جست‌وجوی استاد و پژوهشگر

Maria M. Viveirosمشاهده پروفایل

دانشیار

• Cell and Developmental Biology
• Regenerative Medicine
• Reproductive Physiology
• +۳ مورد دیگر

Maria M. Viveiros is an Associate Professor and Assistant Department Head in the Department of Physiology and Pharmacology at the University of Georgia’s College of Veterinary Medicine. Her research integrates experimental approaches like live cell imaging, molecular biology, and genetic mouse models to study meiotic division accuracy in oocytes, genomic stability, and the effects of environmental toxicants on embryonic development. She co-leads the Dr. Viveiros’s Lab and participates in interdisciplinary programs such as the Interdisciplinary Toxicology and Regenerative Biosciences Programs. Dr. Viveiros holds a PhD in Physiology and Pharmacology from the University of Guelph (Canada), an MSc from the same institution, and a BSc from McMaster University (Canada). She coordinates multiple graduate courses, including Integrative Systems Physiology I and II (VPHY 8210 and VPHY 8250), and leads the Endocrine and Reproductive Systems I course (VETM 5194). Her research interests focus on cell and developmental biology, regenerative medicine, reproductive physiology, and toxicology. Key projects address mechanisms regulating meiotic spindle assembly, monitoring chromosome attachment, and assessing how aging and environmental factors disrupt these processes. She explores epigenetic control of oocyte maturation, centromere function, and the impact of chemicals like bisphenol on gamete and embryo health. Publications highlight her work on pericentric satellite transcription, bisphenol toxicity, and epigenetic modifiers in oogenesis. Her contributions bridge molecular and cellular mechanisms with broader implications for human health, such as Down Syndrome and pregnancy loss linked to meiotic errors. She also investigates the role of proteins like ATRX, NEDD1, and Aurora Kinase A in spindle stability and chromosome segregation.

Raul A. Urrutiaمشاهده پروفایل

استاد

• Genomics
• Epigenomics
• Precision Medicine
• +۴ مورد دیگر

Raul A. Urrutia, MD is a Professor in the Department of Surgery & Biochemistry and the Director of the Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine at the Medical College of Wisconsin. He holds the Warren P. Knowles Endowed Chair of Genomics and Precision Medicine and directs the Pancreas Cancer Program. His research focuses on genomics, epigenomics, and precision medicine, particularly in pancreatic diseases such as cancer and diabetes. He has discovered key tumor suppressor genes and epigenetic pathways operational in pancreatic cancer and other diseases. His lab employs a multidisciplinary team of biochemists, geneticists, and bioinformaticians to advance precision medicine. Education: MD, University of Cordoba Postdoctoral Fellowship, National Institute on Deafness and Other Communication Disorders, NIH Research Interests: Dr. Urrutia’s work integrates genomic and epigenomic approaches to uncover mechanisms underlying pancreatic cancer, diabetes, and other diseases. His lab has made seminal contributions to understanding KLF proteins, histone-modifying enzymes (HDACs, HATs, HMTs), and histone-protein subcodes. Recent studies focus on epigenetic regulators in cancer progression and therapy resistance, mitochondrial genomic variants in transplantation outcomes, and precision medicine simulation models. Publications Trends: Recent articles emphasize targeting epigenetic regulators (e.g., CBX5, EZH2), mitochondrial genomics in hematopoietic transplantation, and systems biology approaches combining germline/somatic mutations for tumor analysis. The work spans disciplines from molecular biology to clinical translation. Awards: Warren P. Knowles Endowed Chair Member, American Society of Clinical Investigation Advising & Grants: Dr. Urrutia has mentored over 50 investigators. His lab is funded by NCI grants, the CIBMTR Data Resource (U24), and philanthropic support like the Theodore W. Batterman Family Foundation. Research units include the Precision Medicine Simulation Unit and collaborations with global institutions. Labs & Teams: Leads the Urrutia Research Laboratory and the Mellowes Center, collaborating with experts in epigenetics, computational biology, and clinical genomics. Key lab members include Angela J. Mathison, PhD (Technology Director) and Gareth Pollin, PhD (Bioinformatics).

Anne Ferguson-Smithمشاهده پروفایل

استاد

• Genomic Imprinting
• Epigenetics
• Developmental Genetics
• +۳ مورد دیگر

Professor Anne Ferguson-Smith is a leading mammalian developmental geneticist and epigeneticist at the University of Cambridge, holding the Arthur Balfour Professorship of Genetics. As Pro-Vice-Chancellor for Research, she oversees the university's research strategy while maintaining her laboratory's focus on genomic imprinting and epigenetic inheritance . Her work bridges experimental and computational approaches through affiliations with the Cambridge Stem Cell Institute, Cambridge Neuroscience, and the Centre for Trophoblast Research. Research in her lab investigates epigenetic mechanisms in developmental processes , particularly through the lens of Dlk1-Dio3 imprinted domain studies. Current themes include: Stem cell epigenetic programming Environmental modulation of epigenetic states Role of repetitive elements in genomic regulation Her group integrates mouse and zebrafish models with high-throughput genomics and mathematical modeling . Key collaborations include: Wellcome Trust UKRI Medical Research Council BBSRC NIH Scientific honors include: Elected EMBO Member (2006) Academy of Medical Sciences (2012) Fellow of the Royal Society (2017) Commander of the Order of the British Empire (CBE) The lab maintains family-friendly research practices and actively participates in interdisciplinary collaborations across Cambridge and internationally.

Subramaniam Ganeshمشاهده پروفایل

استاد

• Neurodegenerative disorders
• Human molecular genetics
• Protein quality control
• +۳ مورد دیگر

Subramaniam Ganesh is a Professor at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur (IITK). His research focuses on neurodegenerative disorders, particularly Lafora disease, and the molecular genetics of protein misfolding and autophagy. Education: BSc (1988), MSc (1990) from University of Madras, PhD (1996) from Banaras Hindu University Professional Affiliations: IITK (2002–present), RIKEN Brain Science Institute (1998–2002), Indian Institute of Science (1997–1998) Research Interests: Dr. Ganesh's work spans three main areas: (1) molecular pathology of Lafora disease through genetic screening and cellular models, (2) mechanisms of disorders caused by amino acid repeat expansions with focus on polyglutamine toxicity, and (3) genetic determinants of complex disorders like stroke and asthma. His group employs clinical genetics, cell biology, and biochemical approaches to uncover shared mechanisms in neurodegenerative diseases. Publication Trends: Recent articles highlight his work on glycogen metabolism in neurodegeneration, autophagy regulation in Lafora disease, and cross-disciplinary studies linking diabetes to Alzheimer's pathology. Keywords across 15 most recent papers include Neuroscience , Genetics , Biochemistry , and Pharmacology , with sub-fields spanning Protein degradation , Metabolic stress , and Neuroinflammation . Scientific Awards: National Bioscience Award for Career Development (2008) Scopus Young Indian Scientists Award (2008) B.M. Birla Science Prize (2008) DAE-SRC Outstanding Research Investigator Award (2010) CDRI Award (2012) ICMR Basanti Devi Amir Chand Prize (2014) OPPI Scientist Award (2016) Advising & Collaborations: Mentored 30+ PhD/MSc students since 2002. Collaborated with institutions like RIKEN, IISc Bangalore, and CDRI Lucknow. Editorial roles include Chief Editor of IITK Directions and Associate Editor of Journal of Genetics . Laboratory & Team: Head of the Ganesh Laboratory at IITK, overseeing 20+ researchers including postdoctoral fellows, PhD students, and technical staff. Key projects involve molecular pathways in Lafora disease, protein quality control, and neurodegenerative therapeutics.

• Aging
• Animal Cell and Molecular Biology
• Genetically Modified Animals
• +۵ مورد دیگر

Judith West-Mays is a Professor in the Department of Pathology & Molecular Medicine at McMaster University . Her research focuses on: Molecular mechanisms of eye development and disease Role of transcription factors (AP-2β, AP-2α) in ocular morphogenesis Transforming Growth Factor Beta (TGF-β) signaling in epithelial-mesenchymal transition (EMT) Matrix Metalloproteinases (MMPs) in vision disorders Biomaterials for intraocular pressure management Key scientific contributions include: Elucidating AP-2β's role in trabecular meshwork formation and glaucoma Characterizing MMP-9's impact on aqueous humor drainage Developing conditional knockout mouse models for vision research Investigating YAP signaling in lens fibrosis Creating mucoadhesive micelles for glaucoma therapy Scientific awards : Brockhouse Canada Prize (2025) for interdisciplinary vision health research Teaching : Biomedical Engineering II (2018) at McMaster University. Collaborators include Taiyab, Sheardown, and Ball. Research hubs involve McMaster's interdisciplinary vision science team.

• Neuroscience
• Psychiatry
• Neuroendocrinology
• +۳ مورد دیگر

William Christopher Wetsel is a Professor in the Department of Psychiatry and Behavioral Sciences and an Associate Professor in Neurobiology at Duke University School of Medicine. He is also a Faculty Network Member of the Duke Institute for Brain Sciences, demonstrating his interdisciplinary approach to neuroscience research. Dr. Wetsel earned his Ph.D. from the Massachusetts Institute of Technology in 1983. His research program focuses on using genetically-modified mice to study the roles of specific genes and gene products in neuroendocrine, neurological, and psychiatric responses. As the Director of the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University, he has extensive experience phenotyping various mouse models for both his own research and for other investigators. Dr. Wetsel's research spans multiple areas of neuroscience and psychiatry, with particular emphasis on developing mouse genetic models of neuroendocrine and neuropsychiatric illnesses. His laboratory employs a range of techniques including biochemical analyses, behavioral assessments, and postmortem analyses to characterize these models. A significant aspect of his work involves collaborating with medicinal chemists and biotechnology companies to identify novel compounds that can ameliorate abnormal responses in mutant mouse models, with some preclinical studies forming the basis for clinical trials. Analysis of Dr. Wetsel's recent publications (2022-2025) reveals a strong focus on neuropharmacology, particularly related to dopamine and serotonin receptor signaling, neuropsychiatric disorders, and pain mechanisms. His research frequently employs genetically-modified mouse models to investigate conditions including schizophrenia, depression, opioid addiction, and neurodevelopmental disorders. There is a clear trend toward investigating biased receptor signaling and developing more targeted therapeutic approaches with fewer side effects. Dr. Wetsel has made significant contributions to the field through his leadership of the Mouse Behavioral and Neuroendocrine Analysis Core Facility, which has supported numerous research projects both at Duke and at other institutions. His work bridges basic neuroscience with translational applications, as evidenced by several publications that have led to clinical trials. Dr. Wetsel's laboratory operates at the intersection of multiple research areas, utilizing advanced techniques in behavioral neuroscience, molecular biology, and neuropharmacology. The Mouse Behavioral and Neuroendocrine Analysis Core Facility under his direction serves as a critical resource for researchers studying neurological and psychiatric conditions using animal models.

Ernestina Schipaniمشاهده پروفایل

استاد

• Skeletal Development
• Hypoxia Biology
• Bone Metabolism
• +۴ مورد دیگر

Dr. Ernestina Schipani is the William Wikoff Smith Professor of Orthopedic Surgery at the University of Pennsylvania's Perelman School of Medicine, where she leads a productive research laboratory focused on skeletal development and disease mechanisms. Her groundbreaking work has established fundamental principles in hypoxia biology and G-protein coupled receptor signaling as they relate to skeletal formation and disease processes. Dr. Schipani's educational journey includes: M.D. and Ph.D. from St. Anna School of Advanced Studies-University of Pisa, Italy Her research has transformed our understanding of skeletal development, beginning with her seminal discovery that gain-of-function mutations of PTHR1 cause Jansen disease. She pioneered the concept that hypoxia-driven pathways control skeletal development, revealing how oxygen gradients serve as regulatory signals in tissue morphogenesis. Her laboratory employs genetically modified mouse models and cutting-edge techniques including single-cell RNA sequencing and metabolomics to investigate how hypoxia, mitochondrial metabolism, and metabolic reprogramming influence skeletal development and disease. Analysis of her recent publications shows a dominant focus on hypoxia-inducible factors (particularly HIF-1 and HIF-2) in bone development, metabolism, and disease. Her work spans molecular mechanisms of skeletal formation, therapeutic approaches for bone disorders, and the intersection of mitochondrial function with skeletal health, demonstrating sustained research excellence with continuous NIH funding since 1997. Dr. Schipani's significant contributions to bone research have been recognized through: ASBMR Paula Stern Achievement Award (2019) Continuous ASBMR membership since 1992 ASCI membership since 2005 She actively mentors the next generation of bone researchers, with her laboratory members regularly presenting at major scientific conferences including the Gordon Bone & Teeth Conference and ASBMR meetings. Her NIH-funded research program includes four major focus areas: HIF-1 in endochondral bone development and somitogenesis, HIF-2 in bone mass regulation, and HIFs in soft tissue tumors and cartilage regeneration. The laboratory recently secured an NIH R01 grant to study mitochondrial respiration and growth plate biology. The Schipani Laboratory at McKay Laboratories-University of Pennsylvania maintains an active research program investigating the fundamental biological processes of skeletal development, with particular emphasis on hypoxia signaling and metabolic regulation. Current projects examine how hypoxia-inducible factors regulate bone formation and disease processes, with significant translational potential for developing new therapies for skeletal disorders including osteoporosis and skeletal dysplasias.

Ralf Herwigمشاهده پروفایل

پژوهشگر

• Computational Biology
• Bioinformatics
• Systems Biology
• +۵ مورد دیگر

Dr. Ralf Herwig is a computational biologist at the Max Planck Institute for Molecular Genetics in Berlin, Germany. His work focuses on statistical methods for integrative analysis of gene expression, proteomics, and metabolomics data to model biological processes in human diseases like cancer and diabetes. He develops tools such as ConsensusPathDB for molecular interaction networks and IsoTools for long-read RNA-seq analysis. Education: Diploma in mathematics (Free University of Berlin), PhD in mathematics/statistics (FU Berlin) on clustering algorithms and information-theoretic methods. Research Interests include computational network biology, multi-omics data integration, machine learning for cancer survival predictions, and alternative splicing analysis. His group pioneered network propagation frameworks to explain drug toxicity and black-box ML models. Key Publications cover deep learning in drug combinations, long-read sequencing for cancer isoforms, and systems biology approaches to metabolic disorders. Tools developed by Herwig's lab are widely cited (~2,500 citations for ConsensusPathDB). Labs & Collaborations: Leads the Herwig Lab, collaborating on projects involving cancer, diabetes, and cardiotoxicity. The lab maintains critical computational resources for the biomedical community.

Oraly Sanchez Ferrasمشاهده پروفایل

دانشیار

• Developmental Genetics
• Urogenital System Diseases
• Kidney Development
• +۸ مورد دیگر

Oraly Sanchez Ferras is an Associate Professor in the Department of Biology at the University of Sherbrooke with secondary affiliation in the Department of Human Genetics at McGill University. Her research program investigates genetic mechanisms underlying kidney and urogenital system development and disease. Education: M.Sc. in Biochemistry (Immunology), University of Havana, 2009 Ph.D. in Biochemistry (Molecular Biology), Université du Québec à Montréal, 2015 Postdoctoral Fellow, Developmental Genetics of the Urogenital System, Rosalind and Morris Goodman Cancer Institute, McGill University, 2015-2021 Research Interests: Dr. Sanchez Ferras explores transcriptional control of cell specification during renal development, collective cell migration, congenital kidney/urinary tract anomalies (CAKUT), and cancer invasion. Her lab integrates genetically modified mouse models with single-cell genomics, spatial transcriptomics, and 3D embryo imaging to dissect genetic networks governing tissue formation and disease pathogenesis. Laboratory: The Sanchez-Ferras Laboratory studies how intermediate mesoderm-derived cells transform through pronephros, mesonephros, and metanephros stages to form adult kidneys, with emphasis on cellular communication, collective migration, and apoptosis mechanisms disrupted in CAKUT and cancer. Advising and Grants: Source material provides no details regarding student supervision, research grants, or funding sources.

• Neurodegenerative Diseases
• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Dementia
• +۶ مورد دیگر

Dr. Rachel Atkinson is a Research Fellow at the Wicking Dementia Research and Education Centre, University of Tasmania. She specializes in neurodegenerative diseases, focusing on mechanisms underlying cell degeneration in ALS and frontotemporal dementia. Her work includes investigating protective responses to cold stress and metabolic alterations in motor neuron disease. She holds the MNDRA Bill Gole Fellowship (2024-2026) and collaborates internationally on projects exploring therapeutic targets like HDAC6 inhibition and leptin repurposing. Education: Bachelor of Biotechnology and Medical Research (University of Tasmania, 2010-2012) Bachelor of Biotechnology and Medical Research with Honours (2013) PhD in FTLD/ALS Proteins (2014-2018) Research Interests: Dr. Atkinson’s research centers on axon degeneration, neurofilament biology, and protective pathways in neurodegenerative diseases. She employs viral techniques, stem cell models, and mouse studies to dissect cellular mechanisms. Key areas include cold shock pathways, metabolic modulation, and protein mislocalization in ALS/FTD. Key Findings: Her work has identified roles for SARM1 and HDAC6 in axonal pathology, and demonstrated synergistic effects of leptin and pioglitazone in Alzheimer’s models. Recent studies explore cold stress as a therapeutic avenue for ALS. Awards: MNDRA Bill Gole Fellowship (2024-2026) Grants & Supervision: Leads over $1.4M in grants, including projects on axon degeneration mechanisms and gene-environment interactions in ALS. Supervises four PhD students and teaches dementia care and neuroscience courses. Labs & Collaborations: Part of the Wicking Centre, collaborating with Spain and UK groups on metabolic and therapeutic research.

Ruhee Dereمشاهده پروفایل

دانشیار

• Primary Cilia Biology
• Ciliopathies
• Renal Cell Carcinoma
• +۴ مورد دیگر

Ruhee Dere, Ph.D., serves as Associate Professor in the Department of Medicine at Baylor College of Medicine, Houston, TX, where she leads research at the Center for Precision Environmental Health. Her work bridges molecular cell biology and translational oncology with focus on ciliary dynamics in disease pathogenesis. Her academic foundation includes: Ph.D. in Genetics from Texas A&M University (2006) Postdoctoral Fellowship at U.T. MD Anderson Cancer Center (2011) M.S. in Life Sciences from Mumbai University (2000) B.S. in Life Sciences from St. Xavier's College, Mumbai, India (1998) Dr. Dere's research program centers on elucidating molecular mechanisms of primary cilia formation/disassembly , with direct implications for ciliopathies and renal cystogenesis . Her seminal work established that VHL tumor suppressor loss triggers ciliary defects via Aurora kinase A (AURKA) activation , identifying AURKA as a direct VHL E3 ligase target. She demonstrated that AURKA-HDAC6 axis inhibition rescues ciliary defects in vitro and in vivo using novel cystogenesis models. Recent breakthroughs reveal nuclear histone modifiers repurposed in cytoplasmic compartments to regulate microtubule dynamics, uncovering unprecedented epigenome-cytoskeleton crosstalk . Analysis of her 15 most recent publications (2018-2024) reveals three dominant research thrusts: (1) epigenetic-cytoskeletal integration via SETD2/PBRM1-mediated microtubule methylation, (2) genomic instability mechanisms in renal carcinogenesis through centrosome/chromatin defects, and (3) therapeutic targeting of VHL-AURKA pathways to rescue ciliary dysfunction. Over 70% of recent work focuses on SETD2's dual roles in chromatin and cytoskeletal regulation. While specific awards are not detailed in source materials, Dr. Dere's contributions to cilia biology and renal cancer mechanisms are evidenced by consistent high-impact publications. Her laboratory has developed high-throughput image-based ciliation assays for compound screening and maintains animal models of cystogenesis . Current work explores nuclear-cytoplasmic shuttling of epigenetic regulators and their therapeutic potential in ciliopathies.

Louis-Éric Trudeauمشاهده پروفایل

استاد

• Neuropharmacology
• Neuroscience
• Dopamine Neurons
• +۵ مورد دیگر

Louis-Éric Trudeau is a Full Professor in the Department of Pharmacology and Physiology and Department of Neuroscience at the University of Montreal's Faculty of Medicine. He directs the Neural Signaling and Circuitry Research Group (SNC) and is a member of the Interdisciplinary Center for Brain and Learning Research (CIRCA). His laboratory focuses on understanding the fundamental mechanisms of dopamine neuron function and their role in Parkinson's disease. Education: BSc (Honors) in Psychology from Concordia University (1990) DEA in Neuroscience from University of Paris (1991) PhD in Neuroscience from University of Montreal (1994) Postdoctoral training at Iowa State University (1994-1996) Dr. Trudeau's research primarily investigates dopamine neurotransmission, with a focus on understanding how dopamine neurons function normally and why they degenerate in Parkinson's disease. His work spans cellular and molecular neuroscience, exploring mechanisms of neurotransmitter release, axonal arborization, mitochondrial function, and the role of the immune system in neurodegeneration. His laboratory employs a wide range of techniques including electrophysiology, electrochemistry, fluorescence imaging, confocal microscopy, and molecular biology approaches using normal and genetically modified mouse brain preparations. Analysis of Dr. Trudeau's recent publications reveals a strong focus on Parkinson's disease mechanisms, particularly examining the selective vulnerability of dopamine neurons, the role of mitochondrial function, immune system involvement, and neurotransmitter co-transmission. His work increasingly integrates immunological perspectives with traditional neuroscience approaches to understand Parkinson's disease pathogenesis. Dr. Trudeau has successfully secured substantial research funding from multiple sources including the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council (NSERC), Parkinson Society Canada, Brain Canada Foundation, and the Michael J. Fox Foundation. His current projects span from basic cellular neuroscience to translational research aimed at developing new therapeutic strategies for Parkinson's disease. As an educator, Dr. Trudeau supervises numerous graduate students and postdoctoral fellows, teaching courses in cellular and molecular neuroscience, neuropharmacology, and the nervous system. His laboratory provides training in advanced neuroscience techniques to the next generation of researchers.

Jan G. Bjaalieمشاهده پروفایل

استاد

• Neuroinformatics
• Digital brain atlasing
• Brain architecture and connectivity
• +۴ مورد دیگر

Jan G. Bjaalie is Professor of Neuroinformatics and Dean of Research and Innovation at the University of Oslo Faculty of Medicine . Since 2023 he heads the faculty’s research and innovation strategy, while directing the Neural Systems and Graphics Computing Laboratory at the Institute of Basic Medical Sciences. Education: 1990 Ph.D. in Neuroanatomy, University of Oslo 1986 M.D., University of Oslo Research interests revolve around collaborative and open neuroscience, digital brain atlasing, and the cyber-infrastructures that enable data sharing. He leads efforts to build next-generation atlases that integrate multi-scale brain architecture and connectivity data, and to develop ontologies and FAIR-compliant platforms for global neuroscience. Recent work emphasizes in silico integration of rodent and human imaging datasets, leveraging machine-learning registration tools and cloud-based services such as EBRAINS. The goal is to transform how brain data are stored, visualised and reused across laboratories worldwide. Scientific output & impact: A scan of publications from 2023-2025 reveals a strong focus on digital atlas frameworks, automated image registration (DeepSlice, DeMBA), open data standards (AtOM ontology), and large-scale analyses of genetic influences on brain structure in Alzheimer’s models. These works collectively advance reproducible, high-throughput neuroanatomy and cross-species translation. Grants & leadership roles: Coordinator/Partner in EU Flagships EBRAINS 2.0, BRAIN Health, Human Brain Project (2013-2026) Infrastructure Director, Human Brain Project (2018-2023) Leader of Neuroinformatics Platform & EBRAINS Data Services (2017-2023) Head of Institute of Basic Medical Sciences (2009-2016) Executive Director, International Neuroinformatics Coordinating Facility (INCF) (2006-2008) Chair, International Brain Initiative (2021-) Editorial & governance service: Founding Chief Editor Frontiers in Neuroinformatics (2007-), Section Editor Brain Structure and Function (2002-2020), member of the INCF Governing Board and EBRAINS AISBL Management Board, and numerous international advisory panels on data governance and ethics. His laboratory hosts the Norwegian Neuroinformatics Node and collaborates closely with global consortia to deliver open-access atlases, software pipelines and FAIR data standards that underpin modern neuroscience.

Gabriele Romanoمشاهده پروفایل

استادیار

• Cancer drug resistance
• Tumor suppressor genes
• Immune evasion
• +۵ مورد دیگر

Gabriele Romano, PhD, is an Assistant Professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine. His research focuses on cancer drug resistance mechanisms, leveraging mouse modeling, functional genomics, and computational biology. He leads the Romano Lab, which explores tumor-stroma interactions in minimal residual disease, tumor suppressor roles in therapy resistance, and HIV-cancer comorbidity. Education: PhD - Molecular and Translational Medicine, University of Milan, Bicocca (2015) MS - Medical Biotechnology, University of Milan, Bicocca (2012) BS - Biotechnology, University of Milan, Bicocca (2010) Research Interests: Cancer drug resistance mechanisms Immune evasion and tumor microenvironment Therapeutic strategies for HIV-associated cancers Functional genomics and nanoparticle delivery His work emphasizes developing novel therapies targeting residual tumor cells and improving outcomes for immunocompromised cancer patients. Key Awards: 2023 WW Smith Trust nominee (Cancer Research) 2022 Pew Biomedical Scholars competition nominee 2019 Maryanne Rosenstein Family Fellowship in Cancer Research Grants & Collaborations: Recipient of multiple institutional and foundation grants Collaborations with global institutions on translational projects Focus on mouse models, CRISPR screens, and bioinformatics Labs & Teams: Romano Lab at Drexel University Partnerships with MD Anderson Cancer Center and The Jackson Lab

Peixin Yangمشاهده پروفایل

استاد

• Diabetic embryopathy
• Neural tube defects
• Congenital heart defects
• +۷ مورد دیگر

Dr. Peixin Yang is the Christopher R. Harman, MD Endowed Professor of Obstetrics, Gynecology, and Reproductive Sciences at the University of Maryland School of Medicine. He serves as Professor with tenure in the Department of Obstetrics, Gynecology and Reproductive Sciences and holds a secondary appointment in the Department of Biochemistry & Molecular Biology. Dr. Yang is the founding director of the Center for Birth Defect Research at the University of Maryland School of Medicine and leads multiple NIH-funded research projects totaling millions of dollars. Dr. Yang's educational background includes: B.S. in Animal Science from Zhejiang Agricultural University (1986-1990) M.S. in Animal Reproductive Sciences from Nanjing Agricultural University (1990-1993) Ph.D. in Biophysics from Tokyo University of Agriculture & Technology and Zhejiang University (1994-1999) Postdoctoral Research Associate at University of Nebraska Medical Center (1999-2002) BIRCWH scholar (NIH K12) at University of Maryland Baltimore (2008-2009) Dr. Yang has built an extensive research program focused on diabetic embryopathy, particularly examining how maternal diabetes induces neural tube defects (NTDs), congenital heart defects (CHDs), and kidney defects. His laboratory was the first to establish a mouse model of diabetic embryopathy and reveal the causal role of JNK1/2 in neural tube defects. He has made significant contributions to understanding the molecular mechanisms of cellular stress, endoplasmic reticulum stress, and autophagy in neural tube defect formation. Dr. Yang also investigates the effects of maternal obesity on placental function and has established the Maryland Maternal Health Research Center of Excellence. His recent work has expanded to include studies on SARS-CoV-2 infection in pregnancy and connections between insulin resistance signaling and Alzheimer's disease. Analysis of Dr. Yang's recent publications reveals a strong focus on the molecular mechanisms of diabetic embryopathy, with particular emphasis on epigenetic regulation, cellular stress signaling pathways, and placental function. His work consistently bridges basic science with clinical applications, developing potential therapeutic approaches for preventing birth defects. A significant portion of his recent research examines the intersection of maternal metabolic conditions (diabetes and obesity) with fetal development, while also expanding into novel areas like viral infections in pregnancy and connections to neurodegenerative diseases. Dr. Yang's notable scientific achievements include: The F. Clarke Fraser New Investigator Award from the Teratology Society (2013) BIRCWH scholar (NIH K12) (2008-2009) The Lalor foundation postdoctoral Fellowship (2002-2003) Dr. Yang currently directs a multi-million dollar NIH-funded research group with multiple active R01 grants. His current projects investigate the intersection of mTOR/p70S6K1 signaling and HIPPO-Yap tissue organizer in neurulation, heightened hypoxia and DNA methylation in heart defects of diabetic embryopathy, hyperglycemia-induced cardiac progenitor dysfunction, and epitranscriptomic alterations in diabetic embryopathy. He has developed a robust research program in maternal diabetes-induced heart defects, which was previously an understudied area. Dr. Yang is also leading efforts to establish the Maryland Maternal Health Research Center of Excellence, focusing on the adverse effects of obesity, placental accreta spectrum, and opioid use disorder. As the founding director of the Center for Birth Defect Research at the University of Maryland School of Medicine, Dr. Yang leads a multidisciplinary team of translational and clinical scientists. His laboratory has made original contributions to understanding the molecular mechanisms underlying maternal diabetes-induced structural birth defects. The team employs genetically modified mouse models, whole-embryo culture systems, and human placental studies to investigate the effects of metabolic conditions on fetal development. Dr. Yang's group has been instrumental in developing natural compounds as potential preventatives for diabetic embryopathy, including trehalose, epigallocatechin-3-gallate, and curcumin.