جست‌وجوی استاد و پژوهشگر

Lin Heمشاهده پروفایل

استاد

• Non-coding RNA Research
• Cancer Biology
• Stem Cell Biology
• +۳ مورد دیگر

Lin He is the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research and Professor of Cell Biology and Physiology at the University of California, Berkeley. His laboratory focuses on understanding the biological functions of non-coding RNAs in development and disease, with particular emphasis on microRNAs (miRNAs) in cancer, stem cell biology, and developmental processes. He developed the CRISPR-EZ method for highly efficient mouse genome editing, significantly advancing genetic research. Research interests include miRNAs' roles in tumor progression, metastasis, and pluripotency regulation in stem cells. His work bridges mouse genetics, genomics, and molecular biology to uncover mechanisms governing non-coding RNA functions. Current projects address miRNAs in oncogenesis, stem cell fate determination, and the interplay between non-coding RNAs and retrotransposons in development. Key contributions include identifying miRNA networks in cancer pathways, demonstrating miRNA requirements for ciliogenesis and lung development, and advancing CRISPR-based genome editing techniques. His interdisciplinary approach integrates genetic, genomic, and cellular tools to explore fundamental questions in biology and medicine. Lab website: helabucb.org CRISPR-EZ technology enables 100% genome editing efficiency in mouse zygotes Pioneering studies on miRNA regulation of PTEN, p53, and oncogene pathways

Pillai Ramesh Shanmughomمشاهده پروفایل

استاد

• Epigenetics
• RNA modifications
• miRNAs
• +۵ مورد دیگر

Ramesh Shanmughom Pillai is a Full Professor at the Department of Molecular Biology, University of Geneva, Switzerland. He holds additional roles as a Visiting Professor at the University of Kumamoto, Japan, and has been a Group Leader at EMBL Grenoble and a postdoctoral fellow at the Friedrich Miescher Institute. His research focuses on RNA modifications, epigenetics, and piRNA pathways in germline biology. Pillai has received prestigious awards including the ERC Consolidator Grant and The RNA Society Scaringe Award. Education: BSc Botany (University of Kerala, India) MSc Biotechnology (IIT Roorkee, India) PhD in Cell Biology (University of Bern, Switzerland) Research Interests: Pillai’s work centers on RNA biology, particularly the role of RNA modifications (e.g., m6A, m6Am) in development and fertility. He investigates piRNA biogenesis, transposon silencing, and the molecular mechanisms of RNA-protein interactions. His studies bridge biochemistry, genetics, and structural biology to elucidate how RNA molecules regulate critical biological processes. Teaching & Service: At the University of Geneva, he teaches Molecular Biology courses (BSc/MSc levels) and advises 5 PhD students and 4 postdocs. He chairs the ERC Consolidator Grant Review Panel and organizes major conferences like the PIWI/piRNAs Meeting and Swiss RNA Workshop. Pillai also serves on editorial boards for Nucleic Acids Research and RNA . Awards: ERC Consolidator Grant (2015) Best PhD Thesis Award (2003) RNA Society Scaringe Award (2005) Grants & Labs: Funded by ERC Starting and Consolidator Grants, his lab explores RNA modification networks in germ cells. Former trainees include Professors Simon Conn (Flinders University) and Hao Wu (CAS, China).

• RNA Metabolism
• Non-coding RNAs
• Cancer Metastasis
• +۳ مورد دیگر

Claudio R. Alarcón is an Associate Professor in Pharmacology at Yale University School of Medicine. His research focuses on RNA metabolism's role in development, health, and disease, particularly RNA modifications and non-coding RNAs. He joined Yale in 2017 after postdoctoral training at The Rockefeller University and holds a PhD from Cornell University (2009) and a BSc from Pontificia Universidad Católica de Chile (1999). Research Interests: Functional roles of m6A RNA modifications MicroRNA biogenesis and cancer progression Non-coding RNA regulation in metastasis Key Appointments: Primary Faculty, Yale Cancer Biology Institute Member, Yale Cancer Center Faculty, Yale Combined Program in Biological and Biomedical Sciences His lab integrates bioinformatics, molecular, and cellular approaches to study cancer metastasis mechanisms, including miRNA processing disruptions and SOX4/TMEM2 pathways linked to clinical outcomes.

Michael Boutrosمشاهده پروفایل

استاد

• Functional Genomics
• Structural Genomics
• Wnt Signaling
• +۷ مورد دیگر

Michael Boutros is a Full Professor at Heidelberg University and Head of Division at the German Cancer Research Center (DKFZ). He currently serves as Dean of the Medical Faculty at Heidelberg University (since 2023) and Director of the Marsilius Kolleg (since 2020). He has held leadership roles including Coordinator of the Functional and Structural Genomics Program at DKFZ (2014–2023) and Acting Scientific Director (2015–2016). His academic base is within the Medical Faculty, focusing on molecular oncology and functional genomics. PhD, Witten/Herdecke University (1993–1996) Postdoctoral Research, Harvard Medical School (1999–2003) MPA, John F. Kennedy School of Government, Harvard University (1999–2001) Additional training: Cold Spring Harbor Laboratory, SUNY Stony Brook His research centers on Wnt signaling, functional genomics, and cancer pathways. He leads major research initiatives such as CRC 1324 on Wnt signaling and the ERC Synergy Grant DECODE. His work integrates high-throughput screening, CRISPR, and systems biology to dissect signaling networks in cancer and development. He has pioneered genome-wide RNAi and CRISPR screens to identify novel regulators of Wnt signaling across models. The 15 most recent articles reflect a strong focus on Wnt pathway regulation using functional genomics in both Drosophila and mammalian systems. Themes include high-throughput screening, CRISPR-based validation, cross-species conservation, and therapeutic targeting. Keywords span Cancer Biology, Systems Biology, and Signal Transduction, with subfields like RNAi, ubiquitination, stem cell regulation, and machine learning in image analysis. Michael Boutros has received numerous scientific honors: Elected member, Leopoldina National Academy of Sciences (2022) Elected member, Heidelberg Academy of Sciences (2022) EMBO Member (2013) ERC Advanced Grant (2012) Johann-Georg Zimmermann Research Award (2007) EMBO Young Investigator (2005) Member, 'Die Junge Akademie' (2003) He has been a recipient of the Emmy-Noether Program, McCloy Fellowship, Boehringer Ingelheim PhD Fellowship, Studienstiftung Fellowship, and Fulbright Fellowship. As a mentor and research leader, he has supervised numerous early-career scientists and coordinated large collaborative grants including the FP7 'CancerPathways' project. He currently serves as Speaker of the Research and Strategy Commission at Heidelberg University and Managing Director of the Health and Life Science Alliance Heidelberg Mannheim. He leads the CRC 1324 on Wnt signaling and is Coordinating PI of the ERC Synergy Grant DECODE. He is also Spokesperson of DFG Research Group 1036 and Coordinator of the former FP7 Coordinated Project 'CancerPathways'. His lab employs cutting-edge functional genomics tools to decode signaling networks in cancer and development.

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Anne G Hoenمشاهده پروفایل

دانشیار

• Microbiome research
• Epidemiology
• Environmental health
• +۷ مورد دیگر

Anne G Hoen is an Associate Professor at the Geisel School of Medicine , Dartmouth College, with joint appointments in Epidemiology , Biomedical Data Science , and Microbiology and Immunology . Her research focuses on microbiome development in infants, environmental exposures, and their associations with health outcomes, using interdisciplinary approaches including statistical modeling and bioinformatics. Research Interests: She explores how microbial communities in early life influence disease risk through environmental and dietary factors. Her work integrates microbiome-metabolome interactions, computational methods for microbial network analysis, and epidemiological studies of infectious diseases. Recent Article Trends: 2025-2024 publications highlight maternal diet-microbiome links, microbial interaction networks, ECHO consortium collaborations, and novel computational approaches for microbiome data. Key sub-fields include perinatal exposome, microRNA profiling, and longitudinal metabolomic analysis. Scientific Awards: K01LM011985: Bioinformatics strategies for early life microbiomics R01LM012723: Multi-omic functional integration using networks Advising: Mentors current PhD students in Dartmouth's Quantitative Biomedical Sciences (QBS) program, including Becky Lebeaux and Quang Nguyen, while alumni like Sara Lundgren and Wes Viles hold postdoctoral and academic positions.

• Extracellular Vesicles
• Biomarker Discovery
• Exosome Biology
• +۷ مورد دیگر

Carlos Salomon Gallo is a Professor and NHMRC Investigator Fellow (EL2) at The University of Queensland's Centre for Clinical Research, affiliated with the School of Biomedical Sciences. He directs the Centre for Extracellular Vesicle Nanomedicine and leads the Exosome Biology Laboratory. A globally recognized key opinion leader in extracellular vesicles (ranked 3rd worldwide by Expertscape), his research focuses on EV biology for diagnostic and therapeutic applications in ovarian cancer, gestational diabetes, preeclampsia, and other obstetrical syndromes. His research integrates proteomics (SWATH-MS), miRNA analysis, and advanced isolation techniques to develop liquid biopsies. Core interests include: EV biomarker discovery and validation for early disease detection. Mechanisms of EV-mediated signaling in metabolic and oncological pathologies. Engineering EVs for targeted drug delivery and CRISPR-Cas therapeutics. Clinical translation of EV-based diagnostics (IVDs) and therapeutics. Analysis of his recent articles reveals a dominant focus on EV profiling in pregnancy complications (gestational diabetes, preeclampsia) and oncology (ovarian cancer), utilizing multi-omics approaches. Key trends include developing high-sensitivity EV biosensors, understanding hypoxia-induced EV signaling, and exploring 3D models for EV research. He has received significant recognition, including: NHMRC Emerging Leadership Fellow NHMRC Investigator Fellow (EL2) He leads the Exosome Biology Laboratory and the UQ Centre for Extracellular Vesicle Nanomedicine, fostering cross-disciplinary collaboration. His work involves extensive national and international partnerships, evidenced by leadership roles in the Centre for Clinical Diagnostics and over 20 invited international talks in 5 years. He actively mentors HDR students and contributes to global EV research standards (MISEV2023).

Zhi-Ping Fengمشاهده پروفایل

پژوهشگر

• Bioinformatics
• Genomics
• Proteomics
• +۳ مورد دیگر

Dr. Zhi-Ping Feng is a Bioinformatician at the John Curtin School of Medical Research (JCSMR), Australian National University (ANU). Her research focuses on integrating omics data with protein structure-function relationships to study interactions between macromolecules. She has expertise in analyzing genomic and transcriptomic data (e.g., RNA-Seq, ChIP-Seq) and protein structure determination via nuclear magnetic resonance (NMR) spectroscopy. Previously, she held a Senior Research Fellow position at the Walter and Eliza Hall Institute (WEHI) from 2009, working on quality control in omics research and genomic data analysis. Her postdoctoral work at WEHI (2002–2005) involved structural biology of malaria-related proteins, supported by an Australian Postdoctoral Fellowship. She holds a PhD in protein bioinformatics from China and a physics background from Peking University. Education: PhD in Protein Bioinformatics (China) Bachelor’s in Physics, Peking University Research Interests: Her work bridges computational biology and structural biology, with emphasis on: Intrinsically unstructured proteins (IUPs) and their applications in malaria proteomics Omics data integration for disease modeling (e.g., cancer, diabetes, neurodegeneration) Protein-protein interaction networks and structural bioinformatics Publications: Recent work spans cancer immunotherapy, miRNA regulation in retinal degeneration, and T cell biology, with contributions to understanding Wnt signaling in joint replacement complications and genetic fusions in pediatric brain tumors. Awards: Australian Postdoctoral Fellowship (2005) Grants/Teams: Currently affiliated with ANU Bioinformatics Consultancy, supporting translational medical research in immunology, cancer, and genomics. Labs/Teams: Collaborates with the JCSMR’s multidisciplinary teams focusing on biomedical informatics and translational research.

Christopher S. Sullivanمشاهده پروفایل

استاد

• Virology
• Non-coding RNA Biology
• RNA Interference
• +۵ مورد دیگر

Christopher S. Sullivan is a Professor in the Department of Molecular Biosciences within the College of Natural Sciences at the University of Texas at Austin. He directs an active research laboratory focused on viral non-coding RNA biology and host-pathogen interactions, with continuous funding evidenced by publications spanning 2005-2025. His work bridges molecular virology, immunology, and RNA biology through investigations of tumor viruses and host defense mechanisms. Research interests center on the role of non-coding RNAs in viral infection and host defense pathways, with particular emphasis on viral microRNAs , RNA interference mechanisms , and host-pathogen coevolution . His lab studies diverse virus families including Polyomaviridae, Herpesviridae, Retroviridae, and avipoxviruses, with key discoveries regarding viral miRNA functions in tumorigenesis and immune evasion. Research approaches integrate molecular virology, next-generation sequencing, and computational analysis to dissect RNA-based regulatory networks. Publications reveal consistent focus on viral non-coding RNA functions, particularly how viruses exploit host RNA machinery (notably DUSP11 phosphatase) to modulate immune responses. Recent work (2021-2025) expands into viral shedding dynamics, SARS-CoV-2 diagnostics, and circular RNA biology in polyomaviruses, demonstrating evolving yet cohesive research trajectory in RNA-virus interactions. Scientific contributions include: Pioneering identification of viral microRNAs across multiple virus families Discovery of DUSP11's critical role in RNA triphosphate regulation during infection Mechanistic insights into viral evasion of RNAi and innate immunity Development of novel RNA-based detection methods The Sullivan lab maintains active collaborations through the Center for Systems and Synthetic Biology, John Ring LaMontagne Center for Infectious Disease, and Interdisciplinary Life Sciences Graduate Programs. Lab culture emphasizes collective scientific inquiry with stated mission to 'increase understanding of pathogen-host interactions while enjoying the company of fellow lab members.' Current research directions include viral exploitation of RNA modification pathways and identification of novel host defense mechanisms using viruses as 'molecular divining rods.'

Sheng Liمشاهده پروفایل

دانشیار

• Cancer Epigenetics
• Aging
• Clonal Hematopoiesis
• +۳ مورد دیگر

Sheng Li is an Associate Professor of Cancer Biology at the University of Southern California's Keck School of Medicine. She co-leads the Epigenetic Regulation in Cancer Program at the Norris Comprehensive Cancer Center. Her research integrates multi-omics and computational approaches to study epigenetic heterogeneity in blood cancers, aging, and clonal hematopoiesis. Her lab focuses on single-cell spatial multi-omics, 3D epigenomics, and long-read sequencing to map epigenetic drivers of leukemogenesis. Awards include the Leukemia & Lymphoma Society Scholar Award and AACR NextGen Star recognition. She mentors PhD students and postdocs, with her team publishing extensively in high-impact journals. Her publications demonstrate a strong emphasis on computational epigenetics, cancer systems biology, and geroscience. Recent work includes developing tools for spatial transcriptomics interpretation and modeling IDH-mutant AML gene networks.

Mansoureh Eghbaliمشاهده پروفایل

استاد

• Pulmonary Hypertension
• Myocardial Ischemia-Reperfusion Injury
• Sex Differences in Cardiovascular Disease
• +۳ مورد دیگر

Mansoureh Eghbali, PhD, is a Professor in the Department of Anesthesiology at the David Geffen School of Medicine, University of California, Los Angeles. Her research program investigates molecular mechanisms of cardiovascular and pulmonary diseases with emphasis on sex-specific pathophysiology. She leads an active NIH-funded laboratory focused on pulmonary hypertension, myocardial ischemia-reperfusion injury, and the role of RNA-binding proteins in vascular remodeling. Her research integrates multiomics approaches to explore: Sex chromosome influences (Y-gene Uty) in pulmonary vascular protection MicroRNA regulation of cardiac fibrosis and calcification (e.g., miR-129-5p/Asporin axis) Gut-heart-lung interactions in diet-induced pulmonary hypertension Endothelial subpopulations (TM4SF1+) in disease progression Analysis of her recent publications reveals strong emphasis on: Integrative multiomics in vascular diseases Sex differences in drug responses Novel therapeutic targeting of RNA-binding proteins Cross-organ communication in cardiopulmonary pathologies She directs multiple NIH grants including: R01HL159865: Role of Chromosome Y gene, Uty (2021-2025) R01HL147586: Role of miR125 in pulmonary hypertension (2019-2023) R01HL129051: Role of miR193 in oxidized lipid-induced PH (2016-2021) R01HL131182: Epigenetic regulation by X chromosome (2016-2021)

ANDREA KASINSKIمشاهده پروفایل

استاد

• Non-coding RNA biology
• MicroRNA therapeutics
• Cancer epigenetics
• +۳ مورد دیگر

Andrea Kasinski is a Professor of Biological Sciences and Deputy Director of the Purdue Institute for Cancer Research at Purdue University. Her research focuses on non-coding RNAs (microRNAs, lncRNAs, circRNAs) in cancer development and their therapeutic applications. She leads a multidisciplinary team investigating RNA delivery systems, extracellular vesicle biology, and epigenetic regulation in cancer. Key projects include ligand-mediated delivery of miRNAs, exosome-based therapies, and high-throughput screens for miRNA inhibitors. Education: PhD in Molecular & Systems Pharmacology (Emory University, 2009), Postdoctoral Fellowship in Genetics (Yale University, 2013). Awards include NIH Pathway to Independence Award (2013), American Cancer Society Research Scholar (2017), and multiple grants from NIH/NCI (R01 CA205420, R01 CA226259). Her lab has pioneered 'FolamiRs' – folate-targeted miRNA therapeutics – and developed novel strategies for endosomal escape of RNA payloads. Major contributions include identifying miRNA drivers of drug resistance, demonstrating exosome-mediated tumor progression, and advancing miR-34a as a clinical candidate. The lab maintains active collaborations with institutions including Harvard Medical School, MD Anderson Cancer Center, and the National Cancer Institute. Current initiatives focus on KMT5C-mediated epigenetic regulation in EGFR-resistant lung cancers and translational development of fully modified miR-34a (FM-miR-34a).

• Non-coding RNA
• Gene Expression
• Developmental Biology
• +۶ مورد دیگر

Matthew Ronshaugen is a Senior Lecturer in the Division of Developmental Biology & Medicine (L5) at the Faculty of Life Sciences, University of Manchester. He has held academic positions since 2007 as a Manchester Fellow, followed by Lecturer (2012-2017), and Senior Lecturer since 2017. 1991-1995: Bachelor of Arts in Philosophy and Linguistics, University of Nevada, Las Vegas 1995-1997: Master of Science in Systematics, University of Nevada, Las Vegas 1997-2002: Doctor of Philosophy in Cell and Molecular Biology, University of California, San Diego 2003-2007: Ruth L. Kirschstein NIH Postdoctoral Fellow at University of California, Berkeley His research focuses on non-coding RNAs (ncRNAs), particularly their roles in gene expression and developmental differentiation. His lab investigates how ncRNA evolution contributes to metazoan body plan diversification, centering on the Hox complex—a conserved genomic region rich in ncRNAs. He uses tiling microarrays and fluorescent in situ hybridization to analyze ncRNA dynamics in Drosophila, Tribolium, and Parhyale. Recent publications highlight his work on miRNA functions in embryonic development, aging-related changes in myeloid cells, and comparative transcriptomics across arthropods. His team employs genetics tools to dissect ncRNA roles in transcriptional regulation, epigenetic control, and silencing mechanisms. Scientific Awards: Ruth L. Kirschstein NIH Postdoctoral Fellow Manchester Fellow He supervises research on developmental transcriptomes and contributes to datasets on piRNA expression and Hox complex analysis. Collaborations span immunology, genomics, and evolutionary development, with outputs cited in fields like RNA interference, transgenics, and wound healing.

C. Brooks Mobleyمشاهده پروفایل

استادیار بالینی

• Skeletal Muscle Physiology
• Molecular Mechanisms of Exercise Training
• Sports Supplements
• +۳ مورد دیگر

Dr. C. Brooks Mobley is an Assistant Clinical Professor at the School of Kinesiology, Auburn University. He directs the TigerFit Health & Fitness Laboratory and serves as Associate Director of the Nutrabolt Applied and Molecular Physiology Lab. With a Ph.D. in Kinesiology from Auburn University and postdoctoral training at the University of Kentucky, he specializes in skeletal muscle physiology and sports nutrition research. B.S. in Animal & Dairy Sciences (Auburn University) M.Ed. in Exercise Physiology (Auburn University) Ph.D. in Kinesiology (Auburn University) Postdoctoral Fellowship at University of Kentucky's College of Medicine His research explores molecular mechanisms of muscle plasticity, focusing on: Cellular adaptations to exercise training Ergogenic effects of sports supplements Muscle atrophy prevention strategies Mechanisms of skeletal muscle hypertrophy Angiogenesis in recovery scenarios Muscle-bone interaction dynamics Recent publications demonstrate expertise in: Mitochondrial adaptations to resistance training Epigenetic regulation of muscle growth Microbiome-exercise interactions Proteomic responses to disuse atrophy Firefighting occupational physiology Supplement efficacy studies Laboratory Leadership: TigerFit Health & Fitness Laboratory Nutrabolt Applied and Molecular Physiology Lab

Ayesha Aliمشاهده پروفایل

استاد

• Graphical Markov models
• Pollination networks
• Multivariate statistics
• +۷ مورد دیگر

Ayesha Ali is a Professor of Statistics and Director of the Master of Data Science program at the University of Guelph. She holds a PhD in Statistics from the University of Washington (2002) and has expertise in statistical methods for complex high-dimensional systems, including ecological networks, causal inference, and bioinformatics. Her research integrates graphical Markov models, machine learning, and statistical computing to address challenges in plant-pollinator networks, livestock genetics, and disease risk modeling. Education: B.Sc. Honours in Statistics and Actuarial Science, University of Western Ontario (1996) M.Sc. in Statistics, University of Toronto (1998) Ph.D. in Statistics, University of Washington (2002) Research Interests: Graphical Markov models and ecological networks Causal inference and longitudinal data analysis Machine learning and high-dimensional predictive modeling Statistical methods for livestock genetics and animal health Computational statistics and bioinformatics Articles Trends: Her recent work spans interdisciplinary applications, including veterinary oncology biomarker discovery, remote sensing for agricultural suitability, and pipeline development for cross-species transcriptomics. She emphasizes graphical structure exploitation in regression and predictive modeling, with contributions to both theoretical and applied statistical methodologies. Awards: Canadian Journal of Statistics Award (2020) for groundbreaking work on doubly sparse regression NSERC Discovery Grant (2018) NSERC Collaborative Research and Development Grant (2015) Advising & Grants: She has supervised numerous graduate and undergraduate students on projects ranging from plant-pollinator network analysis to bioinformatics. Her grants include NSERC-funded research on milk fatty acid genetics and statistical methods for clustered data. Labs/Teams: Involved in the Bioinformatics program at the University of Guelph, contributing to interdisciplinary research collaborations in ecology and animal science.