جستجوی استاد راهنمای دانشگاهی

Nicolas Thomä is a Full Professor and head of the Thomä Lab at the École Polytechnique Fédérale de Lausanne (EPFL), where he holds the Paternot Chair in Cancer Research. He is affiliated with the School of Life Sciences (SV) and the Institute of Chemical and Biological Technology (ISREC), leading the UPTHOMAE research unit. His work bridges structural biology, chemical biology, and cancer research, with a focus on transcriptional regulation and targeted protein degradation. His research interests center on chromatin biology and the molecular mechanisms by which transcription factors access gene promoters within chromatin. He investigates how multi-protein complexes regulate gene expression, particularly focusing on the role of E3 ubiquitin ligases and molecular glues in targeted protein degradation. His lab combines structural techniques (including cryo-EM), biochemical assays, and functional genomics to unravel how small molecules can rewire protein interactions and induce degradation of disease-relevant proteins, especially transcription factors involved in cancer. The recent publications of his lab demonstrate a strong trajectory in understanding the structural basis of transcription factor binding to nucleosomes (e.g., OCT4-SOX2, MYC-MAX, CLOCK-BMAL1) and the mechanism of action of molecular glues like thalidomide. These studies highlight a shift toward therapeutic innovation through chemical biology, aiming to develop novel strategies for targeting 'undruggable' proteins in human diseases. Scientific Awards No specific awards listed in the provided text. Advising and Grants Thomä actively supervises a team of PhD students and postdoctoral researchers, including David Domjan, Laurin Tim Kanis, Alessandro Minafra, and Pierre Alexander Miranda Herrera. His lab is supported by institutional funding from EPFL and likely external grants related to cancer research, structural biology, and chemical biology, though specific grants are not mentioned. The lab’s interdisciplinary approach suggests collaboration with pharmaceutical and biotech partners. Labs and Teams The Thomä Lab, based at EPFL’s SV building, includes a multidisciplinary team of scientists, technical specialists, and administrative support. Key members include Fiona Bello (Technical Specialist), Regina Baur, Alexandra Bendel, Manuel Carminati, and others. The lab is structured around two main research pillars: Transcription Factors in Chromatin Biology and Ubiquitin Biology and Molecular Glues, reflecting its dual focus on fundamental mechanisms and therapeutic applications.

• Chromatin Biology
• Transcription Regulation
• Ubiquitin-Proteasome System
• +۷ مورد دیگر

Vignesh Ram Somnath is a Professor in the Biosciences of Sports at the University of Hildesheim since 2018. Previously, he served as an Acting Professor (2016-2018) and Research Associate (2010-2016) at the Institute of Sports Science, German Sports School Cologne. His work bridges molecular biology with sports science, focusing on skeletal muscle adaptation. Current: University Professor W2, University of Hildesheim 2016-2018: Acting Professor, University of Hildesheim 2010-2016: Research Associate, German Sports School Cologne 2005-2007: Research Assistant, German Sports School Cologne Research Interests: Regulation of molecular signaling pathways in skeletal muscle Mechanoprotective mechanisms during exercise Protein degradation dynamics Optimization of training and nutrition in competitive sports Integration of molecular biology with traditional sports science Key Publications (2020-2017) demonstrate expertise in: Metabolomics of muscle hypertrophy AMPK signaling in training Mitochondrial adaptations Extracellular vesicle analysis Calcium signaling pathways

• Sports Science
• Molecular Biology
• Exercise Physiology
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Beat Fierz is an Associate Professor at École Polytechnique Fédérale de Lausanne (EPFL) in the School of Basic Sciences (SB), affiliated with the Institute of Chemical Sciences and Engineering (ISIC) and the Laboratory of Biophysical Chemistry of Macromolecules (LCBM). He holds additional roles as Director of the Doctoral Program in Chemistry and Chemical Engineering (EDCH) and oversees doctoral education within the SCGC teaching unit. His research focuses on chromatin dynamics, epigenetic regulation, and chemical biology approaches to study histone modifications and protein interactions. He has supervised over 14 PhD students and teaches courses in advanced chemistry and chemical biology. His work bridges molecular mechanisms of chromatin structure with cellular processes like DNA repair and transcriptional regulation. Research Interests: Dr. Fierz investigates how post-translational modifications of histones (e.g., ubiquitylation, acetylation) regulate chromatin compaction, silencing, and accessibility. He employs single-molecule techniques and chemical synthesis to reconstitute and analyze chromatin states, with applications in understanding epigenetic diseases, aging, and CRISPR-Cas9 genome editing dynamics. Recent studies highlight mechanisms of HP1α-mediated heterochromatin assembly and pioneer transcription factor invasion into compact chromatin. Doctoral Program Leadership: As Director of the EDCH program, he oversees training in chemistry and chemical engineering, ensuring academic rigor and interdisciplinary collaboration. His lab collaborates extensively with EPFL's Chemical Biology NCCR and contributes to initiatives like the Chemical Biology Seminar Series. Lab & Teams: The LCBM lab uses innovative tools like 'MagIC beads' and semisynthetic nucleosomes to study chromatin modifications. Current projects include exploring how ubiquitin signals modulate DNA repair proteins and how histone aging impacts chromatin stability. Collaborations span biophysics, biochemistry, and synthetic chemistry.

• Epigenetics
• Chemical Biology
• Molecular Biology
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Ueli Grossniklaus is an Ordinary Professor at the University of Zurich within the Faculty of Mathematical and Natural Sciences , affiliated with the Department of Plant and Microbiology . His work focuses on plant developmental biology, particularly epigenetic and genetic mechanisms governing reproduction and adaptation. Key Courses: Epigenetics, Plant Biology Workshop, Group Seminars on Current Research Laboratory Techniques: Advanced methods in plant cell mechanics, transcriptomics, and genome editing Research Interests span plant epigenetics, reproductive biology, and the interplay between environmental stress and genetic regulation. He investigates: Mechanistic control of gametogenesis and fertilization Epigenetic contributions to plant adaptation Evolutionary implications of asexual reproduction Biophysical forces in plant cell growth Publication Trends (2025–2018) reveal expertise in: Arabidopsis and fern model systems Epigenetic regulation (DNA methylation, histone dynamics) Apomixis and hybrid seed failure mechanisms Biomechanics of pollen tubes and carnivorous plants Genome editing tools (CRISPR) and long-read sequencing Scientific Collaborations include interdisciplinary projects on: Microfluidic devices for plant cell analysis Gene drive ecology and ethics 3D imaging of plant reproductive structures Advising and Grants focus on mentoring through research internships in developmental biology, genetics, and systems biology. His lab engages in: Epigenetic response to environmental stress Cell wall mechanics in reproduction Computational modeling of plant growth Laboratory Teams integrate plant biologists, bioengineers, and computational scientists to study: Mechanistic gene regulation Evolutionary developmental biology Microrobotics for cellular force measurement

• Plant Developmental Biology
• Epigenetics
• Plant Genetics
• +۵ مورد دیگر

Oliver Ullrich is a Professor and Chair of Anatomy / Gravitational Biology and Cell Biomechanics at the University of Zurich. He also holds professorships in Space Biotechnology at Otto-von-Guericke-University Magdeburg, Space Medicine at EAH Jena, and an Adjunct Professor position at Beijing Institute of Technology. As an Academician of the International Academy of Astronautics , he leads the Swiss Parabolic Flight Program and directs the UZH Innovation Cluster “Space and Aviation” (UZH Space Hub). His research spans gravitational biology , space medicine , and cell biomechanics , focusing on cellular responses to altered gravity environments. His work explores Molecular changes in immune cells under microgravity/hypergravity Epigenetic adaptations to gravitational forces Medical challenges in space exploration Sustainable planetary resource utilization Innovations in spaceflight experiment platforms Recent publications highlight trends in space immunology , organoid analysis under gravity stress , and non-governmental parabolic flight infrastructure . Awards include the Albrecht-Ludwig-Berblinger Award of Aerospace Medicine . He serves on advisory boards for aerospace agencies and companies, and as a member of the executive board of the German Society for Aerospace Medicine : Albrecht-Ludwig-Berblinger Award of Aerospace Medicine As an active investigator in European, German, and U.S. space life sciences programs , he has led 19+ parabolic flight missions and contributed to ISS experiments.

• Space Biology
• Gravitational Biology
• Cell Biomechanics
• +۴ مورد دیگر

Prof. Dr. Katrien De Bock is a Full Professor and Deputy Head of the Department of Health Sciences and Technology at ETH Zurich. Her research focuses on angiogenesis, metabolic crosstalk in muscle microenvironments, and the impact of exercise on muscle regeneration. She leads a team investigating cellular interactions in skeletal muscle, particularly how metabolic signals regulate blood vessel growth and muscle repair. Key areas include understanding fibroadipogenic progenitors' role in muscle physiology, the role of histamine in exercise responses, and age-related muscle decline. Her work integrates molecular biology, single-cell transcriptomics, and computational approaches to dissect mechanisms underlying tendon pathologies, ischemic muscle injury, and metabolic adaptations to exercise. She supervises Master's programs in Human Movement Science and collaborates on projects involving muscle stem cell therapies and vascular engineering. Prof. De Bock also explores interventions like NAD+ precursors to counteract age-related sarcopenia and promotes translational research in regenerative medicine. Research Interests: Exercise-induced metabolic pathways in muscle repair Angiogenesis regulation in health and disease Hypoxia signaling in tendons and muscles Epigenetic modifications during tissue regeneration Stem cell fate determination in muscle microenvironments Notable Projects: Developing AI-driven histologic analysis for tendinopathy diagnosis Mapping the human brain vasculature at single-cell resolution Testing sulfur amino acid restriction to enhance exercise capacity

• Muscle Microenvironment
• Angiogenesis
• Metabolic Crosstalk
• +۴ مورد دیگر

Dr. Fen Long is a Researcher affiliated with the Professorship for Translational Nutrition Biology at ETH Zürich. Their work focuses on metabolic disorders, nutritional physiology, and molecular mechanisms underlying metabolic diseases. Key research interests include histone modifications, inflammation, and their roles in cardiovascular and metabolic pathologies. Dr. Long’s research integrates genomic approaches (e.g., single-nucleus transcriptomics) with biochemical studies to dissect mechanisms of obesity, insulin resistance, and vascular dysfunction. Recent studies highlight their expertise in epigenetic regulators like JMJD3 and SMYD3, linking histone modifications to fibrosis, inflammation, and autoimmune responses. They also investigate dietary interventions (e.g., low-carbohydrate diets) and pharmacological targets (e.g., histone methyltransferase inhibitors) in metabolic and cardiovascular contexts. Publications span metabolic signaling (e.g., glucagon, cAMP/PKA pathways), lipid metabolism (ATGL regulation), and cellular stress responses (unfolded protein response). Their work bridges basic molecular mechanisms to translational applications in therapies for metabolic-associated fatty liver disease, rheumatoid arthritis, and post-myocardial infarction recovery. No scientific awards or current advising roles are explicitly listed. Their research is conducted within the Translational Nutrition Biology group at ETH Zürich, leveraging interdisciplinary collaborations in systems biology and clinical translation.

• Metabolic Disorders
• Nutritional Physiology
• Molecular Biology of Metabolism
• +۳ مورد دیگر

Lorenza Penengo is an Assistant Professor and Group Leader at the Institute of Molecular Cancer Research , University of Zurich. She holds a PhD in Molecular Medicine and has held academic roles at the University of Piemonte Orientale and Harvard Medical School. Her research focuses on ubiquitin modifications, genome stability, DNA repair, and the interferon system. M.S. in Biological Sciences, summa cum laude - University of Torino (1996) PhD in Molecular Medicine - University of Piemonte Orientale and Weizmann Institute (2002) Penengo's work investigates non-canonical ubiquitin modifications in DNA damage response and replication, with a focus on ISG15 and RNF168 . Her recent studies highlight ubiquitin phosphorylation as a novel chromatin signaling mechanism and the role of interferon in genome stability. Publications span ubiquitin biology , DNA repair mechanisms , and interferon pathways , reflecting her interdisciplinary approach to cancer molecular biology. Award for best Master thesis, University of Piemonte Orientale (1997) Lion's Club fellowship (1997-1998) EMBO fellowship (2001) AIRC fellowship (2003-2006) 2020 Journal of Cell Biology recognition Penengo's lab has trained 15+ students and researchers, including Samuele Fisicaro , Maria Chiara Raso , and Filip Duzanic . Collaborations include the Mayo Clinic , NIH , and ETH Zurich . Her team's work has been cited for its impact on DNA replication dynamics and ubiquitin signaling.

• Ubiquitin Signaling
• Genome Stability
• DNA Damage Response
• +۳ مورد دیگر

Svantje Tauber is a biologist and researcher at the University of Zurich (UZH) within the Faculty of Medicine and affiliated with the UZH Space Hub . She works in the field of gravitational biology, focusing on how altered gravity impacts cellular mechanisms, particularly in the immune system and gene regulation. Her work bridges fundamental research with applied science through the UZH Innovation Hub. Research focus: Gravitational Biology, Biomechanics, Space Life Sciences Key initiatives: UZH Space Hub, Digital Society Initiative (DSI) Community Mobility Roles: Research Associate, Point of Contact for Space Life Science Projects Her research explores cellular adaptation to microgravity , including cytoskeletal changes, oxidative stress pathways, and epigenetic modifications in immune cells. She has contributed to understanding T cell and macrophage responses to gravitational alterations using parabolic flights, clinostats, and space station experiments. Current projects include the UZH Innovathon: Digitalization of Mobility , an interdisciplinary teaching format combining space research with mobility challenges. Her work emphasizes translational applications for spaceflight and Earth-based health.

• Gravitational Biology
• Biomechanics
• Cell Biology
• +۴ مورد دیگر

Dr. Dieter Kressler is a Senior Researcher at the Department of Biology , Faculty of Science and Medicine , University of Fribourg. Holding a PhD and serving as head of the proteomics platform , his work focuses on the molecular mechanisms of eukaryotic ribosome biogenesis. Email: dieter.kressler@unifr.ch ORCID: 0000-0003-4855-3563 Contact: +41 26 300 8645 Location: PER 05 building, Fribourg Research Interests include: Dedicated chaperones for ribosomal proteins Co-translational regulation of ribosomal protein expression Ubiquitin signaling in ribosome assembly RNA helicase roles in pre-ribosomal particles Structural dynamics of ribosome maturation Stress response coupling to translational control His 15 most recent publications (2025-2016) reveal a consistent focus on ribosome biogenesis, with key articles in eLife , Nature Communications , and Nucleic Acids Research . Research spans from thermal avoidance circuits in C. elegans to ubiquitin fusion mechanisms in yeast ribosomes , integrating structural biology, genetics, and biochemical approaches.

• Ribosome biogenesis
• Molecular Biology
• Genetics
• +۵ مورد دیگر

Professor Susan Mango is a leading researcher in developmental biology at the Biozentrum, University of Basel, where she serves as Professor of Cell and Developmental Biology since 2019. Her laboratory investigates fundamental questions about how complex organs develop from embryonic cells, with a focus on the nematode Caenorhabditis elegans as a model organism. She has made significant contributions to understanding transcriptional regulation, chromatin organization, and epigenetic inheritance during development. PhD, Princeton University (1984-1990) Undergraduate Researcher, MIT (1982-1983) Post-doctoral Fellow, University of Wisconsin (1990-1995) Professor Mango's research spans several interconnected areas of developmental biology. Her laboratory examines how chromosomes are organized in 3D within the cell nucleus and how this organization affects development, with particular focus on heterochromatin formation during embryogenesis. She has pioneered work on pioneer transcription factors, especially PHA-4/FoxA, which determines cell identity in the developing gut. Her research also investigates how environmental conditions experienced by parents can influence embryonic development in subsequent generations, exploring mechanisms of epigenetic inheritance. Her laboratory employs molecular genetics, live imaging, genomics, and innovative chromosome tracing techniques to address these fundamental questions. Professor Mango's publications reveal a consistent focus on nuclear architecture, transcriptional regulation, and developmental mechanisms using C. elegans . Her recent work has advanced chromosome tracing methodologies, explored translational control of mRNA localization, and investigated how neurons can modulate signaling to offspring. Her research shows a progression from foundational studies on organ development to more complex investigations of nuclear organization and transgenerational inheritance. Excellence in Teaching Award, University of Basel and Credit Suisse (2021) Elected to the European Molecular Biology Organization (EMBO) (2019) NIH NIGMS MERIT Award (2011-2020) MacArthur Foundation Fellowship (2009-2013) Harland Winfield Mossman Developmental Biologists' Award (2005) Professor Mango has led a productive research group investigating fundamental developmental processes for over two decades. Her laboratory has been supported by prestigious funding including the MacArthur Fellowship and NIH MERIT Award. She has mentored numerous students and postdoctoral researchers who have gone on to establish independent research careers. Her collaborative approach is evident in her extensive publication record spanning multiple disciplines within developmental biology. Professor Mango leads the Mango Research Group at the Biozentrum, University of Basel, where her team employs advanced imaging techniques including Chromosome Tracing and multiplex FISH to study nuclear organization during embryogenesis. Her laboratory investigates multiple projects simultaneously including Chromosomes in 3D, Epigenetic Inheritance, Pioneer transcription factors, and The Skin I Live in (focusing on epidermal development).

• Developmental Biology
• Embryogenesis
• Chromatin Organization
• +۵ مورد دیگر

Philipp Berger is a Scientist at the Paul Scherrer Institute (PSI) in Switzerland, affiliated with the Center for Life Sciences and leading the Laboratory for Multiscale Bioimaging . His position as a research group head involves developing advanced tools for cellular engineering and microscopy while investigating receptor signaling mechanisms in biomedical contexts. Research focuses on receptor trafficking and signaling pathways , particularly VEGFR-2 and GPCRs. Berger's group demonstrated how VEGF-A isoforms alter coreceptor recruitment and signaling (Ballmer-Hofer et al., 2011), identified TBC1D10 as a VEGFR2 signaling regulator (Xie et al., 2019), and pioneered split nanoluciferase assays to study time-resolved adapter protein recruitment for GPCRs (Romantini et al., 2021). Core expertise spans molecular engineering of cellular processes and quantitative microscopy. Recent publications (2021-2023) reveal diversification into diagnostic applications (polymer brush diagnostics, SARS-CoV-2 nanofluidic devices) and neurodegenerative disease mechanisms (Apolipoprotein E-amyloid interactions), while maintaining foundational work on receptor trafficking. The lab's signature tools—Squassh for image analysis and baculovirus systems for multigene delivery—underpin most studies. Scientific Awards: No awards mentioned in source materials Advising and Grants: Berger leads a research group with active publications indicating supervision of junior scientists, though specific students aren't listed. Extensive tool development and cross-disciplinary collaborations (e.g., nuclear medicine, virology) imply sustained grant funding, though specific grants aren't documented in the provided text. Labs and Teams: He directs the Laboratory for Multiscale Bioimaging at PSI. His team developed the MultiLabel/MultiPrime cre/LoxP-based multigene expression system (Kriz et al., 2010; Mansouri et al., 2016), Squassh image segmentation tools (Rizk et al., 2014, 2015), and split nanoluciferase GPCR assays (Spillmann et al., 2020; Romantini et al., 2021). All tools are publicly available via download packages with manuals.

• Cellular Engineering
• Bioimaging
• Receptor Signaling
• +۴ مورد دیگر

Arianna Baggiolini is an Assistant Professor at the Università della Svizzera italiana (USI), affiliated with the Institute of Oncology Research (IOR) in the BIOS+ network. She leads an independent research group focusing on melanoma oncogenic competence, developmental chromatin programs, and stem cell biology. Previously, she completed a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center (MSKCC) under Dr. Lorenz Studer, where she explored neural crest development and melanoma formation. Her education includes a BSc and MSc in Biology from ETH Zurich and a PhD in Neuroscience from the University of Zurich. Key contributions include defining oncogenic competence in melanoma and elucidating roles of developmental chromatin factors in tumor initiation and neural maturation. Baggiolini’s research integrates cancer biology, stem cell engineering, and developmental pathways to uncover mechanisms underlying tumor progression and therapeutic vulnerabilities. Her work has been recognized with prestigious awards such as the Christopher J. Marshall Award (Society for Melanoma Research), SNSF Starting Grant, and the Hofschneider Professorship. Current research emphasizes lipid metabolism in melanoma, epigenetic barriers to neuronal maturation, and translational approaches to modulate glial cells in spinal cord injury. Baggiolini’s lab employs cutting-edge techniques like patient-derived organoids and CRISPR-based models to study tumor heterogeneity and cellular plasticity. She actively collaborates on projects addressing neurodevelopmental disorders and cancer stem cell therapies, with a focus on translating basic discoveries into clinical applications.

• Cancer Biology
• Neuroscience
• Stem Cell Biology
• +۳ مورد دیگر

Nadine Vastenhouw is an Associate Professor at the University of Lausanne's Center for Integrative Genomics (CIG), part of the Faculty of Biology and Medicine. She leads a research group focusing on transcriptional regulation during vertebrate embryogenesis, particularly in zebrafish. Her work explores how chromatin structure and transcriptional machinery interact to regulate embryonic development during the maternal-to-zygotic transition. She has held positions at Harvard University, the Max Planck Institute in Dresden, and joined UNIL in 2020. Her research is funded by organizations including EMBO, HFSP, NIH, and the Max Planck Society. Education: Masters in Medical Biology, Amsterdam PhD at Hubrecht Institute (Utrecht), studying RNA interference in C. elegans Postdoctoral research at Harvard University, investigating zebrafish embryology Research Interests: Her lab combines molecular biology, genomics, and biophysics to study how transcriptional programs are established during early embryonic development. Key areas include: Chromatin dynamics during genome activation Role of epigenetic factors in developmental transitions Mechanisms linking maternal and zygotic gene expression Labs & Teams: She leads the Vastenhouw Lab at CIG, located in Lausanne. The lab focuses on interdisciplinary approaches to understand transcriptional regulation in zebrafish embryos.

• Developmental Biology
• Molecular Biology
• Genomics
• +۳ مورد دیگر

Peter Sander is a Full Professor at the University of Zurich , leading the Institute of Medical Microbiology 's research group focused on Mycobacterium tuberculosis and Mycobacterium abscessus . His research spans virulence mechanisms, lipoprotein biogenesis, vaccine innovation, and antibiotic resistance. Key research areas include Posttranslational modification of mycobacterial lipoproteins Drug susceptibility and resistance mechanisms RNA metabolism as antibiotic target Recent publications highlight advancements in 3',6'-disubstituted spectinomycins for efflux resistance, Fidaxomicin derivatives with enhanced activity, and Mycobacterium abscessus resistance gene characterization. Collaborations span institutions in Switzerland, France, Italy, and the U.S. Scientific honors include the Young Investigator Award from the German Society for Hygiene and Microbiology (2002). Supported by grants from the Swiss National Science Foundation, European Commission, and industry partners. Students mentored include Ph.D. candidates at the University of Zurich. His lab investigates lipoprotein synthesis pathways and host immunity interactions , with implications for tuberculosis and nontuberculous mycobacteria therapies.

• Mycobacterium tuberculosis Research
• Antibiotic Resistance Mechanisms
• Vaccine Development
• +۳ مورد دیگر