Alexandros Marios Sofiasمشاهده پروفایل
استاد پژوهش
Dr. Alexandros Marios Sofias is head of the "Immune Cell Targeting and Imaging" Research Group at the Institute for Experimental Molecular Imaging (ExMI) of RWTH Aachen University, Germany, and Co-Chair of the Image-Guided Drug Delivery (IGDD) Study Group of the European Society for Molecular Imaging (ESMI). Education: PhD in Nanomedicine (2019) MSc in Pharmaceutical Sciences (2016) Diploma in Pharmacy (2014) Research Focus: His laboratory integrates in vivo multimodal imaging with advanced nanomedicine design to decode the fate of therapeutic nanoparticles and to develop nano-immunotherapeutics that reprogram the tumor immune microenvironment. Core themes include: Real-time tracking of nanoparticle biodistribution via intravital microscopy and PET/MRI. Leveraging immune cells (neutrophils, macrophages) as active carriers (“hitchhiking”) to enhance tumor targeting. Engineering 3-D vascularized tumor models for preclinical validation. Translational development of core-crosslinked polymeric micelles and lipid nanoparticles for image-guided drug delivery. Publication Trends: Across >25 high-impact papers since 2020, Sofias has consistently advanced the intersection of nanomedicine, molecular imaging, and cancer immunotherapy. His work has progressively shifted from passive EPR-based targeting to active immune-cell-mediated delivery, emphasizing real-time imaging feedback to optimize therapy. Grants & Collaborations: Although specific grant numbers are not listed, the extensive co-authorship network with Kiessling, Lammers, Storm, Mulder and others indicates substantial national (DFG, BMBF) and European (ERC, Horizon Europe) funding streams. The team participates in large consortia such as the ESMI IGDD study group. Labs & Teams: He leads the “Immune Cell Targeting and Imaging” group housed within the state-of-the-art ExMI building at RWTH Aachen, equipped with preclinical PET/MRI, high-resolution intravital microscopy, nanoformulation suites, and 3-D bioprinting facilities.






