Heleen H.T. Middelkamp

Heleen H.T. Middelkamp is a Researcher at the University of Twente, working across multiple institutes including Applied Stem Cell Technologies, MESA+ Institute, and TechMed Centre. She completed her PhD in 2023 with a dissertation on microfluidic vessels-on-chips for vascular disease modeling and currently holds external positions as Support coordinator at the European Organ-On-Chip Society and Research assistant at the Institute for Human Organ and Disease Model Technologies (hDMT) since August 2023.

Dr. Middelkamp's research focuses on vascular biology and organ-on-chip technology, with particular expertise in developing and applying vessel-on-chip models to study vascular diseases, thrombosis, and inflammation. Her work integrates stem cell technologies with microfluidic systems to create advanced in vitro models that better recapitulate human physiology and disease states. Recent research has focused on applying these models to study COVID-19 related vascular complications and microthrombosis.

Her publication record shows increasing research activity since 2016, with a significant acceleration in output from 2021 onward. The research trend demonstrates a clear progression from foundational work on vessel-on-chip development toward increasingly complex disease modeling applications, with recent emphasis on standardization of microphysiological systems and regulatory qualification pathways. Her work bridges engineering, vascular biology, and translational medicine, with strong potential for drug development and personalized medicine applications.

Through her involvement with the European Organ-On-Chip Society and hDMT, Dr. Middelkamp contributes to the broader organ-on-chip community and collaborative research networks. Her fingerprint analysis reveals strong connections to vascular bundle modeling, endothelial cell research, induced pluripotent stem cells, macrophage biology, and thrombosis mechanisms.