معرفی
Laura M. Calvi, M.D. is a Professor in the Department of Endocrinology and Metabolism at the University of Rochester School of Medicine and Dentistry, where she serves as SKAWA Foundation Professor in Endocrinology and Metabolism and Vice Chair for Basic & Translational Science in the Department of Medicine. She leads the Cancer Microenvironment Research Program at Wilmot Cancer Center and directs the Calvi Lab focused on bone marrow microenvironment research.
Dr. Calvi earned her BA in Biological Science from Union College (1990) and her MD from Harvard Medical School (1995). She completed her internal medicine residency and endocrinology fellowship at Massachusetts General Hospital, specializing in neuroendocrinology and pituitary tumor management. At Rochester, she co-founded the Multidisciplinary Neuroendocrinology Clinic.
Her research centers on the bone marrow microenvironment's role in regulating hematopoietic stem cells (HSC), with four major projects:
- Identification and manipulation of HSC niche components (osteolineage cells, endothelial cells, mesenchymal stem cells)
- Aging effects on the bone marrow microenvironment and hematopoietic function
- Microenvironmental regulation of malignancies like leukemia and myelodysplastic syndromes
- Mitigation strategies for radiation-induced hematopoietic injury
Analysis of her 15 most recent publications (2023-2025) reveals consistent focus on bone marrow niche dynamics, with particular emphasis on taurine metabolism in leukemia, inflammatory regulation of stromal cells in aging, and therapeutic targeting of microenvironmental pathways. Key trends include single-cell analysis of niche components, metabolic reprogramming in malignancy, and radiation injury mitigation strategies.
Dr. Calvi received the 2017 Davey Award in Cancer Research for her contributions to understanding the hematopoietic stem cell niche. Her patents on hematopoietic stem cell expansion demonstrate translational impact of her basic research.
She mentors numerous graduate students and postdoctoral fellows through the Toxicology Ph.D. Program, Pathology - Cell Biology of Disease program, and Medical Scientist Training Program. Current lab members include Catherine Caballero, Zhiming Sam Jin, and Noah Salama, while alumni include Benjamin Frisch and Jason Mendler who now hold faculty positions.
The Calvi Lab utilizes advanced techniques including intravital 2-photon imaging, mass cytometry (CyTOF), multiparameter flow cytometry, and RNA sequencing to study microenvironmental regulation of stem cells in murine models and primary human samples. The lab maintains affiliations with the James P. Wilmot Cancer Center, Center for Musculoskeletal Research, and NIH T32 Training Grant in Immunology.
