جست‌وجوی استاد و پژوهشگر

Graham Christieمشاهده پروفایل

دانشیار

• Bacterial Spore Biology
• Structural Biology
• Protein Crystallography
• +۲ مورد دیگر

Graham Christie serves as an Associate Professor in the Department of Chemical Engineering and Biotechnology at the University of Cambridge. His research is centered on bacterial spore biology, with particular expertise in spore structure, germination mechanisms, and structural biology approaches including protein crystallography. Christie collaborates with Professor Ian Wilson and Professor Lisa Hall within the Cambridge research ecosystem. Christie's research interests focus on bacterial spore structure and germination , structural biology (protein crystallography) , and coronavirus testing and inactivation . His work bridges fundamental microbiology with practical applications in biotechnology and public health. He has made significant contributions to understanding the molecular mechanisms of spore resistance and germination in Bacillus species, with implications for food safety, decontamination protocols, and antimicrobial development. Analysis of Christie's recent publications reveals a consistent focus on bacterial spore biology, particularly examining cortex lytic enzymes, germination triggers, and spore resistance mechanisms in Bacillus species. His research spans structural biology, molecular microbiology, and applied biotechnology, with increasing attention to antimicrobial applications and environmental microbiology. The publications demonstrate sophisticated integration of biochemical, genetic, and structural approaches to address fundamental questions in spore biology. Christie actively supervises PhD students and contributes to graduate education in chemical engineering and biotechnology at Cambridge. His research program appears to be well-funded through multiple projects examining spore biology from structural, functional, and applied perspectives. His work on holographic sensors for spore detection indicates translational research efforts with potential commercial applications. Christie maintains laboratory facilities within the Department of Chemical Engineering and Biotechnology, with research groups focused on spore structure-function relationships, protein engineering related to spore biology, and antimicrobial applications derived from spore research. His work on coronavirus testing suggests adaptation of spore-related technologies to address pandemic challenges.

Yao Wei Luمشاهده پروفایل

استادیار

• Cardiovascular Biology
• Cardiovascular Disease
• Molecular Medicine
• +۳ مورد دیگر

Yao Wei Lu is an Assistant Professor of Medicine at the University of Southern California, affiliated with the Hastings Center for Pulmonary Research and leading the Lu Lab. Their research focuses on cardiovascular development, regeneration, and diseases, particularly investigating mechanisms underlying cardiac fibrosis, diabetic complications, and the role of non-coding RNAs in cardiovascular pathologies. Key areas include endothelial dysfunction, metabolic disorders, and molecular signaling pathways in heart disease. Research interests emphasize translational studies targeting therapies for cardiac hypertrophy, atherosclerosis, and heart failure. Dr. Lu's work integrates molecular biology, cell biology, and systems biology approaches to understand disease mechanisms and develop novel treatments. Notable achievements include the receipt of the American Heart Association (AHA) Second Century Early Faculty Independence Award in 2023. The lab's studies often involve collaborative projects on nanotherapies, epigenetic regulation, and cellular senescence. Current projects explore therapeutic inhibition of non-coding RNAs and mitochondrial dysfunction's role in cardiomyocyte regeneration.

Pouya Dehghankelishadiمشاهده پروفایل

پژوهشگر ارشد

• Nanomedicine
• Drug Delivery
• Cancer Treatment
• +۳ مورد دیگر

Pouya Dehghankelishadi is a Research Fellow at Monash University's Department of Drug Delivery, Disposition and Dynamic. His work focuses on developing multi-functional drug delivery systems using porous silicon nanoparticles and gold nanoclusters for cancer treatment, particularly glioblastoma and breast cancer. He holds a PhD from the University of South Australia (2022) and a Doctorate of Pharmacy (PharmD) from Tehran University of Medical Sciences (2014). Education: PhD in Nanomedicine, University of South Australia (2022) Doctorate of Pharmacy (PharmD), Tehran University of Medical Sciences (2014) Research Interests: Targeted drug delivery systems for cancer therapy Nanoparticle engineering (porous silicon, gold nanoclusters) Theranostics and biomedical applications of nanomaterials Radiosensitiser delivery to tumour microenvironment Article Trends: His publications emphasize nanoparticle-based drug delivery systems, with recent work focusing on aptamer-targeted carriers, implantable biosensors, and stimuli-responsive nanocarriers for brain cancer treatment. Themes include nanomedicine design, cancer therapeutics, and biomedical imaging. Advising/Grants: No formal advisees listed. Research is conducted under Prof. Nicolas Voelcker's lab, with a focus on translational nanomedicine. Labs/Teams: Active member of Prof. Voelcker's lab at Monash University, contributing to interdisciplinary research in drug delivery and biomedical engineering.

John Swaneyمشاهده پروفایل

استاد

• Lipoprotein Research
• Cholesterol Metabolism
• Reverse Cholesterol Transport
• +۵ مورد دیگر

John Swaney is a Professor in the Department of Biochemistry & Molecular Biology. Since 1998, he has focused on teaching and educational research after closing his research laboratory, continuing his academic contributions through curriculum development and pedagogy. Course Director for Medical Nutrition and Molecular Structure and Metabolism modules Teaching in Medical Biochemistry courses Creator of the web-based educational system "Netrition" His research legacy spans lipoprotein function, particularly high-density lipoproteins (HDL), and their dependence on chemical and physical structure. His work on reverse cholesterol transport identified key players in cellular cholesterol uptake and explored enhancing serum cholesterol extraction through phospholipid reactions. Educational research evaluates student performance and satisfaction with digital interventions. His publications from 1996-1998 highlight studies on Scavenger Receptor B1, HDL phospholipid composition, and serum cholesterol efflux mechanisms, contributing to understanding atherosclerosis prevention through lipid metabolism.

Mette Nyegaardمشاهده پروفایل

استاد

• Genetics
• Genomics
• GWAS
• +۴ مورد دیگر

Mette Nyegaard is a Professor in the Department of Health Science and Technology at Aalborg University, within The Faculty of Medicine. Her research focuses on genetics and genomics, with over 25 years of expertise linking genetic variation to phenotypes in both rare and common complex diseases. She has a strong interest in gender medicine and women’s reproductive health, particularly leading Denmark’s contribution to the largest genome-wide association analysis of endometriosis. Nyegaard has held external positions, including Associate Professor roles at Aarhus University and Senior Scientist at Aarhus University Hospital. Education: PhD in Human Genetics, University of Southern Denmark (2003) MSc in Chemistry-Biotechnology, Aarhus University (1997) Research Interests: Nyegaard’s work spans genetics, genomics, GWAS, endometriosis, coronary artery disease, and personalized medicine. Her research emphasizes translating genetic insights into clinical applications, such as polygenic risk scores and biomarker development. She collaborates internationally, with projects addressing calmodulinopathies, cardiovascular genetics, and reproductive health. Projects & Grants: Lead PI on projects like 'Understanding the Genetic Architecture of Common Complex Diseases' and 'FEMaLe: Finding Endometriosis Using Machine Learning.' Co-Investigator in studies like 'The Deadly, the Deleterious, and the Dangerous – Decoding the Differential Pathogenicity among CALM1, CALM2, and CALM3.' Labs/Teams: Nyegaard’s work is part of interdisciplinary teams at Aalborg University and collaborating institutions, focusing on genomic medicine, endometriosis, and cardiovascular genomics. She contributes to initiatives like Neuroboost and the International Calmodulinopathy Registry.

• Genetics
• Metabolism
• Liver Diseases
• +۵ مورد دیگر

Professor Stefano Romeo leads the Human Translational Genetics group at Karolinska Institutet's Department of Medicine, Huddinge, where his research bridges genetics, metabolism, and clinical medicine to address metabolic diseases. His work focuses on uncovering genetic and molecular mechanisms underlying liver diseases, diabetes, and cardiovascular conditions through innovative translational approaches. Professor Romeo's research has significantly advanced our understanding of metabolic dysfunction-associated steatotic liver disease (MASLD), identifying key genetic variants including PNPLA3 and MBOAT7 genes. He pioneered the development of multilineage 3D in vitro models for fatty liver disease and discovered a protective genetic variant in the PSD3 gene. His landmark achievement is the identification of two distinct MASLD types with different cardiometabolic risk profiles using compartmentalized polygenic risk scores, which has major implications for targeted treatment approaches. In cardiovascular research, Professor Romeo has developed machine learning algorithms for diagnosing familial hypercholesterolemia and elucidated the role of lipoprotein(a) as an independent cardiovascular risk factor. His integrated approach combines genomics, bioinformatics, molecular biology, and clinical investigations to translate discoveries into practical applications. Research Focus Areas: Genetic basis of metabolic liver diseases Cardiometabolic risk stratification 3D disease modeling and therapeutic testing Polygenic risk scoring for precision medicine Molecular pathways in lipid metabolism Professor Romeo's work has resulted in numerous high-impact publications in journals including Nature Medicine and Journal of Hepatology, demonstrating his leadership in translating genetic insights into improved disease prediction, prevention, and therapeutic outcomes for patients with metabolic disorders.

Timothy C. Meredithمشاهده پروفایل

دانشیار

• Bacterial Cell Envelope Biosynthesis
• Lipoprotein Biosynthesis
• Functional Genomics
• +۹ مورد دیگر

Timothy C. Meredith is an Associate Professor in the Department of Biochemistry and Molecular Biology at Pennsylvania State University. His career spans academic research and industry roles at Merck Research Laboratories and Novartis Institutes for Research, with a postdoctoral fellowship at Harvard Medical School and a return to Harvard as an instructor.

Daniel Daleyمشاهده پروفایل

استاد

• Biochemistry
• Protein Folding
• Bacterial Cell Biology
• +۳ مورد دیگر

Daniel Daley is a Professor at the Department of Biochemistry and Biophysics, Stockholm University . His research group focuses on protein trafficking, folding, and assembly in bacterial cell factories , providing molecular insights into fundamental processes like protein secretion and cell division, with applications in engineering more efficient bacterial systems. His educational background includes a B.Sc. Hons and PhD in Biochemistry from the University of Western Australia . He is also a co-founder of biotech startups CloneOpt and Mycropt . Nationality: Australian (implied by education) Contact: daniel.daley@dbb.su.se Workplace: Room A433, Svante Arrhenius väg 16, Stockholm University Dr. Daley’s research integrates biochemistry, molecular biology, and advanced imaging techniques to study Gram-negative bacteria. His work on the divisome revealed its concentric ring structure via super-resolution microscopy, while his studies on chaperones like YfgM uncovered their roles in protein trafficking and substrate identification. His team also pioneered methods for optimizing protein production through translation initiation region engineering and codon substitution strategies. Key themes in his publications include: Cell division mechanics (divisome dynamics, FtsZ/FtsN separation) Protein folding and trafficking (YfgM substrates, SecYEG translocon) Biotechnological tools (TARSyn, CRISPRi validation) Membrane protein production (codon optimization, translation initiation)

Edit Irén Buzásمشاهده پروفایل

استاد

• Extracellular Vesicles
• Immunology
• Autoimmunity
• +۴ مورد دیگر

Edit Irén Buzás is a Professor of Immunology and Chair of the Department of Genetics, Cell- and Immunobiology at Semmelweis University, Budapest, Hungary. She is a leading researcher in extracellular vesicles (EVs), with significant contributions to standardizing EV detection and isolation methodologies. PI of the EV Research Group at Semmelweis University Leader of the MTA-SE Immune Proteogenomics EV Research Group PI of the HCEMM-SE EV group at the Hungarian Center of Excellence Molecular Medicine (EMBL partner) Founding member and Executive Chair of Education at the International Society of Extracellular Vesicles (ISEV) Her research focuses on the cardiovascular aspects of EVs, including the interference of lipoproteins in EV experiments and the development of tools for EV standardization. She has published over 50 peer-reviewed papers and pioneered techniques like differential detergent lysis and protein-to-lipid ratio analysis. Scientific awards include the 2019 Széchenyi Prize (Hungarian Government), 1995 Carol-Nachman Prize for Rheumatology, and multiple fellowships. She has organized major ISEV conferences and serves on the ERC panel. Currently, she is establishing a Central EV Research, Service, and Reference Laboratory at Semmelweis University.

• Lipidomics
• Genetics
• Biochemistry
• +۳ مورد دیگر

Hanna Ruhanen is a researcher affiliated with the Functional Lipidomics Group at the University of Helsinki , specializing in lipidomics and its intersections with genetics, physiology, and environmental biology. She contributes to advanced research on lipid profiles in diverse contexts, including human disease and marine ecosystems. Research Interests: Lipidomics and proteomics of high-density lipoprotein (HDL) Genetic and environmental influences on lipid metabolism Ecological lipid studies in marine organisms Recent Publications span lipid profiling in systemic lupus erythematosus , menopause-related cardiovascular changes, and dietary variability in copepods, reflecting her interdisciplinary focus on lipid dynamics across biological systems. Labs & Teams: She is a key operator in the Helsinki University Lipidomics Unit , collaborating on functional omics projects and ecological lipidomics.

Kevin Williamsمشاهده پروفایل

استاد

• Atherosclerosis
• Lipoproteins
• Cardiovascular Disease
• +۴ مورد دیگر

Kevin Williams, MD is a Professor in the Department of Cardiovascular Sciences at the Lewis Katz School of Medicine, Temple University, with secondary appointments in Medical Genetics and Molecular Biochemistry. He directs research at the Aging + Cardiovascular Discovery Center and serves as principal investigator for multiple NIH-funded projects. His educational credentials include: MD from Johns Hopkins University (1980) Internal Medicine Residency at University of Chicago Medical Center (1983) Clinical Endocrinology Fellowship at Yale-New Haven Hospital (1984) Metabolism Fellowship at Columbia University (1985) Dr. Williams' research revolutionized understanding of atherosclerosis through his work on LDL retention in arterial walls, establishing foundational links between basic science and clinical approaches. His laboratory investigates diabetic dyslipidemia mechanisms and insulin-signaling proteins, emphasizing that atherosclerosis causes 50% of Western deaths and 80% of diabetic cardiovascular events. Current work addresses lipid metabolism in autoimmune diseases and cancer. His 2025 publications reveal intensified focus on cardiovascular risk in lupus/dermatomyositis patients, lipid dysregulation in obesity/cancer, and novel therapeutic targets like SCD inhibition. The work spans molecular mechanisms to clinical management, with strong emphasis on translational applications for high-risk populations. Dr. Williams serves as Consulting Editor for the Journal of Clinical Investigation and on editorial boards for Arteriosclerosis, Thrombosis and Vascular Biology and Rambam Medical Journal. He holds 11 patents related to lipoprotein modification and diabetic dyslipidemia treatment. His laboratory at Temple investigates corrective strategies for postprandial lipid disposal defects in diabetes and explores membrane lipid remodeling in metabolic disease. Current NIH projects focus on early atherosclerotic disease intervention and lipid-based therapeutic approaches for high-risk cardiovascular patients.

• genetic association studies
• single-nucleotide polymorphisms (SNPs)
• gene-environment interactions
• +۳ مورد دیگر

James Engert is an Associate Professor at McGill University 's Faculty of Medicine and Health Sciences , with dual appointments at the McGill University Health Centre ( Division of Cardiology ) and as a Scientist in the Cardiovascular Health Across the Lifespan Program at the Research Institute of the MUHC . His work bridges cardiovascular genetics, epidemiology, and translational medicine. Research Interests: Genetic etiology of cardiovascular diseases (myocardial infarction, dilated cardiomyopathy, aortic stenosis) Gene-environment interactions in disease susceptibility Mendelian randomization and genome-wide association studies (GWAS) Pharmacogenomics of cardiovascular therapies Development of genetic risk scores for prognosis Methodologies: Engert's team integrates clinical data from MUHC patients with large-scale public datasets, focusing on aortic stenosis across diverse ethnicities. They employ advanced statistical genetics, proteomics, and molecular modeling to uncover novel therapeutic targets. Publications: His recent work appears in JAMA Cardiology and Circulation , with a focus on lipoprotein(a) metabolism, TLR3-mediated calcification, and MFSD5 inhibition mechanisms in valvular disease. Collaborative projects emphasize cross-disciplinary approaches to cardiovascular pathogenesis.

Christy L. Averyمشاهده پروفایل

استاد

• Genomic Epidemiology
• Gene-Environment Interactions
• Metabolomics
• +۷ مورد دیگر

Christy L. Avery is a Professor in the Department of Epidemiology at the University of North Carolina at Chapel Hill's Gillings School of Global Public Health. She serves as Program Leader for Cardiovascular Disease Epidemiology. Her research focuses on genomic epidemiology, gene-environment interactions, metabolomics, and assessing cardiovascular disease burden in diverse populations across the life course. Her work integrates longitudinal data and multi-level factors (cellular, individual, contextual) to study health risks like hypertension and hypercholesterolemia, as well as behaviors such as smoking, physical activity, and obesity. She investigates genetic diversity in health risks among multi-ethnic U.S. populations and leads studies on metabolomic correlates of health and disease. Research Themes include: Genomic epidemiology of cardiovascular diseases Gene-environment interactions and omic biomarkers Multi-ethnic population studies Epidemiological methods for life-course analysis Metabolomics in disease prevention Recent Publications highlight trends in: Genetic risk scores for cardiovascular disease Multi-ethnic genome-wide association studies (GWAS) Metabolomic biomarkers in lifespan health Pharmacogenomics and drug-gene interactions Environmental health and exposomics Statistical genetics and causal inference She contributes to trans-ethnic genomics , refining genetic loci and improving precision medicine frameworks. Her collaborations span consortia like the Trans-Omics for Precision Medicine (TOPMed) and the Population Architecture Using Genomics and Epidemiology (PAGE) study.

Anne K. Dunnمشاهده پروفایل

دانشیار

• Microbiology
• Molecular and Cellular Biology
• Anaerobic Microbiology
• +۳ مورد دیگر

Anne K. Dunn is an Associate Professor of Microbiology at The University of Oklahoma. Her research focuses on bacterial physiology and symbiotic interactions, particularly using Vibrio fischeri and Photobacterium leiognathi as model organisms. She earned her B.S. in Biology from Iowa State University (1996), a Ph.D. in Bacteriology from the University of Wisconsin (2002), and completed postdoctoral training at the University of Georgia (2002-2007). Her lab investigates microbial energy conservation pathways, with a focus on the alternative oxidase (AOX) and its role in bacterial stress response and symbiosis. Key research themes include understanding AOX’s functional benefits in marine bacteria and the regulation of bioluminescence in Photobacterium leiognathi . The Dunn Lab integrates physiology, genetics, biochemistry, and bioinformatics to explore how microbial physiology influences survival and ecosystem roles. Her advising includes graduate students like Aaron Russell and Tyer Shadid, and undergraduate researchers. The lab collaborates on projects involving bacterial metabolism, symbiotic interactions, and environmental adaptation. Current work extends to SAR11, SAR86, and Roseobacter group bacteria, leveraging genomic and transcriptomic data for broader ecological insights.

• Lipid Metabolism
• Cholesterol Homeostasis
• Nuclear Receptors
• +۵ مورد دیگر

Peter Tontonoz is a Professor at the University of California Los Angeles, jointly appointed in the Department of Pathology and Laboratory Medicine and the Department of Biological Chemistry. His research integrates molecular biology, metabolism, and immunology to study lipid homeostasis, nuclear receptor signaling (LXRs/PPARs), and metabolic diseases. With over 350 publications, he leads pioneering work on cholesterol transport, adipocyte biology, and atherosclerosis. His research focuses on: Regulation of cholesterol flux via nonvesicular transport pathways (e.g., Aster proteins) Transcriptional control of lipid metabolism by LXRs and PPARs Adipocyte differentiation and thermogenic programming Inflammatory mechanisms linking lipid disorders to atherosclerosis Recent articles (2022–2025) emphasize membrane lipid remodeling, organelle interactions, and sex-specific metabolic regulation. Key trends include: Mechanistic studies on phospholipid-protein interactions in mitochondria/ER Cholesterol-driven inflammation in vascular and neurological contexts PPAR isoform-specific roles in liver/adipose tissue adaptation