جست‌وجوی استاد و پژوهشگر

Antoine Louveauمشاهده پروفایل

استادیار

• Neuroscience
• Neuroimmunology
• Meningeal Lymphatics
• +۴ مورد دیگر

Dr. Antoine Louveau is an Assistant Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University (CCLCM-CWRU), where he serves as Principal Investigator of the Louveau Laboratory within the Lerner Research Institute. His research focuses on the critical interface between the brain and immune system, specifically investigating the role of meningeal lymphatic vessels in normal and pathological brain function. Dr. Louveau's research interests span multiple areas of neuroimmunology and neuroscience: Meningeal lymphatic system and its role in CNS immunity Neuroimmune interactions in neurological disorders Alzheimer's disease and multiple sclerosis pathogenesis Brain barriers and immune cell trafficking Neuroinflammation and therapeutic interventions His laboratory has made significant contributions to understanding how meningeal lymphatic vessels regulate CNS drainage and immune responses. Dr. Louveau's research has revealed connections between meningeal lymphatic dysfunction and neurological disorders including Alzheimer's disease and multiple sclerosis. His team has demonstrated how meningeal lymphatics impact microglial responses and the efficacy of immunotherapies for neurodegenerative conditions. Analysis of his publication record shows consistent focus on meningeal lymphatic structure, function, and therapeutic potential across neurological conditions. Dr. Louveau has received recognition as a "CIMER Trained Mentor," indicating completion of specialized mentorship training aimed at advancing mentoring relationships and promoting cultural change in research. As a principal investigator, Dr. Louveau mentors several trainees including postdoctoral fellows, graduate students, and undergraduate research students. His laboratory collaborates extensively with other researchers at Cleveland Clinic and beyond to investigate the complex relationships between the nervous and immune systems. The Louveau Laboratory is part of the Lerner Research Institute at Cleveland Clinic, a premier biomedical research institution that provides state-of-the-art facilities and resources for cutting-edge neuroscience research.

Erin Reed-Geaghanمشاهده پروفایل

استادیار

• Alzheimer's Disease Mechanisms
• Neuroinflammation
• Microglial Function
• +۳ مورد دیگر

Erin Reed-Geaghan, Ph.D., is an Assistant Professor of Pharmaceutical Sciences and a member of the Graduate Faculty II at the College of Graduate Studies, Northeast Ohio Medical University (NEOMED). Her research focuses on neuroinflammatory mechanisms in Alzheimer’s disease, particularly the role of microglia and inflammatory mediators. She holds a Ph.D. in Neuroscience from Case Western Reserve University (2010) and a B.A. in Biology from Colby College (2003). Education: Ph.D. in Neuroscience, Case Western Reserve University, 2010 B.A. in Biology, Colby College, 2003 Her research interests include microglial function, neuroinflammation, and the molecular pathways driving Alzheimer’s pathology. She has received prestigious awards such as the National Research Service Award (both pre- and post-doctoral) and a BrightFocus Foundation grant. Dr. Reed-Geaghan also teaches immunology and biotechnology courses and was honored with the 2021 Innovation in Teaching Award in Pharmacy. Her publications explore CD14’s role in Alzheimer’s pathology, microglial depletion effects on amyloid plaques, and the origins of myeloid cells in neurodegenerative diseases. She collaborates with institutions like the Clinical and Translational Research Institute and maintains an active lab at NEOMED.

Daniel Wehnerمشاهده پروفایل

پژوهشگر

• Neuroregeneration
• Developmental Biology
• Biomedical Imaging
• +۳ مورد دیگر

Daniel Wehner is a Researcher and head of the Neuroregeneration research group at the Max Planck Institute for the Science of Light and Max-Planck-Zentrum für Physik und Medizin in Erlangen, Germany. His work focuses on understanding spinal cord regeneration in zebrafish, contrasting their regenerative capacity with mammals' inability to recover from spinal cord injuries. B.Sc. in Bio- and Nanotechnologies, South Westphalia University of Applied Sciences Intercalated B.Sc. in Medical Biotechnology, Abertay University Ph.D. in Developmental Biology, Technische Universität Dresden/Ulm University His research investigates the extracellular matrix (ECM) environment post-injury in zebrafish, using advanced optical imaging techniques like Brillouin microscopy and femtosecond laser systems to compare regeneration-permissive vs. scar-forming environments. Recent work highlights the role of microglia in tissue contraction and the inhibition of CNS regeneration by small leucine-rich proteoglycans . Dr. Wehner's group develops humanized zebrafish models for therapeutic spinal cord repair strategies. He was awarded the ISRB Rising Star Award 2024 for pioneering contributions to regenerative biology. Contact: daniel.wehner@mpl.mpg.de 2024: ISRB Rising Star Award

Constanza Garcia Kellerمشاهده پروفایل

استادیار

• Neuropharmacology
• Addiction/Substance Use Disorder
• Stress-Related Disorders
• +۴ مورد دیگر

Dr. Constanza Garcia Keller is an Assistant Professor in the Department of Pharmacology and Toxicology at the Medical College of Wisconsin (MCW), joining in July 2022. Her academic journey includes a BS in Chemical Sciences (2007) and a PhD in Pharmacology (2014) from the National University of Córdoba, Argentina, followed by postdoctoral training and a research assistant professorship in Dr. Kalivas’ laboratory at the Medical University of South Carolina. Her research focuses on the neurobiological mechanisms linking stress, trauma, and addiction, particularly examining synaptic plasticity, extracellular matrix interactions, and neuroimmune-endocrine pathways. Educational Background Bachelor of Science in Chemical Sciences, National University of Córdoba (2007) PhD in Pharmacology, National University of Córdoba (2014) Postdoctoral Training in Neuroscience, Medical University of South Carolina (2014–2019) Research Interests Dr. Garcia Keller’s lab investigates how acute stress and traumatic events increase vulnerability to substance use disorders (SUDs), with a focus on the pentapartite synapse (neurons, astrocytes, microglia, extracellular matrix). Key projects include: Neurocircuitry and cell-type specificity in stress/addiction Role of ECM signaling and microglia activation Development of oligonucleotide-based therapies targeting genes involved in SUDs Awards & Grants 2014: Best Argentinian Neuroscience Thesis Award 2022–2013: Multiple travel and fellowship awards from ACNP, ISN, and CONICET Labs & Collaborations Her lab uses rodent models to study stress-induced neuroplasticity and SUD comorbidity, with a focus on translational therapies targeting synaptic and glial mechanisms.

Antje Kroner-Milschمشاهده پروفایل

دانشیار

• Spinal Cord Injuries
• Neurosciences
• Inflammation
• +۳ مورد دیگر

Dr. Antje Kroner-Milsch is an Associate Professor in the Department of Neurosurgery at the Medical College of Wisconsin. Her research focuses on modifying the inflammatory response after spinal cord injury, with a particular emphasis on macrophages and microglia. She holds an MD from Julius-Maximilians-University (2002) and a PhD in Neuroscience (2008), both from Wuerzburg, Germany. She completed postdoctoral training at McGill University (2009-2015) before joining MCW in 2015. Education: MD, Julius-Maximilians-University, Wuerzburg, Germany (2002) PhD in Neuroscience, Julius-Maximilians-University, Wuerzburg, Germany (2008) Postdoctoral Fellowships: Neurology at McGill University (2009-2014) and Julius-Maximilians-University (2008-2009) Research Associate, McGill University (2014-2015) Research Interests: Dr. Kroner-Milsch investigates the role of inflammation in spinal cord injury, particularly targeting macrophage behavior and ferroptosis. Her work aims to develop therapies that modulate inflammatory responses to improve outcomes. Techniques include flow cytometry, histology, and preclinical mouse models. Awards: Young Investigator Award in Multiple Sclerosis (2005, Wyeth) Advising & Grants: While specific grant details are not listed, her extensive publication record indicates sustained research activity. No students are explicitly named in the provided text. Labs/Teams: Her research is conducted within the Neuroscience Research Labs at the Medical College of Wisconsin, focusing on translational spinal cord injury therapies.

Peter M. Graceمشاهده پروفایل

دانشیار

• Chronic Pain Management
• Neuroimmunology
• Opioid Pharmacology
• +۳ مورد دیگر

Peter M. Grace, Ph.D., is an Associate Professor and interim Department Chair in the Department of Symptom Research at The University of Texas MD Anderson Cancer Center. His research focuses on neuroimmune mechanisms underlying chronic pain, particularly neuropathic pain and opioid pharmacology. He investigates pathways such as Nrf2 antioxidant signaling, inflammasome activation, and immune-mediated pain modulation. His work bridges basic science and translational research, aiming to develop therapies targeting oxidative stress and neuroinflammation. Key research interests include the role of B cells and IgG in neuropathic pain, the impact of opioids on pain amplification, and the protective effects of exercise on nerve injury outcomes. He explores novel therapies like fumarates and HDAC inhibitors to mitigate pain and neurodegeneration. Grace’s interdisciplinary approach integrates immunology, neuroscience, and clinical pain management. His publications highlight advancements in understanding microglial activity in pain-related brain regions, TLR4 signaling in morphine tolerance, and the development of targeted drug delivery systems for oxidative stress disorders. Despite his extensive contributions, specific awards are not listed in the provided materials.

Hongwei Yuمشاهده پروفایل

استاد

• Chronic Pain Management
• Molecular Therapy
• Gene Therapy
• +۷ مورد دیگر

Hongwei Yu, MD is a Professor in the Department of Anesthesiology at the Medical College of Wisconsin. His research focuses on developing recombinant adeno-associated viral (AAV) vectors to manipulate genes in the peripheral sensory nervous system for studying pain mechanisms and treating chronic pain. He leads efforts to create AAV vectors targeting sensory neurons, satellite glial cells, and microglia for therapeutic applications. Education: MD from Binzhou Medical College (China), MS from Shandong University Medical School (China), and postdoctoral training at the Medical University of South Carolina. Research emphasizes gene and molecular therapy for chronic pain, with a focus on sodium channels, Piezo1/2 ion channels, and T-type calcium channels. His lab pioneered SGC-specific AAV vectors (sgcAAV) and microglia-specific AAV (mgAAV) for glial cell targeting. Current projects include AAV-encoded interfering peptide aptamers (AAV-iPAs) for pain modulation and dual AAV strategies targeting neurons and glia. Publications span mechanosensitive ion channel roles in pain, AAV-based gene delivery systems, and translational models of neuropathic pain. His work bridges molecular mechanisms with clinical applications in pain management.

Yuan Panمشاهده پروفایل

استادیار

• Neuroscience
• Cancer Biology
• Neuro-Oncology
• +۴ مورد دیگر

Dr. Yuan Pan is an Assistant Professor at The University of Texas MD Anderson Cancer Center, holding dual appointments in the Department of Symptom Research (Division of Internal Medicine) and the Department of Neuro-Oncology (Division of Cancer Medicine). Her research bridges neuroscience and cancer biology, focusing on neuron-cancer interactions and neurofibromatosis type 1 (NF1)-related gliomas. She leads the Pan Lab, which investigates how neuronal activity, glial biology, and chemotherapy impact nervous system cancers, aiming to improve patient outcomes through novel therapeutic strategies. Dr. Pan trained with renowned scientists Drs. David Gutmann and Michelle Monje, contributing seminal work on NF1 mutations and optic glioma pathogenesis (Pan et al., Nature, 2021). Since establishing her independent lab in 2022, she has secured CPRIT Scholar funding and advanced studies on neuroimmune interactions, tumor microenvironment dynamics, and activity-dependent tumor initiation. Her work highlights the critical role of neural circuits in cancer progression. Key Awards: CPRIT Scholar in Cancer Research (2022) Research Themes: Neuronal-glial crosstalk, neurofibromatosis, tumor immunology, chemotherapy effects Labs/Teams: Pan Lab (MD Anderson Cancer Center) Her publications reveal a focus on low-grade glioma mechanisms, chemokine signaling, and systems biology approaches to identify tumor-specific networks. Clinical and translational efforts aim to translate these findings into improved diagnostics and therapies.

Michael Nicholsمشاهده پروفایل

استاد

• Alzheimer’s Disease
• Protein Biophysics
• Biochemical Analysis
• +۳ مورد دیگر

Dr. Michael Nichols is a Professor and Director of the Biochemistry and Biotechnology Program at the University of Missouri–St. Louis (UMSL). He holds a B.S. from Lindenwood College and a Ph.D. from Purdue University. His postdoctoral training at the Mayo Clinic in Jacksonville, FL, focused on biophysical analysis of proteins. His research interests center on Alzheimer’s Disease, with a focus on amyloid-beta aggregation mechanisms, protein biophysics, cellular signaling, and inflammatory pathways. Key techniques include chromatography, light scattering, microscopy (atomic force, confocal), and cell culture studies. Dr. Nichols explores how amyloid-beta species interact with microglia and their role in neuroinflammation, with implications for therapeutic interventions. His research output spans over 30 peer-reviewed articles, emphasizing structural biology of amyloid proteins, inflammasome activation, and protein aggregation dynamics. Notable trends include investigations into protofibril conformation effects, microglial response modulation, and novel antibody development targeting amyloid species. No scientific awards or grants are explicitly listed in the provided text. Dr. Nichols advises students through his role in the Biochemistry and Biotechnology Program but no specific advisee names are provided.

Imelda McGonnellمشاهده پروفایل

پژوهشگر

• Comparative Medicine
• Developmental Biology
• Oncology
• +۳ مورد دیگر

Imelda McGonnell is a Reader in Comparative Medicine at the Royal Veterinary College's Department of Comparative Biomedical Sciences. Her research bridges human and animal disease models, focusing on developmental disorders and cancer through zebrafish and canine mammary tumor studies. Key Research Areas: Microbiome-neuronal development interactions Mechanisms of canine mammary tumourigenesis Signaling pathways in Tasmanian Devil Facial Tumour Disease Collaborations: University of Tasmania Southampton University She employs germ-free zebrafish models, traditional disease models, and in vitro techniques to investigate molecular disease mechanisms. Her work also explores mechanosensitivity in embryonic limb development and comparative models of Chiari-like malformation.

• Stem Cell Biology
• Neuro-Oncology
• Neurodegenerative Diseases
• +۳ مورد دیگر

Viviane Tabar, MD, is a neurosurgeon-scientist and Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center (MSKCC). Her clinical expertise includes surgical management of brain tumors, such as gliomas, meningiomas, and skull base tumors. She specializes in minimally invasive techniques, intraoperative imaging, and brain mapping to preserve critical neural functions. Dr. Tabar is also a leading researcher in stem cell biology, focusing on regenerative therapies for brain repair (e.g., Parkinson’s disease) and modeling brain tumors using human pluripotent stem cells. Her lab investigates glioma biology, tumor heterogeneity, and radiation-induced brain injury. Education and Training: MD from the American University of Beirut; residencies in General Surgery and Neurosurgery at Case Western Reserve University and University of Massachusetts; fellowship in Neurosurgical Oncology at MSKCC. Board-certified in Neurological Surgery. Research Highlights Her lab’s key projects include: Stem cell-derived grafts for radiation injury repair. Modeling pediatric gliomas (e.g., H3.3K27M mutations) using human embryonic stem cells. Developing clinical trials for stem cell therapies in Parkinson’s disease. Awards and Recognition Recipient of the American Brain Tumor Association Young Investigator Award (2016), Preuss Award (2010), and multiple Castle Connolly honors. Elected to the National Academy of Medicine. Lab Collaborations Collaborates with the Center for Stem Cell Biology and Gerstner Sloan Kettering Graduate School. Current lab members include postdoctoral fellows, research assistants, and a graduate student. Publications span stem cell therapies, glioma models, and clinical innovations, with a focus on translational research to bridge surgical practice and scientific discovery.

Ekaterina Vinogradovaمشاهده پروفایل

استادیار

• Chemical Biology
• Immunology
• Proteomics
• +۴ مورد دیگر

Ekaterina Vinogradova, Ph.D., is an Assistant Professor at The Rockefeller University, leading the Laboratory of Chemical Immunology and Proteomics. Her research focuses on developing chemical probes to study immune protein function and discover novel therapeutic targets for immune and neuroimmunological disorders. She holds faculty roles in the David Rockefeller Graduate Program, Tri-Institutional M.D.-Ph.D. Program, and Tri-Institutional Ph.D. Program in Chemical Biology. Education: PhD in Organic Chemistry, Massachusetts Institute of Technology (2015) MSc in Chemistry, Higher Chemical College of the Russian Academy of Sciences (2010) Postdoctoral Fellow, The Scripps Research Institute (2015–2020) Research Interests: Vinogradova combines chemistry, chemical proteomics, and cell biology to modulate immune protein functions. Key areas include: Designing selective chemical probes targeting cysteine residues in immune proteins Elucidating mechanisms of small molecule-induced protein degradation Mapping signaling pathways in immune and neuroimmunological disorders Her work leverages synthetic chemistry and proteomic technologies to advance drug discovery for cancer, immunology, neuroscience, and microbiology. Awards: Irma T. Hirschl/Monique Weill-Caulier Trust Research Award (2021) Searle Scholar (2021) C&EN Talented 12 (2021) Damon Runyon-Rachleff Innovation Award (2022) Grants & Labs: Vinogradova’s lab explores pharmacological landscapes of immune disorders and collaborates on projects involving microglia and oligodendrocytes in multiple sclerosis. Her work is supported by prestigious grants and fellowships, including the Kellen Women’s Entrepreneurship Fund Proof-of-Concept Award (2022).

Susan Kaechمشاهده پروفایل

استاد

• Immunology
• Cancer Immunology
• T Cell Biology
• +۳ مورد دیگر

Susan Kaech is a Professor and Director of the NOMIS Center for Immunobiology and Microbial Pathogenesis at the Salk Institute for Biological Studies, holding the NOMIS Chair. Her work focuses on understanding how memory T cells form, interact with tissues, and adapt to chronic diseases like cancer. She investigates T cell metabolism, tumor microenvironment interactions, and immune evasion mechanisms. Key contributions include discoveries on IL-7-driven memory T cell formation and metabolic control of T cell function. Education: BS in Cellular and Molecular Biology (University of Washington), PhD in Developmental Biology (Stanford University). Affiliated with the Wu Tsai Human Performance Alliance and Multiple Sclerosis Research Collaborative. Research emphasizes long-term immunity, cancer immunotherapy, and T cell exhaustion. Major findings include metabolic crosstalk between tumors and T cells, roles of scavenger receptors (CD36) in tumor progression, and neuroimmune interactions in the brain. Her lab uses genetic tools, single-cell profiling, and mouse models to explore these areas. Awards include National Academy of Sciences membership (2024), American Academy of Arts & Sciences (2023), and multiple cancer research grants. Her work bridges immunology, metabolism, and oncology, with implications for vaccine design and cancer therapy. Publications highlight recent advances in hypoxia-driven resistance to checkpoint inhibitors, bile acid impacts on liver cancer, and dietary ketolysis enhancing anti-tumor immunity. Ongoing projects explore brain-resident T cells, diet-cancer immunity links, and STING pathway activation in tumors.

Roberta Brambillaمشاهده پروفایل

دانشیار

• Neuroinflammation
• Neuroimmunology
• Glial Biology
• +۶ مورد دیگر

Roberta Brambilla is an Associate Professor of Neurological Surgery at the University of Miami Miller School of Medicine, affiliated with The Miami Project to Cure Paralysis. She holds dual roles in research and teaching, focusing on neuroinflammation and neuroimmune interactions in neurological disorders like multiple sclerosis, spinal cord injury, and traumatic brain injury. Her research emphasizes glial cell biology, TNF signaling pathways, and cholesterol metabolism in CNS diseases. Educations: Ph.D. in Pharmacology/Neuroscience, University of Milan, 2000 M.S. in Pharmacology, University of Milan, 1995 B.S. in Pharmacology/Neuroscience, University of Milan, 1993 Research Interests: Dr. Brambilla investigates neuroinflammation's role in neurodegenerative disorders, particularly TNF's dual functions in membrane-bound and soluble forms. Her work explores TNFR2 signaling in glial cells, oligodendrocyte dysfunction in primary progressive MS, and cholesterol's role in neuroprotection. She also develops novel transgenic mouse models and deep learning tools for CNS injury analysis. Awards: Eureka Institute Course in Translational Medicine (University of Miami) International Society for Neuroimmunology Travel Awards (multiple) First Prize, Italian Society of Pharmacology (1995) Grants & Labs: Dr. Brambilla leads a lab focusing on TNF biology, neurodegeneration, and translational therapies. Her work includes collaborations on anti-ASC monoclonal antibodies (IC100) and selective TNFR2 agonists for MS therapy. She is affiliated with The Miami Project's interdisciplinary research teams.

• Spinal Cord Injury
• Neuroinflammation
• Glial Scar Formation
• +۳ مورد دیگر

Jae K Lee is a Professor of Neurological Surgery at the University of Miami, affiliated with the Miami Project to Cure Paralysis since 2011. His research bridges fundamental neuroscience and translational applications to develop regenerative therapies for central nervous system injuries, with emphasis on spinal cord and traumatic brain injury. His academic credentials include a PhD in Neuroscience from Georgetown University (2005), MS (2000) and BS (1997) from George Washington University. Postdoctoral training at UC San Diego was supported by an NIH Ruth L. Kirschstein Fellowship focusing on axon regeneration inhibitors. Lee's laboratory investigates neuroinflammatory mechanisms driving glial and fibrotic scar formation after CNS trauma. Key research areas include macrophage/microglia regulation of gliosis, NG2 cell contributions to scar formation, and perivascular fibroblast roles in fibrotic scarring. Methodologies integrate transcriptomics, bioinformatics, high-content assays, and in vivo surgical models to identify therapeutic targets for enhancing neural repair. Publication analysis reveals consistent focus on immune cell dynamics in CNS injury, with recent work leveraging single-cell technologies to dissect cellular heterogeneity in traumatic brain/spinal cord injury models. Emerging themes include PI3K/TNFR2 signaling pathways in macrophage/oligodendrocyte function and computational approaches for cell-cell interaction mapping. His scientific recognition includes: UM Neuroscience Graduate Program Faculty Mentor of the Year University of Miami Junior Faculty Award Association of Korean Neuroscientists award NIH Ruth L. Kirschstein Post-doctoral Fellowship As an active neuroscience graduate program member, Lee serves as lecturer, course director, and steering committee member while mentoring undergraduates, graduate students, and postdocs. His lab at the Miami Project maintains collaborations with immunology and bioinformatics teams to advance scar-modulation therapies, supported by multiple NIH grants targeting neuroinflammation and regeneration pathways. The Lee Lab specifically studies how CNS/non-CNS cell interactions form protective yet inhibitory barriers after injury, with current projects examining NG2 cell differentiation into astrocytes and macrophage-mediated fibrotic scar development to identify novel regeneration-promoting strategies.