معرفی
Yuri Persidsky, MD, PhD, is Chair and Professor in the Department of Pathology & Laboratory Medicine at the Lewis Katz School of Medicine at Temple University. He is a board-certified pathologist specializing in anatomic pathology and nephropathology, with extensive experience in clinical laboratory administration.
Education:
- PhD in Pathology, Kiev Research Institute of Urology and Nephrology, Ukrainian Ministry of Health, Kiev, Ukraine
- MD, Bogomolets National Medical University, Kiev, Ukraine
- Residency in Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Dr. Persidsky's research is centered on the molecular mechanisms regulating the blood-brain barrier (BBB) under both physiological and pathological conditions. His work investigates neuroinflammation, HIV-1 brain infection, alcohol and drug abuse, pericyte dysfunction, biomarkers of BBB injury, and neuroprotective strategies. He has pioneered studies on the effects of cannabinoids on neural stem cells and the combined impact of alcohol and e-cigarettes on BBB integrity.
The 12 publications listed, spanning from 1995 to 2015, reflect a sustained research trajectory in neuroimmunology and viral neuropathogenesis. The works consistently focus on the intersection of infectious disease (particularly HIV/SIV), substance abuse, and central nervous system pathology. Key themes include BBB dysfunction, neuroinflammation, and translational animal models. The research evolved from early work on SIV and lymphoid pathology to more recent investigations of alcohol and cannabinoid effects on the BBB, demonstrating both depth and adaptability in his scientific inquiry.
Scientific Awards and Honors:
- MERIT grant, National Institute on Alcohol Abuse and Alcoholism (2010–2020)
- Wybran Award, Society on Neuroimmune Pharmacology (2011)
Dr. Persidsky has secured significant research funding, including a major NIH grant to study the combined effects of alcohol and e-cigarette use on the blood-brain barrier, which provides over half a million dollars annually for five years. He advises no students listed in the text but leads a robust research program with multiple ongoing projects. His work is conducted within the academic and clinical infrastructure of Temple University Hospital and the Lewis Katz School of Medicine.
Research Projects:
- Blood brain barrier injury in HIV infection complicated by diabetes: Mechanisms and protective strategies preventing cognitive impairment
- CNS injury caused by HIV-1 and alcohol: Protective effects of cannabinoid receptor 2 activation
- HIV-induced neuroinflammation associated with opioid abuse and tobacco smoke
- Secoisolariciresinol diglucoside to mitigate inflammation and toxicity in HIV associated dementia
