جست‌وجوی استاد و پژوهشگر

Kathrin Langمشاهده پروفایل

استاد

• Chemical Biology
• Protein Engineering
• Genetic Code Expansion
• +۳ مورد دیگر

Kathrin Lang is a Full Professor at the Department of Chemistry and Applied Biosciences, ETH Zurich, and Head of the Organic Chemistry Laboratory. Her research focuses on chemical biology, particularly the development of tools for genetic code expansion to incorporate non-canonical amino acids into proteins and advance bioorthogonal chemistries for studying biological processes. Keywords: Genetic Code Expansion, Bioorthogonal Chemistry, Protein Engineering, Ubiquitylation Networks, Post-Translational Modifications. Lang’s work emphasizes proximity-triggered crosslinking reactions, bioorthogonal labeling, and in vivo chemistries to address challenges in protein interaction mapping and structural elucidation. Her group’s recent publications highlight methodologies for dual protein labeling, deciphering ubiquitin code, and enhancing cycloaddition reactivity. Current projects include exploring cyclopropene-fused dibenzocyclooctynes for improved labeling and investigating methylated lysine as a conformational regulator in Hsp90. Funding sources include the ERC (Ubl-tool), DFG (SFB1035, SPP1926), and ETH Zurich. She contributes to education through courses like Genetic Code Expansion for Studying Posttranslational Modifications and Chemical Biology and Synthetic Biochemistry . Collaborative efforts span structural biology, microbiology, and synthetic biochemistry, with applications in ubiquitin research and cellular imaging.

Nika Danialمشاهده پروفایل

دانشیار

• Metabolic Biology
• Cancer Research
• Diabetes
• +۴ مورد دیگر

Dr. Nika Danial is an Associate Professor of Cell Biology at Harvard Medical School and the Department of Cancer Biology at Dana-Farber Cancer Institute. She leads the Danial Lab, investigating metabolic mechanisms that regulate cellular adaptation to stress, with a focus on fuel utilization in health and disease. Dr. Danial holds additional roles as Co-Director of the NCI-funded T32 Training Program in Cancer Chemical Biology and Metabolism. Her research integrates biochemistry, mouse models, and metabolomics to study metabolic contributions to cancer, diabetes, and neurological disorders. Education: PhD from Columbia University (1999), postdoctoral training at Harvard Medical School and Dana-Farber under Dr. Stanley Korsmeyer. Key research areas include mitochondrial dynamics, glucose metabolism pathways, and the interplay between inflammation and metabolic signaling. The lab has pioneered studies on how metabolic flexibility impacts disease progression in pancreatic islets, lymphoma subtypes, and neuronal excitability. Publications highlight discoveries in mitochondrial fatty acid oxidation regulation, urea cycle anti-inflammatory mechanisms, and metabolic signatures in cancer subtypes. Her work has implications for developing therapies targeting metabolic vulnerabilities in diseases like diffuse large B-cell lymphoma and type 1 diabetes. The Danial Lab emphasizes rigorous training for the next generation of scientists through mentorship programs and interdisciplinary collaboration.

Rick T. Dobrowskyمشاهده پروفایل

استاد

• Diabetic neuropathy
• Molecular chaperones
• Neurotrophin signaling
• +۳ مورد دیگر

Rick T. Dobrowsky is a Professor in the Department of Pharmacology & Toxicology at the University of Kansas School of Pharmacy. He also serves as Director of the Graduate Program in Neuroscience. His research focuses on diabetic neuropathy and molecular chaperones, exploring how hyperglycemia impacts neurotrophin signaling and mitochondrial function in peripheral nerves. Education: Ph.D. in Pharmacology, North Carolina State University (1990) Postdoctoral Training at Duke University Medical Center (1995) Research Interests: His work examines molecular mechanisms underlying diabetic neuropathy, including neuregulin signaling, mitochondrial proteome changes, and the role of molecular chaperones like Hsp70 and Hsp90. Current projects investigate how hyperglycemia alters IGF-1 signaling and neuregulinism to drive neuropathic damage. Publications: Recent work highlights therapies targeting molecular chaperones to treat diabetic neuropathy and Charcot-Marie-Tooth disease, including cemdomespib and noviomimetic compounds. Key findings include improved mitochondrial function and reduced demyelination in animal models. Advising & Grants: He has advised students like Sukhmanjit Kaur and Yssa Rodriguez. His lab collaborates on NIH-funded projects exploring mitochondrial dysfunction in diabetes and molecular chaperone-based therapies. Labs: Director of the Dobrowsky Lab, which studies signaling pathways in nerve degeneration and develops novel therapeutic approaches for peripheral neuropathies.

William Balchمشاهده پروفایل

استاد

• Proteostasis
• Genetic Variation
• Machine Learning in Biology
• +۶ مورد دیگر

William Balch, PhD, is a Professor in the Department of Molecular and Cellular Biology at Scripps Research. His research focuses on linking genetic variation in human populations to protein function using machine learning tools like Gaussian Process (GP) modeling. He pioneered concepts in proteostasis and spatial covariance, exploring how genetic and environmental factors influence protein folding and disease. Education: Ph.D. in Microbiology from University of Illinois (1979) Research interests include inherited diseases (e.g., CFTR, AATD, NPC1), aging-related proteostasis collapse, and host-pathogen interactions in SARS-CoV-2. His lab develops computational platforms to model protein design and discover therapeutic interventions. Key projects involve GP-based analysis of genetic diversity, small molecule therapeutics targeting chaperone systems, and understanding viral evolution via spatial covariance. His work bridges genomics and phenomics to address disease mechanisms at atomic resolution. Grants and collaborations focus on protein-folding correction, with applications in precision medicine and climate change mitigation through RuBisCo optimization in plants.

Rachel Baileyمشاهده پروفایل

پژوهشگر

• Gene Therapy
• Neurodegenerative Diseases
• Tauopathies
• +۷ مورد دیگر

Rachel Bailey is a researcher at UT Southwestern with a focus on developing gene therapies for neurological disorders. She holds dual bachelor's degrees in Biology/Bioinformatics and Molecular Biology from Rensselaer Polytechnic Institute, a Ph.D. in Neuroscience from the University of Florida, and completed postdoctoral research at the University of North Carolina Chapel Hill. Education : Dual B.S. from Rensselaer Polytechnic Institute, Ph.D. in Neuroscience Her research spans gene therapy for monogenic and complex neurodegenerative diseases, including SLC13A5 epileptic encephalopathy , Giant Axonal Neuropathy , and tauopathies like Alzheimer’s disease. She employs AAV vector engineering for gene replacement and silencing, with expertise in preclinical development and IND-enabling studies . Recent publications highlight her work on tau protein phosphorylation in Parkinson’s disease, AAV9 gene therapy for GAN, and autonomic dysfunction in neurodegenerative models. Key collaboration networks include institutions like the NIH and Mayo Clinic.

Suren Tatulianمشاهده پروفایل

استاد

• Molecular Biophysics
• Biotechnology
• Protein Structure and Function
• +۶ مورد دیگر

Dr. Suren Tatulian is a Professor in the Department of Physics at the University of Central Florida (UCF), with a joint affiliation at the Biomolecular Sciences Center. He holds a BS in Physics from Yerevan State University, Armenia, and a PhD in Biology from the Institute of Cell Biology, St. Petersburg, Russia. Research Focus: Molecular biophysics, protein-membrane interactions, amyloidogenesis, interfacial enzymology, and neurodegenerative disease mechanisms. Key Techniques: Protein engineering, spectroscopy (FTIR, fluorescence), computational modeling, and structural analysis of toxins and amyloid peptides. His recent work explores amyloid β peptide behavior in lipid membranes, cholera toxin disassembly mechanisms, and peptide-based inhibitors of neurotoxic aggregation. Dr. Tatulian has mentored students in biophysical research and leads studies on membrane pore formation and protein folding dynamics. Lab Affiliation: Biomolecular Sciences Center at UCF, where he investigates biophysical aspects of neurodegenerative diseases and toxin translocation.

Ritwick Sawarkarمشاهده پروفایل

عضو هیئت علمی

• Chromatin Biology
• Environmental Stress Response
• Transcriptional Regulation
• +۳ مورد دیگر

Ritwick Sawarkar is a Principal Investigator at the MRC Toxicology Unit and affiliated with the Department of Genetics under the School of Biological Sciences at the University of Cambridge. He leads the Sawarkar Group, focusing on molecular mechanisms linking chromatin biology, environmental stress response, and transcriptional regulation. Education: PhD in Genetics (Indian Institute of Science, 2010) Previous roles: Postdoctoral Fellow at ETH-Zürich (2010-2014), Independent Group Leader at Max Planck Institute (2014-2019) Research Interests : The Sawarkar Group investigates how chromatin interprets environmental stress signals to modulate transcriptional responses. Key questions include: (i) Cellular pathways sensing stress/toxins, (ii) Chromatin's role in stress adaptation, and (iii) Transcriptional mechanisms for cellular survival. Their work integrates genomics, single-cell transcriptomics, proteomics, and mouse models to explore stress response pathways. Article Trends : Recent publications highlight his expertise in chromatin-mediated stress responses, non-coding RNA interactions, and proteostasis networks. Collaborations with pharmaceutical companies emphasize translational applications for drug toxicology and RNA therapeutics. Scientific Awards : ERC Consolidator Grant (2018) Alfred Tissières Young Investigator Award (2019) Group Members : His team includes PhD students (Dimitris Aspri, Roberto Campalastri), Research Associates (Simone Baldan, Christo Christov), and MPhil students (Anfas Muhammed, Keely Xia), among others.

Rick Dobrowskyمشاهده پروفایل

استاد

• Diabetic Neuropathy
• Molecular Chaperones
• Neurotrophin Signaling
• +۳ مورد دیگر

Rick Dobrowsky is a Professor and Director of the Graduate Program in Neuroscience at the University of Kansas School of Pharmacy , Department of Pharmacology & Toxicology. His research focuses on diabetic peripheral neuropathy, molecular chaperones, and sphingolipid signaling in neuronal degeneration. Location: Malott Hall, Room 5064, Lawrence, KS Contact: dobrowsky@ku.edu | 785-864-3531 Research Overview : The Dobrowsky Lab investigates how hyperglycemia alters neurotrophin signaling and mitochondrial proteomes in diabetic neuropathy. Key projects include: Hyperglycemia and IGF-1 signaling effects on superoxide generation Neuregulinism's role in segmental demyelination Development of HSP90 inhibitors for neuroprotection Publications (15 Most Recent): 2025: PERK signaling and Cemdomespib therapy in Charcot-Marie-Tooth disease 2024: Demyelination progression in R75W-Connexin 32 models 2023: Biphenyl amides as HSP90/HSP70 modulators 2022: Cyclohexyl noviomimetics and mitochondrial function 2021: HSP70/thioredoxin interactions in diabetic neurons 2020: HSP90 inhibition and c-Jun proteasomal clearance 2019: Mitochondrial superoxide reduction with KU-596 2018: HSP70 targeting for demyelination 2016: Cemdomespib and neurotrophin receptor dynamics 2015: Molecular chaperones and mitochondrial bioenergetics 2014: KU-32 and heat shock protein mechanisms 2013: Neuregulin-1 isoforms in diabetic neuropathy 2012: C-terminal HSP90 inhibitors in sensory neuron protection 2011: Mitochondrial proteome changes in diabetes 2010: P35/CDK5 in beta-amyloid toxicity

• Structural Biology
• Molecular Biophysics
• Cryo-Electron Microscopy
• +۹ مورد دیگر

David Agard is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), where he leads a research group focused on uncovering the structural basis of biological function at the molecular and cellular levels. His lab specializes in advanced cryo-electron microscopy (cryo-EM) and fluorescence light microscopy, developing novel imaging technologies to study dynamic cellular processes. His research interests span structural biology , molecular chaperone function (particularly Hsp90 and its role in disease), microtubule nucleation , centrosome and cilium structure , and the structure of phage-encoded tubulins . He is deeply involved in methodological innovations in cryo-EM data processing , including deconvolution, heterogeneous reconstruction, and tomography, enabling atomic-level insights into complex biological systems. Recent publications highlight his lab’s work on the structural mechanisms of Hsp90-client regulation, microtubule organization, phage nucleus formation, and high-resolution imaging techniques using functionalized graphene-oxide grids. His work increasingly integrates AI-driven structural modeling and in situ approaches to understand macromolecular complexes in their native cellular context. Dr. Agard has made seminal contributions to understanding the ATPase cycle of Hsp90, the architecture of the gamma-tubulin complex, and the structural dynamics of viral and cellular tubulins. His research bridges biochemistry, biophysics, and cell biology, with implications for cancer, neurodegeneration, and antimicrobial strategies.

• Protein Chemistry
• Molecular Chaperones
• Proteostasis
• +۷ مورد دیگر

Stefan Rüdiger is Professor of Protein Chemistry of Disease at Utrecht University's Faculty of Science, Department of Chemistry. He leads the Rüdiger Group, focusing on molecular mechanisms of protein folding, proteostasis, and chaperone networks in neurodegenerative diseases like Alzheimer's and Parkinson's, as well as cancer. His work combines structural biology, NMR spectroscopy, and biochemical assays to understand chaperone-client interactions and develop therapeutic strategies. Institutional Roles: Head of Department of Chemistry (2021-2022) Former Director of Education, Chemistry Department Coordinator of bachelor course "Protein Folding and Assembly" and master courses "Molecules and Cells" and "Concepts in Science for Life" Research Interests: His research deciphers how molecular chaperones like Hsp70 and Hsp90 maintain proteostasis, prevent protein aggregation, and how their failure contributes to diseases. Key areas include: Mechanistic insights into Hsp90-Tau interactions (Alzheimer's) Peptide-based "Fibril Paint" compounds for amyloid targeting Proteostasis network dynamics in aging and disease Molecular basis of chaperone-client specificity Scientific Contributions: Elucidated Hsp90's role as downstream optimizer of Hsp70 in protein folding (Molecular Cell 2018) Developed FIDA technology for fibril analysis Discovered arginine π-stacking in Tau fibril interactions (Nature Communications 2020) Identified nano-aggregates in Wnt signaling dysregulation (Nature Structural & Molecular Biology 2016) Grants & Collaborations: Lead investigator for NWO Gravitation programme FLOW (national proteostasis consortium) Marie-Curie Innovative Training Networks: WntsApp (2012-2017), ManiFold (2012-2017) NWO ZonMW TOP Grant: "Chaperoning axonal transport in neurodegenerative disease" Education & Mentorship: Redesigned Utrecht's Molecular Life Sciences bachelor curriculum (2012-2014) Directed "Exploring Nature's Molecular Machines" Summer School (2012-2016) Supervised 15+ PhD students across European institutions

Shaojun Duمشاهده پروفایل

استاد

• Molecular Biology
• Biochemistry
• Developmental Biology
• +۷ مورد دیگر

Dr. Shaojun Du is a Professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine and a faculty member at the Institute of Marine and Environmental Technology, University of Maryland. His research focuses on genetic and epigenetic mechanisms regulating muscle development, growth, and repair using zebrafish models. Education: PhD in Biochemistry and Molecular Biology (University of Toronto, 1993), Postdoctoral Fellowship in Genetics (Howard Hughes Medical Institute, University of Washington, 1993–1997) Dr. Du’s work explores the roles of molecular chaperones (e.g., Hsp90α1), histone modifiers (e.g., SmyD1), and fusogenic proteins (Myomaker/Myomixer) in myofibril assembly, sarcomere organization, and myoblast fusion. His lab employs Tol2 transposon, TALEN, and CRISPR technologies to generate transgenic and mutant zebrafish models. The scientific awards section is currently empty, but his research has been funded by the NIH (Grant 1R01AR072703-01A1, 2018–2025). His publications highlight breakthroughs in muscle cell identity specification via Hedgehog signaling and the critical role of post-translational modifications in protein stability. Dr. Du’s lab has developed over 40 zebrafish models to study muscle structural proteins, transcription factors, and microRNA networks, contributing to understanding neuromuscular diseases and advancing aquaculture applications.

• Molecular Chaperones in Cancer
• Heat Shock Proteins (Hsp60, Hsp90, Hsp27)
• Thyroid Pathology
• +۵ مورد دیگر

Francesca Rappa is a Full Professor in the Department of Human Anatomy and Histology within the School of Medicine and Surgery at the University of Palermo. Her academic position (BIOS-12/A classification) centers on biomedicine, neuroscience, and advanced diagnostics with a focus on molecular mechanisms of disease. Her research spans multiple interconnected domains centered on stress response systems. Key interests include: Molecular chaperone networks (particularly Hsp60, Hsp90, Hsp27) in carcinogenesis Thyroid and colorectal cancer pathophysiology Glioblastoma multiforme molecular characterization Probiotic interventions for gut-liver-muscle axis disorders Nanovesicle-based therapeutics from citrus and tomatoes Diagnostic applications of heat shock proteins in inflammatory diseases Publication analysis reveals consistent focus on chaperone systems across cancer types (thyroid, salivary, colorectal, brain), with recent expansion into nutraceutical mechanisms involving citrus nanovesicles and golden tomatoes. Her 2023-2025 output shows increasing emphasis on multi-organ communication pathways (gut-brain, gut-liver-muscle) and industrial-scale therapeutic applications. Methodologically, she integrates immunohistochemistry, proteomics, and animal disease models. Teaching responsibilities include core anatomy courses for Medicine and Radiology programs: Anatomy I (10 CFU) and II (6 CFU) for Medicine Human Anatomy with Histology elements (6 CFU) for Radiology Integrated Anatomy/Biochemistry/Physiology modules (12 CFU) She actively supervises graduate research, with four theses directed between 2020-2024 covering celiac disease histopathology, stress protein interactions in colorectal cancer, glioblastoma biomarkers, and thyroid stress responses. Her laboratory work focuses on immunomorphological analysis of chaperone systems in tumor tissues and development of probiotic/nanovesicle interventions for metabolic and inflammatory conditions.

Daniel Southworthمشاهده پروفایل

استاد

• Molecular Chaperones
• Protein Quality Control
• Neurodegenerative Diseases
• +۳ مورد دیگر

Dr. Daniel Southworth is a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF), affiliated with the Institute for Neurodegenerative Diseases (IND). He earned his BS from UC Santa Cruz and PhD from Johns Hopkins University, followed by postdoctoral training at UCSF. His research focuses on molecular chaperones and protein quality control mechanisms relevant to neurodegenerative diseases like Alzheimer’s and Parkinson’s. Using cryo-electron microscopy (cryo-EM), his lab investigates chaperone machinery structure-function relationships, amyloid aggregation pathways, and therapeutic strategies targeting molecular chaperones. Key research areas include: (1) Structural biology of chaperones like Hsp90, CHIP, and Hsp104; (2) Mechanisms of tau and α-synuclein aggregation; and (3) Development of cryo-EM techniques for studying protein complexes. Recent work has revealed novel filament structures in neurodegenerative diseases and identified polyphosphate’s role in amyloid formation. His lab pioneered studies on VCP/p97 AAA+ ATPases and their adaptors, elucidating their roles in protein quality control. Collaborations include CRISPR-based screening in iPSC-derived neurons and drug design targeting chaperone-driven proteostasis. Notable contributions include cryo-EM structural analysis of SARS-CoV-2 proteins and methodological advancements in cryo-EM imaging using K3 cameras. Current research emphasizes translating structural insights into therapeutic approaches for neurodegenerative disorders.

• Acute Lymphoblastic Leukemia
• Pediatric Brain Tumors
• Genetic Heterogeneity
• +۵ مورد دیگر

Stephen E. Sallan, MD , is a Professor of Pediatrics at Harvard Medical School and a Physician at Dana-Farber Cancer Institute and Children's Hospital . His career spans over five decades in pediatric hematology/oncology , with a focus on acute lymphoblastic leukemia (ALL) and pediatric brain tumors . Education : MD, Wayne State University School of Medicine (1967) Residencies : Boston Floating Hospital (1968), Children's Hospital of Philadelphia (1969), Hospital for Sick Children, London (1970) Fellowship : Pediatric Oncology, Children's Hospital/DFCI (1972) Leadership Roles : Chief of Staff (1995), Chairman of Medical Staff Executive Committee (1995), Chief of Staff Emeritus (2012) Dr. Sallan's research integrates genetic heterogeneity , disease recurrence , and drug resistance in ALL, with efforts to develop targeted therapies like tumor vaccines and antiangiogenesis agents. His work addresses long-term treatment toxicities (cardiac, skeletal, neurocognitive), particularly in survivors of childhood cancers. His 15 most recent publications (2024–2018) demonstrate ongoing engagement with pharmacogenomics, thrombosis risk models, dietary interventions, and molecular markers in brain tumors. Key subfields include TRK-C in medulloblastoma , asparaginase complications , and DFCI ALL Consortium Protocols . Scientific Awards : Distinguished Alumni Award, Wayne State University School of Medicine (1997) James Carreras Prize for International Pediatrician of the Year (1987) As a leader in pediatric leukemia research , Dr. Sallan has shaped treatment protocols that minimize late effects while improving survival. He collaborates with multidisciplinary teams in neuro-oncology and pharmacogenomics, maintaining active roles in clinical trials and laboratory investigations.

Anne Claire Conibearمشاهده پروفایل

استادیار

• Protein chemistry
• Peptide chemistry
• Chemical biology
• +۴ مورد دیگر

Anne Claire Conibear is an Assistant Professor (Tenure Track) in Protein Chemistry at the Faculty of Technical Chemistry, TU Wien (Vienna University of Technology), Austria. She also holds an Honorary Research Fellow position at the School of Biomedical Sciences, The University of Queensland. Her research focuses on using protein and peptide chemistry tools to create site-specifically modified proteins to study post-translational modifications in biological processes. Dr. Conibear's research interests include: Protein and peptide chemistry Chemical biology Post-translational modifications Protein synthesis and semi-synthesis Structural biology NMR spectroscopy Her current research projects focus on understanding how posttranslational modifications of HMGN1 regulate DNA packaging and how phosphorylation regulates β-catenin in oncogenic signaling. She develops chemical tools to create specifically modified proteins that allow precise investigation of how these modifications affect protein structure and function. Dr. Conibear has received several prestigious awards including the Boulder Peptide Foundation Danho Young Investigator Award (2025) and multiple Career Track Awards from the University of Queensland. She supervises multiple PhD students and has successfully mentored several graduate students through their theses. Her teaching includes courses on biomolecule synthesis, bachelor seminars, and foundational chemistry laboratories at TU Wien.