J. Tiago Goncalves

J. Tiago Goncalves is an Associate Professor in the Dominick P. Purpura Department of Neuroscience at the Albert Einstein College of Medicine. His research focuses on understanding the circuit physiology of the hippocampus, particularly how environment, aging, and inflammation influence memory and learning. He pioneered in vivo two-photon calcium imaging techniques to study adult neurogenesis in the dentate gyrus (DG), linking neuronal plasticity to cognitive functions.

Research Interests:
His work examines the role of adult-born neurons in spatial memory encoding, mechanisms underlying age-related cognitive decline, and neuro-immune interactions in hippocampal function. Key areas include:

• Neuronal development and synaptic plasticity
• Environmental influences on neurogenesis
• Microglia and neuro-immune pathways
• Transcriptional profiling of neural circuits

Publications:
Recent work highlights improvements in spatial encoding precision by adult neurogenesis and age-related deficits in neural representation accuracy. His lab also developed novel behavioral assays for assessing spatial memory in mice.

Advising & Grants:
No specific student names or grant details were explicitly listed in the provided text. The lab focuses on collaborative projects involving imaging, molecular biology, and electrophysiology techniques.

Labs/Teams:
His laboratory employs cutting-edge in vivo imaging and genomics approaches to study hippocampal circuits, with a focus on linking molecular mechanisms to cognitive processes.