ENDpoiNTs) and national collaborations. Recent articles highlight his team's work on neurotoxic effects of: Microplastics crossing blood-brain barrier Bisphenols and PFAS disrupting neuronal networks Insecticides altering calcium signaling Organophosphate flame retardants (TCP) linked to aerotoxic syndrome Designer drugs affecting neurotransmission Scientific Contributions: Editorial Board: NeuroToxicology , Toxicology in Vitro Keynote Speaker: 1st International Congress on Global Environmental Contamination (2014) Invited Talks: International Neurotoxicology Association meetings (2012-2017) Westerink leads research into advanced in vitro models to replace animal testing, including development of 48-well microelectrode array platforms and collaborations with Mimetas and RIVM for organ-on-a-chip technology.

• Neurotoxicology
• Toxicology
• In Vitro Toxicology
• +۶ مورد دیگر

Anja Wilmes is an Assistant Professor at the Vrije Universiteit Amsterdam in the Faculty of Science, Department of Chemistry and Pharmaceutical Sciences, and part of the AIMMS research institute, specializing in Molecular and Computational Toxicology with expertise in human cell-based toxicity testing models. Education: PhD in Cell and Molecular Biology from Victoria University of Wellington, New Zealand (supervised by Prof. John H. Miller) Habilitation (venia docendi) in Physiology from Medical University of Innsbruck, Austria (2016) Her research pioneers New Approach Methodologies (NAMs) using advanced human cell culture systems, including primary renal cells, iPSC-derived renal proximal tubular-like cells, podocytes, hepatocytes, endothelial cells, and cardiomyocytes. She develops microporous growth supports and microphysiological systems (organ-on-a-chip) to study personalized medicine, renal transport mechanisms, drug metabolism, and cellular stress responses through transcriptomics, High Content Imaging, and Seahorse mitostress assays. Recent publications demonstrate consistent innovation in iPSC-based toxicity models, mitochondrial dysfunction analysis, and adverse outcome pathway assembly for renal and hepatic toxicity. Scientific Awards: Otto Kraupp Preis (2017) As Master coordinator for the Molecular Toxicology track in the DDS program, she leads courses in Human Cells in Culture and Induced Pluripotent Stem Cells in Toxicology. Her research leadership spans major EU projects including Predict-IV, StemBANCC, EU-ToxRisk, RISK-HUNT3R, VHP4Safety, and ADME4NGRA, alongside project leadership in Stiftung Set and ProCare initiatives. She serves as Associate Editor for Elsevier since 2025. Her laboratory focuses on developing animal-free toxicity testing platforms through advanced cell culture engineering and stem cell differentiation protocols, directly contributing to sustainable drug development and regulatory science.

• Toxicology
• Molecular Toxicology
• Human Cell Culture Models
• +۷ مورد دیگر

K. Vermeul works as a Researcher at the Applied Stem Cell Technologies department within the Faculty of Science and Technology at the University of Twente. With a background in Biomedical Laboratory Research from Saxion University of Applied Sciences, Vermeul has held technician roles at the University of Twente, Sanquin Research Amsterdam, and Beth Israel Deaconess Medical Center at Harvard Medical School in Boston, USA. Research interests include: 3D vascular and cardiac tissue engineering Microfluidic organ-on-chip systems Wnt signaling in mesenchymal stromal cells Oxygen sensing in engineered tissues Inflammatory responses in vascular models Recent publications focus on microfluidic platforms for vascular oxygen monitoring, immune-vascular interactions in coagulation, and automated cardiac tissue analysis. Vermeul manages laboratory operations, differentiates stem cells into cardiomyocytes and endothelial cells, coordinates health/safety/environment protocols, handles GMO permits, and instructs master's level practical courses.

• Stem Cell Differentiation
• Microfluidic Systems
• Vascular Tissue Engineering
• +۳ مورد دیگر

Laura Elise de Heus is a Researcher at the Applied Stem Cell Technologies group within the TechMed Centre at the University of Twente, specializing in advanced tissue engineering models and vascular biology. Her work integrates immunology with micro-engineering to develop physiologically relevant systems for disease modeling. Her primary research interests span Tissue Engineering , Vascular Biology , and Macrophage Biology , with specific focus on organ-on-chip technology and biomaterial development. She investigates how embedded macrophages trigger intravascular coagulation in 3D blood vessel models, addressing critical gaps in understanding vascular inflammation and thrombosis mechanisms. Analysis of her 2019-2024 publications reveals a clear research trajectory: initial work on poly(lactic acid) micro-objects for tissue scaffolding evolved into sophisticated vascular inflammation models incorporating immune cells. This progression demonstrates her contribution to advancing in vitro vascular disease modeling through engineering-immunology integration. Dr. de Heus operates within the Applied Stem Cell Technologies research group at the TechMed Centre, a multidisciplinary institute fostering collaboration between engineering, medicine, and life sciences. Her work exemplifies the center's mission to develop innovative medical technologies through cross-disciplinary approaches.

• Tissue Engineering
• Vascular Biology
• Macrophage Biology
• +۳ مورد دیگر

Bas Lendemeijer is a Researcher at Erasmus MC, affiliated with the Department of Psychiatry. His work focuses on stem cell biology, neuroscience, virology, and medical research. He completed his doctoral thesis in 2021, titled 'Leveraging human induced pluripotent stem cells for modeling brain diseases.' His research includes studying astrocyte functionality derived from pluripotent stem cells, standardizing microphysiological systems, and investigating SARS-CoV-2 variants' neurovirulence. Lendemeijer's contributions span both in vitro and in vivo models to explore cellular mechanisms and disease pathways. His recent work emphasizes translational research, aiming to bridge stem cell technologies with clinical applications in neurology and psychiatry.

• Stem Cell Biology
• Neuroscience
• Virology
• +۵ مورد دیگر

Jelle Slager, MSc, is an active researcher contributing to multiple disciplines including Microbiology, Genetics, and Biomedical Engineering. His work aligns with UN Sustainable Development Goals through research on human pathogens, pharmacogenetics, and microphysiological systems. He has published extensively in high-impact journals and received the Max Gruber Prize 2016 for academic excellence. Expertise in Streptococcus pneumoniae and coeliac disease microbiome dynamics Developed PneumoBrowse 2 for multiomics data analysis Leader in pharmacogenetic passport generation for personalized medicine His research outputs include: 19 peer-reviewed articles (including 15 original papers and 2 reviews) 1 dataset on pneumococcal transcriptomes Collaborations across Europe in microbiome and engineering disciplines Scientific recognition: Max Gruber Prize 2016 - Cell Biology

• Microbiology
• Molecular Biology
• Genetics
• +۴ مورد دیگر

Dr. Linette Willemsen serves as an Associate Professor in the Pharmacology department within the Faculty of Science at Utrecht University. Her research program focuses on Mucosal Immunology and Pharma & Nutrition, with particular emphasis on dietary components' role in immune health. She maintains active laboratory operations at the David de Wiedgebouw building (Universiteitsweg 99, Utrecht) and collaborates extensively with immunology and nutrition research groups. Her primary research interests center on mechanisms by which dietary components—particularly fermentable fibers, bacterial fermentation products, and n-3 long-chain polyunsaturated fatty acids—modulate immune responses to prevent non-communicable immune disorders like food allergy and asthma. Development of advanced mucosal immune co-culture models mimicking allergic sensitization cascades Investigation of human milk oligosaccharides' immunomodulatory effects on epithelial-immune crosstalk Exploration of how non-digestible oligosaccharides enhance defense against viral/bacterial challenges Translational studies on dietary components as adjunct therapy for chronic inflammatory disorders Her work bridges fundamental immunology with nutritional science to identify clinically relevant interventions. Analysis of her 15 most recent publications reveals consistent focus on mucosal immune modeling (73% of articles), food allergy mechanisms (67%), and nutritional immunomodulation (80%). Key methodological trends include sophisticated co-culture systems (87%), human-derived cell models (73%), and prebiotic intervention studies (60%). The research demonstrates progressive integration of organ-on-chip technology (27% of recent work) and nanoparticle delivery systems (20%) for therapeutic applications. Her collaborative network spans multiple institutions, with frequent co-authorship with Garssen, Folkerts, and Willemsen research groups. Current projects appear supported by Dutch national research grants focused on food allergy prevention and mucosal immunology, though specific funding sources aren't detailed in the provided materials. Ongoing work includes developing sequential mucosal models for predicting food allergenicity and testing dietary interventions for barrier protection.

• Immunology
• Allergy
• Mucosal Immunology
• +۳ مورد دیگر

Jesper Hjortnaes serves as an Assistant Professor within the Regenerative Medicine & Stem Cells strategic program, focusing on cardiac tissue engineering and disease modeling through advanced biomaterial platforms. His core research domains include: Cardiac Regeneration via Stem Cell Technologies 3D-Bioprinted Cardiovascular Tissue Models Microphysiological Systems for Fibrosis Research Nanoparticle-Mediated Cardiac Drug Delivery Proteomic and Transcriptomic Disease Analysis Analysis of his 2021-2025 publications reveals consistent innovation in human cardiac disease modeling, particularly through engineered platforms like cardiac fibrosis-on-a-chip systems and 3D-bioprinted aortic valves. His work integrates stem cell biology, mechanotransduction studies, and nanomedicine to develop anti-fibrotic therapies targeting heart failure mechanisms, with significant contributions to understanding pirfenidone's effects and miRNA delivery systems. Collaborative research patterns indicate strong interdisciplinary partnerships across cardiovascular science, biomaterials engineering, and molecular therapeutics, with publications spanning high-impact journals in regenerative medicine and cardiovascular research.

• Regenerative Medicine
• Stem Cell Research
• Tissue Engineering
• +۳ مورد دیگر

Carlo Alberto Paggi is a researcher at the University of Twente, specializing in Developmental BioEngineering . His work focuses on creating advanced microphysiological systems such as cartilage-on-chip and joint-on-chip platforms to study tissue regeneration and disease mechanisms. Key Research Areas: Cartilage biology, biomechanical stimulation, hydrogel-based microsystems, and synovial joint modeling. Recent Publications: Paggi has contributed to significant advancements in tissue engineering, including methods for high-density capillary network formation and dynamic mechanical stimulation of chondrocytes. Collaborations: He collaborates with experts in biomedical engineering and rheumatology, including Prof. Ali Mobasheri, Prof. Jeroen Leijten, and Prof. Marcel Karperien. Activities: Paggi has presented his work at various international conferences and symposia, emphasizing the integration of mechanical cues in tissue regeneration. The articles listed below highlight his innovative approaches to biomedical engineering , particularly in modeling complex joint systems and vascularized tissues using organ-on-chip technologies.

• Tissue Engineering
• Biomechanics
• Biomedical Engineering
• +۳ مورد دیگر

Dr. Quentin Faucher is a Research Fellow in Pharmacology at the Faculty of Science, Utrecht University, Netherlands. He works within the Division of Pharmacology at the Utrecht Institute for Pharmaceutical Sciences, where he conducts innovative research at the intersection of kidney and brain physiology. Faucher is a member of the Brain-on-chip and Kidney-on-chip theme groups at HDMT and holds a prestigious Marie Sklodowska-Curie Action Postdoctoral Fellowship awarded in February 2023. Dr. Faucher earned his PhD in Pharmacology, Infectious diseases and Drug Science from Limoges University, France. His doctoral research was conducted at the INSERM U1248 Pharmacology and Transplantation unit, focusing on translational studies of ischemia-reperfusion effects on tubular transport systems in kidney transplantation. His primary research interests center on the kidney-brain axis, particularly investigating how chronic kidney disease leads to neurological complications through uremic toxin accumulation. Faucher specializes in developing multi-organs-on-chip models to study kidney-brain crosstalk, with emphasis on blood-brain barrier dysfunction in uremic syndrome. His work integrates pharmacology, metabolomics, and organ-on-chip technology to understand disease mechanisms and develop potential therapeutic approaches. Analysis of Dr. Faucher's publication record reveals a strong focus on kidney physiology, drug transporters, and the molecular mechanisms of kidney disease. His research spans from fundamental studies of organic anion transporters to clinical applications in transplantation and chronic kidney disease. Recent work shows increasing emphasis on organ-on-chip technology and the neurological complications of kidney disease, reflecting his current Marie Curie fellowship project. Marie Sklodowska-Curie Action Postdoctoral Fellowship (2023) Dr. Faucher's research is supported by his Marie Sklodowska-Curie Action Postdoctoral Fellowship from the European Research Executive Agency. While specific students aren't listed in the available information, his position as a postdoctoral researcher suggests he likely collaborates with PhD students and junior researchers within the Utrecht Institute for Pharmaceutical Sciences. His work involves significant interdisciplinary collaboration across pharmacology, nephrology, and neuroscience domains. As a member of the Brain-on-chip and Kidney-on-chip theme groups at HDMT, Dr. Faucher works within a cutting-edge research environment focused on developing and applying organ-on-chip technology. His current project involves engineering a miniature kidney-brain axis model to unravel neuropathies associated with chronic kidney disease, representing a novel approach to studying systemic disease effects through integrated microphysiological systems.

• Pharmacology
• Kidney-Brain Crosstalk
• Organ-on-Chip Models
• +۷ مورد دیگر

Dr. Jeroen van Bergenhenegouwen is a Researcher in the Department of Pharmacology at Utrecht University's Faculty of Science. His work bridges pharmacology, immunology, and microbiology, with a focus on gut microbiota interactions and respiratory health. He investigates how probiotics, prebiotics, and synbiotics modulate immune responses in conditions like asthma, COPD, and pollution-induced inflammation. His research explores: Gut-lung axis mechanisms in environmental toxin responses Therapeutic applications of microbial metabolites (e.g., short-chain fatty acids) Preclinical models of inflammatory diseases and mucosal immunity Recent publications emphasize air pollution impacts, maternal-offspring immune programming, and dietary interventions for mucosal repair. His work integrates omics approaches and in vitro systems to evaluate protein interactions and microbial therapeutics.

• Pharmacology
• Immunology
• Gut Microbiota
• +۳ مورد دیگر

Regina Luttge is an Associate Professor at Eindhoven University of Technology (TU/e) in the Department of Mechanical Engineering and Chair of Neuro-Nanoscale Engineering. Her research focuses on developing biomimetic brain-on-chip systems through micro-nanofabrication, combining tissue engineering with microfluidics for studying neurodegenerative diseases. ERC Starting Grant (2011) and Proof of Concept Grant (2015) Chief Scientific Officer at MyLife Technologies BV since 2012 Research Interests : Temporal/spatial cellular microenvironment control Directional neuronal network formation via nanogrooves Hydrogel scaffolds for 3D neural cultures Clinically relevant preclinical models Microfabrication for neurotechnology Recent Publications demonstrate trends in mechanodynamic brain-on-chip , epileptic seizure modeling , and neurodegenerative assembloids , with keywords spanning Biomedical Microsystems, Nanofabrication, and Neurotechnology. Scientific Awards ERC Starting Grant (2011) for "Chatting with Neurons" ERC Proof of Concept Grant (2015) for "Sieving Neuronal Networks" Education & Supervision : PhD from Imperial College London (2003), former researcher at Institut für Mikrotechnik Mainz. Supervised 38 student theses including T. Labeur's hydrogel bead trapping research and T.A. Roza's automated Brain-on-Chip feedback-loop system. Industry Collaboration : Co-founded MyLife Technologies BV, bridging academic research with commercial microsystem development while mentoring student entrepreneurship through TU/e's challenge-based learning initiatives.

• Biomedical Microsystems
• Brain-on-Chip Technology
• Micro-Nanofabrication
• +۵ مورد دیگر

A.D. van der Meer is a Full Professor holding appointments at Applied Stem Cell Technologies, MESA+ Institute, and TechMed Centre. His research focuses on advanced biomedical engineering, particularly organ-on-a-chip technologies and microphysiological systems. These innovations aim to revolutionize in vitro disease modeling, drug development, and regulatory science while reducing reliance on animal testing. His work bridges stem cell technology, vascular biology, and microfluidics to create functional tissue models. Key areas include vascular endothelium studies, thrombosis mechanisms in diseases like COVID-19, and organ-specific systems like retina-on-chip platforms. Collaborations span global experts in tissue engineering and regulatory science. Dr. van der Meer has supervised 10 academic works, though specific student names are not listed. His contributions to labs like MESA+ and TechMed Centre highlight interdisciplinary research at the intersection of engineering, biology, and medicine.

• Organ-on-a-chip technology
• Stem Cell Research
• Microphysiological Systems
• +۳ مورد دیگر

Heleen H.T. Middelkamp is a Researcher at the University of Twente, working across multiple institutes including Applied Stem Cell Technologies, MESA+ Institute, and TechMed Centre. She completed her PhD in 2023 with a dissertation on microfluidic vessels-on-chips for vascular disease modeling and currently holds external positions as Support coordinator at the European Organ-On-Chip Society and Research assistant at the Institute for Human Organ and Disease Model Technologies (hDMT) since August 2023. Dr. Middelkamp's research focuses on vascular biology and organ-on-chip technology , with particular expertise in developing and applying vessel-on-chip models to study vascular diseases, thrombosis, and inflammation. Her work integrates stem cell technologies with microfluidic systems to create advanced in vitro models that better recapitulate human physiology and disease states. Recent research has focused on applying these models to study COVID-19 related vascular complications and microthrombosis. Her publication record shows increasing research activity since 2016, with a significant acceleration in output from 2021 onward. The research trend demonstrates a clear progression from foundational work on vessel-on-chip development toward increasingly complex disease modeling applications, with recent emphasis on standardization of microphysiological systems and regulatory qualification pathways. Her work bridges engineering, vascular biology, and translational medicine, with strong potential for drug development and personalized medicine applications. Through her involvement with the European Organ-On-Chip Society and hDMT, Dr. Middelkamp contributes to the broader organ-on-chip community and collaborative research networks. Her fingerprint analysis reveals strong connections to vascular bundle modeling, endothelial cell research, induced pluripotent stem cells, macrophage biology, and thrombosis mechanisms.

• Vascular Biology
• Organ-on-Chip Technology
• Microphysiological Systems
• +۳ مورد دیگر

Shanna Bastiaan-Net is a VLAG Researcher at Wageningen University & Research, affiliated with the Food, Health & Consumer Research department. Her work focuses on protein digestibility, food allergen mechanisms, and immunological responses to food components. She leads research initiatives involving 3D organoid models and immune system-on-a-chip technologies. Research Interests: Her studies explore protein functionality in digestion, allergen sensitization pathways, and the impact of food components on immune systems. She applies advanced in vitro models like human intestinal organoids and biofabricated systems to simulate biological responses accurately. Collaborations & Projects: Current projects include developing human intestinal organoids, studying probiotic interactions with epithelial cells, and analyzing prenylated phenolics' biotransformation. She has supervised PhD candidates in areas like protein immunogenicity and glycosylation effects on anti-tumor activities. Publications: With 76+ research outputs, her recent work examines Toll-like receptor activation by protein inhibitors, immune system microphysiological systems, and microbial interactions in gut models.

• Food Science
• Immunology
• Protein Digestibility
• +۳ مورد دیگر