جستجوی استاد راهنمای دانشگاهی

Jessica Thaxtonمشاهده پروفایل

دانشیار

• Cancer Cell Biology
• Tumor Microenvironment
• Cellular Stress Signaling
• +۱۰ مورد دیگر

Jessica Thaxton, PhD, MsCR , is an Associate Professor at the Department of Cell Biology and Physiology within the UNC School of Medicine . She is also a member of the UNC Lineberger Comprehensive Cancer Center and co-leader of its Cancer Cell Biology Research Program . Research Focus: Mechanistic studies of immune cell dysfunction in tumors, targeting cell stress signaling, metabolism, and organelle dynamics for novel cancer therapies. Collaborations: Head and neck cancer, melanoma, sarcoma, and metastatic bone disease oncologists. Techniques: Spectral flow cytometry, single-cell RNA sequencing, spatial transcriptomics, metabolomics, proteomics, and Seahorse bioanalysis. Research Interests: The Thaxton Lab investigates how the tumor microenvironment dysregulates immune cell metabolism and organelle dynamics, particularly in T cells. By repairing these processes, they aim to develop translational therapies for cancer patients. Their work bridges basic discovery with clinical applications, focusing on hypoxia-induced stress signaling and lipid metabolism. Scientific Trends: Recent publications highlight her team’s exploration of metabolic enzymes like Acetyl-CoA Carboxylase (ACC) that limit T-cell energy production in tumors. These studies integrate advanced imaging, genomic, and metabolic analyses to identify therapeutic strategies that enhance T-cell persistence and efficacy in solid tumors. Students and Collaborations: Her lab includes graduate students from Cell Biology & Physiology, Microbiology & Immunology, and Pharmacology. Notable contributions include Coral del Mar Alicea Pauneto’s work on stress signaling inhibition and Ellie Hunt’s research on lipid metabolism in T cells. Collaborations with senior scientist Genevieve Clutton and oncologists drive translational impact.

Samir Agrawalمشاهده پروفایل

مدرس ارشد

• Haematology
• Oncology
• Infectious Diseases
• +۶ مورد دیگر

Dr. Samir Agrawal is a Senior Lecturer and Honorary Consultant in Haemato-Oncology at the Blizard Institute, Queen Mary University of London. He holds a BSc, MBChB, PhD, and fellowships from the Royal College of Physicians (FRCP) and Royal College of Pathologists (FRCPath). Research Focus: His work spans blood cancer diagnostics, antimicrobial stewardship (AMS), and invasive fungal disease (IFD) management in high-risk haematology patients. Key contributions include: Developing the CD160-ROR1 assay for minimal residual disease (MRD) in chronic lymphocytic leukemia (CLL), with pending patents Co-authoring ECIL-6 guidelines for antifungal treatment in leukemia and transplant patients Creating the Fungal Audit Tool for Stewardship (FATs) to improve AMS Publication Trends: Agrawal’s research bridges haematology, oncology, and infectious diseases, emphasizing: CD160’s role in B-cell malignancies (2010–2020) Standardization of IFD diagnostics via clinical guidelines (2016) Integration of flow cytometry and biomarker discovery for cancer therapy (2011, 2020) T-cell dysfunction in lymphoid malignancies (1998) Supervision & Collaboration: He mentors clinical fellows in implementing the FATs audit tool and collaborates with UK centres on haemato-oncology and IFD research. Agrawal also leads educational initiatives like the UK’s largest Fungal Update conference.

Paul Armstrongمشاهده پروفایل

مدرس

• Pharmacology
• Hematology
• Thrombosis
• +۳ مورد دیگر

Dr. Paul Armstrong is a Lecturer in Pharmacology at the Centre for Immunobiology within the Blizard Institute at Queen Mary University of London. His research focuses on platelet pharmacology, particularly investigating how platelet turnover in disease states influences thrombotic risk and how platelet-monocyte aggregates contribute to disease pathophysiology. These studies aim to refine therapeutic approaches for cardiovascular diseases. Education : BSc in Pharmacology (University of Edinburgh), PhD at William Harvey Research Institute (2009) Research Themes : Platelet Reactivity, Thrombosis, Immune Cell Interaction, Cardiovascular Pharmacology Collaborations : Timothy D Warner's Lab; international institutions like Baker Institute (Australia) His recent publications emphasize platelet aging dynamics, noncoding RNA biomarkers, and novel assay development for platelet function testing. Collaborative studies explore cross-disciplinary approaches in thrombosis and hemostasis. No formal student advising or specific grants mentioned in available texts. Armstrong's work frequently addresses antiplatelet therapy optimization and platelet-endothelium interactions.

Corentin Le Saos Patrinosمشاهده پروفایل

پژوهشگر ارشد

• Immunology
• T Cell Biology
• Follicular Helper T Cells
• +۳ مورد دیگر

Corentin Le Saos Patrinos is a Research Fellow at the Department of Immunology, University of Oslo, working in Dr. Johanne Tracey Jacobsen's lab. His research focuses on T cell biology within lymph nodes and their role in modulating humoral immune responses. Education: PhD from the University of Bordeaux under Dr. Dorothee Duluc. Previous Experience: Postdoctoral work at the University of Pennsylvania (Penn Medicine) in Dr. Michela Locci’s team. His methodology integrates advanced technologies such as in vivo 2-Photon microscopy (PMDI: 34437125) and the LIPSTIC system (PMDI: 38448581), analyzed via flow cytometry and single-cell RNA sequencing. This work examines cellular interactions in lymph nodes and their impact on immune memory and response quality. His prior research investigated follicular helper T cells (Tfh) in Chronic Lymphocytic Leukemia (CLL), while recent projects include Tfh cell differentiation, long non-coding RNA (LncRNA) studies, and mRNA vaccine development.

• Aquatic Ecology
• Carbon Cycling
• Climate Change
• +۵ مورد دیگر

Dr. Anne Ojala is a Senior Researcher at the University of Helsinki's Department of Environmental Sciences within the Faculty of Biological and Environmental Sciences. She leads multidisciplinary research on freshwater ecosystems, focusing on carbon cycling in lakes and rivers, particularly in the context of climate change. Her work integrates atmospheric physics, forest ecology, and limnology through field measurements at the SMEAR II station's Lake-SMEAR platform and collaboration with the European ICOS infrastructure. Her research spans two main areas: 1) Quantifying carbon fluxes in freshwater systems using advanced methodologies, and 2) Investigating mixotrophy in algae and its implications for nutrient cycling and ecosystem dynamics. She pioneered micrometeorological river studies and applied quantum chemistry to limnological questions. She collaborates closely with Academy professors Timo Vesala and Markku Kulmala, as well as Professor Jaana Bäck (University of Helsinki) and Jukka Pumpanen (University of Eastern Finland). Supervises doctoral programs in Atmospheric Sciences and Interdisciplinary Environmental Sciences Co-led the Cascading carbon flow in forested catchments (CASCAS) project Contributing to the Algological Research Laboratory (ALGOLAB) and AnaEE network Scientific awards include the 2014 Department of Environmental Sciences' encouragement prize for exceptional work. She has supervised 6 PhD students, 1 licentiate, and 25 MSc students, with a teaching focus on aquatic ecosystem ecology and biogeochemistry across academic levels.

Laura M. Calviمشاهده پروفایل

استاد

• Hematopoietic Stem Cell Biology
• Bone Marrow Microenvironment
• Osteoblast Biology
• +۵ مورد دیگر

Laura M. Calvi, M.D. is a Professor in the Department of Endocrinology and Metabolism at the University of Rochester School of Medicine and Dentistry, where she serves as SKAWA Foundation Professor in Endocrinology and Metabolism and Vice Chair for Basic & Translational Science in the Department of Medicine. She leads the Cancer Microenvironment Research Program at Wilmot Cancer Center and directs the Calvi Lab focused on bone marrow microenvironment research. Dr. Calvi earned her BA in Biological Science from Union College (1990) and her MD from Harvard Medical School (1995). She completed her internal medicine residency and endocrinology fellowship at Massachusetts General Hospital, specializing in neuroendocrinology and pituitary tumor management. At Rochester, she co-founded the Multidisciplinary Neuroendocrinology Clinic. Her research centers on the bone marrow microenvironment's role in regulating hematopoietic stem cells (HSC), with four major projects: Identification and manipulation of HSC niche components (osteolineage cells, endothelial cells, mesenchymal stem cells) Aging effects on the bone marrow microenvironment and hematopoietic function Microenvironmental regulation of malignancies like leukemia and myelodysplastic syndromes Mitigation strategies for radiation-induced hematopoietic injury Her lab demonstrated that osteoblastic activation by Parathyroid Hormone expands HSC and improves recovery from myeloablation. Analysis of her 15 most recent publications (2023-2025) reveals consistent focus on bone marrow niche dynamics, with particular emphasis on taurine metabolism in leukemia, inflammatory regulation of stromal cells in aging, and therapeutic targeting of microenvironmental pathways. Key trends include single-cell analysis of niche components, metabolic reprogramming in malignancy, and radiation injury mitigation strategies. Dr. Calvi received the 2017 Davey Award in Cancer Research for her contributions to understanding the hematopoietic stem cell niche. Her patents on hematopoietic stem cell expansion demonstrate translational impact of her basic research. She mentors numerous graduate students and postdoctoral fellows through the Toxicology Ph.D. Program, Pathology - Cell Biology of Disease program, and Medical Scientist Training Program. Current lab members include Catherine Caballero, Zhiming Sam Jin, and Noah Salama, while alumni include Benjamin Frisch and Jason Mendler who now hold faculty positions. The Calvi Lab utilizes advanced techniques including intravital 2-photon imaging, mass cytometry (CyTOF), multiparameter flow cytometry, and RNA sequencing to study microenvironmental regulation of stem cells in murine models and primary human samples. The lab maintains affiliations with the James P. Wilmot Cancer Center, Center for Musculoskeletal Research, and NIH T32 Training Grant in Immunology.

Donna H. Korzickمشاهده پروفایل

استاد

• Aging
• Cardiovascular Disease
• Mitochondrial Dynamics
• +۳ مورد دیگر

Dr. Donna H. Korzick is a Professor of Physiology and Kinesiology at The Pennsylvania State University, with a joint appointment in the College of Health and Human Development. She also serves as the Director of Graduate Training Initiatives at the Huck Institutes of the Life Sciences, where she leads the development and implementation of training programs for graduate students. Her work focuses on interdisciplinary life science graduate training, raising Penn State's recruiting profile nationally and validating excellence in graduate education. Dr. Korzick received her educational credentials from The Pennsylvania State University, earning a Ph.D. in Physiology in 1994, an M.S. in Exercise and Sport Science in 1986, and a B.S. (Honors) in Physical Education from Southern Connecticut State University in 1984. Dr. Korzick's research centers on aging and cardiovascular disease risk using animal models, with particular emphasis on the effects of estrogen deficiency on mitochondrial regulation of cell survival during myocardial infarction. Her work explores PKC-dependent mechanisms and oxidant stress pathways. Her laboratory employs various animal models including rodent aging, estrogen deficiency, ischemia-reperfusion injury, chronic ethanol ingestion, and exercise interventions. She investigates how estrogen receptors and PKC-dependent signaling contribute to cardioprotection, especially in the context of aging and post-menopausal conditions. Dr. Korzick has secured significant funding from multiple National Institutes of Health (NIH) centers, including the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, and National Heart, Lung, and Blood Institute. Her current active project, "Research Training in Physiological Adaptations to Stress," is funded by the National Institute of General Medical Sciences through 2026. She has successfully led multiple T32 training grants that have supported dozens of graduate researchers at Penn State through funding, mentorship, and networking opportunities. As Director of Graduate Training Initiatives, Dr. Korzick guides faculty in developing and submitting training grant proposals and assists training faculty mentors in implementing program features and best mentoring practices. She provides career-development and mentoring trainings available to all life-sciences students and faculty at Penn State. Her leadership has helped Penn State secure over $2.75 million in renewed funding for graduate training programs. Dr. Korzick's laboratory is part of the Integrative and Biomedical Physiology program at Penn State. Her research team employs sophisticated techniques to study cardiac physiology, mitochondrial function, and immune responses in aged female rat models. The lab's work has important implications for understanding and treating cardiovascular disease in post-menopausal women, who face significantly higher risks of heart disease after menopause.

• Molecular Genetics
• DNA Repair
• Aging Research
• +۳ مورد دیگر

Wilbert Vermeij is a Researcher at the Department of Molecular Genetics at Erasmus MC. His work focuses on DNA repair, aging, and the impact of nutritional interventions on health outcomes. Affiliation: Erasmus MC, Molecular Genetics Research Interests: Gene expression profiling under fasting conditions DNA repair mechanisms in progeroid mice Metabolic effects of high-protein/low-carbohydrate diets Cardiac failure in genetic disease models Clinical translation of caloric restriction Publications highlight interdisciplinary work at the intersection of genetics, nutrition, and immunology, with recent studies on fasting, dietary impacts on aging, and cardiac dysfunction imaging.

• Immunology
• Hematology
• Biomarker Discovery
• +۳ مورد دیگر

Ian Dimmick is a researcher at Newcastle University with a focus on immunology, hematology, and biomarker discovery for critical illnesses. His work spans immunophenotyping, stem cell differentiation, and cell surface marker analysis in clinical contexts. Research Interests : Immune dysfunction in critical care Biomarker identification for sepsis T-cell and dendritic cell behavior in disease Hematopoietic stem cell differentiation Flow cytometry methodology Publication Trends : Recent studies highlight immunophenotyping in sepsis and myocardial infarction (2015-2018), with earlier work on stem cell biology and ocular surface markers (2005-2011). Collaborations include clinical immunology and hematopoietic niche modeling.

• Immunology
• Biomedical Research
• Human Immunology
• +۳ مورد دیگر

Merry Gunawan is a researcher at Newcastle University , specializing in immunology and biomedical research with a focus on dendritic cells, macrophages, and immune dysregulation mechanisms. She collaborates extensively with Professor Muzlifah Haniffa, Dr. Laura Jardine, and other experts in the field.

Siva K. Gandhapudiمشاهده پروفایل

استادیار

• Cancer Immunotherapy
• Infectious Disease Vaccinology
• T-Cell Immunology
• +۳ مورد دیگر

Siva K. Gandhapudi is an Assistant Professor at the University of Kentucky, affiliated with the Department of Microbiology, Immunology, and Molecular Genetics and the Markey Cancer Center. As Co-Director of the Flow Cytometry and Immune Monitoring Core Facility, he oversees cutting-edge immunology research infrastructure supporting both academic and industrial collaborators. Ph.D. in Microbiology (University of Kentucky, 2009) Postdoctoral Training: Vaccine Development (University of Louisville), T-Cell Biology (University of Oklahoma) His research focuses on manipulating T-cell immunity for clinical applications through: Combining cancer vaccines with checkpoint inhibitors Developing universal influenza vaccines via T-cell activation Designing novel immunostimulatory molecules Investigating immune cell dynamics in disease contexts Publication trends show expertise in: Adjuvant development (R-DOTAP, lipid A mimetics) T-cell biology across cancer and infectious diseases Immune monitoring technologies Stress immunophysiology In his core facility leadership role, Dr. Gandhapudi provides: High-speed flow cytometry services Advanced immune assay development Technical support for clinical research teams

Xin-Hua Huمشاهده پروفایل

استاد

• Biomedical Optics
• Light-Tissue Interaction
• Multispectral Imaging
• +۳ مورد دیگر

Dr. Xin-Hua Hu is a Professor in the Department of Physics at East Carolina University (ECU). His research focuses on experimental and theoretical studies of light interaction with biological tissues, including multispectral imaging, diffraction imaging of cells, and flow cytometry. He leads the Biomedical Laser Laboratory, developing optical systems for biomedical applications. He holds a PhD from the University of California, Irvine (1991), and prior degrees from Indiana University and Nankai University. His educational background includes a BS (1982) and MS (1985) in Physics from Nankai University, followed by an MS from Indiana University (1986). He teaches courses such as Biomedical Physics, Medical Imaging Physics, and Optics. His work integrates optical engineering with medical diagnostics, emphasizing label-free cell analysis and big data processing using machine learning. Key projects include developing diffraction imaging flow cytometry for rapid cell classification and creating inverse solvers for radiative transfer problems in turbid media. His methods enable non-invasive assessment of blood flow, tissue composition, and cell morphology without markers. Ongoing research explores applications in cancer diagnosis and real-time clinical monitoring. Dr. Hu's lab collaborates on high-performance computing and experimental systems for optical data acquisition. His contributions span instrumentation design, algorithm development, and interdisciplinary biomedical optics, aiming to bridge fundamental optics with practical clinical tools.

• Atmospheric Science
• Marine Science
• Climate Change
• +۴ مورد دیگر

Lauri Laakso is a distinguished academic and researcher holding the title of Extraordinary Professor in Environmental Physics at North-West University, South Africa, alongside his role as Head of Group and Principal Scientist at the Finnish Meteorological Institute (FMI). His primary affiliation is with the FMI's Marine Research Department, where he specializes in atmospheric and marine observations. Laakso holds advanced degrees from the University of Helsinki, including a PhD in Physics (2004) and Docent in Physics (2007). He has held academic positions at the University of Helsinki and North-West University, where he contributed to aerosol physics research. His career includes roles as a Visiting Professor (2008–2010) and University Researcher (2010–2011). His research focuses on aerosol physics, climate change, marine-atmospheric interactions, and defense-related technologies. Key projects include the Utö Marine Research Station (Baltic Sea) and the Welgegund measurement station in South Africa. He has secured over €4.3M in competitive research funding and supervised four PhD students. Laakso's work addresses critical issues like carbon sinks in coastal seas, atmospheric ducting for radar surveillance, and environmental impacts of shipping. His contributions span interdisciplinary fields, combining observational data with advanced modeling to inform climate and environmental policy.

• Cancer Immunotherapy
• Natural Killer (NK) Cells
• Leukemia Treatment
• +۵ مورد دیگر

Dr. Bree Foley is a Lecturer in the School of Biomedical Sciences at The University of Western Australia, with a dual role as a Pathology and Laboratory Science Contractor/Visitor at UWA College. Her research focuses on cellular immunology, particularly leveraging natural killer (NK) cells to combat pediatric cancers. She completed her PhD at UWA on NK cell anti-leukaemic function and conducted postdoctoral research at the University of Minnesota, contributing to clinical trials for relapsed leukemia patients. Dr. Foley teaches immunology and genetics at both undergraduate and postgraduate levels and is active in educational pedagogy research. Education: Master of Teaching (Secondary), University of Western Australia (2023) PhD in Immunology, University of Western Australia (2008) BSc (Biomedical Science, Hons), University of Western Australia (2003) Research Interests: Dr. Foley’s work centers on enhancing NK cell functional capacity using cutting-edge techniques, aiming to develop novel immunotherapies for cancer. Her research integrates immunogenetics, flow cytometry, and translational approaches to improve cancer treatment outcomes. She also explores how external factors like burn injuries impact immune responses in cancer development. Recent Trends in Research: Her articles highlight the modulation of interferon pathways to boost antitumor immunity, the role of NK cells in leukemia, and the synergy between cytokines and vaccines. These studies underscore her focus on translational immunotherapy and cellular mechanisms in cancer. Awards: C. Sanders Prize (2024) Barbara May Scholarship (2017) Grants & Mentorship: Dr. Foley leads multiple grants totaling over AUD 2 million, including projects on NK cell therapies and armored NK cell development. She mentors students and early-career researchers through roles in the Australian Society for Immunology and Medical Research boards. Her educational initiatives emphasize adaptive teaching strategies tailored to student needs. Labs & Collaborations: Her research group collaborates with international institutions and is part of interdisciplinary teams at UWA. Key partnerships include work with the Kids Research Institute Australia as an Honorary Research Associate.

Max Krummelمشاهده پروفایل

استاد

• Immunology
• Cancer Biology
• Cell Signaling
• +۳ مورد دیگر

Max Krummel is a Professor at the University of California San Francisco, leading research on immune system dynamics and tumor microenvironment interactions. His work focuses on T cell signaling, imaging-based analysis of immune responses, and translational applications in cancer therapy. He has pioneered real-time imaging techniques and developed antibody therapies like ipilimumab for melanoma. Krummel's lab integrates fluorescent tagging, flow cytometry, and advanced imaging to study immune cell behavior in tissues such as lymph nodes, lungs, and tumors. Education: B.S. in Biology and Chemistry, University of Illinois (1985-1989) Ph.D. in Immunology, University of California, Berkeley (1989-1995) Postdoctoral training at Walter and Eliza Hall Institute (Melbourne, 1996-1997) and Stanford University (1997-2001) Honors: James Scholar (University of Illinois, 1986) Juvenile Diabetes Foundation Postdoctoral Fellowship (1996-2000) NIH NRSA Postdoctoral Fellowship (1997-2000) Cancer Research Institute Investigator Award (2004-2007) His research emphasizes understanding immune cell communication and stromal interactions in tumors, leveraging imaging tools to dissect complex cellular networks. Recent work includes studying CD206+ macrophage roles in antitumor immunity and developing models to track tumor-educated immune cells. Krummel has secured NIH grants totaling over $50M as Principal Investigator, focusing on tumor immunity, cytoskeletal regulation, and lung biology. Publications highlight innovations in intravital imaging, immune archetyping for cancer classification, and metabolic reprogramming in immune cells. His lab collaborates widely, including the UCSF COMET Consortium for pandemic research and translational studies in lung repair.