Philipp Berger

Philipp Berger is a Scientist at the Paul Scherrer Institute (PSI) in Switzerland, affiliated with the Center for Life Sciences and leading the Laboratory for Multiscale Bioimaging. His position as a research group head involves developing advanced tools for cellular engineering and microscopy while investigating receptor signaling mechanisms in biomedical contexts.

Research focuses on receptor trafficking and signaling pathways, particularly VEGFR-2 and GPCRs. Berger's group demonstrated how VEGF-A isoforms alter coreceptor recruitment and signaling (Ballmer-Hofer et al., 2011), identified TBC1D10 as a VEGFR2 signaling regulator (Xie et al., 2019), and pioneered split nanoluciferase assays to study time-resolved adapter protein recruitment for GPCRs (Romantini et al., 2021). Core expertise spans molecular engineering of cellular processes and quantitative microscopy.

Recent publications (2021-2023) reveal diversification into diagnostic applications (polymer brush diagnostics, SARS-CoV-2 nanofluidic devices) and neurodegenerative disease mechanisms (Apolipoprotein E-amyloid interactions), while maintaining foundational work on receptor trafficking. The lab's signature tools—Squassh for image analysis and baculovirus systems for multigene delivery—underpin most studies.

Scientific Awards:

• No awards mentioned in source materials

Advising and Grants: Berger leads a research group with active publications indicating supervision of junior scientists, though specific students aren't listed. Extensive tool development and cross-disciplinary collaborations (e.g., nuclear medicine, virology) imply sustained grant funding, though specific grants aren't documented in the provided text.

Labs and Teams: He directs the Laboratory for Multiscale Bioimaging at PSI. His team developed the MultiLabel/MultiPrime cre/LoxP-based multigene expression system (Kriz et al., 2010; Mansouri et al., 2016), Squassh image segmentation tools (Rizk et al., 2014, 2015), and split nanoluciferase GPCR assays (Spillmann et al., 2020; Romantini et al., 2021). All tools are publicly available via download packages with manuals.