جست‌وجوی استاد و پژوهشگر

Joshua D Wytheمشاهده پروفایل

دانشیار

• Cardiovascular Biology
• Cerebrovascular Pathologies
• Developmental Biology
• +۱۲ مورد دیگر

Joshua D. Wythe is an Associate Professor in the Department of Cell and Developmental Biology at the University of Virginia School of Medicine. His research focuses on the molecular and genetic mechanisms underlying cardiovascular development and cerebrovascular pathologies, with a particular emphasis on endothelial cell differentiation and brain vascular diseases such as arteriovenous malformations and glioblastoma. He leads the Wythe Lab, which utilizes zebrafish and mouse models combined with bioinformatics, functional genomics, and 3D imaging to investigate blood vessel formation and dysfunction. BA in History, Miami University BS in Botany, Miami University PhD in Oncological Sciences / Cardiovascular Development, University of Utah School of Medicine Postdoctoral Fellowship in Cardiovascular Development and Disease, University of California, San Francisco Dr. Wythe's research interests span cardiovascular biology, developmental biology, transcriptional regulation, and translational science. His lab investigates how transcriptional networks govern endothelial plasticity, the role of RAS/MEK/ERK signaling in brain arteriovenous malformations, and novel therapeutic targets in glioblastoma. The work integrates molecular genetics, imaging, and bioinformatics to understand both normal vascular development and pathological conditions. The recent publications reflect a strong trend in vascular development, disease modeling, and technological innovation. Key themes include transcriptional control of endothelial identity, signaling pathways in vascular malformations, and advanced imaging techniques for 3D tissue visualization. The research spans from basic developmental mechanisms to translational applications in brain cancers and cerebrovascular disorders. Dr. Wythe actively mentors graduate students, postdoctoral fellows, and undergraduates, fostering a collaborative and interdisciplinary research environment. His lab is currently recruiting researchers with expertise in developmental biology, genomics, bioinformatics, and imaging. Funding supports multiple projects aimed at uncovering transcriptional regulators essential for cardiovascular function and disease. The Wythe Lab is equipped to conduct cutting-edge research using genetically modified animal models, single-cell analyses, and advanced microscopy. The team develops and shares resources such as FishNET for zebrafish colony management and EZ Clear for tissue clearing, contributing to the broader scientific community.

Brett Mitchellمشاهده پروفایل

استاد

• Immunity
• Inflammation
• Hypertension
• +۳ مورد دیگر

Brett Mitchell is a Professor of Medical Physiology at Texas A&M University, located in Bryan, Texas. He serves as Director of the Summer Undergraduate Research Program and Director of the Medical Sciences MS Degree Program. His academic journey includes a BA from Gustavus Adolphus College (1995), MS from University of Wisconsin-La Crosse (1996), and PhD from Medical College of Georgia (2003). His postdoctoral work at NASA's Johnson Space Center focused on immunophilins and endothelial function. Research Interests Dr. Mitchell investigates molecular mechanisms linking immune activation to endothelial dysfunction and hypertension. Key areas include renal lymphatic vessels in hypertension, immunosuppressive drug-induced hypertension, and preeclampsia. His lab aims to develop therapies targeting immune-cardiovascular interactions. Awards Distinguished Alumni Award (Augusta University) Established Professional/Research Career Enhancement Awards (APS) Cardiovascular Section Awards/Young Investigator Award (APS) Labs/Teams His lab includes Research Associate Valorie Chiasson (vchiasson@tamu.edu) and Research Assistant Bethany Goodlett (bethany-goodlett@tamu.edu). Focus areas span renal physiology, immunology, and translational hypertension research.

Michelle Hookمشاهده پروفایل

دانشیار

• Spinal Cord Injury (SCI)
• Opioid Pharmacology
• Neuroinflammation
• +۳ مورد دیگر

Michelle Hook, PhD is an Associate Professor in the Department of Neuroscience & Experimental Therapeutics at the Texas A&M University School of Medicine. Her research focuses on the neurobiological and physiological consequences of spinal cord injury (SCI), with an emphasis on opioid-induced recovery impairment, depression/cognitive deficits, and bone loss. She holds a PhD from the University of New England (1998). Education : PhD in Neuroscience, University of New England, 1998 Research Interests : Dr. Hook’s lab investigates three core areas: (1) adverse effects of opioids (e.g., morphine, oxycodone) on SCI recovery mechanisms, including glial activation and neuronal death; (2) sex-dependent depression and cognitive deficits post-SCI, linking inflammatory biomarkers (e.g., cytokines, neurogenesis) to behavioral outcomes; and (3) sympathetic nervous system-driven bone loss via osteocyte dysfunction and marrow niche changes. Her work combines rodent models with translational strategies to identify adjuvants for opioid therapy, neuroprotective interventions, and bone preservation therapies. Key Contributions : Discovered that kappa opioid receptor antagonism mitigates morphine’s detrimental effects on SCI recovery Validated novel methods to assess depression-like behavior in SCI rats Identified osteocyte inflammation as a driver of post-SCI osteoporosis Future Directions : Expanding studies on gut-brain interactions in post-injury mood disorders, optimizing chemogenetic tools to modulate pain pathways, and developing implantable closed-loop systems for gait rehabilitation.

Mendell Rimerمشاهده پروفایل

دانشیار

• Neuroscience
• Molecular Biology
• Neurobiology
• +۳ مورد دیگر

Mendell Rimer, PhD, is an Associate Professor in the Department of Neuroscience & Experimental Therapeutics at Texas A&M University's School of Medicine. His research focuses on molecular and cellular mechanisms of synapse formation, maintenance, and pathology using the neuromuscular junction (NMJ) as a model system. He employs mouse molecular genetics combined with molecular, cellular, and immunological techniques. Education: BS in Biology, Universidad de Los Andes PhD in Molecular and Cell Biology (with Pharmacology minor), University of Maryland, Baltimore Postdoctoral Training: Neurobiology and Molecular Genetics at Stanford University & New York University Research interests include synaptic plasticity, neuromuscular junction pathology in neurodegenerative diseases (e.g., ALS, Duchenne muscular dystrophy), and signaling pathways involving MAP kinases and neuregulins. His work combines genetic models with advanced imaging and molecular biology techniques. Publications span synaptic development, neuromuscular disorders, and signaling mechanisms. Notable work includes studies on lymphatic dysfunction in ALS models and roles of ERK kinases in muscle maintenance. Active in graduate training through the Interdisciplinary Program in Neuroscience and Medical Science PhD program. Labs/Teams: The Rimer Lab focuses on integrative approaches to neuromuscular synapse biology. Collaborations involve clinical translation of synaptic repair mechanisms in neurodegenerative diseases.

María Virumbrales-Muñozمشاهده پروفایل

استادیار

• Microphysiological Systems
• Organ-on-a-Chip
• Cancer Biology
• +۱۲ مورد دیگر

María Virumbrales-Muñoz is an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Wisconsin–Madison, with an affiliate appointment in Biomedical Engineering. She is also the Principal Investigator of the Virumbrales-Muñoz Lab, where she leads research in microphysiological systems to model cancer and reproductive disorders. Position: Assistant Professor, Obstetrics & Gynecology Affiliation: Biomedical Engineering (Affiliate Faculty) Lab: Virumbrales-Muñoz Lab, University of Wisconsin–Madison Email: virumbralesm@wisc.edu She holds a PhD in Biomedical Engineering from the University of Zaragoza, Spain, and completed postdoctoral training at UW-Madison in Biomedical Engineering and Pathology & Laboratory Medicine. Her research lies at the intersection of bioengineering and women's health, focusing on 3D biomimetic modeling of diseases such as high-grade serous ovarian cancer (HGSOC) and preeclampsia. Using microfluidic technologies, her lab develops organ-on-a-chip models to study tumor microenvironments, metabolic heterogeneity, immune-endothelial interactions, and vascular dysfunction in reproductive diseases. The lab's recent publications reveal a strong focus on advancing microphysiological systems for cancer and vascular biology, with applications in drug screening, immune response modeling, and patient-specific disease modeling. Her work integrates molecular biology, bioengineering, and clinical data to improve understanding of disease mechanisms and therapeutic responses. Scientific Awards: Chester B. Martin Graduate Training Program Mentorship Award (2021) Dr. Virumbrales-Muñoz is an active mentor and educator, advising graduate and undergraduate students in biomedical engineering and reproductive sciences. She teaches in courses such as AN SCI 875 and OBS&GYN 710 and collaborates on major research grants, including NIH R01 proposals. Her lab is funded by the American Cancer Society, University of Wisconsin Carbone Cancer Center, and Meriter Foundation, among others. Research Labs and Teams: Virumbrales-Muñoz Lab: Focuses on microphysiological systems for cancer and preeclampsia Collaborations: UW-Madison Department of Biomedical Engineering, Pathology & Laboratory Medicine, and UnityPoint Health-Meriter Foundation Team Members: Includes postdoctoral researchers, PhD students, and research technicians working on ovarian cancer, breast cancer, and vascular modeling projects

Niccolò Terrandoمشاهده پروفایل

استاد

• Neuroinflammation
• Postoperative cognitive dysfunction
• Delirium
• +۹ مورد دیگر

Niccolò Terrando is a Professor of Anesthesiology at Duke University School of Medicine with secondary appointments in Cell Biology and Integrative Immunobiology. He serves as a Faculty Network Member of the Duke Institute for Brain Sciences, where his research bridges neuroimmunology, perioperative medicine, and cognitive neuroscience. Dr. Terrando's research focuses on neuroinflammation mechanisms underlying postoperative cognitive dysfunction and delirium, particularly exploring blood-brain barrier integrity, neurovascular unit function, and specialized pro-resolving mediators. His work investigates how surgical trauma triggers inflammatory cascades that can lead to cognitive decline, especially in vulnerable populations like the elderly and those with pre-existing neurodegenerative conditions. He has pioneered research on vagus nerve stimulation, omega-3 fatty acids, and other interventions to mitigate surgery-induced neuroinflammation. His extensive publication record shows a clear progression from basic mechanisms of neuroinflammation to translational applications. Recent work emphasizes cellular senescence, blood-brain barrier modeling, and the intersection of postoperative cognitive decline with Alzheimer's disease pathology. His research increasingly incorporates advanced techniques like blood-brain barrier-on-chip models and quantum dot biomimetics for neurovirology studies. His scientific recognition includes: New Investigator Award from the International Society to Advance Alzheimer's Research and Treatment (2019) Active Member (by election) of the Association of University Anesthesiologists (2018) Junior Faculty Award from the Association of University Anesthesiologists (2014) New Investigator Award from the International Society for the Study of Fatty Acids and Lipids (2014) Dr. Terrando currently leads multiple NIH-funded projects totaling over $20 million, including studies on hypertension and aging impacts on postoperative delirium (2025-2030), IL-6 trans-signaling in cognitive decline (2024-2029), and cerebrospinal fluid complement activation in delirium (2024-2029). His laboratory employs sophisticated mouse models of surgery-induced cognitive dysfunction and collaborates extensively with Duke's neuroscience and geriatrics programs. His research team utilizes advanced methodologies including blood-brain barrier modeling, neurovascular unit analysis, and biomarker discovery in human subjects undergoing surgery. Current projects investigate pericyte function in delirium superimposed on dementia, bioelectronic regulation of CNS lymphatic drainage, and immunoprofiling of postoperative delirium during aging and neurodegeneration.

• Lymphatic System Physiology
• Inflammation
• Lymphedema
• +۴ مورد دیگر

Pierre-Yves von der Weid serves as Professor in the Department of Physiology and Pharmacology at the Cumming School of Medicine, University of Calgary. He holds multiple leadership roles including Scientific Lead of the Lymphedema Research and Education Program at The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, while maintaining Full Membership in the Snyder Institute and Inflammation Research Network. Additional affiliations include membership in the Libin Cardiovascular Institute and Gastrointestinal Research Group. His educational foundation comprises a Doctor of Philosophy in Biological Sciences (1989) and Diploma (B.Sc. Honours) in Biology (1984), both from the University of Geneva. These credentials underpin his specialized research in lymphatic physiology. von der Weid's research program centers on lymphatic system functions and pathologies, with particular emphasis on lymphatic pumping mechanisms during inflammatory conditions. His laboratory investigates the generation of pacemaker potentials, endothelial modulation of lymphatic contractions, and mechanosensitive responses to vessel distention. Disease-focused work examines lymphatic dysfunction in Crohn's disease, arthritis, and lymphedema models, analyzing immune cell trafficking alterations and modulation by COX metabolites, nitric oxide, and cytokines. This research directly supports the university's strategic initiative on Infections, Inflammations and Chronic Diseases (2015-2021). His scientific contributions have earned recognition through prestigious awards including the AHFMR Visiting Scientist designation and multiple fellowship awards from Swiss foundations. Notable honors include the Warren Veale Award from his department and Novartis Prize for Young Scientist. As an educator, he teaches graduate courses MDSC 620 (Topics in Systems Physiology) annually and MDSC 755 (Directed Study). His laboratory operations are supported by Lab Manager Simon Roizes and Administrative Assistant Barbara Chyz, with facilities located in Health Sciences Centre rooms 1645 (office) and 1606 (lab). Current institutional engagement includes active participation in the Inflammation Research Network seminar series through 2025.

Adviye Ergulمشاهده پروفایل

استاد

• Vascular complications of diabetes and hypertension
• Acute ischemic stroke
• Alzheimer's Disease Related Deteriorias
• +۵ مورد دیگر

Adviye Ergul is a Professor at the Medical University of South Carolina in the Department of Pathology and Laboratory Medicine. She holds secondary appointments at Augusta University and the Charlie Norwood VA Medical Center. Her research focuses on vascular complications of diabetes and hypertension, acute ischemic stroke, and Alzheimer's disease-related dementias, with specific emphasis on endothelial cell biology and vascular pathology. Education : MD from Cerrahpasa Medical School (Istanbul, Turkey, 1987), PhD in Biochemistry & Molecular Biology from University of Miami School of Medicine (1995), postdoctoral training in Vascular Biology at University of Georgia. Her work explores mechanisms of endothelin system dysfunction , microvascular senescence , and inflammatory pathways in diabetic and hypertensive conditions. Recent studies investigate novel therapies like angiotensin receptor agonists and iron chelation for post-stroke cognitive impairment. She has published extensively on diabetes-stroke interactions , endothelin signaling , and sex differences in vascular disease. Key research trends include neurovascular unit remodeling , microemboli-mediated dementia , and mitochondrial quality control in brain injury. Her laboratory developed diabetic stroke models to test interventions like linagliptin and bosentan . Awards : NIH Individual Research Service Award, American Heart Association Scientist Development Award, Veterans Administration Research Career Scientist, Regents’ Professorship, Phi Kappa Phi Honor Society.