- Neuroimmunology
- Microglia Biology
- CNS Inflammation
- +۵ مورد دیگر
Professor Marco Prinz serves as Principal Investigator leading the Innate Immunity research group at the Institute of Neuropathology, University of Freiburg Faculty of Medicine. His laboratory investigates the critical role of brain-specific innate immune cells, particularly microglia, in neurological health and disease. Dr. Prinz's research focuses on understanding how microglia—the brain's resident macrophages—contribute to both protective and pathological processes in the central nervous system. His work examines microglial function in neuroinflammation, neurodegeneration, and autoimmune conditions like multiple sclerosis using advanced mouse models including EAE and cuprizone models. A significant portion of his recent research employs single-cell analysis techniques to characterize the heterogeneity of microglial cells in various disease states, particularly in chronic active lesions and paramagnetic rim lesions in MS patients. The laboratory has made important contributions to understanding microglial development, showing how these cells emerge from specific precursors and establish themselves in defined niches within the CNS. Their work has revealed how microglia act as both guardians and potential contributors to neurological damage, with implications for Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Dr. Prinz's research team includes multiple postdoctoral researchers, PhD students, and technical staff who contribute to ongoing investigations into CNS immunity. His laboratory has pioneered techniques for studying microglia, including novel genetic tools and single-cell analysis approaches that have provided unprecedented insights into the cellular composition of brain lesions and the dynamic behavior of immune cells in neurological disorders.










