Krishna Chatterjee

Professor Krishna Chatterjee is a leading academic in the field of Genetic and Molecular Endocrinology at the University of Cambridge, affiliated with the Institute of Metabolic Science and the Department of Medicine. His research focuses on disorders of nuclear hormone synthesis and action, particularly Resistance to Thyroid Hormone due to defective receptor beta or alpha, and multisystem selenoprotein deficiency disorders. He directs the Cambridge Clinical Research Centre and the PhD for Health Professionals Programme, which trains health professionals as researchers and future leaders.

• Professor of Endocrinology, Department of Medicine
• Director, Cambridge Clinical Research Centre
• Director, PhD for Health Professionals Programme
• Principal Investigator, Institute of Metabolic Science
• Collaborator with British Thyroid Foundation

His laboratory investigates the molecular mechanisms of thyroid hormone resistance, employs candidate gene and whole exome approaches to identify novel genetic aetiologies, and conducts human phenotypic studies to understand how thyroid hormones affect physiological processes via receptor subtypes. Current work includes studying selenoprotein deficiency disorders and translating research into diagnostic technologies and selective thyromimetics for metabolic disorders.

Recent publications highlight his expertise in thyroid hormone resistance syndromes, MCT8 deficiency, and selenoprotein-related pathologies. His clinical research has informed guidelines for managing genetic thyroid disorders and developed NHS gene panels for diagnosis. He collaborates on public engagement initiatives with the British Thyroid Foundation, including patient education materials and webinars.

Key research trends include:

• Elucidating genotype-phenotype correlations in thyroid hormone resistance
• Developing diagnostic biomarkers for genetic endocrine disorders
• Trialing novel therapies like TRIAC for thyroid hormone resistance syndromes
• Investigating selenoprotein deficiency's role in cardiovascular and metabolic dysfunction
• Integrating genomic, structural, and functional analyses for precision medicine