جست‌وجوی استاد و پژوهشگر

Christian Matthias Schlepützمشاهده پروفایل

پژوهشگر

• Synchrotron Radiation
• X-ray Tomography
• 4D Imaging
• +۵ مورد دیگر

Christian Matthias Schlepütz serves as a Beamline Scientist at the Paul Scherrer Institute (PSI), specifically within the Center for Photon Science's Laboratory for Macromolecules and Bioimaging, where he leads research activities at the TOMCAT beamline. With over 15 years of experience in synchrotron-based structural investigations, Dr. Schlepütz has established himself as a leading expert in high-speed X-ray tomographic microscopy. PhD in Experimental Physics, University of Zürich (2009) Postdoctoral Research, University of Michigan (Ann Arbor, USA) Beamline Scientist, Advanced Photon Source (APS), Argonne National Laboratory (2011-2015) Beamline Scientist, TOMCAT Group, Swiss Light Source (2015-Present) Dr. Schlepütz's research focuses on resolving dynamic phenomena at the microscale in space and time through advanced X-ray imaging techniques. His work centers on developing and utilizing the unique capabilities of the TOMCAT beamline to collect X-ray tomographic microscopy datasets at unprecedented temporal resolutions, creating 4-dimensional microscopic movies of dynamic processes. His research spans multiple disciplines including materials science, biomechanics, geoscience, and food processing, with applications ranging from studying carbon fiber oxidation to visualizing sound-induced motion patterns in fish hearing structures. A significant achievement includes setting a speed record of 1000 tomographic scans per second at TOMCAT, while routinely providing sub-second time-resolutions of up to 20 tomographies per second to the user community. Analysis of Dr. Schlepütz's recent publications reveals a strong emphasis on pushing the boundaries of 4D imaging capabilities across diverse scientific domains. His work demonstrates consistent innovation in developing specialized sample environments and real-time reconstruction algorithms to expand the applicability of high-speed tomography. The research trends show increasing interdisciplinary collaboration, with publications spanning biological sciences, materials engineering, geoscience, and biomedical applications, all unified by the common thread of utilizing synchrotron-based X-ray imaging to capture previously invisible dynamic processes. Dr. Schlepütz actively contributes to the development of next-generation imaging capabilities through the SLS 2.0 upgrade project, working to establish the next generation of imaging beamlines at the Swiss Light Source. His technical expertise in both reciprocal space imaging using area detectors and real space 4D tomography positions him at the forefront of synchrotron-based structural investigation methodologies.

Elda Fischi-Gómezمشاهده پروفایل

پژوهشگر

• Medical Imaging
• Magnetic Resonance Imaging (MRI)
• Machine Learning
• +۳ مورد دیگر

Elda Fischi-Gómez is a Research Staff Scientist at the Center for Biomedical Imaging (CIBM), affiliated with EPFL and CHUV. She holds a BSc and MSc in Telecommunication Engineering from Polytechnic University of Catalonia (UPC, Spain) and a PhD in Electrical Engineering from EPFL (2015). Her research focuses on advancing MRI techniques by integrating software algorithms, MR physics/hardware, and neuroscience to improve understanding of brain development and disease. She has received notable grants including the SNFS Early-Postdoc Fellowship [SNF-P2ELP2_172286] and the EPFL-ETH Strategic Focal Area grant [PHRT-2018-425] for microstructure imaging in multiple sclerosis. Her work combines high-resolution dMRI acquisitions with advanced microstructural models and machine learning. As a member of the IEEE BioImaging and Signal Processing Technical Committee (BISP-TC), she chairs the Communications and Outreach subcommittee. She has served as a reviewer for ISBI, ISMRM, and conferences like ICASSP and ICIP, as well as high-impact journals such as Medical Image Analysis and Neuroimage: Clinical.

Oliver Bunkمشاهده پروفایل

پژوهشگر

• X-ray Imaging
• Nanotechnology
• Materials Science
• +۲ مورد دیگر

Dr. Oliver Bunk heads the Laboratory for Macromolecules and Bioimaging (LSB) at the Paul Scherrer Institute and serves as Deputy Head of the Center for Photon Science. His research focuses on cross-disciplinary imaging techniques spanning condensed matter physics, biomedical science, and materials characterization. Education includes a doctorate in physics from the University of Hamburg, with prior industrial and postdoctoral experience at Risø National Laboratory. Research integrates X-ray methods with computational approaches: Nanoscale 3D imaging via ptychography and tomography Structural analysis of biological tissues and biomaterials Detector development for synchrotron applications Phase-contrast techniques for soft matter characterization Recent publications emphasize cancer tissue analysis, collagen nanostructures, synchrotron instrumentation, and radiation therapy characterization. Collaborative works frequently address multiscale material properties using advanced X-ray methods. Dr. Bunk serves on scientific advisory committees for international facilities including ESRF, PETRA IV, and NSRRC. He actively contributes to PhD supervision and academic committees at PSI.

Marianne Liebiمشاهده پروفایل

استادیار

• Materials Science
• Biomedical Engineering
• X-ray Imaging Techniques
• +۳ مورد دیگر

Marianne Liebi is a Tenure-Track Assistant Professor at the École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the School of Engineering’s Institute of Materials. She leads the Structure and Mechanics of Advanced Materials group at the Paul Scherrer Institute (PSI) within the Photon Science Division. Her research focuses on developing advanced X-ray imaging techniques, particularly small-angle X-ray scattering (SAXS) tensor tomography, to study hierarchical materials such as biomimetic composites, cellulose-based materials, and bone tissues. She has held positions at Chalmers University of Technology (Sweden) and Empa, and her work bridges materials science, biomedical engineering, and nanotechnology. Education: PhD in Food Science from ETH Zurich (2013), followed by postdoctoral research at the Swiss Light Source. Professional roles include Assistant Professor at Chalmers University (2017–2020) and Scientific Group Leader at Empa (2020–2021). Research interests emphasize imaging complex structures across scales, with applications in 3D printing, industrial plastics, and biological tissues. Key methods include SAXS, ptychographic tomography, and X-ray fluorescence. Her group collaborates widely, addressing challenges in material design, medical diagnostics, and sustainable polymers. Advising and grants: While specific grants are not detailed, her leadership roles and publications indicate active research funding. Labs/teams: PSI’s Laboratory for Condensed Matter and Materials Science, with ongoing collaborations at synchrotron facilities like ESRF and MAX IV.

Tomas Aidukasمشاهده پروفایل

پژوهشگر

• Ptychography
• Fourier Ptychography
• Tomography
• +۵ مورد دیگر

Tomas Aidukas is a postdoctoral researcher at the Paul Scherrer Institute (PSI) in Switzerland, working in the Laboratory for Macromolecules and Bioimaging within the Center for Photon Science. He is a member of the cSAXS group at the Swiss Light Source, where he conducts research in computational imaging and ptychography. Education: B.Sc. in Theoretical Physics, University of Glasgow (2016) Ph.D. in Intelligent Sensing and Measurement, University of Edinburgh/Glasgow (2021) His research focuses on developing novel computational imaging techniques, particularly ptychography and Fourier ptychography, to overcome limitations in imaging systems. He specializes in algorithm development for image reconstruction and calibration, with current goals of pushing the resolution limits of 3D ptychographic tomography using X-rays and applying data-driven methods for integrated circuit inspection. His work bridges theoretical optics with practical applications in microscopy and tomography. His recent publications (2019-2022) demonstrate a strong focus on Fourier ptychographic microscopy, including high-speed multi-camera systems, low-cost open-source hardware solutions, and quantum correlation techniques. The work consistently addresses phase retrieval challenges while advancing sub-micron resolution capabilities across optical and X-ray domains. Scientific Awards: None mentioned. Dr. Aidukas leads multiple research initiatives including bridging the resolution gap between X-ray nano-tomography and electron microscopy, high-throughput integrated circuit inspection, and data-driven X-ray tomography methods. His industrial collaboration with ZEISS produced a patented depth metrology algorithm, and he provides operational support at the cSAXS beamline. He operates within the cSAXS group at PSI's Swiss Light Source, maintaining academic ties with the University of Glasgow's Imaging Concepts Group and industrial partnerships with companies like ZEISS for algorithm development and hardware implementation.

Jan Pieter Abrahamsمشاهده پروفایل

استاد

• Structural Biology
• Electron Microscopy
• Protein Crystallography
• +۵ مورد دیگر

Jan Pieter Abrahams is a Professor and Group Leader of the Nanodiffraction group at the Laboratory for Multiscale Bioimaging, Paul Scherrer Institute (PSI) in Switzerland. His work focuses on developing electron diffraction technologies for atomic-resolution imaging of frozen hydrated biological samples, leveraging PSI's detector expertise to advance structural biology beyond conventional microscopy limitations. Current applications target mitochondrial stress mechanisms in neurodegeneration and aging, with active collaborations across international institutions. Research Interests: Abrahams pioneers electron diffraction and cryo-EM methodologies, emphasizing computational-phasing innovations and machine learning integration. His group specializes in: Overcoming dynamical scattering for atomic-level cellular visualization Hybrid pixel detector applications (JUNGFRAU, EIGER) in electron microscopy Deep learning frameworks for diffraction data processing (e.g., DiffraGAN) Structural analysis of protein nanocrystals in disease contexts Mitochondrial protease mechanisms in aging Bacterial cell division and sporulation structures Publication Trends: Recent work (2020–2024) reveals heavy emphasis on AI-driven structural biology, including generative networks for diffraction phasing and lossless data compression. Instrumentation advancements (e.g., Boersch phase shifters) and disease-focused studies (Alzheimer’s amyloid-beta, malaria heme processing) dominate, showcasing interdisciplinary convergence of physics, computation, and biomedicine. Scientific Awards: No specific awards or fellowships documented in source text Advising and Collaborations: Abrahams has mentored PhD students including Thakkar, Pooja; Rheinberger, Jan; Schärer, Martin; and Wennmacher, Julian. His team collaborates with PSI's detector group on sensor development (GaAs/CdTe) and international labs for structural studies. Funding likely stems from PSI instrumentation projects and disease-focused research initiatives. Labs and Teams: He directs the Nanodiffraction group under PSI's Center for Life Sciences, comprising scientists (van Genderen, Latychevskaia) and postdocs (Blum). The lab integrates cryo-EM, electron diffraction, and computational modeling to visualize cellular processes at nanometer scales, with strong ties to detector engineering and pharmaceutical structural analysis.

• Neurodegenerative Diseases
• Correlative Light and Electron Microscopy (CLEM)
• Alpha-Synuclein Pathology
• +۴ مورد دیگر

Amanda Lewis is a current researcher at the École polytechnique fédérale de Lausanne (EPFL), affiliated with the LBEM unit within the School of Life Sciences. Her work focuses on neurodegenerative diseases, particularly synucleinopathies like Parkinson’s and Alzheimer’s. She specializes in correlative light and electron microscopy (CLEM) to study protein aggregation and cellular ultrastructure. Key contributions include optimizing CLEM protocols for human brain and skin tissues, elucidating tau pathology maturation stages in Alzheimer’s, and analyzing α-synuclein fibril structures linked to Multiple System Atrophy (MSA). Her doctoral thesis (2025) explored ultrastructural changes in synucleinopathies using CLEM, revealing novel insights into MSA pathology and peripheral biomarker potential. Lewis collaborates with institutions like Amsterdam UMC and Brigham and Women’s Hospital, leveraging interdisciplinary approaches to advance disease modeling and therapeutic development. Her research emphasizes translational applications, such as iPSC-derived models for studying protein inclusions and drug testing. Funding sources include the Aligning Science Across Parkinson’s Initiative and the Basque Biobank. Lewis’s work bridges basic science and clinical relevance, addressing urgent needs in diagnostics and disease mechanism understanding.

Jan Pieter Abrahamsمشاهده پروفایل

استاد

• Structural Biology
• Protein Structure
• High-Resolution Bioimaging
• +۵ مورد دیگر

Prof. Dr. Jan Pieter Abrahams is a distinguished Professor at the Biozentrum of the University of Basel, where he has been leading research since 2015. Previously, he served as Professor at Leiden University from 1997 to 2015. His research group focuses on uncovering the elementary structures of life through the development of innovative high-resolution bioimaging techniques. Dr. Abrahams completed his Ph.D. at Leiden University in 1991, following earlier doctoral and Candidaats diplomas from the same institution. His academic journey began with a European Baccalaureate from the European School in Bergen, the Netherlands in 1979. Prior to his professorial appointments, he worked as a staff scientist and postdoctoral researcher at the MRC Laboratory of Molecular Biology in Cambridge, UK (1990-1997), and was associated with the Netherlands Scientific Organization at Leiden University from 1985-1990. His research interests center on visualizing the molecular and atomic structure of proteins, which play essential roles in all basic life processes. His group develops and combines cutting-edge technologies from physics, biology, and scientific computing to elucidate atomic structures of proteins. A major focus is addressing the challenge that many proteins fail to form 3D crystals, for which they develop novel sample preparation techniques, optimize data acquisition methods, and refine analysis approaches. They employ X-ray crystallography, electron microscopy, atomic force microscopy, and various spectroscopic methods in their work. Analysis of his recent publications reveals a strong emphasis on electron diffraction techniques as a promising tool for visualizing atomic structures of biologically important proteins. His work spans multiple applications including understanding amyloid formation in Alzheimer's disease, malaria parasite mechanisms, bacterial structures, and developing new instrumentation for structural biology. The research shows a clear trajectory toward higher resolution imaging, computational analysis integration, and addressing previously intractable structural biology problems through innovative methodological approaches. Dr. Abrahams' laboratory at the Biozentrum (Room 05.038) maintains an active research program with administrative support from Karen Bergmann. His group's work on protein structure determination has significant implications for understanding molecular processes in both healthy and diseased organisms, with potential applications in drug development and disease treatment strategies.