جست‌وجوی استاد و پژوهشگر

Patricia R. Taylorمشاهده پروفایل

دانشیار

• Immunology
• Ophthalmology
• Diabetic Retinopathy
• +۳ مورد دیگر

Patricia R. Taylor, PhD is an Associate Professor in the Department of Ophthalmology and Visual Sciences at Case Western Reserve University's School of Medicine, with a secondary appointment as Research Health Scientist at the Cleveland VA Medical Center. Her research focuses on immunological mechanisms underlying diabetic retinopathy, particularly the role of IL-17A cytokine signaling. Education: BSc Microbiology (University of Akron, 2005), MSc Biology (University of Akron, 2007), PhD Biomedical Sciences (Kent State University/NEOMED, 2010), Postdoc in Ocular Immunology at Case Western Reserve University (2014). Research Interests: Investigates IL-17A's role in retinal oxidative stress, inflammation, and vascular damage. Current projects include NEI R01-funded studies targeting TRAF signaling proteins and VA Merit-funded clinical trials assessing IL-17A's role in anti-VEGF resistance. Grant Funding: Active NEI R01 and VA Merit awards. Research emphasizes translational approaches to identify novel therapeutics for retinal pathogenesis. Key Labs/Teams: Collaborates with Cleveland VA Medical Center and the Institute of Pathology. Her work bridges immunology and ophthalmology to address diabetic retinopathy mechanisms.

Aaron Weinbergمشاهده پروفایل

استاد

• Innate Immune Responses
• Antimicrobial Peptides
• HIV Pathogenesis
• +۳ مورد دیگر

Overview Aaron Weinberg is a tenured Professor and Chair of the Department of Biological Sciences at the Case Western Reserve University School of Dental Medicine , where he also serves as Associate Dean for Research. He holds secondary appointments in the Department of Pathology and Proteomics & Bioinformatics Core at the School of Medicine, and is a member of the Case Comprehensive Cancer Center's Population and Cancer Prevention Program. Education Doctor of Dental Medicine (DMD), Hebrew University of Jerusalem Doctor of Philosophy (PhD), Hebrew University of Jerusalem Master of Arts, Hebrew University of Jerusalem Bachelor of Arts, George Washington University Research Dr. Weinberg's work focuses on innate immune responses in mucosal epithelia , particularly the role of human beta-defensins (hBDs) in defending against pathogens like HIV, bacteria, and fungi. His lab discovered that hBDs have both antimicrobial and immunoregulatory properties, including anti-HIV activity. Current projects include: Screening oral commensal bacteria (e.g., Fusobacterium nucleatum) that induce hBD expression to protect mucosal surfaces. Investigating defensins' role in oral cancer initiation/progression via collaborations with the CWRU/UH Cancer Center. Developing hBD-based strategies for prophylaxis and immune modulation. His NIH-funded Program Project explores mucosal immune dysfunction in HIV+ populations (2009-2015), with ongoing support for defensin biomarker research and AMP-inducing factors. Awards & Honors 2002: Elected Member, Omicron Kappa Omicron National Honor Society 1988: 2nd Place, Edward H. Hatton Competition (International Association for Dental Research) 1991: NIH National Research Service Award Teaching & Mentorship Teaches oral microbiology/immunology courses (DENT 516) and mentors junior faculty in research. Active in professional societies like the American Society for Microbiology and International Association for Dental Research. Grants & Collaborations Leadership on NIH grants totaling over $14M, including a Program Project Grant (P01) and multiple R01/R56 awards. Collaborates across disciplines within CWRU and with international partners like Taipei Medical University. Labs & Teams Directs the Weinberg Lab , part of the School of Dental Medicine's Biological Sciences Department. Integrates clinical insights with molecular/cellular biology to address oral diseases and host defense mechanisms.

• Virology
• Immunology
• Microbiology
• +۴ مورد دیگر

Judith Olejnik is a Senior Research Scientist in the Muhlberger Lab at Boston University, affiliated with Boston University CAMED and BUMC Cores. Her work focuses on virology, immunology, and microbiology, particularly investigating viral pathogenesis, host responses, and antiviral strategies against pathogens like Ebola, SARS-CoV-2, and RSV. Her research emphasizes understanding mechanisms of viral infection, immune evasion, and age-related susceptibilities. Key interests include STAT3 signaling in respiratory infections, ACE2 regulation during SARS-CoV-2 infection, and the development of robust viral inactivation protocols for genomic analysis. She has contributed to studies on filovirus replication, host-pathogen interactions, and the role of minor introns in viral infections. Notably, she received the 2025 Corwin Award for her contributions. Her work integrates cutting-edge genomics (e.g., ViBE-Seq for filovirus RNA analysis) and interdisciplinary approaches to tackle emerging pathogens. She collaborates with the Muhlberger Lab to advance infectious disease research and translational antiviral strategies.

Yuan Rongمشاهده پروفایل

دانشیار

• Neuropathology
• Glioblastoma
• Molecular Oncology
• +۷ مورد دیگر

Yuan Rong, MD, PhD, is an Associate Professor in the Department of Pathology and Laboratory Medicine at the Lewis Katz School of Medicine, Temple University. She serves as Director of the Autopsy Service and specializes in Neuropathology, with a strong clinical and research focus on brain tumors, particularly glioblastoma. Education: PhD, Nagoya University, Nagoya, Japan MD, Beijing Medical University, Beijing, China Fellowship, Neuropathology, Virginia Commonwealth University, Richmond, VA Residency, Anatomic and Clinical Pathology, Emory University, Atlanta, GA Research Interests: Dr. Rong's research centers on the molecular and pathological mechanisms underlying glioblastoma, with emphasis on hypoxia, pseudopalisading necrosis, tissue factor regulation, and the tumor microenvironment. Her work bridges neuropathology with molecular oncology, exploring how vascular pathology and coagulation pathways influence tumor progression. She has also contributed to tissue engineering and oxidative stress in cardiovascular disease. Publication Trends: Her publications from 2000 to 2014 reflect a consistent focus on cancer biology, particularly glioblastoma pathogenesis. Early work includes studies on apoptosis and flavonoids, while her later research delves into transcriptional regulation, hypoxia response, and extracellular matrix interactions in brain tumors. Several key papers examine tissue factor expression modulated by PTEN, EGFR, and hypoxia, linking coagulation pathways to tumor aggressiveness. Scientific Awards: Lucien J. Robinstein Award for Best Paper in Neuro-oncology, American Association of Pathologists Advising and Grants: No information is available regarding students advised or research grants received. Labs and Teams: Dr. Rong has collaborated extensively with prominent researchers such as Erwin G. Van Meir and Daniel J. Brat, suggesting integration into a well-established neuro-oncology research team at Temple University or prior institutions. Her work implies access to neuropathology laboratories and tissue banking resources, though no specific lab name is mentioned.

Raj Kishoreمشاهده پروفایل

استاد

• Cardiovascular Repair and Regeneration
• Stem Cell Therapy
• Extracellular Vesicles and Exosomes
• +۷ مورد دیگر

Raj Kishore is a Professor at the Lewis Katz School of Medicine at Temple University, where he holds appointments in the Department of Cardiovascular Sciences and the Department of Medicine. He serves as Chair and Professor at the Lemole Center for Integrated Lymphatics and Vascular Research and is a key member of the Aging + Cardiovascular Discovery Center. His work bridges molecular cardiology, regenerative medicine, and vascular biology. Dr. Kishore earned his PhD and MD from the University of Lucknow, India, in 1995 and 1988, respectively, and completed his undergraduate studies there in 1986. His research has been continuously funded and published in top-tier journals. His research interests are centered on cardiovascular repair mechanisms after myocardial infarction. He investigates the therapeutic potential of stem cells, stem cell-derived exosomes, noncoding RNAs (including microRNAs and circular RNAs), and epigenetic modifications. A major focus is on developing cell-free therapies using exosomes as alternatives to whole-cell transplantation. His lab also studies diabetes-induced endothelial dysfunction, inflammation, and the impact of aging and gender on cardiac repair. He explores gene and mRNA-based therapeutics to enhance cardiomyocyte renewal. Analysis of his recent publications reveals a strong trend toward exosome-based therapies, epigenetic regulation, and metabolic reprogramming in stem cells for cardiac repair, particularly in diabetic conditions. His work frequently involves molecular signaling pathways such as STAT3, E2F1, VEGF, and TNF-alpha, and he has contributed significantly to understanding how microenvironmental factors influence regenerative capacity. Dr. Kishore has made significant scientific contributions, though specific awards are not listed in the provided text. His leadership is evident through his role as Chair and his extensive collaborative network. He actively mentors students and postdoctoral researchers, many of whom have become co-authors on high-impact publications. His lab is involved in grant-funded research exploring novel regenerative strategies. While specific grants are not listed, his publication record suggests sustained NIH or equivalent funding. His research is conducted within the Lemole Center for Integrated Lymphatics and Vascular Research and the Aging + Cardiovascular Discovery Center, both at Temple University, where he leads a multidisciplinary team focused on translational cardiovascular discovery.

Yuri Persidskyمشاهده پروفایل

استاد

• Neuroimmunology
• Blood-Brain Barrier
• Neuroinflammation
• +۷ مورد دیگر

Yuri Persidsky, MD, PhD, is Chair and Professor in the Department of Pathology & Laboratory Medicine at the Lewis Katz School of Medicine at Temple University. He is a board-certified pathologist specializing in anatomic pathology and nephropathology, with extensive experience in clinical laboratory administration. Education: PhD in Pathology, Kiev Research Institute of Urology and Nephrology, Ukrainian Ministry of Health, Kiev, Ukraine MD, Bogomolets National Medical University, Kiev, Ukraine Residency in Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE Dr. Persidsky's research is centered on the molecular mechanisms regulating the blood-brain barrier (BBB) under both physiological and pathological conditions. His work investigates neuroinflammation, HIV-1 brain infection, alcohol and drug abuse, pericyte dysfunction, biomarkers of BBB injury, and neuroprotective strategies. He has pioneered studies on the effects of cannabinoids on neural stem cells and the combined impact of alcohol and e-cigarettes on BBB integrity. The 12 publications listed, spanning from 1995 to 2015, reflect a sustained research trajectory in neuroimmunology and viral neuropathogenesis. The works consistently focus on the intersection of infectious disease (particularly HIV/SIV), substance abuse, and central nervous system pathology. Key themes include BBB dysfunction, neuroinflammation, and translational animal models. The research evolved from early work on SIV and lymphoid pathology to more recent investigations of alcohol and cannabinoid effects on the BBB, demonstrating both depth and adaptability in his scientific inquiry. Scientific Awards and Honors: MERIT grant, National Institute on Alcohol Abuse and Alcoholism (2010–2020) Wybran Award, Society on Neuroimmune Pharmacology (2011) Dr. Persidsky has secured significant research funding, including a major NIH grant to study the combined effects of alcohol and e-cigarette use on the blood-brain barrier, which provides over half a million dollars annually for five years. He advises no students listed in the text but leads a robust research program with multiple ongoing projects. His work is conducted within the academic and clinical infrastructure of Temple University Hospital and the Lewis Katz School of Medicine. Research Projects: Blood brain barrier injury in HIV infection complicated by diabetes: Mechanisms and protective strategies preventing cognitive impairment CNS injury caused by HIV-1 and alcohol: Protective effects of cannabinoid receptor 2 activation HIV-induced neuroinflammation associated with opioid abuse and tobacco smoke Secoisolariciresinol diglucoside to mitigate inflammation and toxicity in HIV associated dementia

Bradley D. Gelfandمشاهده پروفایل

استادیار

• Age-Related Macular Degeneration
• Immunology
• Molecular Biology
• +۱۲ مورد دیگر

Bradley D. Gelfand, Ph.D., is an Assistant Professor in the Department of Ophthalmology at the University of Virginia School of Medicine. His research integrates biomedical engineering, immunology, and molecular biology to study age-related macular degeneration (AMD) and retinal disease mechanisms. B.S., University of Iowa, 2004 Ph.D., University of Virginia, 2010 Postdoctoral Training, University of Kentucky, Department of Ophthalmology and Visual Sciences, 2012 Dr. Gelfand's research focuses on the molecular and biomechanical underpinnings of ocular diseases, particularly AMD. His work explores hemodynamics in the choroidal vasculature , DICER1 deficiency , Alu RNA toxicity , and inflammasome activation . Utilizing tools from medical imaging , signal processing , fluid mechanics , and computational modeling , his lab investigates how biomechanical and molecular changes in the eye's microenvironment lead to vision loss. His recent publications reveal key insights into the role of hemodynamic forces , inflammatory signaling (via NLRP3 and MyD88), and RNA processing defects in AMD. These studies, published in journals like Cell , Science , and Nature Communications , highlight converging pathways in retinal degeneration involving iron toxicity , reverse transcriptase inhibition , and endothelial cell regulation . Dr. Gelfand leads active research projects funded through grants focusing on the cellular and molecular consequences of blood supply in the eye. His lab employs high-resolution 3D microscopy and computational fluid dynamics to model choroidal anatomy and hemodynamics. He also uses advanced cell culture systems to simulate ocular hemodynamic environments for mechanistic studies. He advises students through his research laboratory and contributes to training the next generation of physician-scientists and biomedical engineers. Though no formal list of students is provided, his lab environment supports graduate and postgraduate research.

Christian Aalkjærمشاهده پروفایل

استاد

• Physiology
• Vascular Physiology
• Cardiovascular Physiology
• +۹ مورد دیگر

Christian Aalkjær is a Professor in the Department of Biomedicine at Aarhus University, Denmark. His research is centered on vascular and cardiovascular physiology, with a focus on hypertension, blood vessel function, and ion transport mechanisms. He has led major interdisciplinary projects, including the Danish Cardiovascular Giraffe Research Programme, investigating extreme physiological adaptations in giraffes to inform human cardiovascular disease. Research Interests: Physiology of resistance arteries and vascular tone Intracellular pH and ion transport (NBCn1, V-ATPase) Hypertension and cardiovascular remodeling Smooth muscle cell function Acid-base balance and water-salt metabolism Comparative physiology using giraffe models His recent publications (2023–2025) reflect a continued focus on vascular reactivity, small artery structure-function relationships, and molecular mechanisms in hypertension. Articles span topics from prorenin effects on mesenteric arteries to genetic causes of arrhythmia syndromes. Scientific Engagement: Active contributor to peer-reviewed journals such as Acta Physiologica , FASEB Journal , and Heart Rhythm Frequent invited speaker and lecturer on vascular physiology Public science communicator through media appearances on giraffe physiology and hypertension Advising and Research Leadership: While specific students are not listed, Aalkjær has supervised academic theses and mentored early-career researchers. He has been a project manager on major grants, including the DaGIR programme, and has secured long-term funding for cardiovascular research. He leads a research team focused on vascular mechanisms and collaborates extensively across disciplines. Laboratory and Research Environment: Based in the Skou Building at Aarhus University, his lab investigates vascular function using isolated vessel myography, molecular techniques, and in vivo models. The research environment emphasizes translational physiology, integrating basic science with clinical insights.

Rebeccah Bruscaمشاهده پروفایل

دانشیار

• Medical Education
• Health Equity
• Asylum Medicine
• +۵ مورد دیگر

Rebeccah Brusca, MD, MPH is an Associate Clinical Professor of Medicine at the University of California, San Francisco (UCSF) and an academic hospitalist at Zuckerberg San Francisco General Hospital (ZSFG). She is actively involved in medical education, serving as the Site Director for the Internal Medicine Residency at ZSFG and as a Bridges coach with the UCSF School of Medicine. She is also the Associate Medical Director of the UCSF Human Rights Collaborative, where she conducts forensic medical evaluations for asylum seekers. University: University of California, San Francisco School: School of Medicine Department: Department of Medicine Academic Rank: Associate Clinical Professor Email: rebeccah.brusca@ucsf.edu Dr. Brusca earned her M.D. from Johns Hopkins University School of Medicine (2015), completed residency in Internal Medicine at the Johns Hopkins Hospital Osler Program (2018), and holds an M.P.H. from the University of Ghana, School of Public Health (2009), with a focus on Population, Family, and Reproductive Health. She also completed the Diversity, Equity, and Inclusion Champion Training at UCSF in 2020. Her academic interests center on medical education, health equity, and asylum medicine . Her research spans HIV-related cardiovascular disease, critical care outcomes, interstitial lung disease, and public health disparities. She has been involved in major cohort studies such as the Multicenter AIDS Cohort Study (MACS) and the ARIC study, contributing to understanding chronic disease in vulnerable populations. Her 15 most recent publications reflect a strong trend in cardiovascular complications in HIV , critical care outcomes , and health equity . Topics include subclinical atherosclerosis in HIV patients, performance of ICU prediction models, and health disparities in surgical and infectious disease outcomes. Her work combines clinical insight with epidemiological rigor, often focusing on underserved populations. Dr. Brusca has received several honors, including: DHM Outstanding Educator Award, UCSF (2022) SOM Excellence in Teaching Award, UCSF (2022) Distinguished Teaching Society, Johns Hopkins (2018) American Heart Association Predoctoral Fellowship (2013) Rotary Ambassadorial Scholarship (2008) She has advised no publicly listed students but is deeply engaged in resident education and mentorship through her leadership roles. She leads initiatives in medical education reform and human rights advocacy, and is affiliated with the UCSF Health & Human Rights Initiative. There is no indication of retirement, part-time status, or former staff designation.

Christopher Marleyمشاهده پروفایل

مدرس ارشد

• Exercise Physiology
• Cerebrovascular Function
• Cognitive Neuroscience
• +۷ مورد دیگر

Christopher Marley is a Senior Lecturer in the Faculty of Life Sciences and Education at the University of South Wales, affiliated with the Sport and Exercise Research and Innovation Group. His work contributes to the UN Sustainable Development Goal on Education and focuses on the intersection of physical activity, brain health, and cognitive function. Education: PhD in Cardiorespiratory Fitness and its Impact on Cerebrovascular Function Across the Lifespan; Link to Cognition (2016) PgCert in Developing Professional Practice in Higher Education (2016) Diploma in Fitness Instructing and Personal Training (2017) BSc (Hons) Sport and Exercise Science (2010) His research explores how exercise, hypoxia, and metabolic factors influence cerebrovascular and cognitive health, particularly in athletes. Key areas include football heading, concussion, redox balance, and neurovascular coupling. The fingerprint of his work highlights expertise in Middle Cerebral Artery dynamics, football science, nitrosative stress, hypoxia, cognition, and cardiorespiratory fitness. His recent publications (2023–2025) reveal a strong focus on the neurological consequences of sports and environmental stressors, including soccer heading, hypoxia, and post-prandial metabolic challenges. These studies employ physiological and neurocognitive assessments to understand brain health in both young and older adults. Scientific Awards: USW Impact Awards - Impact on Health and Wellbeing (2024) Marley actively contributes to the academic community through peer review for Frontiers in Neurology and Routledge, and serves on committees including the Faculty of Life Sciences and Education and the Welsh Institute of Physical Activity, Health and Sport. He has supervised student research and is co-investigator on two major projects: 'Head injury iN sport: HAUNT' and 'Yr ymennydd ar uchder' (The Brain at Altitude), both running from 2024 to 2027. His public engagement includes media appearances on exercise for brain health and the risks of football heading. Labs and Research Groups: He is an active member of the Sport and Exercise Research and Innovation Group, which conducts interdisciplinary research on physical activity, health, and performance.

• Maternal-Fetal Medicine
• Preeclampsia
• Endothelial Dysfunction
• +۹ مورد دیگر

Molly McAdow, MD, PhD, is Assistant Professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine. She is a physician-scientist specializing in Maternal-Fetal Medicine and serves as Co-Medical Director of the Yale University Reproductive Sciences Biobank. She is actively involved in clinical care, research, and mentoring at Yale. MD and PhD in Microbiology, University of Chicago Residency in Obstetrics and Gynecology, Yale University Fellowship in Maternal-Fetal Medicine, Yale University Dr. McAdow's primary research focuses on the molecular mechanisms of endothelial dysfunction in preeclampsia, particularly the roles of Plasminogen Activator Inhibitors (PAI-1 and PAI-2) in modulating endothelial cell biology and nitric oxide synthase activity. She also investigates the biology of labor induction, comparing endogenous (nipple stimulation) and exogenous (IV oxytocin) pathways, and explores dyadic care models to reduce postpartum health disparities, especially among Black women. Her work bridges basic science, clinical investigation, and health equity. Her recent publications (2022–2024) reflect a strong emphasis on labor induction physiology, preeclampsia mechanisms, and maternal-infant health equity. These studies span clinical trials, mechanistic animal models, and systematic reviews, demonstrating interdisciplinary collaboration across obstetrics, immunology, and public health. Scientific awards and recognitions include: Yale Physician Scientist Development Award Doris Duke Fund to Retain Clinical Scientists - COVID19 Award Perinatal Research Society Young Investigators Workshop Awardee Medical Student Teaching Award C. Lee Buxton Research Day Award Dr. McAdow mentors postgraduate associates and medical students and serves as Principal Investigator for the STIM clinical trial on nipple stimulation therapy. She has received grant support from the Yale Center for Clinical Investigation, Society for Maternal Fetal Medicine, and Perinatal Research Consortium. Her research is conducted in collaboration with the Yale Cardiovascular Research Center and interdisciplinary teams across Yale. She is actively engaged in clinical and translational research through affiliations with the Maternal Fetal Medicine Unit, Reproductive Sciences, and the Janeway Society.

Hilary Carswellمشاهده پروفایل

مدرس ارشد

• Stroke Research
• Brain Damage and Repair
• Neuroinflammation
• +۷ مورد دیگر

Hilary Carswell is a Reader at the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), University of Strathclyde, within the Faculty of Science. Her research is centered on understanding brain damage and repair mechanisms, particularly in the context of stroke. She leads multiple research projects and supervises a team of PhD students and postdoctoral researchers. Research Interests: Her work focuses on two main strategies: modulating inflammation and utilizing stem cells for brain repair. She is particularly interested in in vivo and in vitro models of brain injury, with current projects aiming to improve the success of stem cell therapies and target the blood-brain barrier in stroke. Her research includes developing human cerebral organoids and 'stroke-on-a-chip' models to replace animal testing. Recent Publication Trends: Her latest publications (2023–2025) emphasize regenerative stroke therapies using silk biomaterials, human iPSC-derived organoids, and microfluidic models. These works highlight a shift toward human-relevant, non-animal models for stroke research, reflecting strong interdisciplinary collaboration in biotechnology and neuroscience. Fellow of British Pharmacological Society (FBPhS), 2024 Brain 2022 International Conference Award Winner of Best Teacher in Faculty of Science, Strathclyde Teaching Excellence Award, 2018 Multiple student awards for conference presentations Supervision and Funding: Dr. Carswell currently supervises 3 PhD students and 1 PDRA. Her research is funded by NC3Rs, Tenovus Scotland, Neurosciences Foundation, and international grants from Saudi Arabia and Thailand. She actively mentors students and promotes interdisciplinary science education. Labs and Collaborations: Her lab maintains strong national and international collaborations with stroke clinicians, immunologists, and pharmaceutical industry partners. She is involved in the 3Rs (Replacement, Reduction, Refinement) initiative and contributes to advancing human-relevant models in neuroscience.

• Physiology
• Metabolic Disorders
• Vascular Biology
• +۵ مورد دیگر

Vannina Elena González Marrachelli is an Associate Professor in the Department of Physiology at the Faculty of Medicine and Odontology, Universitat de València. She is a member of the METABOMARK Research Group on Metabolic Biomarkers, where her work focuses on physiological mechanisms underlying metabolic and vascular dysfunction. Her primary research interests lie in physiology , particularly in the context of diabetes and vascular reactivity . Her work explores how metabolic conditions such as experimental diabetes affect arterial responses, with a focus on endothelin-1 signaling in cerebral and renal vasculature. These interests extend to metabolic biomarkers , endothelial dysfunction , and cardiovascular complications of metabolic disease . Although no recent publications are listed in the provided text, her research trajectory suggests strong engagement with experimental models of diabetes and vascular physiology, likely contributing to the identification and validation of metabolic biomarkers relevant to cardiovascular risk. She completed her doctoral studies at the Universitat de València, where she investigated the influence of experimental diabetes on the reactivity of basilar, carotid, and renal arteries in rabbits to endothelin-1, under the supervision of Dr. Francisco Javier Miranda Alonso and Dr. Enrique Alborch Domínguez.

• Vascular Biology
• Chronic Kidney Disease
• Calciprotein Particles
• +۳ مورد دیگر

Dr. Lian Feenstra is a researcher at the University of Groningen , focusing on vascular biology and chronic kidney disease. Her work investigates how calciprotein particles trigger endothelial cell dysfunction and vascular calcification. Active in UN Sustainable Development Goals (SDGs) related to health and well-being Key collaborations include TransplantLines Investigators and international researchers Research Interests Feenstra's research explores the interplay between calciprotein particles and vascular pathology in chronic kidney disease. She examines mechanisms like: Paracrine signaling between endothelial and smooth muscle cells Calcium overload and mitochondrial dysfunction in endothelial cells Nitric oxide metabolism impairment leading to endothelial dysfunction Vascular remodeling in uremic conditions Gene expression profiling in calcification processes Publication Trends Her recent articles (2023–2025) emphasize calciprotein particle dynamics, endothelial cell stress, and their role in cardiovascular complications of chronic kidney disease, with significant cross-disciplinary focus on cell biology and nephrology.

Jens Peter von Kriesمشاهده پروفایل

پژوهشگر

• High-throughput Screening
• Chemical Biology
• Molecular Pharmacology
• +۱۰ مورد دیگر

Dr. Jens Peter von Kries is the Head of the Screening Unit at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin, Germany, within the Research Section of Chemical Biology. He leads a high-throughput screening platform that provides open-access services for academic and small-to-medium enterprise (SME) research projects. His research focuses on high-throughput screening (HTS) technologies, including biochemical and cell-based assays, automated liquid handling systems (Tecan, Beckman Coulter), acoustic dispensing, and advanced data analysis using R, Python, and KNIME workflows. His work supports drug discovery through services such as primary screening, hit validation, IC50 determination, LC-MS quality control, and Surface Plasmon Resonance (SPR) binding studies. He also oversees RNAi and CRISPR-based genetic screening and high-content imaging. A recent publication in Frontiers in Neurology (2023) highlights his involvement in studying the role of endothelial dysfunction and ACE-2 in SARS-CoV-2 pathogenesis and post-COVID neurological damage, indicating an expanding interest in the intersection of molecular pharmacology and neuroinfectious diseases. The publications analyzed show a strong emphasis on translational chemical biology , combining advanced screening technologies with mechanistic insights into disease pathways, particularly in virology and vascular biology. His work bridges assay development, data science, and biomedical application. Lead researcher in high-throughput screening and automation Expertise in assay development and validation for drug discovery Active contributor to research on molecular mechanisms of viral infections Dr. von Kries collaborates with academic teams and manages a multidisciplinary technical team within the Screening Unit. The facility operates as a core technology platform, supporting a wide range of external and internal research projects, with an emphasis on open access and scientific collaboration.