جست‌وجوی استاد و پژوهشگر

Jörg Meurerمشاهده پروفایل

استاد پژوهشی

• Plastid RNA Metabolism
• Photosynthetic Complex Assembly
• Chloroplast Biogenesis
• +۳ مورد دیگر

PD Dr. Jörg Meurer is a Research Professor and Staff Scientist at the Department of Plant Sciences, Faculty of Biology, Ludwig-Maximilians-University Munich (LMU). His research focuses on plastid RNA metabolism and assembly of photosynthetic complexes, with expertise in chloroplast gene expression regulation and proteomics. He holds a Diploma in Botany from Heinrich-Heine University Düsseldorf (1992), completed his PhD in Botany (1996) and Habilitation (2005) at LMU Munich. Professional highlights include postdoctoral fellowships at Friedrich-Schiller University Jena and the Max Planck Institute for Plant Breeding Research. Since 1999, he has led projects at LMU’s Plant Sciences section, organizing the Proteomics Service since 2013. His teaching encompasses Bachelor/Master courses in plant biology. He also serves as Radiation Protection Commissioner and Safety Officer. Research contributions span chloroplast RNA stability, photosystem assembly, and stress responses, with over 150 publications in peer-reviewed journals. Education: 1986-1992: Diploma in Botany, Heinrich-Heine University Düsseldorf 1992-1996: PhD (Dr. rer. nat.) in Botany, supervised by Prof. Peter Westhoff 2005: Habilitation in Botany, LMU Munich Research Interests: Plastid RNA metabolism and regulation Photosynthetic complex assembly mechanisms Chloroplast biogenesis and stress responses Proteomics of chloroplast components Recent Article Trends: Focus on chloroplast epitranscriptomics, thylakoid protein dynamics, and stress response mechanisms. Recent work explores RNA editing via designer proteins, ubiquitin-mediated protein interactions, and nucleotide metabolism impacts on photosynthesis. Lab Activities: Leads the Proteomics Service at LMU Biocenter, providing cutting-edge proteomic analysis for plant research. Collaborates in the Green Hub consortium studying plant acclimation mechanisms.

• Synthetic Biology
• Genetic Engineering
• RNA-based Biotechnology
• +۸ مورد دیگر

Prof. Dr. Daniel Schindler is a Visiting Scientist at the Max Planck Institute for Terrestrial Microbiology in Marburg, Germany, affiliated with the DNA Service Unit . His work focuses on synthetic biology, genetic engineering, and RNA-based technologies. Research Interests : Daniel Schindler's research spans synthetic biology and microbial genomics, with emphasis on RNA engineering, DNA assembly techniques, and metabolic pathway optimization. He explores the application of Golden Gate cloning, synthetic secondary chromosomes, and CRISPR tools for precise genetic manipulation. Recent Publications : His work highlights advancements in synthetic small RNA design, high-throughput DNA assembly, and phage engineering. Themes include microbial systems biology, enzyme evolution, and scalable genome modification. Contact : Email: daniel.schindler@mpi-marburg.mpg.de Phone: +49 6421 178 530 Address: Karl-von-Frisch-Strasse 10, 35043 Marburg, Germany

Mati Karelsonمشاهده پروفایل

استاد

• Computational Chemistry
• QSAR Modeling
• Drug Design
• +۵ مورد دیگر

Mati Karelson is a Full Professor at the University of Tartu's Institute of Chemistry in Estonia, where he has maintained a continuous academic appointment since September 1992. With an educational background in Chemistry from Tartu State University (1992-1995), he has established himself as a leading researcher in computational chemistry and drug design. Professor Karelson's research spans multiple disciplines with a strong focus on computational approaches to drug discovery . His work prominently features: Quantitative Structure-Activity Relationship (QSAR) modeling Molecular docking and virtual screening Epitranscriptomics, particularly RNA methylation (m6A) Neurodegenerative disease research, especially Parkinson's disease Antiviral drug development targeting HIV and flaviviruses His recent publications (2023-2025) demonstrate a strong emphasis on the intersection of computational chemistry and biological applications, particularly in developing small molecule modulators of RNA methylation pathways and their therapeutic potential for neurological disorders and viral infections. Professor Karelson has published 238 papers with over 44,875 reads and 13,947 citations, reflecting significant impact in his field. His research collaborations span multiple institutions internationally, working with experimental biologists to validate computational predictions. The interdisciplinary nature of his work bridges computational chemistry with neuroscience, virology, and molecular biology, creating a robust research program with translational potential.

Robert Schneiderمشاهده پروفایل

استاد

• Epigenetics
• Chromatin Biology
• Metabolism-Epigenetics Crosstalk
• +۴ مورد دیگر

Prof. Robert Schneider serves as Professor at Ludwig-Maximilians-Universität München's Faculty of Biology and Director of the Institute of Functional Epigenetics at Helmholtz Zentrum München. He leads Project A20 within the Collaborative Research Center 1064, investigating how metabolic enzymes and their products regulate chromatin dynamics and gene expression. His dual appointments position him at the nexus of academic research and translational biomedical science in Munich's vibrant research ecosystem. His academic journey began with Biology Diploma studies (1990-1996) and doctoral research (1996) at LMU Munich under Prof. Regine Kahmann. This was followed by an EMBO fellowship at Cambridge's Gurdon Institute (2000-2004), a Max Planck Research Group leadership in Freiburg (2005-2012), and Director de Recherche position at Strasbourg's IGBMC (2012-2016) before his current roles. Research focuses on metabolite-chromatin crosstalk, particularly how short-chain acyl-CoAs drive histone lysine acylations to reprogram gene expression. The lab employs innovative approaches including metabolic enzyme recruitment to specific genes, in vitro chromatin reconstitutions, and single-cell tracing of transcriptional memory. Current work emphasizes RNA modification enzymes (e.g., METTL5/6) in pluripotency and the role of sugar metabolism in epigenetic inheritance. This research provides fundamental insights into how nutrition and metabolism shape genomic regulation with implications for cancer and developmental disorders. Recent publications (2017-2020) reveal a strategic expansion from histone modifications into RNA epigenetics and single-cell dynamics of metabolic-epigenetic interactions. The work consistently bridges biochemical mechanism with functional outcomes in stem cells and disease models, demonstrating increasing technical sophistication through integrative genomics and live-cell imaging approaches. Major recognitions include: ERC Starting Grant (2008) HFSP Career Development Award (2006) Chaire Gutenberg, University of Strasbourg (2012) Multiple labellisation awards from French research foundations (2012-2014) Epigenome Network of Excellence membership Mentorship occurs through structured PhD programs including CRC 1064's graduate initiatives and Helmholtz's doctoral training. The lab maintains active grants from DFG (CRC 1064), ERC, and collaborative consortia, supporting interdisciplinary projects that attract international talent. Prof. Schneider serves on editorial boards (PLOS Genetics) and selection committees, fostering global scientific exchange while maintaining a highly collaborative lab environment focused on mechanistic epigenetics. The Institute of Functional Epigenetics operates as a dynamic hub within Helmholtz Zentrum München, combining biochemical expertise with genomic and computational approaches. The lab's integration into CRC 1064 enables synergistic collaborations across Munich's research institutions, particularly in developing novel methods to probe metabolism-chromatin interfaces in real time.

Antonio Giraldezمشاهده پروفایل

استاد

• Developmental Biology
• Gene Expression Regulation
• Genomics
• +۹ مورد دیگر

Antonio Giraldez is the Fergus F. Wallace Professor of Genetics at Yale School of Medicine, where he has led his research laboratory since 2007. He served as Director of Graduate Studies (2012-2016) and Chair of the Genetics Department (2017-2023). His academic appointments span multiple departments and centers including Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS), the Center for RNA Science and Medicine, Yale Cancer Center, Yale Center for Genomic Health, Yale Combined Program in the Biological and Biomedical Sciences (BBS), and the Yale Stem Cell Center. Professor Giraldez's research focuses on understanding the regulatory code that governs gene expression during vertebrate development after fertilization. His lab investigates four interconnected areas: genome activation during the maternal-to-zygotic transition, post-transcriptional regulation of gene expression, modeling of therapeutic mRNA design, and modeling of gene regulatory networks. Using zebrafish as a primary model organism combined with advanced genomic, computational, and imaging approaches, his lab has made significant contributions to understanding how transcription factors activate the embryonic genome and how RNA regulatory elements control mRNA stability and translation. Analysis of Professor Giraldez's recent publications reveals a strong focus on the molecular mechanisms of embryonic development, particularly the maternal-to-zygotic transition where control of development passes from maternal to embryonic factors. His work increasingly integrates high-throughput genomic approaches with computational modeling to decode regulatory elements in RNA that determine stability, translation efficiency, and tissue-specific expression - knowledge directly applicable to therapeutic mRNA design for gene therapy and vaccines. Scientific Awards and Honors: HHMI Faculty Scholar (2016) Blavatnik Award for Young Scientists National Finalist (2016) Vilcek Prize for Creative Promise in Biomedical Science (2014) Pew Scholar in Biomedical Sciences (2008) NYAS Blavatnik Young Investigator Award Finalist (2007) Professor Giraldez has established a productive research program with consistent funding and publication in top-tier journals. His lab maintains active collaborations with researchers across Yale and beyond, as evidenced by his frequent co-authorship with scientists from multiple departments. He has trained numerous students and postdocs who have gone on to independent research careers. The Giraldez Lab maintains a diverse team of researchers working at the intersection of developmental biology and genomics. The lab provides extensive resources including published datasets, computational tools like CRISPRscan, and detailed genomic annotations available through their data repository. Professor Giraldez's research program continues to advance our understanding of fundamental gene regulatory mechanisms with implications for both basic science and therapeutic applications.

• RNA Biology
• RNA Modifications
• Epitranscriptomics
• +۳ مورد دیگر

Sigrid Nachtergaele serves as Assistant Professor in the Department of Molecular, Cellular, and Developmental Biology at Yale Graduate School of Arts and Sciences, with cross-appointments across Yale Cancer Center, Center for RNA Science and Medicine, and multiple interdisciplinary programs including Biochemistry/Quantitative Biology (BQBS), Genomics/Genetics/Epigenetics, and the Yale Combined Program in Biological and Biomedical Sciences (BBS). Her research program centers on RNA biology with particular emphasis on epitranscriptomics – investigating how chemical modifications to RNA molecules regulate mRNA function and gene expression. This work combines biochemical methodology development with molecular analysis to understand fundamental regulatory mechanisms, leveraging Yale's specialized resources including the Center for RNA Science and Medicine. Her focus bridges basic molecular mechanisms with potential implications for cancer biology through Yale Cancer Center affiliations. Recent publication trends (2023-2024) demonstrate dual expertise in technical methodology (RT-based mapping of RNA modifications) and conceptual analysis of RNA modification roles in mRNA regulation, alongside contributions to scientific culture discourse. This output appears in high-impact venues including Annual Review of Biochemistry and Methods in Enzymology, reflecting both technical leadership and broad scholarly impact. As an active member of Yale Cancer Center's Genomics, Genetics, and Epigenetics Program, she contributes to collaborative cancer research while mentoring through the BBS graduate program. Her laboratory environment benefits from institutional support through Yale's RNA-focused research infrastructure and cancer center resources, though specific lab branding isn't detailed in available sources.

• RNA Biology
• Computational Biology
• Hematologic Neoplasms
• +۵ مورد دیگر

Toma Tebaldi is an Assistant Professor Adjunct in the Medical Oncology and Hematology department at Yale School of Medicine and a member of the Yale Cancer Center. His interdisciplinary work bridges computational biology and cancer research, with a focus on RNA mechanisms in hematologic malignancies. Dr. Tebaldi maintains affiliations with multiple research programs including Genomics, Genetics, and Epigenetics, and Internal Medicine at Yale. Dr. Tebaldi's educational background includes a PhD in Information and Communication Technology from the University of Trento (2010), an MSc in Biotechnologies - Bioinformatics from University of Milano Bicocca (2006), and a BSc in Biotechnologies from the same institution (2003). His training includes postdoctoral fellowships at University of Trento, EMBO Short Fellowship at University of Edinburgh, and international internships at Harvard Medical School, University of Edinburgh, and University of Sheffield. His research focuses on RNA molecular mechanisms underlying disease dysregulation, combining experimental and computational approaches. Key areas include alternative splicing, non-coding RNA binding, mutant RNA binding proteins, RNA modifications (epitranscriptome), translation dynamics, and single-cell expression data. This work has significant implications for understanding and treating hematologic cancers. Dr. Tebaldi's publication record shows consistent output in high-impact journals from 2022-2025, with research spanning cancer biology, RNA mechanisms, and computational approaches. His work demonstrates increasing sophistication in integrating single-cell technologies with traditional molecular biology techniques to address complex questions in cancer biology. Italian National Scientific Qualification as Associate Professor in Applied Biology (2021) Italian National Scientific Qualification as Associate Professor in Molecular Biology (2020) Yale YCCEH Pilot and Feasibility Program Award (2018) RNA Society Travel Award: RNA2016, Kyoto (2016) EMBO Travel Grant Award: Protein synthesis and translational control (2015) Dr. Tebaldi serves as Associate Editor for Frontiers in Genetics - Computational Biology and as a reviewer for PRIN 2020 MIUR. His membership in the Yale Center for Biomedical Data Science and Yale Cancer Center provides access to extensive collaborative networks and resources. His research program benefits from interdisciplinary connections between computational biology, cancer genomics, and clinical hematology/oncology. Through his Italian Society of Yale Students and Affiliates board membership and Visiting Professor appointments at University of Trento, Dr. Tebaldi maintains strong international connections that enrich his research program and provide opportunities for student exchanges and collaborative projects across continents.