Subramaniam Ganesh

Subramaniam Ganesh is a Professor at the Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur (IITK). His research focuses on neurodegenerative disorders, particularly Lafora disease, and the molecular genetics of protein misfolding and autophagy.

• Education: BSc (1988), MSc (1990) from University of Madras, PhD (1996) from Banaras Hindu University
• Professional Affiliations: IITK (2002–present), RIKEN Brain Science Institute (1998–2002), Indian Institute of Science (1997–1998)

Research Interests:
Dr. Ganesh's work spans three main areas: (1) molecular pathology of Lafora disease through genetic screening and cellular models, (2) mechanisms of disorders caused by amino acid repeat expansions with focus on polyglutamine toxicity, and (3) genetic determinants of complex disorders like stroke and asthma. His group employs clinical genetics, cell biology, and biochemical approaches to uncover shared mechanisms in neurodegenerative diseases.

Publication Trends:
Recent articles highlight his work on glycogen metabolism in neurodegeneration, autophagy regulation in Lafora disease, and cross-disciplinary studies linking diabetes to Alzheimer's pathology. Keywords across 15 most recent papers include Neuroscience, Genetics, Biochemistry, and Pharmacology, with sub-fields spanning Protein degradation, Metabolic stress, and Neuroinflammation.

• Scientific Awards:
  • National Bioscience Award for Career Development (2008)
  • Scopus Young Indian Scientists Award (2008)
  • B.M. Birla Science Prize (2008)
  • DAE-SRC Outstanding Research Investigator Award (2010)
  • CDRI Award (2012)
  • ICMR Basanti Devi Amir Chand Prize (2014)
  • OPPI Scientist Award (2016)

Advising & Collaborations:
Mentored 30+ PhD/MSc students since 2002. Collaborated with institutions like RIKEN, IISc Bangalore, and CDRI Lucknow. Editorial roles include Chief Editor of IITK Directions and Associate Editor of Journal of Genetics.

Laboratory & Team:
Head of the Ganesh Laboratory at IITK, overseeing 20+ researchers including postdoctoral fellows, PhD students, and technical staff. Key projects involve molecular pathways in Lafora disease, protein quality control, and neurodegenerative therapeutics.