جست‌وجوی استاد و پژوهشگر

Jerry Stitzelمشاهده پروفایل

استاد

• Behavioral Genetics
• Pharmacogenetics
• Neurogenetics
• +۵ مورد دیگر

Professor Jerry Stitzel at the University of Colorado Boulder's Institute for Behavioral Genetics and Integrative Physiology department specializes in the molecular and physiological mechanisms of nicotine dependence and comorbid psychiatric conditions like schizophrenia and ADHD. His work bridges human genetics with mouse models to study tobacco addiction, epigenetic inheritance, and neuropharmacological effects. Research Focus Genetic determinants of drug-seeking behaviors CHRNA5/CHRNB2 nicotinic receptor polymorphisms Maternal nicotine exposure epigenetics Sex-specific addiction mechanisms Recent Trends : Analysis of transcriptomic networks, intergenerational effects of nicotine, and glial receptor modulation. Key grants include NIDA U01DA043802 (PI) and AB Nexus (Lead PI) funding studies on Chrna5 variants and mitochondrial function. Academic Contributions Principal Instructor for courses in Physiological Genetics (IPHY 4200/5200/6840) Ph.D., Johns Hopkins University (1992) International collaborations in Chile, France, Germany, and Japan Laboratory : Molecular Neurogenetics Laboratory explores nicotine's impact on sleep, circadian rhythms, and gene-environment interactions using transgenic mouse models.

• Structural Biochemistry
• Cryogenic Electron Microscopy
• Bacterial Cell Biology
• +۳ مورد دیگر

Jamie Depelteau is a Researcher at the Faculty of Science , Utrecht University , specializing in Structural Biochemistry . Their work focuses on advancing Cryogenic Electron Microscopy (cryo-EM) tools and studying microbial ultrastructure under environmental stress. Research Areas : Structural biology, cryo-EM methodology, bacterial/archaeal cell structure, Vibrio cholerae pathogenesis. Affiliation : Utrecht University, Faculty of Science, Structural Biochemistry department. Jamie's recent publications highlight innovations in cryo-EM sample preparation (2020, 2022) and investigations into Vibrio cholerae adaptation (2021). They have also contributed to understanding hydrocephalus genetics in H-Tx rats (2000–2002). Contact : j.s.depelteau@uu.nl | jsdepelteau@uu.nl

• Epigenetics
• Plant Biology
• Synthetic Biology
• +۴ مورد دیگر

Dr. Jason Gardiner is an Assistant Professor at Utrecht University's Faculty of Science, specializing in Translational Plant Biology. His research focuses on epigenetic mechanisms in plants, particularly DNA methylation and transcriptional memory. He develops synthetic biology tools to engineer methylation-sensitive gene regulation systems for agricultural applications. Primary affiliation: Utrecht University, Faculty of Science, Environmental Biology Key research themes include: Understanding how DNA methylation maintains gene expression states through cell divisions Designing synthetic promoters responsive to methylation changes Creating targeted epimutagenesis tools for crop improvement Recent publications highlight: CRISPR-based epigenetic engineering (2022) Mechanisms of RNA-directed DNA methylation (2021) Auxin signaling in vascular patterning (multiple publications)

Alejandro Raul Burga Ramosمشاهده پروفایل

پژوهشگر ارشد

• Genetics
• Evolutionary Biology
• Genomics
• +۳ مورد دیگر

Alejandro Raul Burga Ramos is a Tenured Group Leader at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences since 2019. His research focuses on understanding the molecular mechanisms driving the evolution of complex traits, with a particular emphasis on epistatic interactions and genomic conflict. He has held postdoctoral fellowships at UCLA and Princeton University. Research Interests: Genetics, Evolutionary Biology, Genomics, Molecular Biology, Population Genetics, Developmental Biology Scientific Awards: ERC Starting Grant, Jane Coffin Childs Postdoctoral Fellowship, Extraordinary Thesis Prize from Universitat Pompeu Fabra Publications: His work spans topics like selfish genetic elements, genetic modifiers, and the evolution of complex traits, with recent studies on RNA-mediated parent-of-origin effects (2024) and virus-like transposons driving genetic incompatibilities (2023). His research bridges quantitative genetics, genomics, and developmental biology to address fundamental questions in inheritance and adaptation. Advising: Supervises PhD students including Anja KOLLER, Daniel KROGULL, and Polina TIKANOVA. Team: Collaborates with postdocs like Sonya WIDEN and Tianhua LIAO.

Marisa Bartolomeiمشاهده پروفایل

استاد

• Epigenetics
• Genomic Imprinting
• X Chromosome Inactivation
• +۶ مورد دیگر

Marisa Bartolomei is the Perelman Professor of Cell and Developmental Biology at the University of Pennsylvania's Perelman School of Medicine. She leads a research laboratory focused on epigenetic mechanisms in genomic imprinting and X inactivation, utilizing mouse models to explore both fundamental biological processes and environmental influences. B.S. in Biochemistry, University of Maryland (1982) Ph.D. in Biochemistry, Johns Hopkins University School of Medicine (1987) Her research interests include: Elucidating genomic imprinting mechanisms through cis- and trans-acting factor studies Investigating X chromosome inactivation dynamics Analyzing environmental impacts on epigenetics via endocrine disruptors and ART Exploring DNA methylation reprogramming in germline and stem cells Recent studies highlight her work on tissue-specific imprinting regulation, TET1's role in reprogramming, and long-term effects of ART. Publications span molecular epigenetics, environmental health, and developmental biology journals. Laboratory affiliations include the Smilow Center for Translational Research and the Center for Research on Reproduction and Women's Health. She collaborates with experts like Huntington Willard (Duke University) and participates in consortiums such as NIEHS TaRGET II.

Kavitha Sarmaمشاهده پروفایل

دانشیار

• Epigenetics
• Genome Organization
• R-loop Biology
• +۶ مورد دیگر

Dr. Kavitha Sarma is an Associate Professor in the Department of Cell and Developmental Biology at the Perelman School of Medicine, University of Pennsylvania, and holds a joint appointment at The Wistar Institute's Gene Expression and Regulation Program. Her lab is located at The Wistar Institute (Room 234, 3601 Spruce St, Philadelphia). She earned her Ph.D. in Biochemistry from Rutgers University in 2007 and completed postdoctoral training at Massachusetts General Hospital-Harvard Medical School. Her research focuses on RNA-mediated epigenetic regulation, with emphasis on: R-loop biology and their roles in genome stability Non-coding RNA mechanisms in gene silencing Polycomb proteins and chromatin remodeling Neurodevelopmental disorders and cancer epigenetics Development of genomic techniques like MapR for R-loop profiling Her work connects nucleic acid structures (R-loops/G-quadruplexes) to epigenetic regulation and disease mechanisms. Recent publications demonstrate strong emphasis on R-loop dynamics, genome organization, and their implications in neuronal differentiation, B-cell homeostasis, and cancer. Methodological innovations in proximity labeling and strand-specific mapping are consistent themes. Dr. Sarma leads an active research team including postdoctoral fellows, graduate students, and research assistants. Current lab members include: Michelle Lynskey (Postdoc) Phillip Wulfridge (Postdoc) Emanuel Forciniti (Graduate Student) Kelvin Okpokpo (Graduate Student) The lab utilizes embryonic stem cells, neuronal differentiation systems, and cancer models with biochemical and omics approaches. She actively advises trainees and hosts graduate rotations from UPenn programs.

Kenneth S. Zaretمشاهده پروفایل

استاد

• Chromatin biology
• Gene regulation
• Transcription factors
• +۵ مورد دیگر

Kenneth S. Zaret , the Joseph Leidy Professor and Director of the Institute for Regenerative Medicine at the University of Pennsylvania , is affiliated with the Perelman School of Medicine and the Department of Cell and Developmental Biology . Executive Committee, University of Pennsylvania Center for Molecular Studies in Digestive and Liver Disease Member, Institute for Diabetes, Obesity and Metabolism His research focuses on chromatin biology , transcriptional regulation , and cell fate determination , particularly in liver and pancreas development . He discovered pioneer factors that enable chromatin remodeling for cellular reprogramming and identified chromatin domains resisting reprogramming. His work also explores inductive signaling and histone modifications as therapeutic targets. Key publication trends include epigenetic reprogramming , chromatin structure analysis , and transcription factor mechanisms , with collaborations in biochemistry , computational biology , and developmental genetics . He mentors students and researchers in Zaret Lab , including graduate students in Cell and Molecular Biology and Biochemistry and Molecular Biophysics programs. The lab is part of Penn's Institute for Regenerative Medicine and associated with University of Pennsylvania 's core facilities.

Bahar Patlarمشاهده پروفایل

پژوهشگر

• Evolution
• Ecology
• Population Genetics
• +۶ مورد دیگر

Dr. Bahar Patlar is a Research Associate in the Animal Ecology group at the Institute of Biology, Zoology department within the Faculty of Natural Sciences I - Biosciences at Martin Luther University Halle-Wittenberg, Germany. Her research focuses on the evolutionary mechanisms underlying reproductive traits, particularly examining seminal fluid proteins and their role in sexual selection and reproductive fitness. Her educational background includes: Ph.D. in Evolutionary Biology (2014-2019) from Bielefeld University, Germany M.Sc. in Evolutionary Biology (2011-2013) from Hacettepe University, Turkey B.Sc. in Biology (2006-2011) from Hacettepe University, Turkey Dr. Patlar's research interests center on Evolution, Ecology, Population & Quantitative Genetics, with specific focus on Reproduction, Sexual Selection, Male Ejaculate, Sexual Conflict, and Sperm Competition. Her work primarily uses Drosophila melanogaster as a model system to investigate how seminal fluid proteins influence reproductive success, sexual conflict, and non-genetic inheritance. She examines how these proteins affect post-mating behaviors, sperm storage, fertilization success, and even paternal epigenetic effects on offspring. Her current projects include studying human seminal fluid protein evolution across populations, worldwide analyses of seminal fluid protein evolution in Drosophila , and investigating seminal fluid-mediated paternal effects. Analysis of her recent publications (2020-2023) reveals a consistent research trajectory focused on reproductive biology and evolutionary genetics. Her work demonstrates expertise in molecular techniques, evolutionary analysis, and behavioral studies, primarily using Drosophila and flatworm models. The publications show increasing complexity in examining not just the molecular evolution of seminal fluid proteins, but also their functional consequences for reproductive fitness, sexual conflict, and transgenerational effects. Dr. Patlar actively collaborates with researchers internationally, including Axel Wiberg in Sweden, Prof. Claudia Fricke in Halle, and previously with Prof. Amro Zayed in Canada. She maintains an active research website (baharpatlar.wixsite.com/bpatlar) where she shares her scientific insights and popular science writings.

• Cell Cycle Control
• Drosophila Genetics
• Developmental Biology
• +۳ مورد دیگر

Patrick O'Farrell is a distinguished Professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco (UCSF) School of Medicine. With a career spanning several decades, he has established himself as a leading researcher in developmental biology and genetics, particularly using Drosophila (fruit fly) as a model organism to understand fundamental cellular processes. Dr. O'Farrell's research focuses on two major interconnected areas: the control of the cell cycle during development and the genetics and biology of mitochondria. His laboratory investigates how embryonic cell cycles are coordinated with developmental programs during the critical mid-blastula transition in Drosophila embryos. A key discovery was that slowing of early rapid cell cycles occurs due to prolongation of S phase, which is integrated with developmental programs of chromatin changes that introduce epigenetic controls. His more recent work has revealed fascinating evolutionary dynamics between nuclear and mitochondrial genomes, showing how host organisms actively manage mitochondrial genome evolution. His extensive publication record demonstrates consistent innovation across decades, with recent work (2020-2022) advancing understanding of transcription-replication conflicts in embryos, mechanisms for mitigating age-dependent accumulation of defective mitochondrial genomes, and temporal control of DNA replication through Rif1-PP1 hubs. His research combines Drosophila genetics, molecular biology, and advanced microscopy techniques to observe cellular processes in real time. American Academy of Arts and Sciences Elected Member (2009) National Academy of Sciences Elected Member (2017) Univ. of Lethbridge Honorary Doctorate (2012) Japanese Electrophoresis Society Research Prize (2014) Postdoc. Scholars Assoc. UCSF Outstanding Mentorship Award (2006) Dr. O'Farrell has maintained continuous NIH funding for over three decades, with his current research supported by an R35 Maximizing Investigators' Research Award titled 'Embryonic Emergence of Heterochromatin and Nuclear Supervision of Mitochondrial Genetics.' His laboratory at UCSF continues to make significant contributions to our understanding of fundamental biological processes that have implications for human development and disease.

Yves De Koninckمشاهده پروفایل

استاد

• Synaptic transmission
• Chronic pain mechanisms
• Neurophotonics
• +۷ مورد دیگر

Yves De Koninck is Professor of Psychiatry & Neuroscience at Laval University and Adjunct Professor of Pharmacology & Therapeutics at McGill University . He serves as Scientific Director of the Quebec Mental Health Institute, Director of Research at the Quebec Integrated University Health and Social Services Centre, Director of the Neurophotonics Center , and Scientific Director of the Sentinel North Initiative. Education & Training Ph.D. training supported by FRSQ & NSERC studentships at McGill University (1985–1990) Postdoctoral Fellowships from the Medical Research Council of Canada (1991–1994) Research Focus His laboratory investigates synaptic transmission, the delicate balance between excitation and inhibition in the brain and spinal cord, and how its disruption leads to chronic pain, Alzheimer’s disease, and autism. The team employs state-of-the-art neurophotonics and optogenetics to dissect cellular and molecular substrates of pathological conditions in the central nervous system. Mechanisms of chronic pain and hyperalgesia Synaptic plasticity in the sensory spinal cord Impact of ageing on cortical synapses Chloride homeostasis and neuronal excitability Scientific Awards & Honors 2022 Wilder-Penfield Prize, Government of Québec 2020 Education Award, Society for Neuroscience 2019 Emily Gray Award, Biophysical Society 2018 Brockhouse Canada Prize for Interdisciplinary Research 2017 Distinguished Career Award, Canadian Pain Society Canada Research Chair (Tier 1) in Chronic Pain and Related Brain Disorders (2016–2030) Fellow, Canadian Academy of Health Sciences (2013) Fellow, Royal Society of Canada (2015) Funding & Leadership Dr. De Koninck has secured major multi-institutional grants, including a $4.3 M Brain Canada Platform Grant for the Canadian Optogenetics and Vectorology Foundry and leadership of the DecodePain International Research Project launched in 2025. Laboratory & Team The De Koninck lab is home to 8 Ph.D. students, 4 postdoctoral fellows, and several research assistants and staff, all dedicated to advancing understanding of the nervous system through cutting-edge optical, electrophysiological, and computational approaches.

• Epidemiology
• Biostatistics
• Alzheimer's Disease
• +۵ مورد دیگر

Biqi Wang is an Assistant Professor at the T.H. Chan School of Medicine within UMass Chan Medical School , specializing in Medicine . Her research bridges Epidemiology , Biostatistics , and Digital Health , focusing on neurodegenerative diseases, cardiometabolic health, and respiratory disease management. Education: BS in Preventative Medicine, Peking University PhD in Epidemiology & Biostatistics, Peking University Her work explores Alzheimer's disease genetic risk, COPD digital interventions, and cardiometabolic diet interactions. Recent publications highlight epigenetics , machine learning in cardiovascular diagnostics, and public health applications for infectious disease monitoring. Collaborations span institutions like Harvard University and UMass Chan Medical School , with co-authors including David McManus and Adrian Zai . Her studies emphasize telemedicine , community health , and longitudinal cohort analysis .

Eric Richardsمشاهده پروفایل

استاد مدعو

• Epigenetics
• Nuclear Cell Biology
• Genetics & Development
• +۲ مورد دیگر

Eric Richards is an Adjunct Professor in the Department of Molecular Biology and Genetics at Cornell University and a researcher at the Boyce Thompson Institute (BTI). His work focuses on epigenetics and nuclear cell biology, particularly the interplay between DNA methylation, chromatin regulation, and nuclear architecture in plants. Research Areas: Epigenetics, Nuclear Cell Biology, Genetics & Development Richards' research explores how chromatin organization and three-dimensional nuclear structure influence epigenetic inheritance and gene regulation in Arabidopsis thaliana . His lab investigates mechanisms of cytosine methylation, the role of chromatin proteins like DDM1 and VIM, and the impact of nuclear architecture on genome stability. Recent trends in his publications emphasize nuclear lamina structure in tomato, cross-species nuclear morphology, and the integration of epigenetic codes with higher-order nuclear organization. His studies bridge fundamental molecular biology with agricultural and ecological implications of epigenetic variation. Additional contributions include patents related to methylation profiling methods, DNA methylation genes, and artificial chromosome vectors. Richards' lab collaborates with Cornell and BTI, mentoring interns and advancing plant epigenetics research.

Edda Schulzمشاهده پروفایل

استاد

• X-chromosome inactivation
• Epigenetics
• Gene regulation
• +۵ مورد دیگر

Dr. Edda Schulz is a Lise Meitner Group Leader and Research Group Leader at the Max Planck Institute for Molecular Genetics in Berlin, where she leads an active research laboratory focused on epigenetic regulation and chromosome biology. She has been in this position since 2020, following five years as a Max Planck Research Group Leader at the same institution. Dr. Schulz received her PhD from Humboldt Universität und Deutsches Rheumaforschungszentrum in Berlin, where she worked with Professors Thomas Höfer and Andreas Radbruch, and completed postdoctoral training at Institut Curie in Paris with Professor Edith Heard. Her research program centers on X-chromosome inactivation, epigenetic regulation, and gene expression dynamics. Dr. Schulz employs cutting-edge approaches including CRISPR screening, quantitative modeling, and single-cell genomics to investigate how cells establish and maintain epigenetic states during development. Her lab has developed innovative tools like CasTuner for precise gene expression modulation and has made significant contributions to understanding how transcription factors and cis-regulatory elements coordinate Xist expression during early embryonic development. Analysis of her recent publications reveals a strong focus on the molecular mechanisms of X-chromosome inactivation, with particular emphasis on cis-regulatory architecture, chromatin topology changes, and the role of transcription factor networks. Her work bridges quantitative biology with molecular genetics, often incorporating mathematical modeling to understand gene regulatory networks. The lab's research has important implications for understanding developmental disorders, stem cell biology, and epigenetic inheritance. EMBO Young Investigator (2022) ERC Starting Grant (2020) HFSP Career Development Award (2018) HFSP Long-Term Fellowship (2010-2014) Young Female Scientist Award for PhD thesis (2011) Avrion Mitchison Price for Rheumatology (2010) MTZ-Award for Medical Systems Biology for PhD thesis (2010) Dr. Schulz actively mentors PhD students and postdoctoral researchers, with several successful thesis defenses documented in her lab news. She has secured competitive funding including an ERC Starting Grant and serves on the review board of the German Research Foundation (DFG). Her lab collaborates with multiple international groups and she co-organized the 2023 EMBO Workshop on X-chromosome inactivation. The Schulz Lab maintains a dynamic research environment with regular retreats, workshops, and collaborative projects, as evidenced by their active news updates through 2025.

• Neuropathology
• Pediatric Neurology
• Brain Tumors
• +۵ مورد دیگر

Hart Lidov, MD, PhD is an Associate Professor of Pathology at Harvard Medical School and serves as the Director of Neuropathology in the Department of Pathology at Boston Children's Hospital. With a distinguished academic background including undergraduate, graduate, and medical degrees from Johns Hopkins University, Dr. Lidov has established himself as a leading expert in pediatric neuropathology. Dr. Lidov's educational journey includes: Undergraduate: Johns Hopkins University (1974, Baltimore, MD) PhD in Neuroanatomy: Johns Hopkins University (1982, Baltimore, MD) Medical Degree: Johns Hopkins University School of Medicine (1982, Baltimore, MD) Internship in Pediatrics: Massachusetts General Hospital (1983, Boston, MA) Residency in Pediatric Neurology: Massachusetts General Hospital (1987, Boston, MA) Fellowship: National Hospital (1988, London, England) Fellowship: Brigham & Women's Hospital/Boston Children's Hospital (1991, Boston, MA) Dr. Lidov's research focuses on neuropathology with particular emphasis on brain tumors, genetic neurological disorders, and muscular dystrophies. His work spans from basic neuroscience to clinical applications, with numerous publications in high-impact journals. His recent research examines the immune landscape in pediatric high-grade glioma, DNA methylation profiling for choroid plexus tumors, and genetic mechanisms underlying muscular dystrophies. His publications demonstrate significant trends toward molecular diagnostics and precision medicine approaches in pediatric neuropathology, with a strong focus on translating molecular findings into improved diagnostic and therapeutic approaches. Dr. Lidov is board certified by the American Board of Pathology (Neuropathology) and the American Board of Psychiatry and Neurology (Child and Adolescent Neurology), reflecting his dual expertise in both pathology and neurology. His leadership in the Department of Pathology at Boston Children's Hospital has been instrumental in advancing precision medicine approaches for pediatric neurological disorders.

• Glioma
• Brain Tumor Research
• Genomics
• +۶ مورد دیگر

Roel Verhaak, PhD, is the Harvey and Kate Cushing Professor of Neurosurgery at Yale School of Medicine, where he leads a research laboratory focused on brain tumor biology and cancer genomics. He joined Yale in 2023 after previously being affiliated with the Jackson Laboratory for Genomic Medicine (2016-2023) and MD Anderson Cancer Center (2010-2016). Dr. Verhaak's research focuses on understanding tumor evolution and mechanisms of therapy resistance in gliomas, with particular emphasis on extrachromosomal DNA amplifications. He is a founding member of the Glioma Longitudinal Analysis Consortium (GLASS), which has established a significant resource of molecular profiles collected over time from glioma patients. His laboratory employs high-throughput sequencing, computational analysis, and functional studies to investigate how cancer cells evolve during disease progression and in response to therapy. Recent work has focused on characterizing extrachromosomal DNA as a critical driver of oncogene amplification and tumor heterogeneity in glioblastoma and other cancers. Dr. Verhaak has published extensively in top-tier journals including Nature, Cell, and Nature Genetics, with his research revealing fundamental insights into glioma biology, tumor evolution mechanisms, and potential therapeutic targets. His work has established extrachromosomal DNA as a major factor in cancer progression and treatment resistance. AAAS Martin and Rose Wachtel Cancer Research Award (2016) Adult Basic Science Award (2014) Peter Steck Memorial Award (2012) Wilson S. Stone Memorial Award (2011) Dr. Verhaak has mentored numerous graduate students and postdoctoral fellows, contributing to the training of the next generation of cancer researchers. His laboratory maintains active collaborations with multiple institutions through the GLASS Consortium and other research networks.