جستجوی استاد راهنمای دانشگاهی

Rotem Karniمشاهده پروفایل

دانشیار

• Alternative RNA Splicing
• RNA Biology
• Cancer Therapy
• +۴ مورد دیگر

Rotem Karni, PhD, is an Associate Professor of Genetics at the Perelman School of Medicine, University of Pennsylvania, Philadelphia. He leads a research lab focused on understanding how alternative RNA splicing contributes to cancer and genetic diseases, with a strong emphasis on translating these findings into RNA-based therapies. Karni's lab develops decoy oligonucleotides, small molecules, and splice-switching technologies to modulate splicing factors and enhance immunotherapy. Education BSc in Biological Chemistry from The Hebrew University of Jerusalem (1997) PhD in Biological Chemistry from The Hebrew University of Jerusalem, Israel (2002) Postdoctoral Fellowship at Cold Spring Harbor Laboratory, NY (2002-2007) Karni's research explores the deregulation of alternative splicing in oncogenesis, particularly how splicing factors like RBFOX2 and S6K1 influence metastasis, DNA repair, and immune checkpoint modulation. His team investigates m6A RNA modifications for stabilizing mutant genes, with applications in Duchenne Muscular Dystrophy and pancreatic cancer. The lab's work is commercialized through biotech companies: SKIP Therapeutics, Andlit Therapeutics, and RNAble. Selected Research Trends RNA mis-splicing and neoantigen generation (2025) Splicing factor inhibition for tumor suppression (2023) Metastatic splicing signatures in pancreatic cancer (2023) Immune checkpoint splicing in cancer immunotherapy (2021) m6A modulation for mRNA stabilization (2023) Advising & Collaborations Karni has mentored numerous PhD and postdoctoral researchers, many of whom now hold leadership roles in academia, biotech, and medical institutions globally. His lab collaborates extensively on projects involving RNA innovation, including partnerships with the Institute for RNA Innovation. Contact Department of Genetics & Institute for RNA Innovation, One uCity Square, Room 4018, Philadelphia, PA 19104 Phone: 215-898-5072 Email: Rotem.Karni@Upenn.edu

Miler T. Leeمشاهده پروفایل

دانشیار

• Gene Regulation
• Developmental Biology
• Computational Genomics
• +۹ مورد دیگر

Miler T. Lee is an Associate Professor at the University of Pittsburgh , focusing on gene regulation during early embryonic development through high-throughput experimental and computational genomics. He earned his Ph.D. in Genomics and Computational Biology in 2009 from the University of Pennsylvania under Dr. Junhyong Kim, followed by postdoctoral work with Dr. Antonio Giraldez at Yale University. Joining the university in 2016, his research spans maternal-to-zygotic transition (MZT), RNA stability, pluripotency networks, and evolutionary developmental biology, utilizing model organisms like zebrafish, Xenopus, and Hydractinia symbiolongicarpus. Key Research Themes: Maternally inherited RNA dynamics during embryogenesis Mechanisms of RNA degradation and transcriptome remodeling Evolution of pluripotency networks in hybrid species Role of zinc signaling in fertilization barriers Computational tools for RNA regulation and sensing Scientific Awards: Pan-American Society for Evolutionary Developmental Biology Junior Faculty Award (2024) Outstanding New Investigator – International Xenopus Board (2023) Basil O'Connor Scholar – March of Dimes (2017-2019) Recent publications highlight his work on enhancer classification, RNA degradation mechanisms, and cross-species MZT comparisons. His lab develops innovative methods like RESA for regulatory sequence analysis and studies evolutionary divergence in RNA localization patterns. While the articles span computational and experimental approaches, they consistently address RNA's role in cellular identity, developmental timing, and evolutionary adaptation. Applications include understanding pluripotency, designing RNA biosensors, and elucidating fertilization barriers. Prospective Ph.D. students are encouraged to contact him for opportunities in gene regulation, development, evo-devo, and computational genomics.

Catherine Marlerمشاهده پروفایل

استاد

• Behavioral Neuroendocrinology
• Animal Behavior
• Social Neuroscience
• +۷ مورد دیگر

Catherine Marler is a Professor in the Department of Psychology at the University of Wisconsin-Madison, where she leads the Marler Lab focused on the Biology of Brain and Behavior. Her research program investigates the intricate connections between endocrine systems and social behaviors, with particular emphasis on how hormones like testosterone and oxytocin shape complex social interactions in monogamous mammals. Dr. Marler's research primarily utilizes the California mouse (Peromyscus californicus) as a model organism, capitalizing on its unique monogamous, biparental, and territorial nature. Her work spans both laboratory and field settings, allowing for comprehensive investigation of neuroendocrine mechanisms in naturalistic contexts. Key research themes include the role of testosterone in territorial behavior and winner effects, oxytocin's influence on pair bonding and parental behavior, and the neural substrates of ultrasonic vocalizations. Recent publications reveal a strong focus on conditioned place preferences related to testosterone pulses, oxytocin's effects on social behaviors across different developmental stages, and the neuroendocrine mechanisms underlying aggression and pair bonding. Her work demonstrates how social experience, environmental context, and endocrine systems interact to shape complex behavioral outcomes, with particular attention to sex differences and transgenerational transmission of behaviors. Dr. Marler has published extensively in top journals including Hormones and Behavior, Proceedings of the Royal Society, and Animal Behaviour, with her most recent work appearing in high-impact venues throughout 2023-2025. Her research program represents a sophisticated integration of behavioral observation, endocrine manipulation, and neural analysis to unravel the mechanisms underlying social behavior in mammals. As an advisor, Dr. Marler mentors students in behavioral neuroscience and endocrinology, fostering research that bridges laboratory and field approaches to understand the evolution and mechanisms of social behavior. Her lab maintains a strong commitment to rigorous scientific methodology and innovative experimental design in the study of neuroendocrine-behavior relationships.

Manuela Truebanoمشاهده پروفایل

مدرس

• Marine Molecular Biology
• Ecophysiology
• Climate Change Adaptation
• +۳ مورد دیگر

Dr Manuela Truebano is a Lecturer in Marine Molecular Biology at the University of Plymouth, affiliated with the School of Biological and Marine Sciences (part of the Faculty of Science and Engineering). She holds a BSc in Marine Biology from the University of Liverpool, an MSc in Shellfish Biology from Bangor University, and a PhD in Molecular Ecophysiology (focusing on thermal stress) from Swansea University and the British Antarctic Survey. Her research group is part of the Ecophysiology and Development Research group within the Marine Biology and Ecology Research Centre. Her teaching portfolio includes module leadership roles in Marine Molecular Biology, Ecophysiology of Marine Animals, Conservation Physiology, and field courses. She has supervised two postgraduate research degrees: Michael Collins (PhD, 2019) and George Mason (ResM, 2021). Dr Truebano’s research focuses on thermal tolerance, hypoxia, and environmental stress responses in marine organisms, particularly invertebrates. She employs molecular and physiological approaches to study climate change impacts, including the development of tools like Dev-ResNet and HeartCV for automated phenotyping. Her work intersects with global sustainability goals, emphasizing organismal resilience to environmental shifts. Her recent publications highlight advancements in understanding transgenerational plasticity, thermal acclimation, and the interplay of multiple stressors. Teaching and learning grants include a 2015 initiative exploring video tutorials for lab skill training. She collaborates extensively in interdisciplinary projects, contributing to both academic and applied marine science.

Marco Contiمشاهده پروفایل

استاد

• Reproductive Biology
• Oocyte Development
• Signal Transduction
• +۳ مورد دیگر

Dr. Marco Conti is the Fred Gellert Endowed Professor at the University of California San Francisco (UCSF) School of Medicine, where he serves in the Department of Obstetrics, Gynecology and Reproductive Sciences. He previously directed the Center for Reproductive Sciences at UCSF, a leading institution in reproductive biology research. Dr. Conti received his M.D. from the University of Rome School of Medicine in 1974, followed by postdoctoral training in Reproductive Biology at the same institution (1974-75) and Endocrinology at the National Institutes of Health in Bethesda, MD (1975-77). His research career spans over four decades with significant contributions to understanding oocyte development and reproductive biology. Dr. Conti's research program focuses on signal transduction pathways required for germ cell development, particularly those controlling oocyte meiotic maturation and developmental competence. His lab has identified critical signals arising in somatic cells during ovulation that establish oocyte developmental competence. The research examines how disruption of these pathways affects maternal mRNA translation patterns into proteins critical for nuclear reprogramming and early embryo development. This work has significant implications for stem cell research, understanding mechanisms controlling cell replication during preimplantation development, and developing embryonic stem cells into artificial gametes. Additional research interests include fertility preservation for cancer patients. Analysis of Dr. Conti's publication record reveals a consistent focus on reproductive biology with particular emphasis on cAMP signaling pathways, phosphodiesterases, mRNA translation regulation, and oocyte maturation. His work shows progression from foundational studies on cAMP-specific phosphodiesterases in the 1990s to more recent sophisticated analyses of maternal mRNA translation programs using single-cell approaches and multi-omics techniques. The research demonstrates increasing complexity in methodology while maintaining focus on fundamental questions of oocyte developmental competence. International Fogarty Fellow (1975-77) Phi Beta Kappa Teaching Excellence Award (2000) Sandler Foundation Senior Investigator Award (2001) Society for the Study of Reproduction Research Award (2003) Board of Directors Society for the Study of Reproduction (2006) Dr. Conti has mentored numerous researchers in reproductive biology and has been instrumental in establishing genetic models to study oocyte developmental competence. His laboratory work has significant translational potential for improving assisted reproductive technologies and understanding age-related declines in fertility. The Center for Reproductive Sciences at UCSF, which he previously directed, serves as a hub for interdisciplinary research connecting basic science discoveries with clinical applications in reproductive medicine.

Lynn Cooleyمشاهده پروفایل

استاد

• Actin Cytoskeleton
• Cell Biology
• Developmental Biology
• +۳ مورد دیگر

Lynn Cooley is the Dean of the Graduate School of Arts and Sciences and holds the C. N. H. Long Professorship in Genetics at Yale University. She is also Professor of Cell Biology and Molecular, Cellular, and Developmental Biology within the Yale School of Medicine. Her research focuses on cellular mechanisms of gamete development using Drosophila as a model system, particularly studying actin cytoskeleton organization in germline ring canals and somatic muscle development. Education: PhD in Genetics from University of Texas (1984), BA in Zoology from Connecticut College (1976) Her work investigates how intercellular bridges (ring canals) facilitate oocyte growth and maternal mRNA transport. Recent discoveries include novel muscle types in Drosophila ovaries and the role of the Kelch protein in actin dynamics. Cooley’s lab employs genetic, molecular, and imaging techniques to study these processes. Key awards include Fellow of the American Association for the Advancement of Science (2012) and Pew Scholar Award (1991). She has served on committees such as the Genetics Society of America Board and NIH Dev1 Study Section. Her research also explores tissue-specific codon redefinition and the antivirulence properties of antifreeze proteins. Collaborations include work with Andrew Hudson on Drosophila genetics and Joerg Bewersdorf on super-resolution microscopy.

• Neuroscience
• Neuropharmacology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Professor Aideen Sullivan is Head of the Department of Anatomy and Neuroscience at University College Cork (UCC). With a career spanning over two decades at UCC, she leads research on neuroprotective therapies for Parkinson's disease, focusing on growth factors, stem cell applications, and epigenetic mechanisms. She established Ireland's first BSc in Neuroscience and co-developed the cross-College BSc in Medical and Health Sciences (CK707). BSc (First Class Honours) in Pharmacology, University College Dublin (1992) PhD in Neuropharmacology, University of Cambridge (1995) Her research program investigates Parkinson's disease through five key themes: viral vector delivery of neurotrophic factors, molecular mechanisms of neuroprotection, biomarker discovery, neuronal degeneration models, and stem cell-based treatments. She has secured significant grants from Health Research Board, Enterprise Ireland, and the Wellcome Trust. Recent publications (2022-2020) emphasize epigenetic regulation (HDAC inhibitors), microbiome-gut-brain axis interactions, and novel neurotrophic strategies. Articles highlight GDF5's neuroprotective effects, miRNA modulation, and molecular pathways like BMP-Smad and p38-MAPK. Scientific awards include: Postgraduate Certificate in Teaching and Learning (UCC, 2006) FETAC Certificate in Peer-Mentoring (2010) Leadership Foundation Aurora Programme Scholarship (2015) Over €2 million in research grants She mentors undergraduate and postgraduate students, chairs UCC's Athena SWAN 'Flexible Working' group, and serves as Editor-in-Chief of Neuronal Signaling . Her work spans laboratory research, public engagement, and educational innovation.

Keith Lathamمشاهده پروفایل

استاد

• Molecular Biology
• Embryology
• Genomics
• +۳ مورد دیگر

Keith Latham is a Professor at Michigan State University affiliated with the Cell & Molecular Biology Program and Genetics & Genome Sciences Program. His research focuses on molecular mechanisms regulating early mammalian embryogenesis and disease origins from developmental disruptions. Cell & Molecular Biology Program Faculty Genetics & Genome Sciences Program Faculty Research Interests His work explores embryonic development , epigenetics , and reproductive biology , emphasizing how maternal/paternal factors influence embryo viability. Recent studies investigate FSH effects on ovarian stimulation, oocyte transcriptome regulation, and mitochondrial dysfunction transmission via oocytes. Scientific Awards Advising and Grants No student advising or grant information is provided in the text. Further details may exist in external academic records.

Ayşegül Kuşkucuمشاهده پروفایل

دانشیار

• Medical Genetics
• Molecular Biology
• Cancer Research
• +۴ مورد دیگر

Assoc. Prof. Dr. Ayşegül Kuşkucu is an academic staff member at Yeditepe University Faculty of Medicine , Department of Medical Genetics . She holds a PhD in Genetics from Istanbul University (2008) and a specialization in Molecular Cytogenetics from Université Montpellier I (2009). Current research focuses on miRNA regulation in chordomas, cancer stem cells, and metabolic-genetic interactions in cancer models Key projects include TÜBİTAK-funded studies on PD-L1 CAR-NK cell therapy, caloric restriction epigenetics, and amniotic cell differentiation Her award includes First Place Oral Presentation at the International Medical Genetics Congress She supervises PhD and Master's theses on topics like obesity genetics, stem cell differentiation, and cancer epigenetics. Her work appears in journals such as Biological Research , Neurology India , and Gene , with recurring themes in oncomiR profiling , hypoxia-related polymorphisms , and genetic counseling . Administrative roles include Department Chair (2013) and Faculty Board Membership (2021). She actively participates in societies like the European Society of Human Genetics and Medical Genetics Association .

Hugh Clarkeمشاهده پروفایل

استاد

• Reproductive Biology
• Infertility
• Oocyte Development
• +۳ مورد دیگر

Hugh Clarke, PhD is a Senior Scientist at the RI-MUHC, Glen site and a Professor in the Department of Obstetrics and Gynecology at McGill University 's Faculty of Medicine and Health Sciences. His research focuses on oocyte development within ovarian follicles. Research Interests: Oocyte growth and maternal molecule storage Germ cell-somatic cell communication Environmental toxin effects on oocyte quality Intercellular signaling mechanisms mRNA regulation during maturation Chromatin remodeling at fertilization Publications (2015-2024) reveal expertise in reproductive biology, with key projects examining: EGFR signaling in follicular decoupling mTOR pathway in follicle communication CNOT6-mediated mRNA deadenylation Transzonal projection architecture Epigenetic inheritance patterns Actin's role in meiotic processes Location: Lab F3-50, Royal Victoria Hospital, Montreal, QC H3A 1A1

Gregory J. Hannonمشاهده پروفایل

استاد

• Small RNA Biology
• RNA Interference
• Cancer Biology
• +۷ مورد دیگر

Gregory J. Hannon is a distinguished Professor at Cold Spring Harbor Laboratory (CSHL) and an Investigator of the Howard Hughes Medical Institute, renowned as one of the world's foremost authorities on small RNA biology and RNA interference. His research has significantly advanced our understanding of gene regulation mechanisms with profound implications for cancer treatment and genome stability. Hannon's educational background includes training that led to his current position as a leading molecular biologist. His research focuses on the biological roles of small RNAs and the mechanisms by which they operate, with particular emphasis on germ cells (which have the most elaborate set of small RNA pathways) and cancer biology (especially breast and pancreatic cancer). His laboratory's groundbreaking work has identified and characterized major biogenesis and effector complexes for small interfering RNAs and microRNAs, including Dicer, RISC, and elements of the Microprocessor. More recently, his team has made significant discoveries regarding piwi-interacting RNAs (piRNAs) and their role in defending the genome from mobile genetic elements. Among his most significant publications are studies on the structure of human Argonaute protein, mechanisms of transposon defense in germ cells, and how breast tissue 'remembers' a first pregnancy through epigenetic changes. His research has consistently appeared in top-tier journals, with several publications recognized by Science as 'Breakthrough of the Year.' Elected to National Academy of Sciences (2012) NIH MERIT Award from National Institute of General Medical Sciences (2013) National Academy of Sciences Award in Molecular Biology (2007) Geoffrey Marshall Mentoring Award from Northeastern Association of Graduate Schools (2011) Howard Hughes Medical Institute Investigator Hannon has mentored 12 postdoctoral fellows and 17 graduate students, with exceptional outcomes including multiple prestigious awards for his trainees. Over 60% of his 200+ publications include graduate student co-authorship. His laboratory has developed innovative technologies including RNAi libraries targeting entire genomes and methods used in Neanderthal genome sequencing. He also serves as director of the Cancer Research UK Cambridge Institute, demonstrating his international leadership in cancer research.

Krishna Chatterjeeمشاهده پروفایل

استاد

• Genetic and Molecular Endocrinology
• Thyroid Hormone Synthesis and Action
• Nuclear Hormone Receptors
• +۴ مورد دیگر

Professor Krishna Chatterjee is a leading academic in the field of Genetic and Molecular Endocrinology at the University of Cambridge , affiliated with the Institute of Metabolic Science and the Department of Medicine . His research focuses on disorders of nuclear hormone synthesis and action, particularly Resistance to Thyroid Hormone due to defective receptor beta or alpha, and multisystem selenoprotein deficiency disorders . He directs the Cambridge Clinical Research Centre and the PhD for Health Professionals Programme , which trains health professionals as researchers and future leaders. Professor of Endocrinology, Department of Medicine Director, Cambridge Clinical Research Centre Director, PhD for Health Professionals Programme Principal Investigator, Institute of Metabolic Science Collaborator with British Thyroid Foundation His laboratory investigates the molecular mechanisms of thyroid hormone resistance, employs candidate gene and whole exome approaches to identify novel genetic aetiologies, and conducts human phenotypic studies to understand how thyroid hormones affect physiological processes via receptor subtypes. Current work includes studying selenoprotein deficiency disorders and translating research into diagnostic technologies and selective thyromimetics for metabolic disorders. Recent publications highlight his expertise in thyroid hormone resistance syndromes, MCT8 deficiency, and selenoprotein-related pathologies. His clinical research has informed guidelines for managing genetic thyroid disorders and developed NHS gene panels for diagnosis. He collaborates on public engagement initiatives with the British Thyroid Foundation, including patient education materials and webinars. Key research trends include: Elucidating genotype-phenotype correlations in thyroid hormone resistance Developing diagnostic biomarkers for genetic endocrine disorders Trialing novel therapies like TRIAC for thyroid hormone resistance syndromes Investigating selenoprotein deficiency's role in cardiovascular and metabolic dysfunction Integrating genomic, structural, and functional analyses for precision medicine

Simon Moxonمشاهده پروفایل

دانشیار

• Bioinformatics
• Gene Regulation
• Next-Generation Sequencing
• +۳ مورد دیگر

Simon Moxon is an Associate Professor in Bioinformatics at the University of East Anglia (UEA), part of the School of Biological Sciences. His research focuses on applying next-generation sequencing (NGS) technologies to study biological problems, particularly small RNA bioinformatics and mechanisms of gene regulation at transcriptional and post-transcriptional levels. He has developed tools like miRCat2 and the UEA sRNA Workbench for miRNA detection and analysis. Notable collaborations include projects funded by the British Heart Foundation, NIH, and the Natural Environment Research Council, exploring topics such as chromatin landscapes, microRNA biogenesis, and epigenetic reprogramming. His work spans plant genomics, developmental biology, and molecular mechanisms in diseases like cancer. Recent publications highlight advancements in understanding miRNA regulation in plants and animals, epigenetic marks during zygotic reprogramming, and antimicrobial resistance in Bacillus species. Moxon actively mentors PhD students and contributes to editorial roles in journals like Frontiers in Molecular Biosciences.

• Axonal Growth
• Cell Biology
• Cellular Differentiation
• +۱۶ مورد دیگر

Florence Marlow, PhD is an Associate Professor in the Department of Cell, Developmental & Regenerative Biology at the Icahn School of Medicine at Mount Sinai. With a research focus on zebrafish genetics, her work bridges reproductive biology, neurodegeneration, and developmental mechanisms. BS, Rensselaer Polytechnic Institute PhD, Vanderbilt University Postdoctoral Research, University of Pennsylvania Research Interests Maternal gene regulation during early development RNA transport and localization in polarized cells Sex determination and ovarian neoplasia Microtubule and mitochondrial dynamics Comparative studies between oocyte and neuronal polarization Publications highlight her work in maternal-effect genes, germ cell specification, and immune-ovarian interactions, with recent studies on RBPMS2 and DMRT1 functions. Honors: Damon Runyon Cancer Research Foundation Fellow (2004) Location: Annenberg Building, Floor 25 Room 20A, New York, NY 10029. Industry Relationships: Not yet reported.

• Evolutionary Developmental Biology
• Ecology
• Evolution
• +۱۲ مورد دیگر

Dr. Casper Breuker is a Senior Lecturer and Subject Coordinator for Biology and MBiol Biology at the School of Biological and Medical Sciences, Oxford Brookes University. He is also the Erasmus Coordinator for Biological Sciences and an active researcher in evolutionary developmental biology, with a focus on Lepidoptera. His work integrates ecology, evolution, and developmental biology to understand maternal regulation of offspring development under environmental stress. Research Interests: Evolutionary Developmental Biology (Evo-Devo) Maternal and Transgenerational Effects Butterfly Embryonic Development Wing Morphology and Patterning Responses to Environmental Stress (drought, insecticides) Life History Evolution His recent publications span topics from genomic erosion in extinct butterflies to the functional evolution of wing-patterning genes. These works reflect a strong trend in integrating molecular genetics with ecological and evolutionary theory, particularly using Pararge aegeria as a model system. Scientific Awards: Research Excellence Award Supervision and Grants: Dr. Breuker supervises multiple PhD and postgraduate students, including Jay Hands, Scarlett Ferguson, and Luke Evans. He leads a research group focused on butterfly eco-evo-devo and has been involved in projects on gene flow, insecticide effects, and transgenerational plasticity. He serves as academic editor for PLOS ONE and Scientific Reports , and regularly reviews for top journals in ecology, evolution, and genetics. Labs and Research Groups: He is part of the research groupings in Cell and Developmental Biology, Ecology and Evolution, Genetics and Genomics (UoA5), and affiliated with the Ecology and Evolution Centre and the Centre for Functional Genomics (CfG) at Oxford Brookes.