جست‌وجوی استاد و پژوهشگر

Laura H. Saltmanمشاهده پروفایل

استاد آموزشی

• Molecular Biology
• Microbiology
• Bacterial Pathogenesis
• +۳ مورد دیگر

Laura H. Saltman is an Associate Professor of Instruction in the Department of Biological Sciences at Ohio University's College of Arts and Sciences, where she teaches undergraduate courses including Biological Sciences I, General Genetics, and Microbiology. She holds a Ph.D. from Columbia University and has transitioned into full-time science education, previously teaching at Bard High School Early College in Queens, NY. Education: Ph.D., Columbia University Her research background spans molecular biology and microbiology, with a focus on bacterial pathogenesis, phage biology, and molecular interactions between microbes and host cells. Though her recent work emphasizes teaching, her past research contributed to understanding bacterial adhesion, transcriptional regulation, and phage development inhibition. The publications reflect interdisciplinary work in cell biology, genetics, and infectious disease mechanisms. Scientific Contributions: Studied invasin-integrin interactions in Yersinia Explored nuclear compartmentalization of transcription factors Contributed to phage display methodology Investigated plasmid-mediated phage inhibition Laura H. Saltman is deeply committed to undergraduate science education, sharing her passion for microbiology and molecular biology with students. Her career evolution from research to teaching highlights a dedication to science pedagogy. No current research labs, grants, or advisees are listed in the available information.

• Mathematical Biology
• Cell Mechanics
• Cytoskeleton Dynamics
• +۴ مورد دیگر

Angelika Manhart is an Assistant Professor in the Department of Mathematics at the University of Vienna's Faculty of Mathematics. With 26 publications spanning from 2014 to 2025, she has established herself as a leading researcher at the intersection of mathematical modeling and biological processes. Her work bridges rigorous mathematical analysis with biological insight to address fundamental questions in cellular mechanics and dynamics. Dr. Manhart's research focuses on mathematical biology, particularly the mechanics of cellular processes including cell movement, cytoskeletal dynamics, and tissue morphogenesis. She specializes in developing computational frameworks that capture the intricate interplay between physical forces and biological functions at the cellular level. Her work explores how mathematical models can elucidate complex phenomena such as actin network dynamics, nuclear positioning in muscle cells, and epithelial tissue formation. She employs techniques from partial differential equations, dynamical systems theory, and computational mathematics to address biological questions across multiple scales. Her publication record reveals a consistent trajectory of increasingly sophisticated modeling approaches, with recent work incorporating machine learning techniques and multiscale modeling. The research spans diverse biological contexts including wound healing, muscle development, microbial communities, and epithelial morphogenesis, demonstrating the versatility of mathematical approaches in biological inquiry. Several of her papers have received significant citations, with 'Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers' (2019) accumulating 49 citations and 'Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel' (2018) receiving 83 citations. Dr. Manhart actively collaborates with experimental biologists across institutions, as evidenced by her co-authorship with researchers from various biological disciplines. Her work has been presented at conferences including talks on 'Alignment processes in cells - From individual interactions to collectivity' (December 2024) and earlier presentations on 'Model and Simulation of Actin-dependent Cell Movement' (2014), reflecting her continued engagement with both theoretical and applied aspects of her field.

Timothy R Zacharewskiمشاهده پروفایل

استاد

• Nuclear Receptor-mediated Toxicity
• Gene Expression Regulation
• Environmental Toxicology
• +۶ مورد دیگر

Timothy R Zacharewski is a Professor at the Department of Biochemistry & Molecular Biology at Michigan State University, affiliated with the Genetics & Genome Sciences Program and Cell & Molecular Biology Program. His research focuses on nuclear receptor-mediated toxicity, particularly how environmental chemicals, drugs, and natural products affect gene expression in the liver and endocrine system. Ph.D. (1990) - Texas A&M University B.S. (1986) - University of Guelph Using in vivo rodent and in vitro cell line models, he compares human, mouse, and rat responses to reduce cross-species extrapolation uncertainties. His work integrates toxicology, genomics, and computational approaches to study mechanisms like coagulation-driven fibrosis, pyruvate kinase isoform switching, and circadian rhythm disruption linked to TCDD exposure. Recent publications highlight aryl hydrocarbon receptor pathways , metabolic reprogramming , and cross-species gene expression comparisons in mouse models. The lab employs bioinformatics and multi-omics analyses (lipidomics, transcriptomics) to explore environmental contaminant impacts on bile acid homeostasis, antibiotic resistance gene reservoirs, and REV-ERBα/β activation in hepatotoxicity. Professor Zacharewski's research has significant implications for understanding human risk from xenobiotic exposures and improving toxicity modeling frameworks.

Jianhua Ruanمشاهده پروفایل

استاد

• Bioinformatics
• Computational Systems Biology
• Machine Learning for Life Sciences
• +۷ مورد دیگر

Dr. Jianhua Ruan is a Professor in the Department of Computer Science at The University of Texas at San Antonio (UTSA), affiliated with the College of Sciences. He holds a Ph.D. in Computer Science from Washington University in St. Louis and has been a faculty member at UTSA since 2007. His research focuses on bioinformatics, computational systems biology, and machine learning applied to life sciences. Specific areas include modeling cis-regulatory networks, analyzing biological networks via graph algorithms, and biomarker discovery using omics data. Dr. Ruan collaborates extensively with biologists at UTSA and the UT Health Science Center on genomic, transcriptomic, proteomic, and epigenomic studies. Key research interests include: Machine learning for cis-regulatory network modeling Graph algorithms for biological network analysis Integrated omics data analysis for disease prediction Epigenetic regulation and cancer biology His work has been supported by NIH, NSF, and the San Antonio Life Sciences Institute. Notable achievements include a Best Performer award in the DREAM Reverse Engineering Challenges (2008) and the UTSA Faculty Research Award (2007). Dr. Ruan organizes the UTSA Computer Science Graduate Research Seminar, fostering interdisciplinary collaboration. He has developed software tools like TSCAN for single-cell RNA-seq analysis and contributes to computational methods for biomarker discovery and network-based classification.

Deni S. Galileoمشاهده پروفایل

استاد

• Cell Migration
• Neurobiology
• Developmental Biology
• +۳ مورد دیگر

Deni S. Galileo is a Professor in the Department of Biological Sciences at the University of Delaware. His research focuses on cell migration mechanisms in the developing brain and malignant gliomas, utilizing chick embryo models and retroviral gene transfer technologies. His work explores how integrins, extracellular matrix molecules, and adhesion proteins like L1CAM regulate normal and abnormal cell migration. Key projects include developing novel models for studying glioma invasiveness and breast cancer brain metastases, and investigating the role of QSOX1 and PMCA4 in tumor progression. Education: B.A., New College of Florida Ph.D., University of Florida College of Medicine and Whitney Laboratory Postdoctoral Research, Washington University School of Medicine (St. Louis) Research interests span developmental neurobiology, tumor biology, and gene therapy. Current projects include: Control of glioma invasiveness via L1CAM Integrins' roles in neuronal migration and survival Ex vivo analysis of glioblastoma behavior using chick embryos His lab has pioneered the use of replication-competent retroviral vectors and in ovo electroporation for widespread protein misexpression in developing brains. Collaborations with Dr. John Koh (Chemistry and Biochemistry) explore axon outgrowth on gene-patterned cell monolayers. Lab Resources: Office 232 Wolf Hall, Lab 248 Wolf Hall Teaching: Courses include Cell Biology (BISC 305), Developmental Neurobiology (BISC 439/639), and Special Topics in Modern Biological Microscopy (BISC 400). Notable contributions include establishing chick embryo models for studying glioma and breast cancer metastasis to the brain, and discovering roles for integrin α6β1 and α8β1 in cell migration and survival.

Ioana Ilieمشاهده پروفایل

استادیار

• Computational Chemistry
• Biophysics
• Peptide Therapeutics
• +۳ مورد دیگر

Dr. Ioana Ilie is an Assistant Professor in Computational Chemistry at the van 't Hoff Institute for Molecular Sciences , part of the Faculty of Science at the University of Amsterdam . Her research focuses on developing multiscale computational tools to study polypeptide aggregation, design peptide-based therapeutics, and engineer smart biomaterials. She combines atomistic simulations, coarse-grained modeling, and machine learning to address challenges in neurodegenerative diseases and cancer. Dr. Ilie holds a PhD from the University of Twente (Netherlands), with postdoctoral training at the Technical University of Darmstadt (Germany) and the University of Zurich (Switzerland). She leads the Multiscale Simulation of Biomolecular Systems group , which aims to bridge computational and experimental approaches in biomedicine and materials science. Her lab has received a Career Development Award from the Synapsis Foundation (2022) and recognition in ChemComm 's Emerging Investigators edition. Her research spans amyloidogenic targets , cyclic peptide design , and coarse-grained modeling . She emphasizes interdisciplinary collaboration, leveraging computational methods to advance therapeutic strategies and biomaterial innovation. Her team's future goals include expanding machine learning applications and deepening international partnerships. For more information, visit her lab webpage or follow her on Twitter .

Edna Cukiermanمشاهده پروفایل

استاد

• Tumor Microenvironment
• Pancreatic Cancer Research
• Cancer Biology
• +۳ مورد دیگر

Edna Cukierman is a Professor and Program Leader at the Lewis Katz School of Medicine at Temple University, holding the Marvin & Concetta Greenberg Chair in Pancreatic Cancer Research and the ACS Wilmott Family Professorship. She leads the Cukierman Laboratory, focused on understanding the role of desmoplasia (dense mesenchymal microenvironment) in tumor progression, particularly in pancreatic cancer. Her work employs 3D culturing systems and innovative tools like HOST (Harmonic Output of Stromal Traits) to analyze tumor microenvironment dynamics. Affiliations: Fox Chase Cancer Center, Greenberg Pancreatic Cancer Institute, AACR TME Working Group Chair (2024-2026). Education: PhD in Molecular and Cell Biology (Technion-Israel Institute of Technology, 1997), Postdoctoral training at NIH (1997-2002). Research interests include cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), and tumor immunology. Key achievements include developing the HOST-Factor metric to assess TME prognostic indicators and identifying therapeutic targets like Netrin G1 and FABP4-tastic pancreatic stellate cells. Awards: AACR TME Working Group Chair, Pancreatic Cancer Cure Foundation Awards, NIH study section membership, and multiple imaging awards for microscopy contributions. Her lab collaborates with institutions like Drexel University and Penn Medicine, focusing on translational research to improve patient outcomes through stroma-targeted therapies.

Mary Kay Pflumمشاهده پروفایل

استاد

• Protein Post-Translational Modification
• Histone Deacetylase Proteins
• Chemical Genetics
• +۴ مورد دیگر

Mary Kay Pflum is a Professor in the Department of Chemistry at Wayne State University's College of Liberal Arts and Sciences. Holding the A. Paul and Carol C. Schaap Endowed Chair in Chemistry, she leads a research program at the Chemistry-Biology interface focusing on kinase and histone deacetylase (HDAC) enzymes in cancer biology. Education: B.A., Carleton College (1992) Ph.D., Yale University (1999) NIH Postdoctoral Fellow, Harvard University (1999-2001) Her research integrates organic synthesis, biochemistry, and cell biology to develop chemical tools for studying protein post-translational modifications. Key projects include: ATP analog-based kinase substrate labeling HDAC substrate trapping mutants Selective HDAC inhibitor development Recent publications highlight her work in HDAC6 substrate discovery (e.g., PRMT5 deacetylation), EGFR-HDAC1 signaling, and innovations in kinase substrate identification methods like K-BIPS and K-CLIP. Awards include the Charles H. Gershenson Distinguished Faculty Fellowship (2019) and multiple NIH grants (R01GM079529, R35GM131821). Scientific Awards & Grants: American Chemical Society Pre-doctoral Fellowship (1996) NIH Postdoctoral Fellowship (1999) Research Corporation Innovation Award (2002) NIH R01 Grants (2001-present) Charles H. Gershenson Distinguished Faculty Fellowship (2019)

• Physiology
• Neuroscience
• Synaptic Plasticity
• +۳ مورد دیگر

Karen Ting Chang, PhD , is an Associate Professor of Physiology and Neuroscience at the University of Southern California's Keck School of Medicine. Her research focuses on synaptic plasticity, mitochondrial dynamics, and molecular mechanisms in neurodegenerative diseases and developmental disorders. Using Drosophila models, she investigates how pathways like secretory autophagy, DSCR1 regulation, and integrin signaling affect neural function. Research Trends : Her publications highlight synaptic remodeling, calcium signaling, and cross-disease connections between Down syndrome and Alzheimer's pathology. Key methodologies include genetic models, endocytosis studies, and mitochondrial transport analysis. Contact : Email: changkt@usc.edu

Lee Makowskiمشاهده پروفایل

استاد

• Biophysical Data Analysis
• Alzheimer's Disease
• Molecular Biophysics
• +۳ مورد دیگر

Lee Makowski is a Professor of Bioengineering and Chemistry and Chemical Biology at Northeastern University’s College of Engineering. He holds affiliations with the Electrical and Computer Engineering department and directs the Bioinnovation Center in Ghana, focusing on affordable medical technologies. With a B.S. in Physics from Brown University and a Ph.D. in Electrical Engineering from MIT, his career includes roles at Columbia University, Florida State University, and the National Science Foundation. His research integrates image/signal processing with biophysical data to study Alzheimer’s molecular mechanisms and amyloid fibrils. Key research projects include NIH-funded studies on fibrillar polymorphs in Alzheimer’s brain tissue and a Northeastern initiative to cultivate biomedical innovation in Ghana. Awards include the 2025 Impact Award and Fellow status from the American Institute for Medical and Biological Engineers. His grants include a $2.1M NIH award for Alzheimer’s studies. He advises on undergraduate research programs and has mentored students in bioengineering and global health initiatives. His work spans structural proteomics, enzyme catalysis, and x-ray imaging technologies, published in over 100 peer-reviewed articles.

Phoebe L. Stewartمشاهده پروفایل

استاد

• Cryo-Electron Microscopy
• Structural Biology
• Virology
• +۳ مورد دیگر

Phoebe L. Stewart is a Professor in the Department of Pharmacology at the School of Medicine, Case Western Reserve University. She also serves as Vice Chair of Educational Programs in the Department of Pharmacology. Her research focuses on applying cryo-electron microscopy to study viral structures and their interactions with host factors, particularly adenovirus and engineered oncolytic viruses. Dr. Stewart's work integrates multiple structural methods including X-ray crystallography, NMR, and molecular dynamics to understand viral mechanisms and develop therapeutic strategies against cancer. She holds affiliations with the Cleveland Center for Membrane and Structural Biology and the Case Comprehensive Cancer Center. Education: AB in Biochemistry (Harvard University), PhD in Chemistry (University of Pennsylvania). Postdoctoral training included cryo-EM at the Wistar Institute and EMBL Heidelberg. Research interests emphasize viral structure, host-pathogen interactions, and oncolytic virotherapy. Notable projects include structural analysis of adenovirus-complement interactions and designing viruses that evade innate immunity for systemic cancer therapy. Publications span structural virology, cryo-EM applications, and nanoparticle design. Her lab collaborates on engineering viral vectors for targeted drug delivery and immune modulation.

Kathleen O'Connorمشاهده پروفایل

استاد

• Cancer Biology
• Integrin Signaling
• Cell Invasion and Metastasis
• +۷ مورد دیگر

Kathleen O'Connor is a Professor in the Department of Molecular and Cellular Biochemistry at the University of Kentucky, where she also serves as the Associate Director of Cancer Education in the Markey Cancer Center. She is a member of the Markey Cancer Center’s Cancer Research Priority Initiative and the Molecular and Cellular Oncology Research Program, as well as the UNITE Research Priority Area. Her interdisciplinary roles reflect her leadership in cancer research and education. Doctor of Philosophy, Case Western Reserve University, 1996 Bachelor of Science, James Madison University, 1988 Dr. O'Connor's research focuses on the molecular mechanisms of cancer progression, particularly how integrin receptors—especially α6β4—mediate signaling that drives carcinoma cell invasion. Her lab investigates the interplay between integrin signaling and cyclic AMP metabolism, Rho GTPase regulation, and the expression of pro-invasive genes such as autotaxin, S100A4, and EGFR ligands. This work has significant implications for understanding the aggressive behavior of cancers in the breast, colon, and pancreas. Her recent publications (2022–2025) highlight sustained contributions to cancer biology, with studies on integrin-mediated chemosensitization, cytoskeletal regulation of invasion, and social determinants of breast cancer outcomes. These works span disciplines including molecular oncology, cell signaling, and health disparities, reflecting a broad and impactful research portfolio. Scientific awards include: Distinguished Faculty Teaching Award, Nominee (2006) Wethington Excellence in Research Award (2013, 2014, 2017) Women in Medicine and Science Mentorship, Finalist (2018) Dr. O'Connor is actively involved in mentoring and training the next generation of scientists. She leads several funded initiatives, including the Markey STRONG Post-baccalaureate Program and a Diversity in Cancer Research Supplement from the American Cancer Society, aimed at increasing representation of underrepresented minorities in biomedical research. She is the Principal Investigator (PI) on multiple active grants, including projects focused on triple-negative breast cancer and chemotherapy optimization, funded by the American Cancer Society and the National Cancer Institute. Her work bridges basic science and translational applications, with collaborations across institutions and disciplines. She is embedded in a vibrant research ecosystem at the Markey Cancer Center, where she contributes to education, mentorship, and collaborative research networks aimed at combating cancer through innovative science and inclusive training programs.

• Muscle Metabolism
• Insulin Resistance
• Diabetes Research
• +۱۱ مورد دیگر

Dr. Richard Mackenzie is a Reader in Insulin Resistance & Metabolism at the School of Life and Health Sciences, University of Roehampton , where he also serves as Research Director for the Sport & Exercise Science Research Group. He previously held a Senior Lecturer position at the University of Westminster (2008-2015) and was a Research Physiologist at the University of Brighton (2005-2008). His research focuses on metabolic regulation in health and disease states, particularly type 2 diabetes and elite athlete physiology. Dr. Mackenzie's work explores: Muscle metabolism in health, obesity, and diabetes Role of obesity in insulin resistance and metabolic disease Hematological and muscular adaptations to acute hypoxia Akt/PKB inhibition via IP6K1 and IP7 in insulin signaling Myostatin signaling and skeletal muscle protein turnover His peer-reviewed publications examine topics ranging from hypoxia-induced metabolic changes to dietary interventions for glucose homeostasis. Dr. Mackenzie also engages in media appearances (BBC Radio 4, Horizon documentaries) and consultancy work for metabolic device development (e.g., Mediwise glucose-monitoring technology).

• Metabolism
• Molecular Medicine
• Exercise Physiology
• +۵ مورد دیگر

Curtis Hughey serves as Assistant Professor of Medicine within the Division of Molecular Medicine, conducting interdisciplinary research at the nexus of metabolism, molecular physiology, and metabolic disease pathogenesis. His work bridges basic science with clinical implications through innovative methodologies in metabolomics and metabolic flux analysis. His research program critically examines: Mitochondrial metabolism in liver, skeletal muscle, and placental tissues Exercise-induced metabolic adaptations and dysregulation in obesity NAFLD pathogenesis mechanisms involving lipotoxicity and inflammation Metabolomic biomarker discovery for metabolic diseases Regulation of gluconeogenesis and glucose homeostasis Analysis of Hughey's recent publications (2019-2023) reveals a dominant focus on tissue-specific metabolic crosstalk, particularly hepatic-muscle interactions during exercise and disease states. His work consistently employs advanced techniques including 2 H/ 13 C flux analysis, untargeted metabolomics, and genetically modified mouse models to dissect molecular mechanisms. Recurring themes include the dual roles of metabolic enzymes (e.g., PEPCK, pyruvate carboxylase), the impact of dietary interventions on liver metabolism, and the discovery of analytical artifacts in lipidomics that could confound biomarker research.

Inês M.A. Ribeiroمشاهده پروفایل

پژوهشگر

• Neurogenetics
• Behavioral Neuroscience
• Sensory Processing
• +۳ مورد دیگر

Inês M.A. Ribeiro is a Researcher and Group Leader at the Institute of Medical Psychology, Ludwig Maximilian University of Munich (LMU Munich), focusing on neurogenetics and behavior in Drosophila melanogaster. Her work integrates molecular genetics, sensory processing, and neural circuits to study social behaviors like courtship and aggression. Current research explores how visual cues and internal states influence neural circuits governing social interactions. She employs optogenetics, functional imaging, and behavioral assays to dissect sensory-motor transformations in fruit flies. Her lab emphasizes training students for STEM careers, reflecting her commitment to education and mentorship. The lab's publications highlight interdisciplinary approaches bridging neuroscience, molecular biology, and developmental studies, particularly in sensory integration and neural circuit dynamics. Students and collaborators are actively involved in advancing these research themes.