جست‌وجوی استاد و پژوهشگر

Monticelli Silviaمشاهده پروفایل

استاد پژوهشی

• Molecular Immunology
• T lymphocyte biology
• Mast cell biology
• +۴ مورد دیگر

Silvia Monticelli is a Group Leader in Molecular Immunology at the Institute for Research in Biomedicine (IRB) in Bellinzona, Switzerland. She earned her Ph.D. from the University of Milan and has held research positions at San Raffaele Scientific Institute, King’s College London, and Harvard Medical School. Her research focuses on transcriptional and post-transcriptional regulation of immune responses, particularly in T lymphocytes and mast cells. Education: Ph.D. – University of Milan, Italy Postdoctoral training – San Raffaele Scientific Institute, Milan Research training – Randall Institute, King’s College London Research training – Center for Blood Research, Harvard Medical School Research Interests: Silvia Monticelli’s lab investigates the molecular mechanisms that control gene expression in immune cells. Her work spans epigenetic regulation , microRNA function , transcription factor networks , and RNA methylation in T cells and mast cells. A central theme is understanding how these mechanisms shape immune cell identity and function in health and disease. Publication Trends: Her recent publications (2020–2024) reflect a strong emphasis on RNA biology , epigenetic control , and immune regulation . She has contributed to high-impact journals such as Nature , Nature Immunology , and Science Advances , with work ranging from microRNA-mediated control of T cell activation to epigenetic regulation in mast cells and cancer immunity. Scientific Recognition: While no formal awards are listed, her work has been highlighted by editorial commentary and co-corresponding authorships in high-impact journals, indicating recognition within the immunology community. Labs & Affiliations: She leads a research group at the IRB in Bellinzona, focusing on immune cell regulation at the molecular level. Her lab is part of a broader European research network and collaborates with institutions like Harvard and the University of Milan.

Jill A Kreilingمشاهده پروفایل

دانشیار

• Aging Biology
• Molecular Biology
• Cell Biology
• +۴ مورد دیگر

Jill A Kreiling is an Associate Professor (Research) in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University School of Medicine. She also serves as the Associate Director of the Brown Center on the Biology of Aging since July 2018. Her research focuses on the molecular mechanisms of aging, particularly examining the role of transposable elements, epigenetic changes, and cellular senescence in the aging process. Dr. Kreiling's research interests span several key areas in aging biology and molecular mechanisms of age-related changes. Her work has significantly contributed to understanding how retrotransposable elements become active during aging, how heterochromatin formation changes with age, and how these molecular changes impact tissue function and age-related diseases. She has developed innovative approaches to study aging processes using various model systems including mouse models, zebrafish, and cell culture systems. Her research program has been consistently supported by NIH funding, including her current role as Principal Investigator on an R01 grant focused on identifying biomarkers in salivary vesicles for preclinical Alzheimer's disease. She has published extensively in high-impact journals including Nature, Cell, and Aging Cell, with her work being cited widely in the aging research community. Dr. Kreiling has received several prestigious awards including the Mentored Research Scientist Development Award (K01) from the National Institute on Aging (2011-2017). Her collaborative network includes prominent researchers in the aging field such as John Sedivy and Nicola Neretti at Brown University. As an educator, Dr. Kreiling has taught Introductory Microbiology and has mentored numerous students and postdoctoral fellows in her laboratory. Her research program provides valuable training opportunities for students interested in aging research, molecular biology, and translational approaches to age-related diseases.

Christopher J. Cooperمشاهده پروفایل

استاد

• Cardiovascular Medicine
• Interventional Cardiology
• Renovascular Hypertension
• +۴ مورد دیگر

Christopher J. Cooper, M.D., is Distinguished University Professor of Medicine at the University of Toledo, Ohio, where he also served as Dean of the College of Medicine (2014-2024), CEO of University of Toledo Physicians, and Executive Vice-President for Clinical Affairs. Triple-board-certified in Internal Medicine, Cardiovascular Disease, and Interventional Cardiology, he directs the UT Clinical Coordinating Center and has led national randomized trials on renal-artery stenosis. Education & Training: B.A. magna cum laude in Biology (Philosophy minor), Wittenberg University, 1985 M.D., University of Cincinnati College of Medicine, 1988 — Valedictorian, Alpha Omega Alpha Internship & Residency, Brigham and Women’s Hospital / Harvard Medical School, 1988-1991 Cardiology Fellowship, Brigham and Women’s Hospital, 1991-1994 Harvard School of Public Health, Clinical Effectiveness Program, 1992 Research Focus: Cooper’s group investigates renovascular hypertension, renal-artery stenosis, and cell-based therapies for vascular disease. As PI of the NIH-funded CORAL trial and multiple industry grants, he has published pivotal papers defining when renal stenting benefits patients and elucidating inflammatory and signaling pathways that couple renal artery narrowing to hypertension and renal failure. Recent work integrates large-scale clinical outcomes databases with mechanistic studies on Na/K-ATPase signaling, microRNA regulation of cardiac fibrosis, and biomarkers such as CD40-ligand in renovascular disease. Honors & Awards: Best Doctors in America — multiple years (2002-2014) America’s Top Doctors, Castle Connolly — consecutive listings (2006-2015) College of Medicine Award for Excellence in Clinical Research, UT (2008) Elected Fellow, American Heart Association Council on High Blood Pressure Research (2004) Valedictorian & Alpha Omega Alpha, Univ. of Cincinnati (1988) Leadership & Grants: Cooper has held continuous NIH and industry funding for multicenter trials; he founded and directs the UT Clinical Coordinating Center, overseeing regulatory, data, and biostatistical cores for national studies. His administrative leadership spans Department Chair, Heart & Vascular Center Director, and Dean of the College of Medicine, while maintaining an active interventional cardiology practice. Laboratory & Teams: He leads the Cooper Renal & Vascular Research Group within the UT Cardiovascular Research Institute, mentoring faculty, fellows, and graduate students in translational protocols that bridge molecular cardiology, interventional imaging, and large pragmatic trials.

Pabitra Sahooمشاهده پروفایل

استادیار

• Molecular & Cellular Neuroscience
• Localized Protein Synthesis
• Stress Granules
• +۸ مورد دیگر

Pabitra Sahoo is an Assistant Professor in the Department of Biological Sciences at Rutgers University, leading a research group focused on axonal mRNA dynamics and stress granule biology. His work bridges molecular neuroscience and regenerative medicine with direct implications for neural repair mechanisms. His educational background includes: B.S. from Utkal University, India (2005) M.S. from University of Hyderabad, India (2007) Ph.D. from National Centre for Cell Science, University of Pune (2013) Postdoctoral fellowship at Twiss Lab, University of South Carolina (2023) Dr. Sahoo's research centers on stress granules in axons and their dual role in physiological mRNA storage and pathological inhibition of nerve regeneration. His lab investigates how localized protein synthesis mechanisms govern neural repair, neurodevelopment, and neurodegenerative processes through cutting-edge approaches in spatial transcriptomics and axonal biology. Key discoveries include the identification of G3BP1 as a critical regulator of axonal mRNA translation and the demonstration that stress granules exist under normal physiological conditions in neurons. Analysis of his 2021-2025 publications reveals a dominant focus on stress granule disassembly mechanisms (particularly involving G3BP1), RNA-binding protein functions in axonal mRNA stability, and therapeutic targeting of these pathways for nerve regeneration. His work consistently connects fundamental molecular mechanisms to applications in spinal cord injury, peripheral nerve repair, and neurodegenerative conditions like ALS. The Sahoo Lab operates as a collaborative team of "curiosity driven, fun, and coffee loving scientists" investigating how mRNA storage granules respond to neuronal signals. Current projects specifically examine stress granule dynamics in neuronal development models and their dysfunction in neurodevelopmental disorders (e.g., Down syndrome) and neurodegenerative diseases, with therapeutic strategies emerging from multiple patent filings.

Sheng Liمشاهده پروفایل

دانشیار

• Cancer Epigenetics
• Aging
• Clonal Hematopoiesis
• +۳ مورد دیگر

Sheng Li is an Associate Professor of Cancer Biology at the University of Southern California's Keck School of Medicine. She co-leads the Epigenetic Regulation in Cancer Program at the Norris Comprehensive Cancer Center. Her research integrates multi-omics and computational approaches to study epigenetic heterogeneity in blood cancers, aging, and clonal hematopoiesis. Her lab focuses on single-cell spatial multi-omics, 3D epigenomics, and long-read sequencing to map epigenetic drivers of leukemogenesis. Awards include the Leukemia & Lymphoma Society Scholar Award and AACR NextGen Star recognition. She mentors PhD students and postdocs, with her team publishing extensively in high-impact journals. Her publications demonstrate a strong emphasis on computational epigenetics, cancer systems biology, and geroscience. Recent work includes developing tools for spatial transcriptomics interpretation and modeling IDH-mutant AML gene networks.

• Immunology
• Cancer Therapy
• Oncology
• +۳ مورد دیگر

Angelo Porciuncula is an Associate Research Scientist in the Department of Pathology at Yale School of Medicine, affiliated with the Schalper Lab. He holds a PhD from the University of Navarra. His research focuses on immunology, cancer therapy, and stem cell biology, with a particular emphasis on immune microenvironment modulation in oncology and translational drug development. Key projects include studying STING pathway activation via antibody-drug conjugates (e.g., TAK-500) targeting CCR2-expressing myeloid cells, as well as investigating immunotherapeutic biomarkers in lung cancer and glioblastoma. His work spans clinical-stage drug evaluation, tumor immunology, and epigenetic reprogramming of stem cells. Publications highlight contributions to understanding senescence mechanisms in cancer, pancreatic differentiation of iPSCs, and the role of OX40/OX40L pathways in tumor immunity. Porciuncula collaborates widely, including with Kurt Schalper and teams at Takeda Pharmaceuticals. His research bridges basic science and clinical applications, aiming to advance targeted therapies and regenerative medicine strategies.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

Dean Bryantمشاهده پروفایل

مدرس

• Computational Cancer Biology
• Hematology
• Genomics
• +۳ مورد دیگر

Dean Bryant is a Lecturer in Computational Cancer Biology at the University of Southampton. He holds a BSc (Hons) and PhD, and is a Fellow of the Higher Education Academy (FHEA). His research focuses on computational approaches to understanding cancer biology, particularly in hematological malignancies such as leukemia and lymphoma. He is affiliated with the Institute for Life Sciences and the Bioinformatics and Genomics research groups. Current research projects include the Early Cancer Research Initiative Network (ECRIN-M3) funded by Cancer Research UK and studies on SDH-deficient gastrointestinal stromal tumors. Dean supervises PhD students in Cancer Sciences and Biomedicine, and actively contributes to research on tumor immunoglobulin sequencing, genomic landscapes, and metabolic alterations in cancer. His academic background includes roles in bioinformatics and cancer genomics, with a strong emphasis on integrating computational methods with experimental biology. Dean collaborates with institutions such as Wessex Medical Research and maintains active research partnerships within Southampton’s academic community.

Lars Aagaardمشاهده پروفایل

دانشیار

• Gene therapy
• RNA interference
• Viral vectors
• +۱۱ مورد دیگر

Lars Aagaard is an Associate Professor at the Department of Biomedicine - Research and Education, Aarhus University, Denmark. He is based at the Bartholin Building in Aarhus C and is actively engaged in research and teaching in the fields of gene therapy, RNA interference, and genome editing. His work focuses on developing viral vectors, particularly AAV and lentiviral vectors, for ocular gene therapy targeting retinal diseases such as age-related macular degeneration and diabetic retinopathy. His research interests include the development of Dicer-independent RNAi systems, combinatorial gene therapy using microRNA and CRISPR/Cas9, and the delivery of RNA- and protein-based therapeutics. He also teaches Genetics and Personalized Medicine and supervises postdoctoral researchers, PhD, master's, and undergraduate students. The recent publications (2022–2024) reflect a strong trend in RNAi therapeutics, viral vector engineering, and translational applications in ocular and systemic diseases. Themes include gene silencing, immune modulation, and regenerative approaches using engineered cells. Aagaard actively contributes to the scientific community as a reviewer for journals such as Nature and Molecular Therapy . He has participated in key international conferences including ARVO, ASGCT, and ESGCT, demonstrating ongoing engagement with the global gene therapy community. Supervision of postdocs, PhD, master’s, and undergraduate students Active participation in international conferences and workshops Collaborative research across institutions, including Universidade Federal de Sao Paulo He is involved in both basic and translational research, with potential for clinical applications in gene and cell therapy.

ANDREA KASINSKIمشاهده پروفایل

استاد

• Non-coding RNA biology
• MicroRNA therapeutics
• Cancer epigenetics
• +۳ مورد دیگر

Andrea Kasinski is a Professor of Biological Sciences and Deputy Director of the Purdue Institute for Cancer Research at Purdue University. Her research focuses on non-coding RNAs (microRNAs, lncRNAs, circRNAs) in cancer development and their therapeutic applications. She leads a multidisciplinary team investigating RNA delivery systems, extracellular vesicle biology, and epigenetic regulation in cancer. Key projects include ligand-mediated delivery of miRNAs, exosome-based therapies, and high-throughput screens for miRNA inhibitors. Education: PhD in Molecular & Systems Pharmacology (Emory University, 2009), Postdoctoral Fellowship in Genetics (Yale University, 2013). Awards include NIH Pathway to Independence Award (2013), American Cancer Society Research Scholar (2017), and multiple grants from NIH/NCI (R01 CA205420, R01 CA226259). Her lab has pioneered 'FolamiRs' – folate-targeted miRNA therapeutics – and developed novel strategies for endosomal escape of RNA payloads. Major contributions include identifying miRNA drivers of drug resistance, demonstrating exosome-mediated tumor progression, and advancing miR-34a as a clinical candidate. The lab maintains active collaborations with institutions including Harvard Medical School, MD Anderson Cancer Center, and the National Cancer Institute. Current initiatives focus on KMT5C-mediated epigenetic regulation in EGFR-resistant lung cancers and translational development of fully modified miR-34a (FM-miR-34a).

Laura Fonkenمشاهده پروفایل

دانشیار

• Neuroimmunology
• Circadian Rhythms
• Aging and Neurodegeneration
• +۵ مورد دیگر

Laura Fonken, Ph.D. is an Associate Professor of Pharmacology & Toxicology at the University of Texas at Austin's College of Pharmacy. She holds the prestigious Lonnie F. Hollingsworth, Sr. Centennial Fellowship in Pharmacy and leads an active research laboratory focused on neuroimmunology. Dr. Fonken's research broadly investigates how interactions among the immune, nervous, and endocrine systems regulate complex behavioral processes such as cognitive and mood-related behaviors. Her lab particularly focuses on two main research directions: (1) Targeting neuroinflammatory responses in the aged brain to improve cognitive function, and (2) Understanding the mechanisms by which the circadian system regulates neuroimmune function across the lifespan. Her work centers on microglia, the brain's resident immune cells, and how they shape behavior across the lifespan through endogenous factors like circadian rhythms and aging, as well as exogenous factors such as environmental pollutants, infection, and injury. Her research has identified that microglia become more reactive or 'primed' over an animal's lifespan, worsening outcomes when immune challenges are encountered. Her lab is investigating mechanisms by which Mycobacterium vaccae vaccination prevents exacerbated neuroinflammatory and behavioral deficits in aging, supported by NIH R01 AG062716. She is also examining how circadian rhythms in immune cell trafficking become disrupted with age and Alzheimer's Disease-like pathology, supported by NIH R01 AG078758. Dr. Fonken's publications reveal a strong focus on neuroimmunology, circadian biology, and aging. Her work demonstrates significant contributions to understanding sex differences in microglial function, the impact of hormonal changes on neuroinflammation, and the therapeutic potential of immunomodulation for age-related cognitive decline. Lonnie F. Hollingsworth, Sr. Centennial Fellowship in Pharmacy NIH R01 AG062716 grant NIH R01 AG078758 grant Dr. Fonken actively mentors graduate students across multiple programs, including Pharmaceutical Sciences (Division of Pharmacology & Toxicology) and Neuroscience (Institute for Neuroscience). Her lab has successfully graduated two PhD students (Dr. Kevin Sanchez and Dr. Rachel Chen in 2023) and currently mentors several graduate students including Kate Davis, Brandy Routh, Kiersten Bell, Drew Hynes, and Kate Callahan. She has successfully guided her students to win numerous prestigious awards including the CCST Science & Technology Policy Fellowship, NIH predoctoral fellowships, and national competition wins. The Fonken Lab maintains an active research presence with collaborations across disciplines and participation in major conferences including the Society for Neuroscience and the International Behavioral Neuroscience Society.

Justin Chu Jang Hannمشاهده پروفایل

دانشیار

• Molecular RNA Virology
• Antiviral Strategies
• Viral Pathogenesis
• +۳ مورد دیگر

Associate Professor Justin Chu Jang Hann is affiliated with the Department of Microbiology and Immunology at the National University of Singapore (NUS), within the Yong Loo Lin School of Medicine. He holds additional roles as Assistant Dean (Academic Affairs) in the School of Medicine, Director of the NUS Medicine BSL-3 & ABSL-3 Core Facility, and Joint Senior Principal Investigator at the Institute of Molecular and Cell Biology (IMCB) A*STAR. His research focuses on molecular RNA virology, antiviral strategies, and high-throughput imaging technologies to study host-pathogen interactions. Key projects include genomic screening of viral-host interactions, high-content bio-imaging platforms, and development of anti-viral compounds against pathogens like SARS-CoV-2, dengue, and enteroviruses. Recent work explores broad-spectrum antivirals, vaccine candidates, and diagnostic approaches for viral infections. His contributions span virology, immunology, and translational medicine, with a strong emphasis on combating emerging and re-emerging RNA viruses.

• Cellular quiescence
• Metabolic regulation
• Cancer metabolism
• +۴ مورد دیگر

Professor Hilary Coller holds joint appointments in Molecular, Cell and Developmental Biology and Biological Chemistry at UCLA. Her NIH-funded research explores cellular quiescence mechanisms, metabolic adaptations in dormant states, and stromal contributions to cancer progression. She currently serves as Editor-in-Chief of Physiological Genomics. Research domains: Metabolic regulation of quiescent stem cells Epigenetic control of cell cycle transitions MicroRNA networks in proliferation arrest Cancer-associated fibroblast biology Her laboratory developed novel biosensing technologies for in vivo metabolomics and contributed fundamental insights into mitochondrial regulation of cell cycle checkpoints. Educational leadership includes directing undergraduate genomics research programs.

• Non-coding RNA
• Gene Expression
• Developmental Biology
• +۶ مورد دیگر

Matthew Ronshaugen is a Senior Lecturer in the Division of Developmental Biology & Medicine (L5) at the Faculty of Life Sciences, University of Manchester. He has held academic positions since 2007 as a Manchester Fellow, followed by Lecturer (2012-2017), and Senior Lecturer since 2017. 1991-1995: Bachelor of Arts in Philosophy and Linguistics, University of Nevada, Las Vegas 1995-1997: Master of Science in Systematics, University of Nevada, Las Vegas 1997-2002: Doctor of Philosophy in Cell and Molecular Biology, University of California, San Diego 2003-2007: Ruth L. Kirschstein NIH Postdoctoral Fellow at University of California, Berkeley His research focuses on non-coding RNAs (ncRNAs), particularly their roles in gene expression and developmental differentiation. His lab investigates how ncRNA evolution contributes to metazoan body plan diversification, centering on the Hox complex—a conserved genomic region rich in ncRNAs. He uses tiling microarrays and fluorescent in situ hybridization to analyze ncRNA dynamics in Drosophila, Tribolium, and Parhyale. Recent publications highlight his work on miRNA functions in embryonic development, aging-related changes in myeloid cells, and comparative transcriptomics across arthropods. His team employs genetics tools to dissect ncRNA roles in transcriptional regulation, epigenetic control, and silencing mechanisms. Scientific Awards: Ruth L. Kirschstein NIH Postdoctoral Fellow Manchester Fellow He supervises research on developmental transcriptomes and contributes to datasets on piRNA expression and Hox complex analysis. Collaborations span immunology, genomics, and evolutionary development, with outputs cited in fields like RNA interference, transgenics, and wound healing.

Dorothy Teegardenمشاهده پروفایل

استاد

• Breast Cancer
• Obesity
• Cellular Energy Metabolism
• +۶ مورد دیگر

Dorothy Teegarden is a Professor in the Department of Nutrition Science at Purdue University . She serves as Director of the Women's Global Health Institute and Associate Director of the Purdue Institute for Cancer Research , leading the Cancer Education and Research Training Program. Her research spans breast cancer , obesity , and cellular energy metabolism , with a focus on dietary targets like vitamin D and calcium . Education : PhD in Human Nutrition (University of Chicago, 1987), Postdoctoral Fellowships at Purdue University (1987–1993) Her work integrates lipid metabolism , vitamin D , and pyruvate carboxylase in cancer progression, supported by NIH and USDA grants. Recent publications highlight metabolic shifts in metastatic breast cancer and interdisciplinary collaborations across biologists , engineers , and educational specialists . Key Awards : Outstanding Cancer Research Award (2023) Violet Haas Award (2022) Purdue University Faculty Scholar (2011–2016) She directs educational programs like the Cancer Prevention Internship Program (CPIP) and Transdisciplinary Obesity Prevention Research (TOPRs) , emphasizing interdisciplinary training and undergraduate research .