جست‌وجوی استاد و پژوهشگر

• Liver Diseases
• Alcoholic Liver Disease
• Hepatic Lymphangiogenesis
• +۴ مورد دیگر

Matthew McConnell, MD is an Assistant Professor of Medicine in the Department of Medicine (Digestive Diseases) at Yale School of Medicine. His research focuses on liver diseases, particularly alcoholic liver disease, portal hypertension, and the role of endothelial dysfunction in hepatic pathology. He holds academic appointments in Digestive Diseases and is affiliated with the Liver Center and Iwakiri Lab. Education: MD from Weill Cornell Medical College (2012), BA in Chemistry from Amherst College (2006). Residency at Johns Hopkins Hospital (2015), Fellowship at Yale-New Haven Hospital (2018). Research Interests: Investigates liver sinusoidal endothelial cells (LSECs), hepatic lymphangiogenesis, and the pathophysiology of liver diseases such as alcoholic hepatitis. His work explores molecular mechanisms driving endothelial dysfunction and novel therapeutic targets for portal hypertension. Key Publications: Includes studies on IL-7-based identification of liver lymphatic endothelial cells, sympathetic nervous system regulation of lymphangiogenesis, and alcohol-induced Hsp90 acetylation's role in LSEC dysfunction. Recent work also examines liver injury in COVID-19 and proteomic signatures in alcohol-associated cirrhosis. Awards: Samuel Kushlan Junior Faculty Award for Excellence in Clinical Research (2020) Samuel Kushlan Award for Excellence in Research during Digestive Diseases Fellowship (2018) Lab & Collaborations: Active in the Iwakiri Lab and collaborates with researchers like Yasuko Iwakiri, Jeong Jain, and Xuchen Zhang on liver disease mechanisms. His work integrates clinical observations with translational research. Grants & Funding: Research supported by NIH grants and institutional funding at Yale School of Medicine.

• Vascular Biology
• Tumor Microenvironment
• Cancer Therapies
• +۳ مورد دیگر

Alejandra González Loyola is a Senior Scientist and Maria Zambrano Fellow at the M2BE lab within the I3A research institute at the University of Zaragoza, Spain. Her research focuses on vascular biology, tumor microenvironment dynamics, and therapeutic strategies for cancer. She holds a PhD from the National Center of Oncological Research (CNIO) under Prof. Marcos Malumbres, followed by postdoctoral training in Prof. Tatiana Petrova's lab in Switzerland. Key achievements include discovering lymphatic vessels' role in organ coordination, elucidating microbiota-lymphatic interactions, and developing a single-cell atlas of mesenteric lymphatic endothelial subtypes. Current projects include EU-funded initiatives such as VASTO (organoid tumor models) and ICoMICS (immune cell migration studies), led by Prof. J.M. García Aznar. Her work bridges mechanobiology, vascular engineering, and cancer therapy, with a focus on modulating lymphatic systems for clinical applications. Notable contributions include publishing in Journal of Experimental Medicine , Science Advances , and EMBO Journal . Awards include the prestigious Maria Zambrano Fellowship for scientific talent.

• Microfluidics
• Bioengineering
• Biomedical Engineering
• +۵ مورد دیگر

Dr. Esak (Isaac) Lee is an Assistant Professor at the Meinig School of Biomedical Engineering at Cornell University since 2019. He combines principles from engineering, biology, and medicine to develop novel approaches for improving human health, focusing on lymphatic and blood vessel biology. Current: Assistant Professor, Biomedical Engineering, Cornell University Previous: Postdoctoral Fellow, Wyss Institute & Boston University Education: Ph.D. in Bioengineering, Johns Hopkins University His research interests include: Microfluidics and organ-on-chip technology Tissue engineering and biomaterials Biomechanics and mechanobiology in vascular systems Molecular and cellular engineering for disease modeling Regenerative medicine applications for cancer and immune diseases Edema and lymphedema treatment strategies Dr. Lee's work emphasizes creating 3D organ-on-chip systems to study vascular interactions. His publications demonstrate expertise in lymphatic biology, cancer metastasis, and neurovascular modeling. Awarded: NSF Career Award (2024) Nancy and Peter Meinig Investigatorship (2019) Microcirculatory Society Lymphatic Research Award (2021) GRC Lymphatics Young Investigator Award (2018) BMES Cellular & Molecular Bioengineering Young Innovator (2023) As an educator, Dr. Lee teaches core topics in biomedical engineering including cancer immuno-engineering and biomaterials. His lab at Cornell fosters interdisciplinary research through bioengineered in vitro models that replicate human physiology with high precision.

• Diabetic Retinopathy
• Microvascular Dysfunction
• Vascular Endothelial Growth Factor (VEGF)
• +۷ مورد دیگر

Nikita Ved is a Research Professor at the Department of Physiology, Anatomy and Genetics, University of Oxford, affiliated with Merton College. They work in Prof Paterson's group, focusing on diabetic microvascular complications and vaccine uptake disparities in British Indian communities. Education: Undergraduate in Neuroscience, University of Bristol PhD in Ophthalmology, University College London (2016) Research Interests: Nikita Ved investigates diabetic retinopathy and neuropathy, emphasizing VEGF splice variants. Additional work examines maternal diabetes effects on embryonic heart defects and health inequalities in ethnic minorities. Scientific Awards: MBE (2023) for vaccine advocacy STEM for Britain Finalist (2019) European Society of Cardiology Prize (2018) British Microcirculation Society Young Investigator’s Prize (2015) Advising & Grants: They received a Novo Nordisk Postdoctoral Fellowship (2016) and co-founded the 1928 Institute (2020) to address vaccine misinformation in the British Indian community. Outreach: Nikita Ved is a key organizer for Pint of Science, British Science Association, and House of Commons science policy events, bridging public and academic discourse.

Joshua D Wytheمشاهده پروفایل

دانشیار

• Cardiovascular Biology
• Cerebrovascular Pathologies
• Developmental Biology
• +۱۲ مورد دیگر

Joshua D. Wythe is an Associate Professor in the Department of Cell and Developmental Biology at the University of Virginia School of Medicine. His research focuses on the molecular and genetic mechanisms underlying cardiovascular development and cerebrovascular pathologies, with a particular emphasis on endothelial cell differentiation and brain vascular diseases such as arteriovenous malformations and glioblastoma. He leads the Wythe Lab, which utilizes zebrafish and mouse models combined with bioinformatics, functional genomics, and 3D imaging to investigate blood vessel formation and dysfunction. BA in History, Miami University BS in Botany, Miami University PhD in Oncological Sciences / Cardiovascular Development, University of Utah School of Medicine Postdoctoral Fellowship in Cardiovascular Development and Disease, University of California, San Francisco Dr. Wythe's research interests span cardiovascular biology, developmental biology, transcriptional regulation, and translational science. His lab investigates how transcriptional networks govern endothelial plasticity, the role of RAS/MEK/ERK signaling in brain arteriovenous malformations, and novel therapeutic targets in glioblastoma. The work integrates molecular genetics, imaging, and bioinformatics to understand both normal vascular development and pathological conditions. The recent publications reflect a strong trend in vascular development, disease modeling, and technological innovation. Key themes include transcriptional control of endothelial identity, signaling pathways in vascular malformations, and advanced imaging techniques for 3D tissue visualization. The research spans from basic developmental mechanisms to translational applications in brain cancers and cerebrovascular disorders. Dr. Wythe actively mentors graduate students, postdoctoral fellows, and undergraduates, fostering a collaborative and interdisciplinary research environment. His lab is currently recruiting researchers with expertise in developmental biology, genomics, bioinformatics, and imaging. Funding supports multiple projects aimed at uncovering transcriptional regulators essential for cardiovascular function and disease. The Wythe Lab is equipped to conduct cutting-edge research using genetically modified animal models, single-cell analyses, and advanced microscopy. The team develops and shares resources such as FishNET for zebrafish colony management and EZ Clear for tissue clearing, contributing to the broader scientific community.

Michelle Hookمشاهده پروفایل

دانشیار

• Spinal Cord Injury (SCI)
• Opioid Pharmacology
• Neuroinflammation
• +۳ مورد دیگر

Michelle Hook, PhD is an Associate Professor in the Department of Neuroscience & Experimental Therapeutics at the Texas A&M University School of Medicine. Her research focuses on the neurobiological and physiological consequences of spinal cord injury (SCI), with an emphasis on opioid-induced recovery impairment, depression/cognitive deficits, and bone loss. She holds a PhD from the University of New England (1998). Education : PhD in Neuroscience, University of New England, 1998 Research Interests : Dr. Hook’s lab investigates three core areas: (1) adverse effects of opioids (e.g., morphine, oxycodone) on SCI recovery mechanisms, including glial activation and neuronal death; (2) sex-dependent depression and cognitive deficits post-SCI, linking inflammatory biomarkers (e.g., cytokines, neurogenesis) to behavioral outcomes; and (3) sympathetic nervous system-driven bone loss via osteocyte dysfunction and marrow niche changes. Her work combines rodent models with translational strategies to identify adjuvants for opioid therapy, neuroprotective interventions, and bone preservation therapies. Key Contributions : Discovered that kappa opioid receptor antagonism mitigates morphine’s detrimental effects on SCI recovery Validated novel methods to assess depression-like behavior in SCI rats Identified osteocyte inflammation as a driver of post-SCI osteoporosis Future Directions : Expanding studies on gut-brain interactions in post-injury mood disorders, optimizing chemogenetic tools to modulate pain pathways, and developing implantable closed-loop systems for gait rehabilitation.

M. Nasir Uddinمشاهده پروفایل

عضو هیئت علمی

• Preeclampsia
• Hypertension in Pregnancy
• Ovarian Cancer Metastasis
• +۳ مورد دیگر

M. Nasir Uddin is a Research Associate Professor at Texas A&M University's Health Science Center College of Medicine, specializing in Medical Physiology. His research focuses on translational studies in maternal fetal medicine, particularly hypertension during pregnancy and ovarian cancer metastasis. He holds a PhD from Gifu University (Japan) and completed postdoctoral training at Texas A&M and Baylor Scott & White Healthcare. Education: B.Sc. (Hons) and M.Sc. in Biochemistry and Molecular Biology, University of Dhaka, Bangladesh (1988 & 1990) PhD in Molecular Biology, Gifu University, Japan (2000) Postdoctoral Fellow, Japan Society for Promotion of Science in Molecular Medicine (2003-2005) Postdoctoral Research Associate/Assistant Research Scientist at Texas A&M Health Science Center (2006-2010) Research Interests: Dr. Uddin’s lab investigates pathogenic mechanisms of preeclampsia (focusing on marinobufagenin and angiogenic imbalance) and novel therapeutic targets for ovarian cancer metastasis. He uses rodent/small monkey models, cell lines, and patient studies, collaborating with institutions like Baylor Scott & White Healthcare. Key Scientific Contributions: His work has identified marinobufagenin as a key biomarker for preeclampsia and explored pravastatin’s protective effects on cytotrophoblasts. He also discovered a novel inhibitor for ovarian cancer metastasis using plant-derived compounds like trimethylquercetin. Awards & Recognition: Not explicitly listed but includes FAHA (Fellow of the American Heart Association). Labs/Teams: Leads a multidisciplinary lab integrating molecular biology, pharmacology, and clinical research in maternal health and oncology. Collaborators include David Zawieja (lymphatic physiology), Thomas Kuehl (vascular biology), and others.

Mendell Rimerمشاهده پروفایل

دانشیار

• Neuroscience
• Molecular Biology
• Neurobiology
• +۳ مورد دیگر

Mendell Rimer, PhD, is an Associate Professor in the Department of Neuroscience & Experimental Therapeutics at Texas A&M University's School of Medicine. His research focuses on molecular and cellular mechanisms of synapse formation, maintenance, and pathology using the neuromuscular junction (NMJ) as a model system. He employs mouse molecular genetics combined with molecular, cellular, and immunological techniques. Education: BS in Biology, Universidad de Los Andes PhD in Molecular and Cell Biology (with Pharmacology minor), University of Maryland, Baltimore Postdoctoral Training: Neurobiology and Molecular Genetics at Stanford University & New York University Research interests include synaptic plasticity, neuromuscular junction pathology in neurodegenerative diseases (e.g., ALS, Duchenne muscular dystrophy), and signaling pathways involving MAP kinases and neuregulins. His work combines genetic models with advanced imaging and molecular biology techniques. Publications span synaptic development, neuromuscular disorders, and signaling mechanisms. Notable work includes studies on lymphatic dysfunction in ALS models and roles of ERK kinases in muscle maintenance. Active in graduate training through the Interdisciplinary Program in Neuroscience and Medical Science PhD program. Labs/Teams: The Rimer Lab focuses on integrative approaches to neuromuscular synapse biology. Collaborations involve clinical translation of synaptic repair mechanisms in neurodegenerative diseases.

Xin Wuمشاهده پروفایل

استادیار مدعو

• Mechanotransduction
• Neuropharmacology
• Ion Channel Biology
• +۵ مورد دیگر

Xin Wu, MD is an Adjunct Assistant Professor and Research Assistant Professor in the Department of Neuroscience & Experimental Therapeutics at Texas A&M University's School of Medicine. His work focuses on mechanotransduction pathways in cardiovascular and neuronal systems, integrating advanced techniques like atomic force microscopy and electrophysiology. Dr. Wu holds dual appointments in cardiology and neuroscience research. Education: MD from Nantong Medical College (1985), MS in Medical Physiology from Suzhou Medical College (1993). Research Interests: Mechanical stress effects on ion channels Integrin-mediated signaling in neurons and cardiomyocytes Epilepsy mechanisms and neurosteroid therapies Drug development for refractory seizures ECM-integrin interactions in disease Technical Expertise: AFM-based cellular mechanics analysis In vivo electrophysiology and imaging Single-cell isolation techniques Lymphatic/vascular modeling LC-MS/MS drug analysis Laboratory Focus: Cardiomyocyte mechanosensitivity, neuronal plasticity in epilepsy, and translational neuropharmacology. Current projects explore sex differences in antiseizure efficacy and novel neuroprotectant development.

María Virumbrales-Muñozمشاهده پروفایل

استادیار

• Microphysiological Systems
• Organ-on-a-Chip
• Cancer Biology
• +۱۲ مورد دیگر

María Virumbrales-Muñoz is an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Wisconsin–Madison, with an affiliate appointment in Biomedical Engineering. She is also the Principal Investigator of the Virumbrales-Muñoz Lab, where she leads research in microphysiological systems to model cancer and reproductive disorders. Position: Assistant Professor, Obstetrics & Gynecology Affiliation: Biomedical Engineering (Affiliate Faculty) Lab: Virumbrales-Muñoz Lab, University of Wisconsin–Madison Email: virumbralesm@wisc.edu She holds a PhD in Biomedical Engineering from the University of Zaragoza, Spain, and completed postdoctoral training at UW-Madison in Biomedical Engineering and Pathology & Laboratory Medicine. Her research lies at the intersection of bioengineering and women's health, focusing on 3D biomimetic modeling of diseases such as high-grade serous ovarian cancer (HGSOC) and preeclampsia. Using microfluidic technologies, her lab develops organ-on-a-chip models to study tumor microenvironments, metabolic heterogeneity, immune-endothelial interactions, and vascular dysfunction in reproductive diseases. The lab's recent publications reveal a strong focus on advancing microphysiological systems for cancer and vascular biology, with applications in drug screening, immune response modeling, and patient-specific disease modeling. Her work integrates molecular biology, bioengineering, and clinical data to improve understanding of disease mechanisms and therapeutic responses. Scientific Awards: Chester B. Martin Graduate Training Program Mentorship Award (2021) Dr. Virumbrales-Muñoz is an active mentor and educator, advising graduate and undergraduate students in biomedical engineering and reproductive sciences. She teaches in courses such as AN SCI 875 and OBS&GYN 710 and collaborates on major research grants, including NIH R01 proposals. Her lab is funded by the American Cancer Society, University of Wisconsin Carbone Cancer Center, and Meriter Foundation, among others. Research Labs and Teams: Virumbrales-Muñoz Lab: Focuses on microphysiological systems for cancer and preeclampsia Collaborations: UW-Madison Department of Biomedical Engineering, Pathology & Laboratory Medicine, and UnityPoint Health-Meriter Foundation Team Members: Includes postdoctoral researchers, PhD students, and research technicians working on ovarian cancer, breast cancer, and vascular modeling projects

Niccolò Terrandoمشاهده پروفایل

استاد

• Neuroinflammation
• Postoperative cognitive dysfunction
• Delirium
• +۹ مورد دیگر

Niccolò Terrando is a Professor of Anesthesiology at Duke University School of Medicine with secondary appointments in Cell Biology and Integrative Immunobiology. He serves as a Faculty Network Member of the Duke Institute for Brain Sciences, where his research bridges neuroimmunology, perioperative medicine, and cognitive neuroscience. Dr. Terrando's research focuses on neuroinflammation mechanisms underlying postoperative cognitive dysfunction and delirium, particularly exploring blood-brain barrier integrity, neurovascular unit function, and specialized pro-resolving mediators. His work investigates how surgical trauma triggers inflammatory cascades that can lead to cognitive decline, especially in vulnerable populations like the elderly and those with pre-existing neurodegenerative conditions. He has pioneered research on vagus nerve stimulation, omega-3 fatty acids, and other interventions to mitigate surgery-induced neuroinflammation. His extensive publication record shows a clear progression from basic mechanisms of neuroinflammation to translational applications. Recent work emphasizes cellular senescence, blood-brain barrier modeling, and the intersection of postoperative cognitive decline with Alzheimer's disease pathology. His research increasingly incorporates advanced techniques like blood-brain barrier-on-chip models and quantum dot biomimetics for neurovirology studies. His scientific recognition includes: New Investigator Award from the International Society to Advance Alzheimer's Research and Treatment (2019) Active Member (by election) of the Association of University Anesthesiologists (2018) Junior Faculty Award from the Association of University Anesthesiologists (2014) New Investigator Award from the International Society for the Study of Fatty Acids and Lipids (2014) Dr. Terrando currently leads multiple NIH-funded projects totaling over $20 million, including studies on hypertension and aging impacts on postoperative delirium (2025-2030), IL-6 trans-signaling in cognitive decline (2024-2029), and cerebrospinal fluid complement activation in delirium (2024-2029). His laboratory employs sophisticated mouse models of surgery-induced cognitive dysfunction and collaborates extensively with Duke's neuroscience and geriatrics programs. His research team utilizes advanced methodologies including blood-brain barrier modeling, neurovascular unit analysis, and biomarker discovery in human subjects undergoing surgery. Current projects investigate pericyte function in delirium superimposed on dementia, bioelectronic regulation of CNS lymphatic drainage, and immunoprofiling of postoperative delirium during aging and neurodegeneration.

• Lymphatic System Physiology
• Inflammation
• Lymphedema
• +۴ مورد دیگر

Pierre-Yves von der Weid serves as Professor in the Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds multiple leadership roles including Scientific Lead of the Lymphedema Research and Education Program at The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, while maintaining Full Membership in the Snyder Institute and Inflammation Research Network. Additional affiliations include membership in the Libin Cardiovascular Institute and Gastrointestinal Research Group. His educational foundation comprises a Doctor of Philosophy in Biological Sciences (1989) and Diploma (B.Sc. Honours) in Biology (1984), both from the University of Geneva. These credentials underpin his specialized research in lymphatic physiology. von der Weid's research program centers on lymphatic system functions and pathologies, with particular emphasis on lymphatic pumping mechanisms during inflammatory conditions. His laboratory investigates the generation of pacemaker potentials, endothelial modulation of lymphatic contractions, and mechanosensitive responses to vessel distention. Disease-focused work examines lymphatic dysfunction in Crohn's disease, arthritis, and lymphedema models, analyzing immune cell trafficking alterations and modulation by COX metabolites, nitric oxide, and cytokines. This research directly supports the university's strategic initiative on Infections, Inflammations and Chronic Diseases (2015-2021). His scientific contributions have earned recognition through prestigious awards including the AHFMR Visiting Scientist designation and multiple fellowship awards from Swiss foundations. Notable honors include the Warren Veale Award from his department and Novartis Prize for Young Scientist. As an educator, he teaches graduate courses MDSC 620 (Topics in Systems Physiology) annually and MDSC 755 (Directed Study). His laboratory operations are supported by Lab Manager Simon Roizes and Administrative Assistant Barbara Chyz, with facilities located in Health Sciences Centre rooms 1645 (office) and 1606 (lab). Current institutional engagement includes active participation in the Inflammation Research Network seminar series through 2025.

Adviye Ergulمشاهده پروفایل

استاد

• Vascular complications of diabetes and hypertension
• Acute ischemic stroke
• Alzheimer's Disease Related Deteriorias
• +۵ مورد دیگر

Adviye Ergul is a Professor at the Medical University of South Carolina in the Department of Pathology and Laboratory Medicine. She holds secondary appointments at Augusta University and the Charlie Norwood VA Medical Center. Her research focuses on vascular complications of diabetes and hypertension, acute ischemic stroke, and Alzheimer's disease-related dementias, with specific emphasis on endothelial cell biology and vascular pathology. Education : MD from Cerrahpasa Medical School (Istanbul, Turkey, 1987), PhD in Biochemistry & Molecular Biology from University of Miami School of Medicine (1995), postdoctoral training in Vascular Biology at University of Georgia. Her work explores mechanisms of endothelin system dysfunction , microvascular senescence , and inflammatory pathways in diabetic and hypertensive conditions. Recent studies investigate novel therapies like angiotensin receptor agonists and iron chelation for post-stroke cognitive impairment. She has published extensively on diabetes-stroke interactions , endothelin signaling , and sex differences in vascular disease. Key research trends include neurovascular unit remodeling , microemboli-mediated dementia , and mitochondrial quality control in brain injury. Her laboratory developed diabetic stroke models to test interventions like linagliptin and bosentan . Awards : NIH Individual Research Service Award, American Heart Association Scientist Development Award, Veterans Administration Research Career Scientist, Regents’ Professorship, Phi Kappa Phi Honor Society.

Marc Aurel Buscheمشاهده پروفایل

پژوهشگر

• Neurodegenerative Diseases
• Alzheimer's Disease Pathophysiology
• Neural Circuit Dysfunction
• +۵ مورد دیگر

Dr Marc Aurel Busche is a Group Leader at the UK Dementia Research Institute (UK DRI) at University College London (UCL) and serves as an Honorary Consultant Psychiatrist at the Queen Square Institute of Neurology . With a unique dual focus on clinical psychiatry and cutting-edge Alzheimer's research, Dr Busche bridges translational neuroscience and patient care through his work. His research explores early functional circuit biomarkers in Alzheimer’s disease using magnetoencephalography (MEG) and machine learning , alongside two-photon imaging , optogenetics , and Neuropixels technology in disease models. Collaborations with UCL’s Ray Dolan and Nick Fox, as well as Oxford’s David Dupret, underscore his interdisciplinary approach to discovering therapeutic targets and early detection methods . Dr Busche’s publications span amyloid-beta dynamics , tau pathology , and neural hyperactivity , reflecting a commitment to uncovering the cellular mechanisms behind Alzheimer’s. He has received notable awards, including the UKRI Future Leaders Fellowship (2019) and the EMBO Fellowship (2016) , which have supported his innovative work.

• Lymphatic system function and dysfunction
• Vascular physiology
• Calcium signaling in lymphatic vessels
• +۷ مورد دیگر

Jorge A. Castorena, PhD, is an Assistant Professor in the Department of Pharmacology at Tulane University School of Medicine, where he leads research on lymphatic system function and dysfunction. His academic journey began with Bachelor's and Master's degrees in Physics from Universidad de Guanajuato in México, followed by a PhD in Bioengineering from the University of Missouri. After completing a postdoctoral fellowship under Dr. Michael J. Davis at the University of Missouri School of Medicine, he served as a Research Assistant Professor before joining Tulane University in 2020. Dr. Castorena's research program focuses on understanding the mechanisms through which the lymphatic system becomes dysfunctional and contributes to cardiovascular diseases. His lab investigates the critical relationship between obesity and lymphatic dysfunction, as well as the effects of aging on lymphatic system function. The lymphatic system serves multiple vital roles including returning interstitial fluid to circulation, immune cell trafficking, dietary lipid absorption, and unfortunately, serving as a pathway for cancer metastasis. His laboratory employs a sophisticated array of techniques including simultaneous multi-channel confocal microscopy for intracellular calcium imaging, pressure myography on isolated lymphatic vessels from animal models and humans, lymphatic primary cell cultures, and electron microscopy. The lab also develops innovative computational tools for automated data and image analysis, reflecting Dr. Castorena's strong physics and engineering background. Analysis of Dr. Castorena's publication record (2020-2025) reveals a strong focus on lymphatic physiology, with particular emphasis on calcium signaling mechanisms, lymphatic valve function, and the impact of metabolic stress on lymphatic contractility. His work frequently examines the role of specific ion channels (KATP, TRPV4, T-type calcium channels) and connexin proteins in lymphatic function. Recent publications demonstrate expanding research into connections between lymphatic function and neurological conditions via the glymphatic system. Dr. Castorena serves as a TIPS Mentor in Tulane's Biomedical Sciences Graduate Program, providing research opportunities for students interested in vascular biology, lymphatic physiology, and related interdisciplinary fields. His lab offers comprehensive training in advanced physiological techniques and computational analysis methods, preparing students for careers at the intersection of engineering, physics, and biomedical sciences.