جستجوی استاد راهنمای دانشگاهی

Yong Xuمشاهده پروفایل

استاد

• Neural Circuits
• Metabolism
• Energy Homeostasis
• +۳ مورد دیگر

Yong Xu is a Professor at Baylor College of Medicine, holding positions in the Department of Pediatrics and the Children's Nutrition Research Center (CNRC), where he serves as Associate Director for Basic Sciences. He also holds a secondary professorship in Molecular and Cellular Biology. Dr. Xu earned his M.D. from Tongji Medical University and his Ph.D. from the University of Alberta. His research focuses on neural circuits regulating metabolism, energy balance, and glucose homeostasis, utilizing advanced techniques like optogenetics and mouse modeling. Key projects include studying estrogen receptor-α neurons in glucose regulation and the role of nuclear receptor coactivators in obesity and diabetes. His lab has identified circuits linking motion sickness to metabolic balance and uncovered mechanisms behind serotonin's role in memory and feeding behavior. Education: MD (Tongji Medical University), PhD (University of Alberta). Professional Statement: Dr. Xu's work integrates genetic models with electrophysiology to dissect neural networks controlling metabolism. Current projects explore estrogen's effects on energy homeostasis, nuclear receptor coactivators in obesity, and serotonin's regulation of feeding and memory. Awards: Not explicitly listed for Dr. Xu himself, but lab members like Dr. Mengjie Wang have received accolades. Grants: Funded by NIH grants (e.g., R01 DK117281, P01 DK113954) and USDA/CRIS projects. Labs/Teams: Leads the CNRC-based lab with a multidisciplinary team of postdocs and researchers. Future Work: Expanding studies on neural circuits in metabolic disorders and translational applications of mouse models.

Jijie Pangمشاهده پروفایل

دانشیار

• Retinal Neurophysiology
• Retinal Ion Channels and Synaptic Circuitry
• Mechanosensitive Channels in Retinal Pathology
• +۳ مورد دیگر

Jijie Pang, M.D., Ph.D., is an Associate Professor in the Department of Ophthalmology at Baylor College of Medicine, located in Houston, Texas. His research focuses on retinal visual signaling, exploring retinal neurons (photoreceptors, bipolar cells, amacrine cells, and ganglion cells) using advanced techniques like patch-clamp electrophysiology, genetic engineering, and microscopy. He investigates mechanosensitive ion channels' roles in normal retinal function and diseases such as glaucoma and retinal injury. Education: M.D. and Ph.D. from Medical School, Xi'an Jiaotong University, Xi'an, China Postdoctoral Fellowships in Neurology and Ophthalmology at Baylor College of Medicine Research Interests: His work emphasizes retinal neuronal circuitry, ion channel dynamics, and pressure-related retinal disorders. Key projects include characterizing light-evoked activities in retinal neurons and studying glaucoma pathogenesis through intraocular pressure models. Professional Memberships: Association for Research in Vision and Ophthalmology Society for Neuroscience Royal Society of Medicine (London) Recent Research Trends: Publications highlight investigations into retinal dysfunction in glaucoma, synaptic inputs in ganglion cells, and challenges to traditional retinal circuit models. Techniques include multi-cell patch-clamp recordings and immunohistochemical analysis.

• Biochemistry
• Biophysics
• Cardiovascular Sciences
• +۵ مورد دیگر

Susan L. Hamilton, Ph.D., is a Professor and L. F. McCollum Chair in Molecular Physiology at Baylor College of Medicine's Department of Integrative Physiology. She is also a member of the Dan L Duncan Comprehensive Cancer Center. Her research focuses on skeletal muscle physiology, particularly excitation-contraction coupling, ryanodine receptors (RyR1), and L-type Ca²⁺ channels in disease contexts like malignant hyperthermia and central core disease. She holds a Ph.D. from the University of Colorado School of Medicine and a B.S. from Indiana University. Her lab employs multidisciplinary approaches, including biochemistry, imaging, and animal models, to study muscle metabolism and Ca²⁺ signaling pathways. Funding sources include the NIH, American Heart Association, and Muscular Dystrophy Association. Recent work highlights therapeutic strategies for RyR1-linked disorders and the role of calcium channels in metabolic regulation. Education : Ph.D., University of Colorado School of Medicine; B.S., Indiana University Labs/Teams : Hamilton Lab (focusing on muscle disease mechanisms and metabolism) Grants/Funding : NIH, AHA, MDA

Jeannie Chinمشاهده پروفایل

استاد

• Alzheimer's Disease
• Epilepsy
• Neurodegenerative Disorders
• +۴ مورد دیگر

Jeannie Chin, Ph.D., is a Professor in the Department of Neuroscience at Baylor College of Medicine. She holds a BA/BS in Zoology/Biology from the University of Texas, Austin, a PhD in Neuroscience from the University of Texas Graduate School of Biomedical Sciences, and completed postdoctoral training at the Gladstone Institute of Neurological Disease and UCSF. Her research focuses on understanding cellular and network mechanisms underlying cognitive impairments in Alzheimer’s disease, epilepsy, and other neurological disorders, combining biochemistry, molecular biology, in vivo physiology, and behavioral paradigms. Key interests include activity-dependent epigenetic regulation, neural stem cell dynamics, and corticothalamic network dysfunction. Recent work highlights therapeutic strategies targeting ΔFosB, Tiam1, and thalamic activity to improve cognition and reduce disease progression. Dr. Chin’s lab is part of the Memory & Brain Research Center at BCM, and she serves as Deputy Editor for a scientific journal. Education: Postdoctoral Training: Gladstone Institute of Neurological Disease and UCSF (2007) PhD: University of Texas Graduate School of Biomedical Sciences (Neuroscience, 2001) BA/BS: University of Texas, Austin (Zoology/Biology, 1994) Research interests emphasize linking cellular alterations to memory deficits in mouse models of AD using EEG, biochemical assays, and viral gene expression. Her lab investigates molecular mechanisms of cognitive dysfunction and identifies therapeutic entry points. Notable contributions include studies on PTEN mutations, Aβ-induced neuronal activity, and corticothalamic network dysfunction. Awards include the Deputy Editor role, reflecting her leadership in neuroscience publishing. Advising includes graduate students (Joseph Campbell, Pei-Yun Chuang, Yoshitaka Furuta) and MD/PhD candidates (Corey St. Romain). Collaborative grants focus on Alzheimer’s and epilepsy, with ongoing work on molecular MRI probes and interventional strategies to restore cognition. The Chin Lab’s interdisciplinary approach bridges basic science and clinical applications, aiming to translate discoveries into therapies for neurological diseases.

Mingshan Xueمشاهده پروفایل

دانشیار

• Cortical Circuit Function
• Neurodevelopmental Disorders
• Gene Therapy
• +۶ مورد دیگر

Dr. Mingshan Xue is an Associate Professor at Baylor College of Medicine, holding appointments in the Departments of Neuroscience and Molecular and Human Genetics. He is affiliated with the Jan and Dan Duncan Neurological Research Institute and the Cain Foundation Laboratories. His research focuses on synaptic mechanisms underlying neural circuit function, with a particular emphasis on neurodevelopmental disorders such as epilepsy and autism. Dr. Xue’s work combines molecular, electrophysiological, and computational approaches to study synaptic excitatory/inhibitory (E/I) balance, genetic causes of neurodevelopmental disorders, and gene therapy strategies. Education: PhD (Baylor College of Medicine), Postdoctoral Fellowship (UC San Diego), BS (Fudan University) Affiliations: Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute Research interests include: Mechanisms of E/I ratio regulation in cortical circuits Mouse models of neurodevelopmental disorders (e.g., STXBP1 encephalopathy) Development of optogenetic tools and deep-learning algorithms for EEG analysis Key achievements include the creation of STXBP1 mouse models and the development of antisense oligonucleotide therapies for Angelman syndrome. His lab has received funding from NIH, McKnight Foundation, and the Whitehall Foundation, among others. Awards: McKnight Scholar Award (2018), NARSAD Young Investigator Award (2016), Caroline DeLuca Scholar (2014). Current students and postdocs are actively involved in projects spanning synaptic physiology, gene therapy, and neurotechnology development. The lab collaborates with clinical teams to translate findings into therapeutic strategies for neurodevelopmental disorders.

Jeffrey L Noebelsمشاهده پروفایل

استاد

• Neurogenetics
• Epilepsy
• Neurological Disorders
• +۳ مورد دیگر

Jeffrey L Noebels, M.D., Ph.D., holds the Cullen Trust for Health Care Endowed Chair in Neurogenetics and serves as Professor in Neurology, Neuroscience, and Molecular & Human Genetics at Baylor College of Medicine. He directs the Blue Bird Circle Developmental Neurogenetics Laboratory and participates in graduate programs in Integrative Molecular and Biomedical Sciences and Translational Biology and Molecular Medicine. Education includes a BA from Reed College (1972), MD from Yale University (1981), PhD from Stanford University (1977), residency at Massachusetts General Hospital (Boston), and postdoctoral training at Harvard University (1983). Certifications include Neurology from the American Board of Psychiatry and Neurology. Research focuses on gene regulation of neuronal excitability and inherited neurological diseases, particularly epilepsy and Alzheimer's. His lab uses mouse models to study ion channel mutations, synaptic plasticity, and network synchronization defects. Key advances include discoveries of epilepsy-linked mouse mutants (e.g., stargazer) and identification of Zn transporters' neuroprotective roles. Recent work explores Alzheimer's hyperexcitability mechanisms and translational genomic studies of ion channel genes in epilepsy. Major projects include a NIH-funded Human Channelopathy Project analyzing ion channel variants and a Center studying neurocardiac risk prediction. His work bridges basic science and clinical translation, addressing disease mechanisms in epilepsy, sudden death syndromes, and cognitive impairments. Lab activities employ electrophysiology, 2-photon imaging, and genomic tools to dissect network dysfunction. Collaborations with the Baylor Human Genome Sequencing Center highlight commitment to large-scale genomic research in neurological disorders.

• Voltage-gated ion channel research
• Epilepsy mechanisms
• Neurogenetics
• +۴ مورد دیگر

Edward C Cooper, M.D., Ph.D., is an Associate Professor in the Departments of Neurology, Neuroscience, and Molecular & Human Genetics at Baylor College of Medicine. His research focuses on understanding ion channel dysfunction in epilepsy and psychiatric disorders, particularly the role of KCNQ2/3 potassium channels in axonal excitability. He leads a multidisciplinary lab investigating genetic mechanisms of epilepsy, including KCNQ2 encephalopathy and ANK3-related psychiatric conditions. Dr. Cooper’s work integrates molecular, electrophysiological, and computational approaches, with translational goals to develop therapies for channelopathies. Education: PhD in Cellular and Molecular Physiology (Yale University, 1991), MD (Yale University, 1990), Neurology residency at UCSF (1994), and postdoctoral training at UC San Francisco (2002). Research Interests: Voltage-gated sodium/potassium channels in epilepsy, KCNQ2/3 channelopathies, ANK3’s role in psychiatric disorders, axonal ion channel targeting, and molecular evolution of ion channel systems. Key projects include the KCNQ2/3 case registry and variant curation efforts. Lab & Funding: The Cooper Lab is supported by NINDS, CURE Epilepsy, and the American Epilepsy Society. Collaborations span basic science, clinical research, and translational medicine, with a focus on developing treatments for channelopathy-related conditions.

Atul Maheshwariمشاهده پروفایل

دانشیار

• Epilepsy
• Neurology
• Neuroscience
• +۴ مورد دیگر

Atul Maheshwari, M.D., is an Associate Professor in the Department of Neurology and Neuroscience at Baylor College of Medicine. His research focuses on epilepsy mechanisms, brain oscillations, and comorbidities such as ADHD. He completed his MD at Baylor College of Medicine and a BA at Rice University, followed by postdoctoral training. His work explores neuronal circuits in epilepsy using mouse models and clinical studies. Education: Internal Medicine MD (Baylor College of Medicine, 2006), BA (Rice University, 2002) Training: Clinical Neurophysiology Fellowship (Baylor College of Medicine), Epilepsy Residency (Massachusetts General/Brigham and Women's Hospitals), Neurology Internship (Beth Israel Deaconess Medical Center) Research interests include thalamocortical microcircuits, interneuron dysfunction, and neuronal oscillations in epilepsy and ADHD. His recent studies investigate how brain oscillations develop abnormally in these conditions, aiming to improve treatments. Over 30 peer-reviewed articles highlight his contributions to epilepsy pathophysiology and clinical neurophysiology. Notably, he developed a neurologist-initiated psychoeducation program for psychogenic nonepileptic seizures and identified novel roles for KCNQ2/3 potassium channels in seizure mechanisms. His lab collaborates with Jeffrey Noebels, leveraging mouse models to study genetic epilepsy syndromes.

• Spreading Depolarization
• Epilepsy
• Sudden Unexpected Death in Epilepsy (SUDEP)
• +۳ مورد دیگر

Isamu Aiba, Ph.D., is an Assistant Professor in the Department of Neurology at Baylor College of Medicine, Houston, Texas. He holds a Ph.D. from the University of New Mexico. His research focuses on spreading depolarization, epilepsy mechanisms, sudden unexpected death in epilepsy (SUDEP), and autonomic dysfunction. Key contributions include elucidating the role of spreading depolarization in SUDEP and identifying molecular mechanisms underlying epilepsy. Education: PhD in Neuroscience from the University of New Mexico (Albuquerque, NM) Research Interests: Spreading depolarization dynamics and their clinical implications in epilepsy and SUDEP Molecular and cellular mechanisms of seizure initiation and propagation Autonomic nervous system interactions with brain pathology Novel therapeutic targets for epilepsy and SUDEP prevention Awards & Funding: Career Development Award (American Heart Association) Junior Investigator Research Award (American Epilepsy Society, 2021–2022) Grants & Collaborations: Investigates adrenergic signaling in cardiac preganglionic neurons Develops CRISPR-based glioblastoma models to study tumor-induced epileptogenesis Explores fenfluramine’s inhibitory effects on cortical spreading depolarization

Scott Johnstoneمشاهده پروفایل

استادیار

• Cardiovascular Disease
• Cell Signaling
• Inflammation
• +۶ مورد دیگر

Scott Johnstone, Ph.D., is an Assistant Professor at the Fralin Biomedical Research Institute at Virginia Tech Carilion (VTC), the Department of Biological Sciences (College of Science), and the Department of Surgery (Virginia Tech Carilion School of Medicine). His research focuses on understanding vascular disease mechanisms, particularly how healthy blood vessels are altered in conditions like atherosclerosis and restenosis. Key areas include cell signaling pathways, pannexin channels, and connexin proteins in inflammation and proliferation. Education includes a Ph.D. and BSc from Glasgow Caledonian University, and a Postgraduate Certificate in Academic Practice from the University of Glasgow. Previous roles include postdoctoral fellowships at the University of Virginia and Glasgow Cardiovascular Research Centre. Research interests span inflammation in vascular disease, proliferation pathways in stent-induced blockages, and developing peptide inhibitors targeting connexin interactions. He also explores pannexin channels' roles in blood pressure regulation and their implications for conditions like hypertension and obesity-related vascular dysfunction. Key publications include works on pannexin 1's role in inflammation, renin secretion regulation, and endothelial dysfunction in COVID-19. Awards include the 2009 University of Virginia Outstanding Post-Doc Award and the 2004 Institute of Biomedical Science President's Prize. Led the Johnstone Lab, which collaborates on translational projects, including NIH-funded studies on obesity-heart disease links and novel therapies for vascular diseases. Lab members include postdoctoral associates and medical students like Meghan Sedovy and Adam Hoch. Active in professional activities like co-chairing international gap junction conferences and serving on advisory boards.

Hee Jung Chungمشاهده پروفایل

دانشیار

• Epilepsy Research
• Neurological Disorders
• Ion Channel Function
• +۳ مورد دیگر

Hee Jung Chung is an Associate Professor in the Department of Molecular and Integrative Physiology at the University of Illinois at Urbana-Champaign (UIUC), with affiliations in the Neuroscience Program and the Beckman Institute for Advanced Science and Technology. Her research focuses on understanding mechanisms underlying homeostatic plasticity and epilepsy, particularly the role of ion channels like KCNQ/Kv7 in neuronal excitability. She holds a B.S. from Cornell University (1995), a Ph.D. from Johns Hopkins University School of Medicine (2002), and completed postdoctoral training at the University of California, San Francisco (2002-2009). Her work combines interdisciplinary approaches—neuronal culture, microscopy, biochemistry, and mouse genetics—to investigate how ion channel mutations contribute to epilepsy and how homeostatic plasticity regulates neuronal activity. Key projects include studying Kv7 channel localization and function in axons, and the role of STEP61 in synaptic plasticity and disease. Her lab develops novel tools, such as in vitro platforms for neuronal interfacing and advanced imaging techniques like artificial confocal microscopy. Dr. Chung’s research has been recognized with awards including the James E. Heath Award for teaching excellence (2014) and grants from the Epilepsy Foundation and March of Dimes. Her recent publications span topics like exosome-mediated brain-muscle communication, STEP61’s role in hyperexcitability disorders, and Kv7 channel dysfunction in epileptic encephalopathy. Her lab’s future directions include developing transgenic models to study homeostatic plasticity in vivo and exploring therapeutic strategies for epilepsy mutations. Collaborations extend to imaging technology, neuroengineering, and translational medicine.

• Neuropharmacology
• Ion Channel Biology
• Neurology
• +۳ مورد دیگر

Dr. Han Chow Chua is a Lecturer in the Sydney Pharmacy School at the University of Sydney's Faculty of Medicine and Health. He holds an NHMRC Emerging Leadership Fellowship and is affiliated with The Centre for Drug Discovery Innovation and the Charles Perkins Centre. His research focuses on ion channels, particularly ligand-gated, voltage-gated, and leak channels, with an emphasis on GABAA receptors in epilepsy and neurodevelopmental disorders. Education: Doctor of Philosophy (Neuropharmacology), University of Sydney (2012-2016) Bachelor of Pharmacy (Hons I/Medal), University of Sydney (2008-2011) Research Interests: Dr. Chua investigates ion channel dysfunction in neurological diseases, leveraging structural biology, pharmacology, and genetic approaches. His work spans GABAA receptor pharmacology, NALCN channel physiology, and the molecular mechanisms underlying epilepsy and hearing disorders. Awards: Carlsberg Foundation Research Infrastructure Grant (2022) Travel Award, Biophysical Society Annual Meeting (2020) John A. Lamberton Research Scholarship (2013) University Medal (2012) Grants & Advising: Active grants include studies on CACNA1A channelopathies and hearing-related molecular mechanisms. He advises one current PhD student, Sze Hon KAN, exploring GABAA receptor therapies in genetic epilepsies. Labs & Teams: Member of interdisciplinary teams at the Charles Perkins Centre and the Centre for Drug Discovery Innovation, focusing on translating ion channel research into clinical applications.

• Neuroscience
• Pain Research
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr Michelle Gerke-Duncan is a Lecturer in the Department of Anatomy & Histology at the School of Medical Sciences, University of Sydney. She is affiliated with the Bosch Institute and focuses on neuroscience research, particularly in pain mechanisms, neurodegenerative disorders, and neuroimmunology. University of Sydney School of Medical Sciences Anatomy & Histology Department Bosch Institute Her research spans neurosciences and healthy ageing, with specific interests in pain signaling, nervous system diseases, and neuro-immune interactions. She employs cellular/molecular and immunological approaches to investigate these areas. Recent publications (2002–2023) highlight her work on lectin-based neuronal labeling, neurodegenerative disease mechanisms, migraine pathophysiology, opioid withdrawal neurophysiology, and pain signaling pathways. These contributions align with themes of neurosciences, pain research, and neuroimmunology.

• Nephrology
• Kidney Disease
• Diabetic Kidney Disease
• +۴ مورد دیگر

Dr. Chunling Huang is a Senior Research Fellow and NHMRC Early Career Fellow at the Northern Clinical School, Faculty of Medicine and Health, University of Sydney. Her research focuses on kidney diseases, particularly diabetic nephropathy and renal fibrosis. Key areas include the role of ion channels (KCa3.1), mitochondrial dysfunction, and therapeutic strategies such as exosomes and photobiomodulation. Her work spans experimental models of renal injury, drug repurposing (e.g., metformin), and biomarker discovery involving miRNAs. Collaborations with Prof. Christopher Pollock and Prof. Xiao Chen underscore her interdisciplinary approach. Recent grants include investigations into kidney fibroblast biology, therapeutic targeting of microRNA-200b, and the development of novel i-body therapies targeting CXCR4. Awards include the prestigious NHMRC Early Career Fellowship. Grants: JDRF Innovative Grant (2022), Sydney Ignition Seed Fund (2019), Diabetes Australia Research Trust Grant (2018) Key Themes: Renal fibrosis, diabetic complications, autophagy, and mitochondrial biology

Alfredo Kirkwoodمشاهده پروفایل

استاد

• Developmental Neuroscience
• Systems Neuroscience
• Computational Neuroscience
• +۵ مورد دیگر

Alfredo Kirkwood is a Professor of Neuroscience at Johns Hopkins University, affiliated with the Mind/Brain Institute. His research focuses on mechanisms of cortical modification, particularly the influence of sensory experience on shaping the functional organization of the cerebral cortex. He investigates activity-dependent synaptic plasticity including long-term potentiation (LTP) and long-term depression (LTD) in visual cortical slices. Kirkwood's education includes a PhD from Brandeis University and a Master's degree from Universidad de Chile. His research examines how synaptic inhibition and neuromodulators regulate plasticity induction during development, proposing that the development of synaptic inhibition restricts plasticity to a critical period, while neuromodulators enhance plasticity during arousal. His recent publications focus on synaptic plasticity mechanisms, neural circuit function in development and aging, and neurodegenerative processes. The research demonstrates a consistent focus on cortical plasticity across mammalian species, with recent investigations into therapeutic approaches for neurodegenerative conditions and neurodevelopmental disorders. Dr. Kirkwood leads a laboratory with several postdoctoral fellows and maintains active collaborations through graduate program affiliations in Neuroscience Training, Psychological and Brain Sciences, and Visual Neuroscience.